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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Journal Article


Abstract


  • Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300–10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

UOW Authors


  •   Ripke, Stephan (external author)
  •   O'Dushlaine, Colm (external author)
  •   Chambert, Kimberly (external author)
  •   Moran, Jennifer L. (external author)
  •   Kahler, Anna K. (external author)
  •   Akterin, Susanne (external author)
  •   Bergen, Sarah E. (external author)
  •   Collins, Ann L. (external author)
  •   Crowley, James J. (external author)
  •   Schwab, Sibylle

Publication Date


  • 2013

Citation


  • Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J. L., Kahler, A. K., Akterin, S., Bergen, S. E., Collins, A. L., Crowley, J. J., Schwab, S. G. et al (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45 1150-1159.

Scopus Eid


  • 2-s2.0-84885020424

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/560

Number Of Pages


  • 9

Start Page


  • 1150

End Page


  • 1159

Volume


  • 45

Abstract


  • Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300–10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

UOW Authors


  •   Ripke, Stephan (external author)
  •   O'Dushlaine, Colm (external author)
  •   Chambert, Kimberly (external author)
  •   Moran, Jennifer L. (external author)
  •   Kahler, Anna K. (external author)
  •   Akterin, Susanne (external author)
  •   Bergen, Sarah E. (external author)
  •   Collins, Ann L. (external author)
  •   Crowley, James J. (external author)
  •   Schwab, Sibylle

Publication Date


  • 2013

Citation


  • Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J. L., Kahler, A. K., Akterin, S., Bergen, S. E., Collins, A. L., Crowley, J. J., Schwab, S. G. et al (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45 1150-1159.

Scopus Eid


  • 2-s2.0-84885020424

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/560

Number Of Pages


  • 9

Start Page


  • 1150

End Page


  • 1159

Volume


  • 45