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Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice

Journal Article


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Abstract


  • Scope

    Obesity impairs cognition, and the leptin-induced increase of brain-derived neurotrophic factor (BDNF) and neurogenesis. Tea consumption improves cognition and increases brain activation in the prefrontal cortex.

    Methods and results

    This study examined whether teasaponin, an active ingredient in tea, could improve memory and central leptin effects on neurogenesis in the prefrontal cortex of obese mice, and in vitro in cultured prefrontal cortical neurons. Teasaponin (10 mg/kg, intraperitoneal) for 21 days improved downstream leptin signaling (JAK2 and STAT3), and leptin's effect on BDNF, in the prefrontal cortex of high-fat diet (HFD) fed mice. Prefrontal cortical neurons were cultured with teasaponin and palmitic acid (the most abundant dietary saturated fatty acid) to examine their effects on neurogenesis and BDNF expression in response to leptin. Palmitic acid decreased leptin's effect on neurite outgrowth, postsynaptic density protein 95, and BDNF expression in cultured cortical neurons, which was reversed by teasaponin.

    Conclusion

    Teasaponin improved the leptin sensitivity of prefrontal cortical neurons in obese mice or when treated by palmitic acid. This in turn increased BDNF expression and neurite growth. Therefore, teasaponin supplementation may be used to prevent obesity-associated neurodegeneration and improve cognitive function.

Authors


  •   Yu, Yinghua
  •   Wu, Yizhen (external author)
  •   Szabo, Alexander M. (external author)
  •   Wang, Sen (external author)
  •   Yu, Shijia (external author)
  •   Wang, Dennis (external author)
  •   Huang, Xu-Feng

Publication Date


  • 2015

Citation


  • Yu, Y., Wu, Y., Szabo, A. M., Wang, S., Yu, S., Wang, Q. & Huang, X. (2015). Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice. Molecular Nutrition and Food Research, 59 (12), 2371-2382.

Scopus Eid


  • 2-s2.0-84954375743

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1575&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/553

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 2371

End Page


  • 2382

Volume


  • 59

Issue


  • 12

Place Of Publication


  • Germany

Abstract


  • Scope

    Obesity impairs cognition, and the leptin-induced increase of brain-derived neurotrophic factor (BDNF) and neurogenesis. Tea consumption improves cognition and increases brain activation in the prefrontal cortex.

    Methods and results

    This study examined whether teasaponin, an active ingredient in tea, could improve memory and central leptin effects on neurogenesis in the prefrontal cortex of obese mice, and in vitro in cultured prefrontal cortical neurons. Teasaponin (10 mg/kg, intraperitoneal) for 21 days improved downstream leptin signaling (JAK2 and STAT3), and leptin's effect on BDNF, in the prefrontal cortex of high-fat diet (HFD) fed mice. Prefrontal cortical neurons were cultured with teasaponin and palmitic acid (the most abundant dietary saturated fatty acid) to examine their effects on neurogenesis and BDNF expression in response to leptin. Palmitic acid decreased leptin's effect on neurite outgrowth, postsynaptic density protein 95, and BDNF expression in cultured cortical neurons, which was reversed by teasaponin.

    Conclusion

    Teasaponin improved the leptin sensitivity of prefrontal cortical neurons in obese mice or when treated by palmitic acid. This in turn increased BDNF expression and neurite growth. Therefore, teasaponin supplementation may be used to prevent obesity-associated neurodegeneration and improve cognitive function.

Authors


  •   Yu, Yinghua
  •   Wu, Yizhen (external author)
  •   Szabo, Alexander M. (external author)
  •   Wang, Sen (external author)
  •   Yu, Shijia (external author)
  •   Wang, Dennis (external author)
  •   Huang, Xu-Feng

Publication Date


  • 2015

Citation


  • Yu, Y., Wu, Y., Szabo, A. M., Wang, S., Yu, S., Wang, Q. & Huang, X. (2015). Teasaponin improves leptin sensitivity in the prefrontal cortex of obese mice. Molecular Nutrition and Food Research, 59 (12), 2371-2382.

Scopus Eid


  • 2-s2.0-84954375743

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1575&context=ihmri

Ro Metadata Url


  • http://ro.uow.edu.au/ihmri/553

Has Global Citation Frequency


Number Of Pages


  • 11

Start Page


  • 2371

End Page


  • 2382

Volume


  • 59

Issue


  • 12

Place Of Publication


  • Germany