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Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum

Journal Article


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Abstract


  • One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of

    Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds

    were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with

    IC50 values of 2.460.12 and 1.380.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant

    cytotoxicity.

UOW Authors


  •   Jaidee, Atchara (external author)
  •   Promchai, Thanika (external author)
  •   Trisuwan, Kongkiat (external author)
  •   Laphookhieo, Surat (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2015

Citation


  • Jaidee, A., Promchai, T., Trisuwan, K., Laphookhieo, S., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Ritthiwigrom, T. (2015). Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum. Natural Product Communications: an international journal for communications and reviews, 10 (7), 1175-1177.

Scopus Eid


  • 2-s2.0-84946913030

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3995&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2973

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 1175

End Page


  • 1177

Volume


  • 10

Issue


  • 7

Place Of Publication


  • United States

Abstract


  • One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of

    Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds

    were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with

    IC50 values of 2.460.12 and 1.380.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant

    cytotoxicity.

UOW Authors


  •   Jaidee, Atchara (external author)
  •   Promchai, Thanika (external author)
  •   Trisuwan, Kongkiat (external author)
  •   Laphookhieo, Surat (external author)
  •   Rattanajak, Roonglawan (external author)
  •   Kamchonwongpaisan, Sumalee (external author)
  •   Pyne, Stephen
  •   Ritthiwigrom, Thunwadee (external author)

Publication Date


  • 2015

Citation


  • Jaidee, A., Promchai, T., Trisuwan, K., Laphookhieo, S., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Ritthiwigrom, T. (2015). Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum. Natural Product Communications: an international journal for communications and reviews, 10 (7), 1175-1177.

Scopus Eid


  • 2-s2.0-84946913030

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3995&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2973

Has Global Citation Frequency


Number Of Pages


  • 2

Start Page


  • 1175

End Page


  • 1177

Volume


  • 10

Issue


  • 7

Place Of Publication


  • United States