A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy

Journal Article


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Abstract


  • Nearly 30% of epilepsy cases cannot be adequately controlled with current medical treatments. The reasons for

    this are still not well understood, but there is a significant body of evidence pointing to the blood–brain barrier.

    Resective surgery can provide an alternative method of epilepsy control; however this treatment option is not

    suitable for most epilepsy sufferers. Local drug delivery through micro-injection to or implantation into the brain

    provides an innovative approach to bypass the blood–brain barrier for epilepsy treatment. In order to develop

    effective local delivery systems for anti-epilepsy drug (AED), we have prepared a variety of core–shell microcapsules

    via electrojetting, where a more hydrophobic polymer shell acts as a physical barrier to control the rate

    of drug release from the drug-loaded polymeric core. The resulting microcapsules demonstrate highly drug

    encapsulation efficiency, narrow size distribution and uniform morphology. Moreover, the release rate of AED

    can be modulated by controlling the morphologies of the core–shell microcapsules.

Publication Date


  • 2015

Citation


  • Chen, Y., Yue, Z., Moulton, S. E., Hayes, P., Cook, M. J. & Wallace, G. G. (2015). A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy. Journal of Materials Chemistry B, 3 7255-7266.

Scopus Eid


  • 2-s2.0-84941285675

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2687&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1685

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 7255

End Page


  • 7266

Volume


  • 3

Place Of Publication


  • United Kingdom

Abstract


  • Nearly 30% of epilepsy cases cannot be adequately controlled with current medical treatments. The reasons for

    this are still not well understood, but there is a significant body of evidence pointing to the blood–brain barrier.

    Resective surgery can provide an alternative method of epilepsy control; however this treatment option is not

    suitable for most epilepsy sufferers. Local drug delivery through micro-injection to or implantation into the brain

    provides an innovative approach to bypass the blood–brain barrier for epilepsy treatment. In order to develop

    effective local delivery systems for anti-epilepsy drug (AED), we have prepared a variety of core–shell microcapsules

    via electrojetting, where a more hydrophobic polymer shell acts as a physical barrier to control the rate

    of drug release from the drug-loaded polymeric core. The resulting microcapsules demonstrate highly drug

    encapsulation efficiency, narrow size distribution and uniform morphology. Moreover, the release rate of AED

    can be modulated by controlling the morphologies of the core–shell microcapsules.

Publication Date


  • 2015

Citation


  • Chen, Y., Yue, Z., Moulton, S. E., Hayes, P., Cook, M. J. & Wallace, G. G. (2015). A simple and versatile method for microencapsulation of anti-epileptic drugs for focal therapy of epilepsy. Journal of Materials Chemistry B, 3 7255-7266.

Scopus Eid


  • 2-s2.0-84941285675

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2687&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1685

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 7255

End Page


  • 7266

Volume


  • 3

Place Of Publication


  • United Kingdom