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Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata

Journal Article


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Abstract


  • Five new oxoprotoberberine alkaloids, miliusacunines A–E (1–5), along with nine known compounds, 6–14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC50 value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC50 value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Jaidee, Atchara (external author)
  •   Cheenpracha, Sarot (external author)
  •   Trisuwan, Kongkiat (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2016

Citation


  • Promchai, T., Jaidee, A., Cheenpracha, S., Trisuwan, K., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., Pyne, S. G. & Ritthiwigrom, T. (2016). Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata. Journal of Natural Products, 79 (4), 978-983.

Scopus Eid


  • 2-s2.0-84969695160

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4732&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3709

Number Of Pages


  • 5

Start Page


  • 978

End Page


  • 983

Volume


  • 79

Issue


  • 4

Abstract


  • Five new oxoprotoberberine alkaloids, miliusacunines A–E (1–5), along with nine known compounds, 6–14, were isolated from an acetone extract of the leaves and twigs of Miliusa cuneata. Their structures were elucidated by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicities against the KB and Vero cell lines and for antimalarial activities against the Plasmodium falciparum strains TM4 and K1 (a sensitive and a multi-drug-resistant strain, respectively). Compound 1 showed in vitro antimalarial activity against the TM4 strain, with an IC50 value of 19.3 ± 3.4 μM, and compound 2 demonstrated significant activity against the K1 strain, with an IC50 value of 10.8 ± 4.1 μM. Both compounds showed no discernible cytotoxicity to the Vero cell line at the concentration levels evaluated.

UOW Authors


  •   Promchai, Thanika (external author)
  •   Jaidee, Atchara (external author)
  •   Cheenpracha, Sarot (external author)
  •   Trisuwan, Kongkiat (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Laphookhieo, Surat (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2016

Citation


  • Promchai, T., Jaidee, A., Cheenpracha, S., Trisuwan, K., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., Pyne, S. G. & Ritthiwigrom, T. (2016). Antimalarial oxoprotoberberine alkaloids from the leaves of Miliusa cuneata. Journal of Natural Products, 79 (4), 978-983.

Scopus Eid


  • 2-s2.0-84969695160

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4732&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3709

Number Of Pages


  • 5

Start Page


  • 978

End Page


  • 983

Volume


  • 79

Issue


  • 4