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Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride)

Journal Article


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Abstract


  • Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three-dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive β-phase and show a crystallinity degree of ~ 45%. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young's modulus decrease, allowing tuning scaffold properties for specific tissues.

Authors


  •   Correia, Daniela M. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Sencadas, Vitor
  •   Vikingsson, L (external author)
  •   Oliver Gasch, M (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Botelho, Gabriela (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2016

Citation


  • Correia, D. M., Ribeiro, C., Sencadas, V., Vikingsson, L., Gasch, M. Oliver., Gomez Ribelles, J. L., Botelho, G. & Lanceros-Méndez, S. (2016). Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride). Materials and Design, 92 674-681.

Scopus Eid


  • 2-s2.0-84954548985

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6151&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5124

Number Of Pages


  • 7

Start Page


  • 674

End Page


  • 681

Volume


  • 92

Abstract


  • Cell supports based on electroactive materials, that generate electrical signal variations as a response to mechanical deformations and vice-versa, are gaining increasing attention for tissue engineering applications. In particular, poly(vinylidene fluoride), PVDF, has been proven to be suitable for these applications in the form of films and two-dimensional membranes. In this work, several strategies have been implemented in order to develop PVDF three-dimensional scaffolds. Three processing methods, including solvent casting with particulate leaching and three-dimensional nylon, and freeze extraction with poly(vinyl alcohol) templates are presented in order to obtain three-dimensional scaffolds with different architectures and interconnected porosity. Further, it is shown that the scaffolds are in the electroactive β-phase and show a crystallinity degree of ~ 45%. Finally, quasi-static mechanical measurements showed that an increase of the porous size within the scaffold leads to a tensile strengths and the Young's modulus decrease, allowing tuning scaffold properties for specific tissues.

Authors


  •   Correia, Daniela M. (external author)
  •   Ribeiro, Clarisse (external author)
  •   Sencadas, Vitor
  •   Vikingsson, L (external author)
  •   Oliver Gasch, M (external author)
  •   Gomez Ribelles, J L. (external author)
  •   Botelho, Gabriela (external author)
  •   Lanceros-Méndez, Senentxu (external author)

Publication Date


  • 2016

Citation


  • Correia, D. M., Ribeiro, C., Sencadas, V., Vikingsson, L., Gasch, M. Oliver., Gomez Ribelles, J. L., Botelho, G. & Lanceros-Méndez, S. (2016). Strategies for the development of three dimensional scaffolds from piezoelectric poly(vinylidene fluoride). Materials and Design, 92 674-681.

Scopus Eid


  • 2-s2.0-84954548985

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=6151&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/5124

Number Of Pages


  • 7

Start Page


  • 674

End Page


  • 681

Volume


  • 92