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Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation

Journal Article


Abstract


  • Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.

Authors


  •   Tran, H (external author)
  •   Karamitros, M (external author)
  •   Ivanchenko, V N. (external author)
  •   Guatelli, Susanna
  •   McKinnon, Sally (external author)
  •   Murakami, K (external author)
  •   Sasaki, Takashi (external author)
  •   Okada, Susumu (external author)
  •   Bordage, M (external author)
  •   Francis, Z (external author)
  •   El Bitar, Z (external author)
  •   Bernal, M A. (external author)
  •   Shin, James (external author)
  •   Lee, Sang Bae (external author)
  •   Barberet, P (external author)
  •   Tran, T T. (external author)
  •   Brown, Jeremy M. C. (external author)
  •   Nhan Hao, T V. (external author)
  •   Incerti, Sebastien (external author)

Publication Date


  • 2016

Citation


  • Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S., Barberet, P., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V. & Incerti, S. (2016). Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 373 126-139.

Scopus Eid


  • 2-s2.0-84961201868

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5396

Number Of Pages


  • 13

Start Page


  • 126

End Page


  • 139

Volume


  • 373

Abstract


  • Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy.

Authors


  •   Tran, H (external author)
  •   Karamitros, M (external author)
  •   Ivanchenko, V N. (external author)
  •   Guatelli, Susanna
  •   McKinnon, Sally (external author)
  •   Murakami, K (external author)
  •   Sasaki, Takashi (external author)
  •   Okada, Susumu (external author)
  •   Bordage, M (external author)
  •   Francis, Z (external author)
  •   El Bitar, Z (external author)
  •   Bernal, M A. (external author)
  •   Shin, James (external author)
  •   Lee, Sang Bae (external author)
  •   Barberet, P (external author)
  •   Tran, T T. (external author)
  •   Brown, Jeremy M. C. (external author)
  •   Nhan Hao, T V. (external author)
  •   Incerti, Sebastien (external author)

Publication Date


  • 2016

Citation


  • Tran, H. N., Karamitros, M., Ivanchenko, V. N., Guatelli, S., McKinnon, S., Murakami, K., Sasaki, T., Okada, S., Bordage, M. C., Francis, Z., El Bitar, Z., Bernal, M. A., Shin, J. I., Lee, S., Barberet, P., Tran, T. T., Brown, J. M. C., Nhan Hao, T. V. & Incerti, S. (2016). Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 373 126-139.

Scopus Eid


  • 2-s2.0-84961201868

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5396

Number Of Pages


  • 13

Start Page


  • 126

End Page


  • 139

Volume


  • 373