Tehei, Moeava Dr

Head of the Targeted Nano-Therapies

  • School of Physics
  • Faculty of Engineering and Information Sciences
  • Centre for Medical Radiation Physics

Overview


Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

Research Overview


  • From Neutron Scattering and Instrumentation through Physical Chemistry to Human Health Applications

    Tehei is a recognized expert in the use of radiation (neutrons, X-rays and Synchrotron) to study biological systems. During his Ph.D. in Physics, Dr Tehei initiated neutron scattering experiments on complex biological samples (ribosomes, proteins, entire cells). He was financed by a competitive studentship from the Région Rhône-Alpes (France), and worked on the development of neutron scattering methods, coupled with protein purification and biochemical sample characterization. The studies were highly successful, yielding publications in high impact journals and the Thesis Prize from the French Neutron Society. His postdoctoral period in New Zealand fostered Tehei's capacity for high quality research in different biomedical/biotechnology fields. For his Ph.D. and postdoctoral works, he was awarded the Young Researcher Prize from the French Society of Biophysics. In 2004, he was physicist and co-manager of the backscattering instrument IN13 at the world leader neutron centre Institut Laue Langevin in Grenoble. In parallel with his neutron work on protein dynamics, he has used SANS and synchrotron radiation to characterize the structures of the systems studied. 

    Dr Tehei's neutron studies of molecular dynamics in whole cells and in DHFR combined with his work on the medical beam line at the European Synchrotron Radiation Facility (ESRF-Grenoble-France), led to his interest in human health applications of his work and inspired him to develop an independent research program on the effects of radiation and drugs on various cell types in a cancer context. 

    At the University of Wollongong from 2008, he initiated a collaborative interaction with Prof. Nick Dixon. Prof. Dixon strives for a better understanding of the relations between dynamics, structures and function of proteins in the multiprotein molecular machine that synthesizes and repairs DNA. The study of DNA replication and reparation not only reveal the elegance of the cellular world, but also has potential to guide the rational design of new therapeutics and to optimize our cancer treatment approach.  Since January 2010, Tehei started to collaborate with all the investigators from the CMRP at the UOW and founded the team Targeted Nano Therapies at the Illawarra Health and Medical Research Institute.  The main research program of the team is to elaborate cancer therapies by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale.

Available as Research Supervisor

Available for Collaborative Projects

Selected Publications


Investigator On


Impact Story


Available as Research Supervisor

Potential Supervision Topics


  • Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer

  • Investigations into the dynamics involved in the magnetic transitions in Nanoparticles

  • Oncothermia in normal and cancerous cell lines

  • Targeted Nano-Therapies - Investigating uptake and distribution of high-Z in rodents for optimized radiation therapies guided multi-imaging

  • Targeted Nano-Therapies - Synchrotron Microbeam Activated Radiation Therapy

  • Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

    Biophysics, Nanomedicine, Radiation Biology, Neutron Scattering, Nanophysics, Solid State Physics

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Multifunctional Metal Oxide Nanoparticles for Biomcdical Applications Cardillo, Dean
    Doctor of Philosophy Engineering and study of multifunctional biocompatible nanoceramics. Bogusz, Kathrin
    Doctor of Philosophy Drug Delivery Multifunctional Systems Based on Nanoceramic Particles for Cancer Treatment Hsu, Nai-sheng
    Doctor of Philosophy Synthesis and Characterisation of Nanoparticles Such As Bismuth Ferrite For Implementation in MRI and CT Westlake, Matt
    Doctor of Philosophy Lanthanide nanoparticles for image guided multimodal therapies Engels, Elette
    Doctor of Philosophy (Integrated) Multimodal Therapy: A Combination of Oncothermia, Microbeam Radiation Therapy and Nano Therapy Hollis, Carolyn
    Master of Science - Research (Faculty of Engineering) In vitro investigation of the effectiveness of cerium oxide nano particles as radio protectors of cancer and noncancer cells in megavoltage photon fields Taylor, Lee
    Doctor of Philosophy Improving the Efficacy of Radiotherapy for Cancer Treatment McDonald, Marjorie

Outreach Overview


  • EDITORIAL BOARD MEMBER
    Scientific Reports (Nature Publishing Group)

    PEER REVIEWER IN SCIENTIFIC JOURNALS
    Nanoscale
    Small
    Nanomedicine: Nanotechnology, Biology, and Medicine
    Physics Review Letters
    Physics Review E, A
    International Journal of Radiation Biology
    BBA - General Subjects
    Biophysical Journal
    Physical Chemistry Chemical Physics
    Interfaces
    Soft Matter
    The Journal of Physical Chemistry
    Journal of the American Chemical Society
    The FEBS Journal
    The Journal of Biological Chemistry
    European Journal of Biophysics

Full Name


  • M Moeava Tehei

Mailing Address


  • School of Physics - University of Wollongong

    Faculty of Engineering and Information Sciences

    Northfields Ave - Wollongong

    NSW

    2522

    Australia

Research Overview


  • From Neutron Scattering and Instrumentation through Physical Chemistry to Human Health Applications

    Tehei is a recognized expert in the use of radiation (neutrons, X-rays and Synchrotron) to study biological systems. During his Ph.D. in Physics, Dr Tehei initiated neutron scattering experiments on complex biological samples (ribosomes, proteins, entire cells). He was financed by a competitive studentship from the Région Rhône-Alpes (France), and worked on the development of neutron scattering methods, coupled with protein purification and biochemical sample characterization. The studies were highly successful, yielding publications in high impact journals and the Thesis Prize from the French Neutron Society. His postdoctoral period in New Zealand fostered Tehei's capacity for high quality research in different biomedical/biotechnology fields. For his Ph.D. and postdoctoral works, he was awarded the Young Researcher Prize from the French Society of Biophysics. In 2004, he was physicist and co-manager of the backscattering instrument IN13 at the world leader neutron centre Institut Laue Langevin in Grenoble. In parallel with his neutron work on protein dynamics, he has used SANS and synchrotron radiation to characterize the structures of the systems studied. 

    Dr Tehei's neutron studies of molecular dynamics in whole cells and in DHFR combined with his work on the medical beam line at the European Synchrotron Radiation Facility (ESRF-Grenoble-France), led to his interest in human health applications of his work and inspired him to develop an independent research program on the effects of radiation and drugs on various cell types in a cancer context. 

    At the University of Wollongong from 2008, he initiated a collaborative interaction with Prof. Nick Dixon. Prof. Dixon strives for a better understanding of the relations between dynamics, structures and function of proteins in the multiprotein molecular machine that synthesizes and repairs DNA. The study of DNA replication and reparation not only reveal the elegance of the cellular world, but also has potential to guide the rational design of new therapeutics and to optimize our cancer treatment approach.  Since January 2010, Tehei started to collaborate with all the investigators from the CMRP at the UOW and founded the team Targeted Nano Therapies at the Illawarra Health and Medical Research Institute.  The main research program of the team is to elaborate cancer therapies by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale.

Selected Publications


Investigator On


Impact Story


Potential Supervision Topics


  • Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer

  • Investigations into the dynamics involved in the magnetic transitions in Nanoparticles

  • Oncothermia in normal and cancerous cell lines

  • Targeted Nano-Therapies - Investigating uptake and distribution of high-Z in rodents for optimized radiation therapies guided multi-imaging

  • Targeted Nano-Therapies - Synchrotron Microbeam Activated Radiation Therapy

  • Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

    Biophysics, Nanomedicine, Radiation Biology, Neutron Scattering, Nanophysics, Solid State Physics

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Multifunctional Metal Oxide Nanoparticles for Biomcdical Applications Cardillo, Dean
    Doctor of Philosophy Engineering and study of multifunctional biocompatible nanoceramics. Bogusz, Kathrin
    Doctor of Philosophy Drug Delivery Multifunctional Systems Based on Nanoceramic Particles for Cancer Treatment Hsu, Nai-sheng
    Doctor of Philosophy Synthesis and Characterisation of Nanoparticles Such As Bismuth Ferrite For Implementation in MRI and CT Westlake, Matt
    Doctor of Philosophy Lanthanide nanoparticles for image guided multimodal therapies Engels, Elette
    Doctor of Philosophy (Integrated) Multimodal Therapy: A Combination of Oncothermia, Microbeam Radiation Therapy and Nano Therapy Hollis, Carolyn
    Master of Science - Research (Faculty of Engineering) In vitro investigation of the effectiveness of cerium oxide nano particles as radio protectors of cancer and noncancer cells in megavoltage photon fields Taylor, Lee
    Doctor of Philosophy Improving the Efficacy of Radiotherapy for Cancer Treatment McDonald, Marjorie

Outreach Overview


  • EDITORIAL BOARD MEMBER
    Scientific Reports (Nature Publishing Group)

    PEER REVIEWER IN SCIENTIFIC JOURNALS
    Nanoscale
    Small
    Nanomedicine: Nanotechnology, Biology, and Medicine
    Physics Review Letters
    Physics Review E, A
    International Journal of Radiation Biology
    BBA - General Subjects
    Biophysical Journal
    Physical Chemistry Chemical Physics
    Interfaces
    Soft Matter
    The Journal of Physical Chemistry
    Journal of the American Chemical Society
    The FEBS Journal
    The Journal of Biological Chemistry
    European Journal of Biophysics

Full Name


  • M Moeava Tehei

Mailing Address


  • School of Physics - University of Wollongong

    Faculty of Engineering and Information Sciences

    Northfields Ave - Wollongong

    NSW

    2522

    Australia

Geographic Focus