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Interaction of BDNF with cytokines in chronic schizophrenia

Journal Article


Abstract


  • Brain-derived neurotrophic factor (BDNF) interacts with cytokines. Although both BDNF and cytokines occur at abnormal levels in schizophrenia patients, their interactions have not yet been examined. We therefore compared serum BDNF, TNF-alpha, interleukin (IL)-2, IL-6, and IL-8 levels in 92 chronically medicated schizophrenia patients and 60 healthy controls. We correlated these serum levels within these subject groups with each other and with clinical symptoms assessed according to the Positive and Negative Syndrome Scale (PANSS). Compared to the control group, the schizophrenia patients had significantly lower BDNF and TNF-alpha levels, and higher IL-2, IL-6, and IL-8 levels. The patients also showed a significant positive correlation between BDNF and both IL-2 and IL-8 levels, and low BDNF and TNF-alpha levels together were associated with poor performance on the PANSS cognitive factor. Thus, an interaction between cytokines and neurotrophic factors may be implicated in the pathophysiology of chronic schizophrenia. In particular, the cytokine TNF-alpha may interact with BNDF causing cognitive impairment.

Authors


  •   Zhang, Xiang Yang (external author)
  •   Tan, Yun-Long (external author)
  •   Chen, Da Chun (external author)
  •   Tan, Shu-Ping (external author)
  •   Yang, Fu-De (external author)
  •   Wu, Hanjing (external author)
  •   Zunta-Soares, Giovana B. (external author)
  •   Huang, Xu-Feng
  •   Kosten, Thomas R. (external author)
  •   Soares, Jair C. (external author)

Publication Date


  • 2016

Citation


  • Zhang, X., Tan, Y., Chen, D., Tan, S., Yang, F., Wu, H. Emily., Zunta-Soares, G. B., Huang, X., Kosten, T. R. & Soares, J. C. (2016). Interaction of BDNF with cytokines in chronic schizophrenia. Brain, Behavior, and Immunity, 51 169-175.

Scopus Eid


  • 2-s2.0-84948800339

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/676

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 169

End Page


  • 175

Volume


  • 51

Place Of Publication


  • United States

Abstract


  • Brain-derived neurotrophic factor (BDNF) interacts with cytokines. Although both BDNF and cytokines occur at abnormal levels in schizophrenia patients, their interactions have not yet been examined. We therefore compared serum BDNF, TNF-alpha, interleukin (IL)-2, IL-6, and IL-8 levels in 92 chronically medicated schizophrenia patients and 60 healthy controls. We correlated these serum levels within these subject groups with each other and with clinical symptoms assessed according to the Positive and Negative Syndrome Scale (PANSS). Compared to the control group, the schizophrenia patients had significantly lower BDNF and TNF-alpha levels, and higher IL-2, IL-6, and IL-8 levels. The patients also showed a significant positive correlation between BDNF and both IL-2 and IL-8 levels, and low BDNF and TNF-alpha levels together were associated with poor performance on the PANSS cognitive factor. Thus, an interaction between cytokines and neurotrophic factors may be implicated in the pathophysiology of chronic schizophrenia. In particular, the cytokine TNF-alpha may interact with BNDF causing cognitive impairment.

Authors


  •   Zhang, Xiang Yang (external author)
  •   Tan, Yun-Long (external author)
  •   Chen, Da Chun (external author)
  •   Tan, Shu-Ping (external author)
  •   Yang, Fu-De (external author)
  •   Wu, Hanjing (external author)
  •   Zunta-Soares, Giovana B. (external author)
  •   Huang, Xu-Feng
  •   Kosten, Thomas R. (external author)
  •   Soares, Jair C. (external author)

Publication Date


  • 2016

Citation


  • Zhang, X., Tan, Y., Chen, D., Tan, S., Yang, F., Wu, H. Emily., Zunta-Soares, G. B., Huang, X., Kosten, T. R. & Soares, J. C. (2016). Interaction of BDNF with cytokines in chronic schizophrenia. Brain, Behavior, and Immunity, 51 169-175.

Scopus Eid


  • 2-s2.0-84948800339

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/676

Has Global Citation Frequency


Number Of Pages


  • 6

Start Page


  • 169

End Page


  • 175

Volume


  • 51

Place Of Publication


  • United States