This paper describes the applicability of concept of Response Surface Methodology (RSM) to identify an approximate response surface model from experimental investigations on the engineering properties of sand and sand-tire crumb mixture (STCM). The objective of the present study is to generate an appropriate polynomial functions for output data obtained from the experimental studies through regression analysis for a range of expected variations in the input parameters. A regression model for both individual and interactive effects of selected input parameters has been generated. It has been found that multiple regression models reproduced the results obtained from the experimental studies with reasonable accuracy. The developed model is also checked for model adequacy and hypothesis testing. None of the developed models revealed any model inadequacy ensuring adequate approximation of the engineering behavior of STCM.