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Ozonation of carbamazepine, diclofenac, sulfamethoxazole and trimethoprim and formation of major oxidation products

Journal Article


Abstract


  • The degradation of four pharmaceuticals, carbamazepine (CBZ), diclofenac (DCF), sulfamethoxazole (SMX) and trimethoprim (TMP) by ozonation was studied under a range of experimental conditions, including ozone dosage and concentration of target compounds. The concentration profile of the pharmaceuticals and detection of any by-products formed was carried out using liquid chromatography mass spectrometry. CBZ, DCF, TMP and SMX at initial concentration of 5 mg/L each were degraded to below the method detection limit (1 μg/L) when they reacted with 1.6, 2.3, 2.8 and 4.5 mg/L of ozone, respectively. For each parent compound several by-products were detected after the ozone treatment. A number of these by-products have not been previously reported in the literature. Some of these by-products were founds to be quite resistant to ozone up to applied ozone dosages of 15 mg/L.

Authors


  •   Alharbi, Sultan (external author)
  •   Price, William E.
  •   Kang, Jinguo (external author)
  •   Fujioka, Takahiro (external author)
  •   Nghiem, Long D. (external author)

Publication Date


  • 2016

Citation


  • Alharbi, S. K., Price, W. E., Kang, J., Fujioka, T. & Nghiem, L. D. (2016). Ozonation of carbamazepine, diclofenac, sulfamethoxazole and trimethoprim and formation of major oxidation products. Desalination and Water Treatment, 57 (60), 29340-29351.

Scopus Eid


  • 2-s2.0-84963600233

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4119

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 29340

End Page


  • 29351

Volume


  • 57

Issue


  • 60

Place Of Publication


  • United Kingdom

Abstract


  • The degradation of four pharmaceuticals, carbamazepine (CBZ), diclofenac (DCF), sulfamethoxazole (SMX) and trimethoprim (TMP) by ozonation was studied under a range of experimental conditions, including ozone dosage and concentration of target compounds. The concentration profile of the pharmaceuticals and detection of any by-products formed was carried out using liquid chromatography mass spectrometry. CBZ, DCF, TMP and SMX at initial concentration of 5 mg/L each were degraded to below the method detection limit (1 μg/L) when they reacted with 1.6, 2.3, 2.8 and 4.5 mg/L of ozone, respectively. For each parent compound several by-products were detected after the ozone treatment. A number of these by-products have not been previously reported in the literature. Some of these by-products were founds to be quite resistant to ozone up to applied ozone dosages of 15 mg/L.

Authors


  •   Alharbi, Sultan (external author)
  •   Price, William E.
  •   Kang, Jinguo (external author)
  •   Fujioka, Takahiro (external author)
  •   Nghiem, Long D. (external author)

Publication Date


  • 2016

Citation


  • Alharbi, S. K., Price, W. E., Kang, J., Fujioka, T. & Nghiem, L. D. (2016). Ozonation of carbamazepine, diclofenac, sulfamethoxazole and trimethoprim and formation of major oxidation products. Desalination and Water Treatment, 57 (60), 29340-29351.

Scopus Eid


  • 2-s2.0-84963600233

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/4119

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 29340

End Page


  • 29351

Volume


  • 57

Issue


  • 60

Place Of Publication


  • United Kingdom