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Protective effect of the orientin on noise-induced cognitive impairments in mice

Journal Article


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Abstract


  • There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noise-induced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline.

Authors


  •   Wang, Shu-Ting (external author)
  •   Yu, Yinghua
  •   Feng, Yan (external author)
  •   Zou, Fang (external author)
  •   Zhang, Xiaofei (external author)
  •   Huang, Jie (external author)
  •   Zhang, Yuyun (external author)
  •   Zheng, Xian (external author)
  •   Huang, Xu-Feng
  •   Zhu, Yufu (external author)
  •   Liu, Yi (external author)

Publication Date


  • 2016

Citation


  • Wang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

Scopus Eid


  • 2-s2.0-84942774279

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1576&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/554

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 290

End Page


  • 300

Volume


  • 296

Place Of Publication


  • Netherlands

Abstract


  • There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noise-induced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline.

Authors


  •   Wang, Shu-Ting (external author)
  •   Yu, Yinghua
  •   Feng, Yan (external author)
  •   Zou, Fang (external author)
  •   Zhang, Xiaofei (external author)
  •   Huang, Jie (external author)
  •   Zhang, Yuyun (external author)
  •   Zheng, Xian (external author)
  •   Huang, Xu-Feng
  •   Zhu, Yufu (external author)
  •   Liu, Yi (external author)

Publication Date


  • 2016

Citation


  • Wang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

Scopus Eid


  • 2-s2.0-84942774279

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1576&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/554

Has Global Citation Frequency


Number Of Pages


  • 10

Start Page


  • 290

End Page


  • 300

Volume


  • 296

Place Of Publication


  • Netherlands