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Towards soft robotic devices for site-specific drug delivery

Journal Article


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Abstract


  • Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications.

Publication Date


  • 2015

Citation


  • Alici, G. (2015). Towards soft robotic devices for site-specific drug delivery. Expert Review of Medical Devices, 12 (6), 703-715.

Scopus Eid


  • 2-s2.0-84947029916

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5834&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/4807

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 703

End Page


  • 715

Volume


  • 12

Issue


  • 6

Place Of Publication


  • United Kingdom

Abstract


  • Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specific drug delivery (site-specific, controlled, targeted or smart drug delivery are terms used interchangeably in the literature, to mean to transport a drug or a therapeutic agent to a desired location within the body and release it as desired with negligibly small toxicity and side effect compared to classical drug administration means such as peroral, parenteral, transmucosal, topical and inhalation) based on mechanical/physical systems consisting of implantable and robotic drug delivery systems. While we specifically focus on the robotic or autonomous DDS, which can be reprogrammable and provide multiple doses of a drug at a required time and rate, we briefly cover the implanted DDS, which are well-developed relative to the robotic DDS, to highlight the design and performance requirements, and investigate issues associated with the robotic DDS. Critical research issues associated with both DDSs are presented to describe the research challenges ahead of us in order to establish soft robotic devices for clinical and biomedical applications.

Publication Date


  • 2015

Citation


  • Alici, G. (2015). Towards soft robotic devices for site-specific drug delivery. Expert Review of Medical Devices, 12 (6), 703-715.

Scopus Eid


  • 2-s2.0-84947029916

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5834&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/4807

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 703

End Page


  • 715

Volume


  • 12

Issue


  • 6

Place Of Publication


  • United Kingdom