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Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study

Journal Article


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Abstract


  • Background. Acute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function.

    Methods. Prospective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD).

    Results. Flow mediated dilatation was 6.0 1.1% in acute stroke/TIA patients and 4.7 1.0% among control subjects (p = 0.18). The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18). Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 4.3%) and control subjects (19.1 2.6%; p = 0.43).

    Conclusions. Despite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD. © 2010 Beer et al; licensee BioMed Central Ltd.

Authors


  •   Etherton-Beer, Christopher (external author)
  •   Potter, Kathleen (external author)
  •   Blacker, David (external author)
  •   Arnolda, Leonard F.
  •   Hankey, Gaeme J. (external author)
  •   Puddey, Ian B. (external author)

Publication Date


  • 2010

Citation


  • Beer, C. D., Potter, K., Blacker, D., Arnolda, L., Hankey, G. J. & Puddey, I. B. (2010). Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. Cardiovascular Ultrasound, 8 (1), 1-5.

Scopus Eid


  • 2-s2.0-77957901186

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1813&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/790

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • 8

Issue


  • 1

Abstract


  • Background. Acute ischaemic stroke is associated with alteration in systemic markers of vascular function. We measured forearm vascular function (using forearm flow mediated dilatation) to clarify whether recent acute ischaemic stroke/TIA is associated with impaired systemic vascular function.

    Methods. Prospective case control study enrolling 17 patients with recent acute ischaemic stroke/TIA and 17 sex matched controls with stroke more than two years previously. Forearm vascular function was measured using flow medicated dilatation (FMD).

    Results. Flow mediated dilatation was 6.0 1.1% in acute stroke/TIA patients and 4.7 1.0% among control subjects (p = 0.18). The mean paired difference in FMD between subjects with recent acute stroke and controls was 1.25% (95% CI -0.65, 3.14; p = 0.18). Endothelium independent dilatation was measured in six pairs of participants and was similar in acute stroke/TIA patients (22.6 4.3%) and control subjects (19.1 2.6%; p = 0.43).

    Conclusions. Despite the small size of this study, these data indicate that recent acute stroke is not necessarily associated with a clinically important reduction in FMD. © 2010 Beer et al; licensee BioMed Central Ltd.

Authors


  •   Etherton-Beer, Christopher (external author)
  •   Potter, Kathleen (external author)
  •   Blacker, David (external author)
  •   Arnolda, Leonard F.
  •   Hankey, Gaeme J. (external author)
  •   Puddey, Ian B. (external author)

Publication Date


  • 2010

Citation


  • Beer, C. D., Potter, K., Blacker, D., Arnolda, L., Hankey, G. J. & Puddey, I. B. (2010). Systemic vascular function, measured with forearm flow mediated dilatation, in acute and stable cerebrovascular disease: a case-control study. Cardiovascular Ultrasound, 8 (1), 1-5.

Scopus Eid


  • 2-s2.0-77957901186

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1813&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/790

Number Of Pages


  • 4

Start Page


  • 1

End Page


  • 5

Volume


  • 8

Issue


  • 1