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Processing and size range separation of pristine and magnetic poly(l-lactic acid) based microspheres for biomedical applications

Journal Article


Abstract


  • Biodegradable poly(l-lactic acid) (PLLA) and PLLA/CoFe2O4 magnetic microspheres with average sizes ranging between 0.16-3.9 μm and 0.8-2.2 μm, respectively, were obtained by an oil-in-water emulsion method using poly(vinyl alcohol) (PVA) solution as the emulsifier agent. The separation of the microspheres in different size ranges was then performed by centrifugation and the colloidal stability assessed at different pH values. Neat PLLA spheres are more stable in alkaline environments when compared to magnetic microspheres, both types being stable for pHs higher than 4, resulting in a colloidal suspension. On the other hand, in acidic environments the microspheres tend to form aggregates. The neat PLLA microspheres show a degree of crystallinity of 40% whereas the composite ones are nearly amorphous (17%). Finally, the biocompatibility was assessed by cell viability studies with MC3T3-E1 pre-osteoblast cells.

UOW Authors


  •   Correia, Daniela M. (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Ribeiro, Clarisse (external author)
  •   Martins, P (external author)
  •   Gama, F M. (external author)
  •   Botelho, Gabriela (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2016

Citation


  • Correia, D. M., Sencadas, V., Ribeiro, C., Martins, P. M., Martins, P., Gama, F. M., Botelho, G. & Lanceros-Méndez, S. (2016). Processing and size range separation of pristine and magnetic poly(l-lactic acid) based microspheres for biomedical applications. Journal of Colloid and Interface Science, 476 79-86.

Scopus Eid


  • 2-s2.0-84968747328

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5584

Number Of Pages


  • 7

Start Page


  • 79

End Page


  • 86

Volume


  • 476

Abstract


  • Biodegradable poly(l-lactic acid) (PLLA) and PLLA/CoFe2O4 magnetic microspheres with average sizes ranging between 0.16-3.9 μm and 0.8-2.2 μm, respectively, were obtained by an oil-in-water emulsion method using poly(vinyl alcohol) (PVA) solution as the emulsifier agent. The separation of the microspheres in different size ranges was then performed by centrifugation and the colloidal stability assessed at different pH values. Neat PLLA spheres are more stable in alkaline environments when compared to magnetic microspheres, both types being stable for pHs higher than 4, resulting in a colloidal suspension. On the other hand, in acidic environments the microspheres tend to form aggregates. The neat PLLA microspheres show a degree of crystallinity of 40% whereas the composite ones are nearly amorphous (17%). Finally, the biocompatibility was assessed by cell viability studies with MC3T3-E1 pre-osteoblast cells.

UOW Authors


  •   Correia, Daniela M. (external author)
  •   Gomes da Silva Sencadas, Vitor
  •   Ribeiro, Clarisse (external author)
  •   Martins, P (external author)
  •   Gama, F M. (external author)
  •   Botelho, Gabriela (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2016

Citation


  • Correia, D. M., Sencadas, V., Ribeiro, C., Martins, P. M., Martins, P., Gama, F. M., Botelho, G. & Lanceros-Méndez, S. (2016). Processing and size range separation of pristine and magnetic poly(l-lactic acid) based microspheres for biomedical applications. Journal of Colloid and Interface Science, 476 79-86.

Scopus Eid


  • 2-s2.0-84968747328

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5584

Number Of Pages


  • 7

Start Page


  • 79

End Page


  • 86

Volume


  • 476