Keller, Paul A.

Research Areas

Selected Publications

Journal Article

Year	Title
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii Published In Natural Product Communications: an international journal for communications and reviews Volume 14 Pages 1 - 6 ISSN 1555-9475 Altmetric
2018	A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 74 Pages 1294 - 1306 ISSN 1464-5416 Altmetric
2018	An improved synthesis of pyrido[2,3-: d] pyrimidin-4(1 H)-ones and their antimicrobial activity Published In Organic and Biomolecular Chemistry Volume 16 Pages 3389 - 3395 ISSN 1477-0520 Altmetric
2018	Body Odor and Sex: Do Cuticular Hydrocarbons Facilitate Sexual Attraction in the Small Hairy Maggot Blowfly? Published In Journal of Chemical Ecology Volume 44 Pages 248 - 256 ISSN 0098-0331 Altmetric
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry Volume 16 Pages 6006 - 6016 ISSN 1477-0520 Altmetric
2018	Design and synthesis of new functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Monatshefte fuer Chemie: an international journal of chemistry Volume 149 Pages 2103 - 2111 ISSN 0026-9247 Altmetric
2018	Molecular docking studies to explore potential binding pockets and inhibitors for chikungunya virus envelope glycoproteins Published In Interdisciplinary Sciences: Computational Life Sciences Volume 10 Pages 515 - 524 Altmetric
2018	Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses Published In Biological Research Volume 51 Pages 49-1 - 49-13 ISSN 0716-9760 Altmetric
2018	Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1478-6419 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Antarctic moss biflavonoids show high antioxidant and ultraviolet-screening activity Published In Journal of Natural Products Volume 80 Pages 2224 - 2231 ISSN 0163-3864 Altmetric
2017	Phytochemical Studies on Two Australian Anigozanthos Plant Species Published In Journal of Natural Products Volume 80 Pages 2141 - 2145 ISSN 0163-3864 Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Flowers in Australia: phytochemical studies on the Illawarra flame tree and Alstonville Published In Australian Journal of Chemistry: an international journal for chemical science Volume 69 Pages 925 - 927 ISSN 0004-9425 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 8357 - 8367 ISSN 1464-5416 Altmetric
2015	A twist of nature-the significance of atropisomers in biological systems Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 32 Pages 1562 - 1583 ISSN 0265-0568 Altmetric
2015	Arsenous chloride-free synthesis of cyclic tertiary organoarsines from arylarsine oxides and di-Grignard reagents Published In Journal of Organometallic Chemistry Volume 785 Pages 77 - 83 ISSN 0022-328X Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Bioactive glycosides from the African medicinal plant Boerhavia erecta L. Published In Natural Product Research Volume 29 Pages 1954 - 1958 ISSN 1478-6419 Altmetric
2015	Cyclic phosphine oxides and phosphinamides from di-grignard reagents and phosphonic dichlorides: modular access to annulated phospholanes Published In Journal of Organic Chemistry Volume 80 Pages 9774 - 9780 ISSN 0022-3263 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Enantiopure trans -4,5-disubstituted 2-imidazolidinones via copper(I)-catalyzed ring opening of 1,1′-DiBoc-2,2′-biaziridine with Grignard reagents Published In Journal of Organic Chemistry Volume 80 Pages 5992 - 5998 ISSN 0022-3263 Altmetric
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry Volume 11 Pages 481 - 492 ISSN 1860-5397 Altmetric
2015	Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches Published In Journal of Molecular Graphics and Modelling Volume 57 Pages 1 - 8 ISSN 1093-3263 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2014	Chikungunya virus: emerging targets and new opportunities for medicinal chemistry Published In Journal of Medicinal Chemistry Volume 57 Pages 1147 - 1166 ISSN 0022-2623 Altmetric
2014	Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus Published In Journal of Molecular Modeling Volume 20 Pages 2216-1 - 2216-12 ISSN 0948-5023 Altmetric
2014	Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia Published In Forensic Science International Volume 241 Pages 102 - 111 ISSN 0379-0738 Altmetric
2014	Efficient synthesis and antioxidant activity of coelenterazine analogues Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 6212 - 6215 ISSN 1873-3581 Altmetric
2014	Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei Published In ACS Medicinal Chemistry Letters Volume 5 Pages 496 - 500 ISSN 1948-5875 Altmetric
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	Ring-opening and -expansion of 2,2′-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines Published In Organic Letters Volume 16 Pages 4344 - 4347 ISSN 1523-7060 Altmetric
2014	Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands Published In Organic and Biomolecular Chemistry Volume 12 Pages 783 - 794 ISSN 1477-0520 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology Volume 150 Pages 953 - 959 ISSN 0378-8741 Altmetric
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology Volume 148 Pages 305 - 310 ISSN 0378-8741 Altmetric
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 733 - 736 ISSN 1555-9475
2013	Constituents of the Indonesian Epiphytic Medicinal Plant Drynaria rigidula Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 703 - 705 ISSN 1555-9475
2013	Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis Published In Pharmacology and Therapeutics Volume 137 Pages 266 - 282 ISSN 0163-7258 Altmetric
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 1305 - 1308 ISSN 1555-9475
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology Volume 148 Pages 1013 - 1017 ISSN 0378-8741 Altmetric
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry Volume 78 Pages 7639 - 7647 ISSN 0022-3263 Altmetric
2013	Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins Published In Journal of Molecular Graphics and Modelling Volume 44 Pages 241 - 252 ISSN 1093-3263 Altmetric
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology Volume 143 Pages 310 - 313 ISSN 0378-8741 Altmetric
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 575 - 580 ISSN 1555-9475
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology Volume 134 Pages 813 - 823 ISSN 0378-8741 Altmetric
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology Volume 137 Pages 730 - 742 ISSN 0378-8741 Altmetric
2011	Investigation into the extension of the non-nucleoside reverse transcriptase binding pocket Published In Australian Journal of Chemistry: an international journal for chemical science Volume 64 Pages 916 - 918 ISSN 0004-9425 Altmetric
2011	Revealing indigenous Indonesian traditional medicine: anti-infective agents Published In Natural Product Communications: an international journal for communications and reviews Volume 6 Pages 1953 - 1966 ISSN 1555-9475
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 1464-3391 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1433-7851 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 1464-3391 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 1464-3391 Altmetric
2010	Synthesis of reaction-ready 6,6 '-biindole and 6,6 '-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation Published In Chemical Communications Volume 46 Pages 4076 - 4078 ISSN 1364-548X Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 6947 - 6950 ISSN 1873-3581 Altmetric
2009	Reactions of electron-rich indoles with triflic anhydride Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 2501 - 2504 ISSN 1873-3581 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2009	The Medicinal Chemistry of Dengue Fever Published In Journal of Medicinal Chemistry Volume 52 Pages 7911 - 7926 ISSN 0022-2623 Altmetric
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters Volume 10 Pages 1315 - 1317 ISSN 1523-7060 Altmetric
2008	Antimalarial Activity of 2,4-Diaminopyrimidines Published In Letters in Drug Design and Discovery Volume 5 Pages 277 - 280 ISSN 1570-1808 Altmetric
2008	Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11603 - 11610 ISSN 1464-5416 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 7787 - 7795 ISSN 1464-5416 Altmetric
2007	A new methodology for the simulation of flexible protein-ligand interactions Published In Journal of Molecular Graphics and Modelling Volume 26 Pages 187 - 197 ISSN 1093-3263 Altmetric
2007	Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 37 Pages 2777 - 2786 ISSN 0039-7911 Altmetric
2007	Control of HIV through the inhibition of HIV-1 integrase: a medicinal chemistry perspective Published In Medicinal Chemistry Volume 3 Pages 199 - 220 ISSN 1573-4064 Altmetric
2007	Corticotropin releasing hormone - a GPCR drug target Published In Current Drug Targets Volume 8 Pages 105 - 115 ISSN 1389-4501 Altmetric
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Pages 753 - 7536 ISSN 1873-3581 Altmetric

Chapter

Year	Title
2013	Ring synthesis Published In Pyridine: from Lab to Production Publisher Academic Press Pages 15 - 152 Altmetric
2008	Pyridines and their Benzo Derivatives: Synthesis Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 217 - 308

Investigator On

Year	Title
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	New photoinitiators and polymers for tack-free LED cured surface coatings Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2014 - 2017	Modelling spatial patterns and identifying environmental drivers for temporal change in Antarctic moss communities Awarded by: Australian Antarctic Division Funding Scheme: Australian Antarctic Science Program
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011 - 2014	Mapping Antarctic climate change in space and time using mosses as biological proxies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	State-of-the-art facility for human and animal virus research in the Canberra surrounding regions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The Design and Development of the Next Generation Anti-HIV Drugs Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2008	Mechanisms of Chikungunya virus disease: mouse model, virulent determinants and the development of novel therapeutics Awarded by: Department of Education, Science and Training (DEST) Funding Scheme: Australia-India Strategic Research Fund
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Understanding the tolerance of Antarctic mosses to climate change Awarded by: Australian Antarctic Division Funding Scheme: Grant
2007	Novel strategies in the design and development of antivirals against dengue virus Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2007	The development of sigma-1 and sigma-2 receptor ligands as diagnostic probes for cancer and neurodegeneration Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Grant

Impact Story

TEDx The extraordinary Antarctic plants with superhero powers
Summary
In 2016 I gave a <a href="https://www.youtube.com/watch?v=V4PsZlTGedU" title="YouTube: Antarctic Plants In A Time Of Change" target="_blank" rel="noopener">TEDX Antarctic plants in a time of change</a>.<br /><br />In 2017, this was featured in a story on <a href="https://ideas.ted.com/the-extraordinary-antarctic-plants-with-superhero-powers/" title="Featured Story: Extraordinary Antarctic Plants with Superhero Powers" target="_blank" rel="noopener">ideas.ted.com.</a>

Detail View

Detail View Summary View
Field of Research
Countries / Regions
Beneficiaries

Beneficiary Quantification Description
External Partners
Evidence of Impact

Evidence Description
UOW Centres / Programs
UOW Researchers / Collaborators

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Transition metals in reaction development and medicinal chemistry	Brown, Ronald
Doctor of Philosophy	The design & synthesis of Medical ligands	Smyth, Jamie
Doctor of Philosophy	Old Dye, New Tricks Diversity-Oriented Synthesis of Heterocycles from Cascade Reactions of Indigo	Butler, Nicholas
Doctor of Philosophy (Integrated)	The development of novel fluorescent and radiopharmaceutical probes for imaging neurodegenerative disorders	Wongso, Hendris
Doctor of Philosophy	The evolution of cuticular hydrocarbons in blowflies (Diptera: Calliphoridae)	Butterworth, Nathan
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Drug Design and Development Targetting Viruses	Metwaly, Mohamed
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	The investigation of libraries of chiral ligands for metal catalysis	Gaston, Jayden
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy

Research Areas

Selected Publications

Journal Article

Year	Title
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry Volume 170 Pages 203 - 224 ISSN 0223-5234 Altmetric
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry Volume 168 Pages 386 - 404 ISSN 0223-5234 Altmetric
2019	Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii Published In Natural Product Communications: an international journal for communications and reviews Volume 14 Pages 1 - 6 ISSN 1555-9475 Altmetric
2018	A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 74 Pages 1294 - 1306 ISSN 1464-5416 Altmetric
2018	An improved synthesis of pyrido[2,3-: d] pyrimidin-4(1 H)-ones and their antimicrobial activity Published In Organic and Biomolecular Chemistry Volume 16 Pages 3389 - 3395 ISSN 1477-0520 Altmetric
2018	Body Odor and Sex: Do Cuticular Hydrocarbons Facilitate Sexual Attraction in the Small Hairy Maggot Blowfly? Published In Journal of Chemical Ecology Volume 44 Pages 248 - 256 ISSN 0098-0331 Altmetric
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry Volume 16 Pages 6006 - 6016 ISSN 1477-0520 Altmetric
2018	Design and synthesis of new functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Monatshefte fuer Chemie: an international journal of chemistry Volume 149 Pages 2103 - 2111 ISSN 0026-9247 Altmetric
2018	Molecular docking studies to explore potential binding pockets and inhibitors for chikungunya virus envelope glycoproteins Published In Interdisciplinary Sciences: Computational Life Sciences Volume 10 Pages 515 - 524 Altmetric
2018	Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses Published In Biological Research Volume 51 Pages 49-1 - 49-13 ISSN 0716-9760 Altmetric
2018	Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don Published In Natural Product Research Volume Online First Pages 1 - 7 ISSN 1478-6419 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Antarctic moss biflavonoids show high antioxidant and ultraviolet-screening activity Published In Journal of Natural Products Volume 80 Pages 2224 - 2231 ISSN 0163-3864 Altmetric
2017	Phytochemical Studies on Two Australian Anigozanthos Plant Species Published In Journal of Natural Products Volume 80 Pages 2141 - 2145 ISSN 0163-3864 Altmetric
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews Volume 11 Pages 1801 - 1804 ISSN 1555-9475
2016	Flowers in Australia: phytochemical studies on the Illawarra flame tree and Alstonville Published In Australian Journal of Chemistry: an international journal for chemical science Volume 69 Pages 925 - 927 ISSN 0004-9425 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 8357 - 8367 ISSN 1464-5416 Altmetric
2015	A twist of nature-the significance of atropisomers in biological systems Published In Natural Product Reports: a journal of current development in bioorganic chemistry Volume 32 Pages 1562 - 1583 ISSN 0265-0568 Altmetric
2015	Arsenous chloride-free synthesis of cyclic tertiary organoarsines from arylarsine oxides and di-Grignard reagents Published In Journal of Organometallic Chemistry Volume 785 Pages 77 - 83 ISSN 0022-328X Altmetric
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry Volume 13 Pages 5743 - 5756 ISSN 1477-0520 Altmetric
2015	Bioactive glycosides from the African medicinal plant Boerhavia erecta L. Published In Natural Product Research Volume 29 Pages 1954 - 1958 ISSN 1478-6419 Altmetric
2015	Cyclic phosphine oxides and phosphinamides from di-grignard reagents and phosphonic dichlorides: modular access to annulated phospholanes Published In Journal of Organic Chemistry Volume 80 Pages 9774 - 9780 ISSN 0022-3263 Altmetric
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports Volume 5 Pages 12845-1 - 12845-10 ISSN 2045-2322 Altmetric
2015	Enantiopure trans -4,5-disubstituted 2-imidazolidinones via copper(I)-catalyzed ring opening of 1,1′-DiBoc-2,2′-biaziridine with Grignard reagents Published In Journal of Organic Chemistry Volume 80 Pages 5992 - 5998 ISSN 0022-3263 Altmetric
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry Volume 11 Pages 481 - 492 ISSN 1860-5397 Altmetric
2015	Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches Published In Journal of Molecular Graphics and Modelling Volume 57 Pages 1 - 8 ISSN 1093-3263 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry Volume 2015 Pages 195 - 201 ISSN 1099-0690 Altmetric
2014	Chikungunya virus: emerging targets and new opportunities for medicinal chemistry Published In Journal of Medicinal Chemistry Volume 57 Pages 1147 - 1166 ISSN 0022-2623 Altmetric
2014	Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus Published In Journal of Molecular Modeling Volume 20 Pages 2216-1 - 2216-12 ISSN 0948-5023 Altmetric
2014	Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia Published In Forensic Science International Volume 241 Pages 102 - 111 ISSN 0379-0738 Altmetric
2014	Efficient synthesis and antioxidant activity of coelenterazine analogues Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 55 Pages 6212 - 6215 ISSN 1873-3581 Altmetric
2014	Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei Published In ACS Medicinal Chemistry Letters Volume 5 Pages 496 - 500 ISSN 1948-5875 Altmetric
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society Volume 136 Pages 10890 - 10893 ISSN 0002-7863 Altmetric
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 9 Pages 957 - 960 ISSN 1555-9475
2014	Ring-opening and -expansion of 2,2′-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines Published In Organic Letters Volume 16 Pages 4344 - 4347 ISSN 1523-7060 Altmetric
2014	Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands Published In Organic and Biomolecular Chemistry Volume 12 Pages 783 - 794 ISSN 1477-0520 Altmetric
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 46383 - 46398 ISSN 2046-2069 Altmetric
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology Volume 150 Pages 953 - 959 ISSN 0378-8741 Altmetric
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology Volume 148 Pages 305 - 310 ISSN 0378-8741 Altmetric
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 733 - 736 ISSN 1555-9475
2013	Constituents of the Indonesian Epiphytic Medicinal Plant Drynaria rigidula Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 703 - 705 ISSN 1555-9475
2013	Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis Published In Pharmacology and Therapeutics Volume 137 Pages 266 - 282 ISSN 0163-7258 Altmetric
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews Volume 8 Pages 1305 - 1308 ISSN 1555-9475
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology Volume 148 Pages 1013 - 1017 ISSN 0378-8741 Altmetric
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry Volume 78 Pages 7639 - 7647 ISSN 0022-3263 Altmetric
2013	Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins Published In Journal of Molecular Graphics and Modelling Volume 44 Pages 241 - 252 ISSN 1093-3263 Altmetric
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology Volume 143 Pages 310 - 313 ISSN 0378-8741 Altmetric
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews Volume 7 Pages 575 - 580 ISSN 1555-9475
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology Volume 134 Pages 813 - 823 ISSN 0378-8741 Altmetric
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology Volume 137 Pages 730 - 742 ISSN 0378-8741 Altmetric
2011	Investigation into the extension of the non-nucleoside reverse transcriptase binding pocket Published In Australian Journal of Chemistry: an international journal for chemical science Volume 64 Pages 916 - 918 ISSN 0004-9425 Altmetric
2011	Revealing indigenous Indonesian traditional medicine: anti-infective agents Published In Natural Product Communications: an international journal for communications and reviews Volume 6 Pages 1953 - 1966 ISSN 1555-9475
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 1464-3391 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1433-7851 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 1464-3391 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 1464-3391 Altmetric
2010	Synthesis of reaction-ready 6,6 '-biindole and 6,6 '-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation Published In Chemical Communications Volume 46 Pages 4076 - 4078 ISSN 1364-548X Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 6947 - 6950 ISSN 1873-3581 Altmetric
2009	Reactions of electron-rich indoles with triflic anhydride Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 2501 - 2504 ISSN 1873-3581 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2009	The Medicinal Chemistry of Dengue Fever Published In Journal of Medicinal Chemistry Volume 52 Pages 7911 - 7926 ISSN 0022-2623 Altmetric
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters Volume 10 Pages 1315 - 1317 ISSN 1523-7060 Altmetric
2008	Antimalarial Activity of 2,4-Diaminopyrimidines Published In Letters in Drug Design and Discovery Volume 5 Pages 277 - 280 ISSN 1570-1808 Altmetric
2008	Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11603 - 11610 ISSN 1464-5416 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 7787 - 7795 ISSN 1464-5416 Altmetric
2007	A new methodology for the simulation of flexible protein-ligand interactions Published In Journal of Molecular Graphics and Modelling Volume 26 Pages 187 - 197 ISSN 1093-3263 Altmetric
2007	Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 37 Pages 2777 - 2786 ISSN 0039-7911 Altmetric
2007	Control of HIV through the inhibition of HIV-1 integrase: a medicinal chemistry perspective Published In Medicinal Chemistry Volume 3 Pages 199 - 220 ISSN 1573-4064 Altmetric
2007	Corticotropin releasing hormone - a GPCR drug target Published In Current Drug Targets Volume 8 Pages 105 - 115 ISSN 1389-4501 Altmetric
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Pages 753 - 7536 ISSN 1873-3581 Altmetric

Chapter

Year	Title
2013	Ring synthesis Published In Pyridine: from Lab to Production Publisher Academic Press Pages 15 - 152 Altmetric
2008	Pyridines and their Benzo Derivatives: Synthesis Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 217 - 308

Investigator On

Year	Title
2018 - 2020	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	New photoinitiators and polymers for tack-free LED cured surface coatings Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2014 - 2017	Modelling spatial patterns and identifying environmental drivers for temporal change in Antarctic moss communities Awarded by: Australian Antarctic Division Funding Scheme: Australian Antarctic Science Program
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011 - 2014	Mapping Antarctic climate change in space and time using mosses as biological proxies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	State-of-the-art facility for human and animal virus research in the Canberra surrounding regions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The Design and Development of the Next Generation Anti-HIV Drugs Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2008	Mechanisms of Chikungunya virus disease: mouse model, virulent determinants and the development of novel therapeutics Awarded by: Department of Education, Science and Training (DEST) Funding Scheme: Australia-India Strategic Research Fund
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Understanding the tolerance of Antarctic mosses to climate change Awarded by: Australian Antarctic Division Funding Scheme: Grant
2007	Novel strategies in the design and development of antivirals against dengue virus Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2007	The development of sigma-1 and sigma-2 receptor ligands as diagnostic probes for cancer and neurodegeneration Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Grant

Impact Story

TEDx The extraordinary Antarctic plants with superhero powers
Summary
In 2016 I gave a <a href="https://www.youtube.com/watch?v=V4PsZlTGedU" title="YouTube: Antarctic Plants In A Time Of Change" target="_blank" rel="noopener">TEDX Antarctic plants in a time of change</a>.<br /><br />In 2017, this was featured in a story on <a href="https://ideas.ted.com/the-extraordinary-antarctic-plants-with-superhero-powers/" title="Featured Story: Extraordinary Antarctic Plants with Superhero Powers" target="_blank" rel="noopener">ideas.ted.com.</a>

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Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Transition metals in reaction development and medicinal chemistry	Brown, Ronald
Doctor of Philosophy	The design & synthesis of Medical ligands	Smyth, Jamie
Doctor of Philosophy	Old Dye, New Tricks Diversity-Oriented Synthesis of Heterocycles from Cascade Reactions of Indigo	Butler, Nicholas
Doctor of Philosophy (Integrated)	The development of novel fluorescent and radiopharmaceutical probes for imaging neurodegenerative disorders	Wongso, Hendris
Doctor of Philosophy	The evolution of cuticular hydrocarbons in blowflies (Diptera: Calliphoridae)	Butterworth, Nathan
Doctor of Philosophy	Phytochemical and Biological studies on Nigerian Medicinal Plants	Dawurung, Christiana
Doctor of Philosophy	Drug Design and Development Targetting Viruses	Metwaly, Mohamed
Doctor of Philosophy	Development of new antibacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo: Synthesis and physicochemical studies	McCosker, Patrick
Doctor of Philosophy	The investigation of libraries of chiral ligands for metal catalysis	Gaston, Jayden
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy

Keller, Paul A.

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Impact Story

TEDx The extraordinary Antarctic plants with superhero powers

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Overview

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Selected Publications

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Impact

Impact Story

TEDx The extraordinary Antarctic plants with superhero powers

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