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N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review

Journal Article


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Abstract


  • Objective

    Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area.

    Methods

    PubMed, Web of Science and Cochrane Library Database were searched for human clinical trials or case reports investigating NAC in the treatment of obsessive compulsive disorder (OCD) or obsessive compulsive related disorders. Researchers with known involvement in NAC studies were contacted for any unpublished data.

    Results

    Four clinical trials and five case reports/series were identified. Study durations were commonly 12-weeks, using 2,400?3,000 mg/day of NAC. Overall, NAC demonstrates activity in reducing the severity of symptoms, with a good tolerability profile and minimal adverse effects. Currently there are three ongoing randomized controlled trials using NAC for OCD (two adults and one pediatric), and one for excoriation.

    Conclusion

    Encouraging results have been demonstrated from the few pilot studies that have been conducted. These results are detailed, in addition to a discussion of future potential research.

Authors


  •   Sarris, Jerome (external author)
  •   Oliver, Georgina (external author)
  •   Dean, Olivia (external author)
  •   Blair-West, Scott (external author)
  •   Ng, Chee (external author)
  •   Berk, Michael (external author)
  •   Camfield, David A.

Publication Date


  • 2015

Citation


  • Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M. & Sarris, J. (2015). N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clinical Psychopharmacology and Neuroscience, 13 (1), 12-24.

Scopus Eid


  • 2-s2.0-84929467871

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2918&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/1919

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 12

End Page


  • 24

Volume


  • 13

Issue


  • 1

Abstract


  • Objective

    Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area.

    Methods

    PubMed, Web of Science and Cochrane Library Database were searched for human clinical trials or case reports investigating NAC in the treatment of obsessive compulsive disorder (OCD) or obsessive compulsive related disorders. Researchers with known involvement in NAC studies were contacted for any unpublished data.

    Results

    Four clinical trials and five case reports/series were identified. Study durations were commonly 12-weeks, using 2,400?3,000 mg/day of NAC. Overall, NAC demonstrates activity in reducing the severity of symptoms, with a good tolerability profile and minimal adverse effects. Currently there are three ongoing randomized controlled trials using NAC for OCD (two adults and one pediatric), and one for excoriation.

    Conclusion

    Encouraging results have been demonstrated from the few pilot studies that have been conducted. These results are detailed, in addition to a discussion of future potential research.

Authors


  •   Sarris, Jerome (external author)
  •   Oliver, Georgina (external author)
  •   Dean, Olivia (external author)
  •   Blair-West, Scott (external author)
  •   Ng, Chee (external author)
  •   Berk, Michael (external author)
  •   Camfield, David A.

Publication Date


  • 2015

Citation


  • Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M. & Sarris, J. (2015). N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clinical Psychopharmacology and Neuroscience, 13 (1), 12-24.

Scopus Eid


  • 2-s2.0-84929467871

Ro Full-text Url


  • http://ro.uow.edu.au/cgi/viewcontent.cgi?article=2918&context=sspapers

Ro Metadata Url


  • http://ro.uow.edu.au/sspapers/1919

Has Global Citation Frequency


Number Of Pages


  • 12

Start Page


  • 12

End Page


  • 24

Volume


  • 13

Issue


  • 1