Development and characterization of novel hybrid hydrogel fibers

Journal Article


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Abstract


  • Biopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the sheath, were fabricated for the first time without using a template. Hereby, the necessary conditions to achieve chitosan-alginate core-sheath fibre via a wet-spinning process are presented. SEM micrographs show the cylinder-shaped monofilament structure of the chitosan core surrounded by the alginate sheath. The coaxial fibres exhibit a 260% increase in ultimate stress and more than 300% enhancement in the Young's modulus compared to the alginate counterpart. Release profiles from the coaxial fibre were determined using a model component. The obtained results suggest that the fibres are likely to find applications as 3D tissue scaffolds capable of drug delivery.

Publication Date


  • 2015

Citation


  • Mirabedini, A., Foroughi, J., Romeo, T. & Wallace, G. G. (2015). Development and characterization of novel hybrid hydrogel fibers. Macromolecular Materials and Engineering, 300 (12), 1217-1225.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2655&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1653

Number Of Pages


  • 8

Start Page


  • 1217

End Page


  • 1225

Volume


  • 300

Issue


  • 12

Abstract


  • Biopolymeric continuous core-sheath fibres, with an inner core of chitosan and alginate as the sheath, were fabricated for the first time without using a template. Hereby, the necessary conditions to achieve chitosan-alginate core-sheath fibre via a wet-spinning process are presented. SEM micrographs show the cylinder-shaped monofilament structure of the chitosan core surrounded by the alginate sheath. The coaxial fibres exhibit a 260% increase in ultimate stress and more than 300% enhancement in the Young's modulus compared to the alginate counterpart. Release profiles from the coaxial fibre were determined using a model component. The obtained results suggest that the fibres are likely to find applications as 3D tissue scaffolds capable of drug delivery.

Publication Date


  • 2015

Citation


  • Mirabedini, A., Foroughi, J., Romeo, T. & Wallace, G. G. (2015). Development and characterization of novel hybrid hydrogel fibers. Macromolecular Materials and Engineering, 300 (12), 1217-1225.

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2655&context=aiimpapers

Ro Metadata Url


  • http://ro.uow.edu.au/aiimpapers/1653

Number Of Pages


  • 8

Start Page


  • 1217

End Page


  • 1225

Volume


  • 300

Issue


  • 12