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P2X and P2Y receptor signaling in red blood cells

Journal Article


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Abstract


  • Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation, and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology.

Publication Date


  • 2015

Citation


  • Sluyter, R. (2015). P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences, 2 (October), 60-1-60-7.

Scopus Eid


  • 2-s2.0-84970978814

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4285&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3262

Start Page


  • 60-1

End Page


  • 60-7

Volume


  • 2

Issue


  • October

Place Of Publication


  • Switzerland

Abstract


  • Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation, and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology.

Publication Date


  • 2015

Citation


  • Sluyter, R. (2015). P2X and P2Y receptor signaling in red blood cells. Frontiers in Molecular Biosciences, 2 (October), 60-1-60-7.

Scopus Eid


  • 2-s2.0-84970978814

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4285&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3262

Start Page


  • 60-1

End Page


  • 60-7

Volume


  • 2

Issue


  • October

Place Of Publication


  • Switzerland