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In vitro mechanical fatigue behavior of poly-ɛ-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel

Journal Article


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Abstract


  • Polymeric scaffolds used in regenerative therapies

    are implanted in the damaged tissue and submitted to

    repeated loading cycles. In the case of articular cartilage

    engineering, an implanted scaffold is typically subjected to

    long-term dynamic compression. The evolution of the

    mechanical properties of the scaffold during bioresorption

    has been deeply studied in the past, but the possibility of

    failure due to mechanical fatigue has not been properly

    addressed. Nevertheless, the macroporous scaffold is susceptible

    to failure after repeated loading-unloading cycles. In

    this work fatigue studies of polycaprolactone scaffolds were

    carried by subjecting the scaffold to repeated compression

    cycles in conditions simulating the scaffold implanted in the

    articular cartilage. The behavior of the polycaprolactone

    sponge with the pores filled with a poly(vinyl alcohol) gel

    simulating the new formed tissue within the pores was compared

    with that of the material immersed in water. Results

    were analyzed with Morrow’s criteria for failure and accurate

    fittings are obtained just up to 200 loading cycles. It is also

    shown that the presence of poly(vinyl alcohol) increases the

    elastic modulus of the scaffolds, the effect being more pronounced

    with increasing the number of freeze/thawing

    cycles.

UOW Authors


  •   Panadero, J A. (external author)
  •   Vikingsson, L (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)
  •   Gomes da Silva Sencadas, Vitor

Publication Date


  • 2015

Citation


  • Panadero, J. A., Vikingsson, L., Gomez Ribelles, J. L., Lanceros-Méndez, S. & Sencadas, V. (2015). In vitro mechanical fatigue behavior of poly-ɛ-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 103 (5), 1037-1043.

Scopus Eid


  • 2-s2.0-84931834818

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6278&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5251

Number Of Pages


  • 6

Start Page


  • 1037

End Page


  • 1043

Volume


  • 103

Issue


  • 5

Abstract


  • Polymeric scaffolds used in regenerative therapies

    are implanted in the damaged tissue and submitted to

    repeated loading cycles. In the case of articular cartilage

    engineering, an implanted scaffold is typically subjected to

    long-term dynamic compression. The evolution of the

    mechanical properties of the scaffold during bioresorption

    has been deeply studied in the past, but the possibility of

    failure due to mechanical fatigue has not been properly

    addressed. Nevertheless, the macroporous scaffold is susceptible

    to failure after repeated loading-unloading cycles. In

    this work fatigue studies of polycaprolactone scaffolds were

    carried by subjecting the scaffold to repeated compression

    cycles in conditions simulating the scaffold implanted in the

    articular cartilage. The behavior of the polycaprolactone

    sponge with the pores filled with a poly(vinyl alcohol) gel

    simulating the new formed tissue within the pores was compared

    with that of the material immersed in water. Results

    were analyzed with Morrow’s criteria for failure and accurate

    fittings are obtained just up to 200 loading cycles. It is also

    shown that the presence of poly(vinyl alcohol) increases the

    elastic modulus of the scaffolds, the effect being more pronounced

    with increasing the number of freeze/thawing

    cycles.

UOW Authors


  •   Panadero, J A. (external author)
  •   Vikingsson, L (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Lanceros-Méndez, Senentxu (external author)
  •   Gomes da Silva Sencadas, Vitor

Publication Date


  • 2015

Citation


  • Panadero, J. A., Vikingsson, L., Gomez Ribelles, J. L., Lanceros-Méndez, S. & Sencadas, V. (2015). In vitro mechanical fatigue behavior of poly-ɛ-caprolactone macroporous scaffolds for cartilage tissue engineering: Influence of pore filling by a poly(vinyl alcohol) gel. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 103 (5), 1037-1043.

Scopus Eid


  • 2-s2.0-84931834818

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6278&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5251

Number Of Pages


  • 6

Start Page


  • 1037

End Page


  • 1043

Volume


  • 103

Issue


  • 5