Keller, Paul A.

Research Areas

Research Overview

Keller Research Group News

Congratulation to PhD student Pat McCosker for his journal cover in the November 2021 edition of 'Chemistry: a European Journal'

PhD student Stephanie Beaupark hits the research news
https://www.uow.edu.au/research-and-innovation/magazine/2021/combining-chemistry-and-aboriginal-art.php

Available as Research Supervisor

Selected Publications

Journal Article

Year	Title
2020	Anti-cancer evaluation of depsides isolated from indonesian folious lichens: Physcia millegrana, parmelia dilatata and parmelia aurulenta Published In Biomolecules
2020	Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action Published In Journal of Medicinal Chemistry
2020	How To Make Nitroaromatic Compounds Glow: Next-Generation Large X-Shaped, Centrosymmetric Diketopyrrolopyrroles Published In Angewandte Chemie - International Edition
2020	Major Transitions in Cuticular Hydrocarbon Expression Coincide with Sexual Maturity in a Blowfly (Diptera: Calliphoridae) Published In Journal of Chemical Ecology
2020	Perylene-Monoimides: Singlet Fission Down-Conversion Competes with Up-Conversion by Geminate Triplet-Triplet Recombination Published In The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory
2020	Predicting phosphirane air stability using density functional theory Published In Journal of Physical Organic Chemistry
2020	Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents Published In RSC Advances: an international journal to further the chemical sciences
2020	Solvent-Dependent Singlet Fission in Diketopyrrolopyrrole Dimers: A Mediating Charge Transfer versus a Trapping Symmetry-Breaking Charge Separation Published In Advanced Energy Materials
2020	Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters Published In Angewandte Chemie - International Edition
2020	The evolution of sexually dimorphic cuticular hydrocarbons in blowflies (Diptera: Calliphoridae) Published In Journal of Evolutionary Biology
2020	Vascular epiphytic medicinal plants as sources of therapeutic agents: Their ethnopharmacological uses, chemical composition, and biological activities Published In Biomolecules
2019	Alkaloids from the root of Indonesian Annona muricata L Published In Natural Product Research
2019	Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities Published In Molecules
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry
2019	Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1 H,3′ H]-3-Aryl-2,2′-diindol-3′-ones Published In Journal of Organic Chemistry
2019	Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii Published In Natural Product Communications: an international journal for communications and reviews
2019	Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don Published In Natural Product Research
2019	Synthesis and density functional theory studies of azirinyl and oxiranyl functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Molecules
2018	A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2018	An improved synthesis of pyrido[2,3-: d] pyrimidin-4(1 H)-ones and their antimicrobial activity Published In Organic and Biomolecular Chemistry
2018	Body Odor and Sex: Do Cuticular Hydrocarbons Facilitate Sexual Attraction in the Small Hairy Maggot Blowfly? Published In Journal of Chemical Ecology
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry
2018	Design and synthesis of new functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Monatshefte fuer Chemie: an international journal of chemistry
2018	Molecular docking studies to explore potential binding pockets and inhibitors for chikungunya virus envelope glycoproteins Published In Interdisciplinary Sciences: Computational Life Sciences
2018	Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses Published In Biological Research
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2017	Antarctic moss biflavonoids show high antioxidant and ultraviolet-screening activity Published In Journal of Natural Products
2017	Phytochemical Studies on Two Australian Anigozanthos Plant Species Published In Journal of Natural Products
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews
2016	Flowers in Australia: phytochemical studies on the Illawarra flame tree and Alstonville Published In Australian Journal of Chemistry: an international journal for chemical science
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2015	A twist of nature-the significance of atropisomers in biological systems Published In Natural Product Reports: a journal of current development in bioorganic chemistry
2015	Arsenous chloride-free synthesis of cyclic tertiary organoarsines from arylarsine oxides and di-Grignard reagents Published In Journal of Organometallic Chemistry
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry
2015	Bioactive glycosides from the African medicinal plant Boerhavia erecta L. Published In Natural Product Research
2015	Cyclic phosphine oxides and phosphinamides from di-grignard reagents and phosphonic dichlorides: modular access to annulated phospholanes Published In Journal of Organic Chemistry
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports
2015	Enantiopure trans -4,5-disubstituted 2-imidazolidinones via copper(I)-catalyzed ring opening of 1,1′-DiBoc-2,2′-biaziridine with Grignard reagents Published In Journal of Organic Chemistry
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry
2015	Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches Published In Journal of Molecular Graphics and Modelling
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry
2014	Chikungunya virus: emerging targets and new opportunities for medicinal chemistry Published In Journal of Medicinal Chemistry
2014	Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus Published In Journal of Molecular Modeling
2014	Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia Published In Forensic Science International
2014	Efficient synthesis and antioxidant activity of coelenterazine analogues Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2014	Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei Published In ACS Medicinal Chemistry Letters
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews
2014	Ring-opening and -expansion of 2,2′-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines Published In Organic Letters
2014	Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands Published In Organic and Biomolecular Chemistry
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews
2013	Constituents of the Indonesian Epiphytic Medicinal Plant Drynaria rigidula Published In Natural Product Communications: an international journal for communications and reviews
2013	Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis Published In Pharmacology and Therapeutics
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry
2013	Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins Published In Journal of Molecular Graphics and Modelling
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology
2011	Investigation into the extension of the non-nucleoside reverse transcriptase binding pocket Published In Australian Journal of Chemistry: an international journal for chemical science
2011	Revealing indigenous Indonesian traditional medicine: anti-infective agents Published In Natural Product Communications: an international journal for communications and reviews
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry
2010	Synthesis of reaction-ready 6,6 '-biindole and 6,6 '-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation Published In Chemical Communications
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2009	Reactions of electron-rich indoles with triflic anhydride Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry
2009	The Medicinal Chemistry of Dengue Fever Published In Journal of Medicinal Chemistry
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters
2008	Antimalarial Activity of 2,4-Diaminopyrimidines Published In Letters in Drug Design and Discovery
2008	Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2007	A new methodology for the simulation of flexible protein-ligand interactions Published In Journal of Molecular Graphics and Modelling
2007	Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry
2007	Control of HIV through the inhibition of HIV-1 integrase: a medicinal chemistry perspective Published In Medicinal Chemistry
2007	Corticotropin releasing hormone - a GPCR drug target Published In Current Drug Targets
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry

Chapter

Year	Title
2013	Ring synthesis Published In Pyridine: from Lab to Production
2008	Pyridines and their Benzo Derivatives: Synthesis Published In Comprehensive Heterocyclic Chemistry III

Investigator On

Year	Title
2018 - 2021	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	New photoinitiators and polymers for tack-free LED cured surface coatings Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2014 - 2017	Modelling spatial patterns and identifying environmental drivers for temporal change in Antarctic moss communities Funding Scheme: Australian Antarctic Science Program
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011 - 2014	Mapping Antarctic climate change in space and time using mosses as biological proxies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	State-of-the-art facility for human and animal virus research in the Canberra surrounding regions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The Design and Development of the Next Generation Anti-HIV Drugs Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2008	Mechanisms of Chikungunya virus disease: mouse model, virulent determinants and the development of novel therapeutics Awarded by: Department of Education, Science and Training (DEST) Funding Scheme: Australia-India Strategic Research Fund
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Understanding the tolerance of Antarctic mosses to climate change Funding Scheme: Grant
2007	Novel strategies in the design and development of antivirals against dengue virus Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2007	The development of sigma-1 and sigma-2 receptor ligands as diagnostic probes for cancer and neurodegeneration Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Grant

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	The Design, Synthesis and Upscaling of Chiral Helical Ligand Libraries for Asymmetric Syntheses	Smyth, Jamie
Doctor of Philosophy	Development of new anti-bacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	New Photoinitiators for LED Activation: Fundamental Studies and Applications	Burns, Brett
Doctor of Philosophy	New Cascade Reactions of Indigo to Give Structurally Complex Heterocycles in Medicinal Chemistry	Ali, Sarfaraz
Doctor of Philosophy	Defining the Art and Science of Eucalyptus Dyes from Indigenous Principles	Beaupark, Stephanie
Doctor of Philosophy	The Design and Development of Inhibitors of Sporulation Targeting Clostridium Difficile Bacteria	Semken, Jess

Full Name

Paul A Keller

Mailing Address

School of Chemistry and Molecular Bioscience

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Science, Medicine and Health (SMAH)

Fax

+61 2 4221 4287

Orcid Id

http://orcid.org/0000-0003-4868-845X (confirmed)

Scopus Id

7202451005

Research Areas

Research Overview

Keller Research Group News

Congratulation to PhD student Pat McCosker for his journal cover in the November 2021 edition of 'Chemistry: a European Journal'

PhD student Stephanie Beaupark hits the research news
https://www.uow.edu.au/research-and-innovation/magazine/2021/combining-chemistry-and-aboriginal-art.php

Selected Publications

Journal Article

Year	Title
2020	Anti-cancer evaluation of depsides isolated from indonesian folious lichens: Physcia millegrana, parmelia dilatata and parmelia aurulenta Published In Biomolecules
2020	Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action Published In Journal of Medicinal Chemistry
2020	How To Make Nitroaromatic Compounds Glow: Next-Generation Large X-Shaped, Centrosymmetric Diketopyrrolopyrroles Published In Angewandte Chemie - International Edition
2020	Major Transitions in Cuticular Hydrocarbon Expression Coincide with Sexual Maturity in a Blowfly (Diptera: Calliphoridae) Published In Journal of Chemical Ecology
2020	Perylene-Monoimides: Singlet Fission Down-Conversion Competes with Up-Conversion by Geminate Triplet-Triplet Recombination Published In The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory
2020	Predicting phosphirane air stability using density functional theory Published In Journal of Physical Organic Chemistry
2020	Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents Published In RSC Advances: an international journal to further the chemical sciences
2020	Solvent-Dependent Singlet Fission in Diketopyrrolopyrrole Dimers: A Mediating Charge Transfer versus a Trapping Symmetry-Breaking Charge Separation Published In Advanced Energy Materials
2020	Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters Published In Angewandte Chemie - International Edition
2020	The evolution of sexually dimorphic cuticular hydrocarbons in blowflies (Diptera: Calliphoridae) Published In Journal of Evolutionary Biology
2020	Vascular epiphytic medicinal plants as sources of therapeutic agents: Their ethnopharmacological uses, chemical composition, and biological activities Published In Biomolecules
2019	Alkaloids from the root of Indonesian Annona muricata L Published In Natural Product Research
2019	Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities Published In Molecules
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides ( Clostridium ) dif fi cile : Synthesis, antibacterial evaluation and an in vivo C. dif fi cile infection model Published In European Journal of Medicinal Chemistry
2019	Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies Published In European Journal of Medicinal Chemistry
2019	Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1 H,3′ H]-3-Aryl-2,2′-diindol-3′-ones Published In Journal of Organic Chemistry
2019	Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii Published In Natural Product Communications: an international journal for communications and reviews
2019	Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don Published In Natural Product Research
2019	Synthesis and density functional theory studies of azirinyl and oxiranyl functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Molecules
2018	A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2018	An improved synthesis of pyrido[2,3-: d] pyrimidin-4(1 H)-ones and their antimicrobial activity Published In Organic and Biomolecular Chemistry
2018	Body Odor and Sex: Do Cuticular Hydrocarbons Facilitate Sexual Attraction in the Small Hairy Maggot Blowfly? Published In Journal of Chemical Ecology
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry
2018	Design and synthesis of new functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives Published In Monatshefte fuer Chemie: an international journal of chemistry
2018	Molecular docking studies to explore potential binding pockets and inhibitors for chikungunya virus envelope glycoproteins Published In Interdisciplinary Sciences: Computational Life Sciences
2018	Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses Published In Biological Research
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2017	Antarctic moss biflavonoids show high antioxidant and ultraviolet-screening activity Published In Journal of Natural Products
2017	Phytochemical Studies on Two Australian Anigozanthos Plant Species Published In Journal of Natural Products
2016	Anti-inflammatory, anti-bacterial and anti-acetylcholinesterase activities of two isoquinoline alkaloids-scoulerine and cheilanthifoline Published In Natural Product Communications: an international journal for communications and reviews
2016	Flowers in Australia: phytochemical studies on the Illawarra flame tree and Alstonville Published In Australian Journal of Chemistry: an international journal for chemical science
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2015	A twist of nature-the significance of atropisomers in biological systems Published In Natural Product Reports: a journal of current development in bioorganic chemistry
2015	Arsenous chloride-free synthesis of cyclic tertiary organoarsines from arylarsine oxides and di-Grignard reagents Published In Journal of Organometallic Chemistry
2015	Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria Published In Organic and Biomolecular Chemistry
2015	Bioactive glycosides from the African medicinal plant Boerhavia erecta L. Published In Natural Product Research
2015	Cyclic phosphine oxides and phosphinamides from di-grignard reagents and phosphonic dichlorides: modular access to annulated phospholanes Published In Journal of Organic Chemistry
2015	Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis Published In Scientific Reports
2015	Enantiopure trans -4,5-disubstituted 2-imidazolidinones via copper(I)-catalyzed ring opening of 1,1′-DiBoc-2,2′-biaziridine with Grignard reagents Published In Journal of Organic Chemistry
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry
2015	Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches Published In Journal of Molecular Graphics and Modelling
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry
2015	Synthesis of mono and bis[60]fullerene-based dicationic peptoids Published In European Journal of Organic Chemistry
2014	Chikungunya virus: emerging targets and new opportunities for medicinal chemistry Published In Journal of Medicinal Chemistry
2014	Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus Published In Journal of Molecular Modeling
2014	Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia Published In Forensic Science International
2014	Efficient synthesis and antioxidant activity of coelenterazine analogues Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2014	Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei Published In ACS Medicinal Chemistry Letters
2014	Fullerene van der Waals oligomers as electron traps Published In Journal of the American Chemical Society
2014	Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews
2014	Ring-opening and -expansion of 2,2′-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines Published In Organic Letters
2014	Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands Published In Organic and Biomolecular Chemistry
2014	[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications Published In RSC Advances: an international journal to further the chemical sciences
2013	A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain Published In Journal of Ethnopharmacology
2013	An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: textual understanding and the current practices Published In Journal of Ethnopharmacology
2013	Antimicrobial, antimalarial and cytoxicity activities of constituents of a Bhutanese variety of Ajania nubigena Published In Natural Product Communications: an international journal for communications and reviews
2013	Constituents of the Indonesian Epiphytic Medicinal Plant Drynaria rigidula Published In Natural Product Communications: an international journal for communications and reviews
2013	Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis Published In Pharmacology and Therapeutics
2013	GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile Published In Natural Product Communications: an international journal for communications and reviews
2013	Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants Published In Journal of Ethnopharmacology
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry
2013	Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins Published In Journal of Molecular Graphics and Modelling
2012	Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia Published In Journal of Ethnopharmacology
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry
2012	Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa Published In Natural Product Communications: an international journal for communications and reviews
2011	Ethnobotanical authentication and identification of Khrog-sman (lower elevation medicinal plants) of Bhutan Published In Journal of Ethnopharmacology
2011	Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities Published In Journal of Ethnopharmacology
2011	Investigation into the extension of the non-nucleoside reverse transcriptase binding pocket Published In Australian Journal of Chemistry: an international journal for chemical science
2011	Revealing indigenous Indonesian traditional medicine: anti-infective agents Published In Natural Product Communications: an international journal for communications and reviews
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry
2010	Synthesis of reaction-ready 6,6 '-biindole and 6,6 '-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation Published In Chemical Communications
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2009	Reactions of electron-rich indoles with triflic anhydride Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry
2009	The Medicinal Chemistry of Dengue Fever Published In Journal of Medicinal Chemistry
2008	A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines Published In Organic Letters
2008	Antimalarial Activity of 2,4-Diaminopyrimidines Published In Letters in Drug Design and Discovery
2008	Effective synthetic routes to activated pyrrolo[3,2,1-hi]indoles Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2007	A new methodology for the simulation of flexible protein-ligand interactions Published In Journal of Molecular Graphics and Modelling
2007	Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry
2007	Control of HIV through the inhibition of HIV-1 integrase: a medicinal chemistry perspective Published In Medicinal Chemistry
2007	Corticotropin releasing hormone - a GPCR drug target Published In Current Drug Targets
2007	Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry

Chapter

Year	Title
2013	Ring synthesis Published In Pyridine: from Lab to Production
2008	Pyridines and their Benzo Derivatives: Synthesis Published In Comprehensive Heterocyclic Chemistry III

Investigator On

Year	Title
2018 - 2021	Anti-sporulation strategies for Clostridium difficile infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017 - 2020	From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018	New photoinitiators and polymers for tack-free LED cured surface coatings Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2014 - 2017	Modelling spatial patterns and identifying environmental drivers for temporal change in Antarctic moss communities Funding Scheme: Australian Antarctic Science Program
2013 - 2016	The development of novel antibacterials targeting Clostridium Difficile Infections Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011 - 2014	Mapping Antarctic climate change in space and time using mosses as biological proxies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	State-of-the-art facility for human and animal virus research in the Canberra surrounding regions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The Design and Development of the Next Generation Anti-HIV Drugs Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2008	Mechanisms of Chikungunya virus disease: mouse model, virulent determinants and the development of novel therapeutics Awarded by: Department of Education, Science and Training (DEST) Funding Scheme: Australia-India Strategic Research Fund
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Understanding the tolerance of Antarctic mosses to climate change Funding Scheme: Grant
2007	Novel strategies in the design and development of antivirals against dengue virus Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2007	The development of sigma-1 and sigma-2 receptor ligands as diagnostic probes for cancer and neurodegeneration Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	The Design, Synthesis and Upscaling of Chiral Helical Ligand Libraries for Asymmetric Syntheses	Smyth, Jamie
Doctor of Philosophy	Development of new anti-bacterial agents	Mahadari, Muni
Doctor of Philosophy	Cascade Reactions of Indigo	Perry, Matthew
Doctor of Philosophy	Synthesis of Glyphaeaside C and its Analogues for Structure Elucidation and Biological Assays Against Glycosidases	Byatt, Brendan
Doctor of Philosophy	Design and synthesis of novel amphiphilic peptidomimetics targeting multidrug-resistant bacteria.	Cun, Wendy
Doctor of Philosophy	New Photoinitiators for LED Activation: Fundamental Studies and Applications	Burns, Brett
Doctor of Philosophy	New Cascade Reactions of Indigo to Give Structurally Complex Heterocycles in Medicinal Chemistry	Ali, Sarfaraz
Doctor of Philosophy	Defining the Art and Science of Eucalyptus Dyes from Indigenous Principles	Beaupark, Stephanie
Doctor of Philosophy	The Design and Development of Inhibitors of Sporulation Targeting Clostridium Difficile Bacteria	Semken, Jess

Full Name

Paul A Keller

Mailing Address

School of Chemistry and Molecular Bioscience

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Science, Medicine and Health (SMAH)

Fax

+61 2 4221 4287

Orcid Id

http://orcid.org/0000-0003-4868-845X (confirmed)

Scopus Id

7202451005

Overview

Research Areas

Research Overview

Available as Research Supervisor

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Contact

Full Name

Mailing Address

Located In Facility

Fax

Identity

Orcid Id

Scopus Id

Overview

Research Areas

Research Overview

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Contact

Full Name

Mailing Address

Located In Facility

Fax

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas