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Probing molecular choreography through single-molecule biochemistry

Journal Article


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Abstract


  • Single-molecule approaches are having a dramatic impact on views of how proteins work. The ability to observe molecular properties at the single-molecule level allows characterization of subpopulations and acquisition of detailed kinetic information that would otherwise be hidden in the averaging over an ensemble of molecules. In this Perspective, we discuss how such approaches have successfully been applied to in vitro–reconstituted systems of increasing complexity.

Publication Date


  • 2015

Citation


  • van Oijen, A. M. & Dixon, N. E. (2015). Probing molecular choreography through single-molecule biochemistry. Nature Structural and Molecular Biology, 22 (12), 948-952.

Scopus Eid


  • 2-s2.0-84949500361

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4394&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3371

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 948

End Page


  • 952

Volume


  • 22

Issue


  • 12

Place Of Publication


  • United States

Abstract


  • Single-molecule approaches are having a dramatic impact on views of how proteins work. The ability to observe molecular properties at the single-molecule level allows characterization of subpopulations and acquisition of detailed kinetic information that would otherwise be hidden in the averaging over an ensemble of molecules. In this Perspective, we discuss how such approaches have successfully been applied to in vitro–reconstituted systems of increasing complexity.

Publication Date


  • 2015

Citation


  • van Oijen, A. M. & Dixon, N. E. (2015). Probing molecular choreography through single-molecule biochemistry. Nature Structural and Molecular Biology, 22 (12), 948-952.

Scopus Eid


  • 2-s2.0-84949500361

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4394&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3371

Has Global Citation Frequency


Number Of Pages


  • 4

Start Page


  • 948

End Page


  • 952

Volume


  • 22

Issue


  • 12

Place Of Publication


  • United States