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Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens

Journal Article


Abstract


  • Silver nanoparticles (AgNPs) containing hydrogel composite were first synthesized by preparing a new hydrogel from carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and the cross-linker ethylene glycol diglycidyl ether (EGDE), followed by the incorporation of AgNPs by microwave radiation. The resulting neat hydrogels and AgNPs-hydrogel composites were characterized using spectral, thermal, microscopic analysis and X-ray diffraction (XRD) analyses. The SEM and TEM results demonstrated that the synthesized AgNPs were spherical with diameters ranging from 8 to 14 nm. In addition, the XRD analysis confirmed the nanocrystalline phase of silver with face-centered cubic (FCC) crystal structure. Energy dispersive spectroscopy (EDS) analysis of the AgNPs confirmed the presence of an elemental silver signal, and no peaks of any other impurities were detected. Additionally, the antibacterial activities of the neat hydrogel and AgNPs-hydrogel composites were measured by Kirby-Bauer method against urinary tract infection (UTI) pathogens. The rheology measurement revealed that the values of storage modulus (G′) were higher than that of loss modulus (G″). The AgNPs-hydrogel composites exhibited higher antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus and Proteus mirabilis compared to the corresponding neat hydrogel.

Authors


  •   Alshehri, Saad M. (external author)
  •   Aldalbahi, Ali (external author)
  •   Al-Hajji, Abdullah Baker (external author)
  •   Chaudhary, Anis Ahmad (external author)
  •   in het Panhuis, Marc
  •   Alhokbany, Norah (external author)
  •   Ahamad, Tansir (external author)

Publication Date


  • 2016

Citation


  • Alshehri, S. M., Aldalbahi, A., Al-Hajji, A., Chaudhary, A., in het Panhuis, M., Alhokbany, N. & Ahamad, T. (2016). Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens. Carbohydrate Polymers, 138 229-236.

Scopus Eid


  • 2-s2.0-84949548978

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3596

Number Of Pages


  • 7

Start Page


  • 229

End Page


  • 236

Volume


  • 138

Abstract


  • Silver nanoparticles (AgNPs) containing hydrogel composite were first synthesized by preparing a new hydrogel from carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and the cross-linker ethylene glycol diglycidyl ether (EGDE), followed by the incorporation of AgNPs by microwave radiation. The resulting neat hydrogels and AgNPs-hydrogel composites were characterized using spectral, thermal, microscopic analysis and X-ray diffraction (XRD) analyses. The SEM and TEM results demonstrated that the synthesized AgNPs were spherical with diameters ranging from 8 to 14 nm. In addition, the XRD analysis confirmed the nanocrystalline phase of silver with face-centered cubic (FCC) crystal structure. Energy dispersive spectroscopy (EDS) analysis of the AgNPs confirmed the presence of an elemental silver signal, and no peaks of any other impurities were detected. Additionally, the antibacterial activities of the neat hydrogel and AgNPs-hydrogel composites were measured by Kirby-Bauer method against urinary tract infection (UTI) pathogens. The rheology measurement revealed that the values of storage modulus (G′) were higher than that of loss modulus (G″). The AgNPs-hydrogel composites exhibited higher antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus and Proteus mirabilis compared to the corresponding neat hydrogel.

Authors


  •   Alshehri, Saad M. (external author)
  •   Aldalbahi, Ali (external author)
  •   Al-Hajji, Abdullah Baker (external author)
  •   Chaudhary, Anis Ahmad (external author)
  •   in het Panhuis, Marc
  •   Alhokbany, Norah (external author)
  •   Ahamad, Tansir (external author)

Publication Date


  • 2016

Citation


  • Alshehri, S. M., Aldalbahi, A., Al-Hajji, A., Chaudhary, A., in het Panhuis, M., Alhokbany, N. & Ahamad, T. (2016). Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens. Carbohydrate Polymers, 138 229-236.

Scopus Eid


  • 2-s2.0-84949548978

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3596

Number Of Pages


  • 7

Start Page


  • 229

End Page


  • 236

Volume


  • 138