Abstract
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M-type K+ channels control excitability of many neuron types. M channel activity is potently enhanced by oxidative modification of triple cysteine pocket within the cytosolic linker between transmembrane domains 2 and 3. Thus, in sensory neurons from dorsal root (DRG) and trigeminal (TG) ganglia M channel activity is increased by the mitochondrial release of reactive oxygen species (ROS) induced by neuromodulator substance P. Here we identified a new signalling role for nitric oxide (NO) in TG sensory neurons.