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Striatal atrophy in the behavioural variant of frontotemporal dementia: correlation with diagnosis, negative symptoms and disease severity

Journal Article


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Abstract


  • Introduction

    Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition.

    Materials and Methods

    Magnetic resonance imaging scans from 28 patients with bvFTD and 26 healthy controls were manually traced using image analysis software (ITK-SNAP). The resulting 3-D objects underwent volumetric analysis and shape analysis, through spherical harmonic description with point distribution models (SPHARM-PDM). Correlations with size and shape were sought with clinical measures in the bvTFD group, including Frontal Behavioural Inventory, Clinical Dementia Rating for bvFTD, Color Word Interference, Hayling part B and Brixton tests, and Trail-Making Test.

    Results

    Caudate nuclei and putamina were significantly smaller in the bvFTD group compared to controls (left caudate 16% smaller, partial eta squared 0.173, p=0.003; right caudate 11% smaller, partial eta squared 0.103, p=0.023; left putamen 18% smaller, partial eta squared 0.179, p=0.002; right putamen 12% smaller, partial eta squared 0.081, p=0.045), with global shape deflation in the caudate bilaterally but no localised shape change in putamen. In the bvFTD group, shape deflations on the left, corresponding to afferent connections from dorsolateral prefrontal mediofrontal/anterior cingulate and orbitofrontal cortex, correlated with worsening disease severity. Global shape deflation in the putamen correlated with Frontal Behavioural Inventory scores—higher scoring on negative symptoms was associated with the left putamen, while positive symptoms were associated with the right. Other cognitive tests had poor completion rates.

    Conclusion

    Behavioural symptoms and severity of bvFTD are correlated with abnormalities in striatal size and shape. This adds to the promise of imaging the striatum as a biomarker in this disease.

UOW Authors


  •   Looi, Jeffrey C. L. (external author)
  •   Jakabek, David D. (external author)
  •   Vestberg, Susanna (external author)
  •   Wilkes, Fiona A. (external author)
  •   Van Westen, Danielle (external author)
  •   Santillo, Alexander Frizell (external author)
  •   Nilsson, Christer (external author)
  •   Walterfang, Mark (external author)
  •   Velakoulis, Dennis (external author)
  •   Macfarlane, Matthew D.

Publication Date


  • 2015

Citation


  • Macfarlane, M. D., Jakabek, D., Walterfang, M., Vestberg, S., Velakoulis, D., Wilkes, F. A., Nilsson, C., van Westen, D., Looi, J. C. L. & Santillo, A. (2015). Striatal atrophy in the behavioural variant of frontotemporal dementia: correlation with diagnosis, negative symptoms and disease severity. PLoS One, 10 (6), e0129692-1-e0129692-14.

Scopus Eid


  • 2-s2.0-84937013097

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3936&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2914

Has Global Citation Frequency


Number Of Pages


  • 0

Start Page


  • e0129692-1

End Page


  • e0129692-14

Volume


  • 10

Issue


  • 6

Abstract


  • Introduction

    Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition.

    Materials and Methods

    Magnetic resonance imaging scans from 28 patients with bvFTD and 26 healthy controls were manually traced using image analysis software (ITK-SNAP). The resulting 3-D objects underwent volumetric analysis and shape analysis, through spherical harmonic description with point distribution models (SPHARM-PDM). Correlations with size and shape were sought with clinical measures in the bvTFD group, including Frontal Behavioural Inventory, Clinical Dementia Rating for bvFTD, Color Word Interference, Hayling part B and Brixton tests, and Trail-Making Test.

    Results

    Caudate nuclei and putamina were significantly smaller in the bvFTD group compared to controls (left caudate 16% smaller, partial eta squared 0.173, p=0.003; right caudate 11% smaller, partial eta squared 0.103, p=0.023; left putamen 18% smaller, partial eta squared 0.179, p=0.002; right putamen 12% smaller, partial eta squared 0.081, p=0.045), with global shape deflation in the caudate bilaterally but no localised shape change in putamen. In the bvFTD group, shape deflations on the left, corresponding to afferent connections from dorsolateral prefrontal mediofrontal/anterior cingulate and orbitofrontal cortex, correlated with worsening disease severity. Global shape deflation in the putamen correlated with Frontal Behavioural Inventory scores—higher scoring on negative symptoms was associated with the left putamen, while positive symptoms were associated with the right. Other cognitive tests had poor completion rates.

    Conclusion

    Behavioural symptoms and severity of bvFTD are correlated with abnormalities in striatal size and shape. This adds to the promise of imaging the striatum as a biomarker in this disease.

UOW Authors


  •   Looi, Jeffrey C. L. (external author)
  •   Jakabek, David D. (external author)
  •   Vestberg, Susanna (external author)
  •   Wilkes, Fiona A. (external author)
  •   Van Westen, Danielle (external author)
  •   Santillo, Alexander Frizell (external author)
  •   Nilsson, Christer (external author)
  •   Walterfang, Mark (external author)
  •   Velakoulis, Dennis (external author)
  •   Macfarlane, Matthew D.

Publication Date


  • 2015

Citation


  • Macfarlane, M. D., Jakabek, D., Walterfang, M., Vestberg, S., Velakoulis, D., Wilkes, F. A., Nilsson, C., van Westen, D., Looi, J. C. L. & Santillo, A. (2015). Striatal atrophy in the behavioural variant of frontotemporal dementia: correlation with diagnosis, negative symptoms and disease severity. PLoS One, 10 (6), e0129692-1-e0129692-14.

Scopus Eid


  • 2-s2.0-84937013097

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=3936&context=smhpapers

Ro Metadata Url


  • http://ro.uow.edu.au/smhpapers/2914

Has Global Citation Frequency


Number Of Pages


  • 0

Start Page


  • e0129692-1

End Page


  • e0129692-14

Volume


  • 10

Issue


  • 6