Accuracy and utility of deformable image registration in 68Ga 4D PET/CT assessment of pulmonary perfusion changes during and after lung radiation therapy

Purpose: Measuring changes in lung perfusion resulting from radiation therapy dose requires registration of the functional imaging to the radiation therapy treatment planning scan. This study investigates registration accuracy and utility for positron emission tomography (PET)/computed tomography (CT) perfusion imaging in radiation therapy for non-small cell lung cancer.