Nearly 30% of epilepsy cases cannot be adequately controlled with current medical treatments. The reasons for
this are still not well understood, but there is a significant body of evidence pointing to the blood–brain barrier.
Resective surgery can provide an alternative method of epilepsy control; however this treatment option is not
suitable for most epilepsy sufferers. Local drug delivery through micro-injection to or implantation into the brain
provides an innovative approach to bypass the blood–brain barrier for epilepsy treatment. In order to develop
effective local delivery systems for anti-epilepsy drug (AED), we have prepared a variety of core–shell microcapsules
via electrojetting, where a more hydrophobic polymer shell acts as a physical barrier to control the rate
of drug release from the drug-loaded polymeric core. The resulting microcapsules demonstrate highly drug
encapsulation efficiency, narrow size distribution and uniform morphology. Moreover, the release rate of AED
can be modulated by controlling the morphologies of the core–shell microcapsules.