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BrachyView: multiple seed position reconstruction and comparison with CT post-implant dosimetry

Journal Article


Abstract


  • BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 μ m diameter. BrachyView was able to resolve the seed positions within 1–2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan.

Authors


  •   Alnaghy, Saree (external author)
  •   Loo, Kevin J. (external author)
  •   Cutajar, Dean L.
  •   Jalayer, Masoud (external author)
  •   Tenconi, Chiara (external author)
  •   Favoino, Marco (external author)
  •   Rietti, Roberta (external author)
  •   Carriero, Francesco (external author)
  •   Safavi-Naeini, Mitra (external author)
  •   Bucci, Joseph A. (external author)
  •   Jakubek, Jan (external author)
  •   Pospisil, S (external author)
  •   Zaider, Marco (external author)
  •   Rosenfeld, Anatoly B.
  •   Petasecca, Marco

Publication Date


  • 2016

Citation


  • Alnaghy, S., Loo, K. J., Cutajar, D. L., Jalayer, M., Tenconi, C., Favoino, M., Rietti, R., Tartaglia, M., Carriero, F., Safavi-Naeini, M., Bucci, J., Jakubek, J., Pospisil, S., Zaider, M., Lerch, M. L. F., Rosenfeld, A. B. & Petasecca, M. (2016). BrachyView: multiple seed position reconstruction and comparison with CT post-implant dosimetry. Journal of Instrumentation, 11 (5), P05002-1-P05002-16.

Scopus Eid


  • 2-s2.0-84969234024

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/6000

Start Page


  • P05002-1

End Page


  • P05002-16

Volume


  • 11

Issue


  • 5

Abstract


  • BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 μ m diameter. BrachyView was able to resolve the seed positions within 1–2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan.

Authors


  •   Alnaghy, Saree (external author)
  •   Loo, Kevin J. (external author)
  •   Cutajar, Dean L.
  •   Jalayer, Masoud (external author)
  •   Tenconi, Chiara (external author)
  •   Favoino, Marco (external author)
  •   Rietti, Roberta (external author)
  •   Carriero, Francesco (external author)
  •   Safavi-Naeini, Mitra (external author)
  •   Bucci, Joseph A. (external author)
  •   Jakubek, Jan (external author)
  •   Pospisil, S (external author)
  •   Zaider, Marco (external author)
  •   Rosenfeld, Anatoly B.
  •   Petasecca, Marco

Publication Date


  • 2016

Citation


  • Alnaghy, S., Loo, K. J., Cutajar, D. L., Jalayer, M., Tenconi, C., Favoino, M., Rietti, R., Tartaglia, M., Carriero, F., Safavi-Naeini, M., Bucci, J., Jakubek, J., Pospisil, S., Zaider, M., Lerch, M. L. F., Rosenfeld, A. B. & Petasecca, M. (2016). BrachyView: multiple seed position reconstruction and comparison with CT post-implant dosimetry. Journal of Instrumentation, 11 (5), P05002-1-P05002-16.

Scopus Eid


  • 2-s2.0-84969234024

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/6000

Start Page


  • P05002-1

End Page


  • P05002-16

Volume


  • 11

Issue


  • 5