Skip to main content
placeholder image

Roles of extracellular nucleotides and P2 receptors in ectodomain shedding

Journal Article


Download full-text (Open Access)

Abstract


  • Ectodomain shedding of integral membrane receptors results in the release of soluble molecules and modification of the transmembrane portions to mediate or modulate extracellular and intracellular signalling. Ectodomain shedding is stimulated by a variety of mechanisms, including the activation of P2 receptors by extracellular nucleotides. This review describes in detail the roles of extracellular nucleotides and P2 receptors in the shedding of various cell surface molecules, including amyloid precursor protein, CD23, CD62L, and members of the epidermal growth factor, immunoglobulin and tumour necrosis factor families. This review discusses the mechanisms involved in P2 receptor-mediated shedding, demonstrating central roles for the P2 receptors, P2X7 and P2Y2, and the sheddases, ADAM10 and ADAM17, in this process in a number of cell types.

Publication Date


  • 2016

Citation


  • Pupovac, A. & Sluyter, R. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73 4159-4173.

Scopus Eid


  • 2-s2.0-84968543949

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1951&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/926

Number Of Pages


  • 14

Start Page


  • 4159

End Page


  • 4173

Volume


  • 73

Abstract


  • Ectodomain shedding of integral membrane receptors results in the release of soluble molecules and modification of the transmembrane portions to mediate or modulate extracellular and intracellular signalling. Ectodomain shedding is stimulated by a variety of mechanisms, including the activation of P2 receptors by extracellular nucleotides. This review describes in detail the roles of extracellular nucleotides and P2 receptors in the shedding of various cell surface molecules, including amyloid precursor protein, CD23, CD62L, and members of the epidermal growth factor, immunoglobulin and tumour necrosis factor families. This review discusses the mechanisms involved in P2 receptor-mediated shedding, demonstrating central roles for the P2 receptors, P2X7 and P2Y2, and the sheddases, ADAM10 and ADAM17, in this process in a number of cell types.

Publication Date


  • 2016

Citation


  • Pupovac, A. & Sluyter, R. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cellular and Molecular Life Sciences, 73 4159-4173.

Scopus Eid


  • 2-s2.0-84968543949

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1951&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/926

Number Of Pages


  • 14

Start Page


  • 4159

End Page


  • 4173

Volume


  • 73