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Dean-flow-coupled elasto-inertial three-dimensional particle focusing under viscoelastic flow in a straight channel with asymmetrical expansion–contraction cavity arrays

Journal Article


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Abstract


  • In this paper, 3D particle focusing in a straight channel with asymmetrical

    expansion–contraction cavity arrays (ECCA channel) is achieved by exploiting the

    dean-flow-coupled elasto-inertial effects. First, the mechanism of particle focusing

    in both Newtonian and non-Newtonian fluids was introduced. Then particle focusing

    was demonstrated experimentally in this channel with Newtonian and non-

    Newtonian fluids using three different sized particles (3.2 lm, 4.8 lm, and 13 lm),

    respectively. Also, the effects of dean flow (or secondary flow) induced by expansion–

    contraction cavity arrays were highlighted by comparing the particle distributions

    in a single straight rectangular channel with that in the ECCA channel.

    Finally, the influences of flow rates and distances from the inlet on focusing performance

    in the ECCA channel were studied. The results show that in the ECCA

    channel particles are focused on the cavity side in Newtonian fluid due to the synthesis

    effects of inertial and dean-drag force, whereas the particles are focused on

    the opposite cavity side in non-Newtonian fluid due to the addition of viscoelastic

    force. Compared with the focusing performance in Newtonian fluid, the particles

    are more easily and better focused in non-Newtonian fluid. Besides, the Dean flow

    in visco-elastic fluid in the ECCA channel improves the particle focusing performance

    compared with that in a straight channel. A further advantage is threedimensional

    (3D) particle focusing that in non-Newtonian fluid is realized according

    to the lateral side view of the channel while only two-dimensional (2D) particle

    focusing can be achieved in Newtonian fluid. Conclusively, this novel Dean-flowcoupled

    elasto-inertial microfluidic device could offer a continuous, sheathless, and

    high throughput (>10 000 s-1) 3D focusing performance, which may be valuable

    in various applications from high speed flow cytometry to cell counting, sorting,

    and analysis.

Authors


  •   Yuan, Dan (external author)
  •   Zhang, Jun (external author)
  •   Yan, Sheng (external author)
  •   Pan, Chao (external author)
  •   Alici, Gursel
  •   Nguyen, Nam-Trung (external author)
  •   Li, Weihua

Publication Date


  • 2015

Citation


  • Yuan, D., Zhang, J., Yan, S., Pan, C., Alici, G., Nguyen, N. T. & Li, W. H. (2015). Dean-flow-coupled elasto-inertial three-dimensional particle focusing under viscoelastic flow in a straight channel with asymmetrical expansion–contraction cavity arrays. Biomicrofluidics, 9 044108-1-044108-13.

Scopus Eid


  • 2-s2.0-84938125329

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5295&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/4274

Has Global Citation Frequency


Start Page


  • 044108-1

End Page


  • 044108-13

Volume


  • 9

Place Of Publication


  • United States

Abstract


  • In this paper, 3D particle focusing in a straight channel with asymmetrical

    expansion–contraction cavity arrays (ECCA channel) is achieved by exploiting the

    dean-flow-coupled elasto-inertial effects. First, the mechanism of particle focusing

    in both Newtonian and non-Newtonian fluids was introduced. Then particle focusing

    was demonstrated experimentally in this channel with Newtonian and non-

    Newtonian fluids using three different sized particles (3.2 lm, 4.8 lm, and 13 lm),

    respectively. Also, the effects of dean flow (or secondary flow) induced by expansion–

    contraction cavity arrays were highlighted by comparing the particle distributions

    in a single straight rectangular channel with that in the ECCA channel.

    Finally, the influences of flow rates and distances from the inlet on focusing performance

    in the ECCA channel were studied. The results show that in the ECCA

    channel particles are focused on the cavity side in Newtonian fluid due to the synthesis

    effects of inertial and dean-drag force, whereas the particles are focused on

    the opposite cavity side in non-Newtonian fluid due to the addition of viscoelastic

    force. Compared with the focusing performance in Newtonian fluid, the particles

    are more easily and better focused in non-Newtonian fluid. Besides, the Dean flow

    in visco-elastic fluid in the ECCA channel improves the particle focusing performance

    compared with that in a straight channel. A further advantage is threedimensional

    (3D) particle focusing that in non-Newtonian fluid is realized according

    to the lateral side view of the channel while only two-dimensional (2D) particle

    focusing can be achieved in Newtonian fluid. Conclusively, this novel Dean-flowcoupled

    elasto-inertial microfluidic device could offer a continuous, sheathless, and

    high throughput (>10 000 s-1) 3D focusing performance, which may be valuable

    in various applications from high speed flow cytometry to cell counting, sorting,

    and analysis.

Authors


  •   Yuan, Dan (external author)
  •   Zhang, Jun (external author)
  •   Yan, Sheng (external author)
  •   Pan, Chao (external author)
  •   Alici, Gursel
  •   Nguyen, Nam-Trung (external author)
  •   Li, Weihua

Publication Date


  • 2015

Citation


  • Yuan, D., Zhang, J., Yan, S., Pan, C., Alici, G., Nguyen, N. T. & Li, W. H. (2015). Dean-flow-coupled elasto-inertial three-dimensional particle focusing under viscoelastic flow in a straight channel with asymmetrical expansion–contraction cavity arrays. Biomicrofluidics, 9 044108-1-044108-13.

Scopus Eid


  • 2-s2.0-84938125329

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=5295&context=eispapers

Ro Metadata Url


  • http://ro.uow.edu.au/eispapers/4274

Has Global Citation Frequency


Start Page


  • 044108-1

End Page


  • 044108-13

Volume


  • 9

Place Of Publication


  • United States