Skip to main content
placeholder image

External control of reactions in microdroplets

Journal Article


Download full-text (Open Access)

Abstract


  • Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. Droplet-based microfluidics have evolved as a powerful platform to allow many chemical reactions within small volumes that each can be controlled and manipulated. A significant technical challenge is the ability to change the concentration of reactants inside a droplet. Here we describe a strategy that relies on the use of reactants that are soluble in both oil and water and allow a passive, diffusive exchange of reactants between the oil and aqueous phases to externally control composition of the droplets. We demonstrate the applicability of our approach by externally changing the pH inside microdroplets without the need for physical manipulation or droplet merging.

Publication Date


  • 2015

Citation


  • Mashaghi, S. & van Oijen, A. M. (2015). External control of reactions in microdroplets. Scientific Reports, 5 11837-1-11837-8.

Scopus Eid


  • 2-s2.0-84934277724

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4222&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3199

Start Page


  • 11837-1

End Page


  • 11837-8

Volume


  • 5

Abstract


  • Scale reduction of chemical reactions enables novel screening and synthesis approaches that facilitate a highly parallelized and combinatorial exploration of chemical space. Droplet-based microfluidics have evolved as a powerful platform to allow many chemical reactions within small volumes that each can be controlled and manipulated. A significant technical challenge is the ability to change the concentration of reactants inside a droplet. Here we describe a strategy that relies on the use of reactants that are soluble in both oil and water and allow a passive, diffusive exchange of reactants between the oil and aqueous phases to externally control composition of the droplets. We demonstrate the applicability of our approach by externally changing the pH inside microdroplets without the need for physical manipulation or droplet merging.

Publication Date


  • 2015

Citation


  • Mashaghi, S. & van Oijen, A. M. (2015). External control of reactions in microdroplets. Scientific Reports, 5 11837-1-11837-8.

Scopus Eid


  • 2-s2.0-84934277724

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=4222&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/3199

Start Page


  • 11837-1

End Page


  • 11837-8

Volume


  • 5