Tehei, Moeava

Overview

Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

Research Areas

0299 - OTHER PHYSICAL SCIENCES

Research Overview

From Neutron Scattering and Instrumentation through Physical Chemistry to Human Health Applications

Tehei is a recognized expert in the use of radiation (neutrons, X-rays and Synchrotron) to study biological systems. During his Ph.D. in Physics, Dr Tehei initiated neutron scattering experiments on complex biological samples (ribosomes, proteins, entire cells). He was financed by a competitive studentship from the Région Rhône-Alpes (France), and worked on the development of neutron scattering methods, coupled with protein purification and biochemical sample characterization. The studies were highly successful, yielding publications in high impact journals and the Thesis Prize from the French Neutron Society. His postdoctoral period in New Zealand fostered Tehei's capacity for high quality research in different biomedical/biotechnology fields. For his Ph.D. and postdoctoral works, he was awarded the Young Researcher Prize from the French Society of Biophysics. In 2004, he was physicist and co-manager of the backscattering instrument IN13 at the world leader neutron centre Institut Laue Langevin in Grenoble. In parallel with his neutron work on protein dynamics, he has used SANS and synchrotron radiation to characterize the structures of the systems studied.

Dr Tehei's neutron studies of molecular dynamics in whole cells and in DHFR combined with his work on the medical beam line at the European Synchrotron Radiation Facility (ESRF-Grenoble-France), led to his interest in human health applications of his work and inspired him to develop an independent research program on the effects of radiation and drugs on various cell types in a cancer context.

At the University of Wollongong from 2008, he initiated a collaborative interaction with Prof. Nick Dixon. Prof. Dixon strives for a better understanding of the relations between dynamics, structures and function of proteins in the multiprotein molecular machine that synthesizes and repairs DNA. The study of DNA replication and reparation not only reveal the elegance of the cellular world, but also has potential to guide the rational design of new therapeutics and to optimize our cancer treatment approach. Since January 2010, Tehei started to collaborate with all the investigators from the CMRP at the UOW and founded the team Targeted Nano Therapies at the Illawarra Health and Medical Research Institute. The main research program of the team is to elaborate cancer therapies by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale.

Geographic Focus

Australia Country

Available as Research Supervisor

Available for Collaborative Projects

Member Of

Animal House User Group Member
Centre for Medical Radiation Physics THEME LEADER: TARGETED NANO-THERAPY TECHNOLOGIES
Illawarra Health and Medical Research Institute Diagnostics and Therapeutics Theme Leadership Group Member
The Centre for Oncology Education and Research Translation (CONCERT) Member

Selected Publications

Journal Article

Year	Title
2018	Biocompatible Bi(OH)3nanoparticles with reduced photocatalytic activityas possible ultraviolet ﬁlter in sunscreens Published In Materials Research Bulletin Volume 108 Pages 130 - 141 ISSN 0025-5408 Altmetric
2018	High toxicity of Bi(OH)3 and α-Bi2O3 nanoparticles towards malignant 9L and MCF-7 cells Published In Materials Science and Engineering C: Materials for Biological Applications Volume 93 Pages 958 - 967 ISSN 0928-4931 Altmetric
2018	Investigation of track structure and condensed history physics models for applications in radiation dosimetry on a micro and nano scale in Geant4 Published In Biomedical Physics and Engineering Express Volume 4 Pages 024001-1 - 024001-11 Altmetric
2018	Radiosensitisation enhancement effect of BrUdR and Ta2O5 NSPs in combination with 5-Fluorouracil antimetabolite in kilovoltage and megavoltage radiation Published In Biomedical Physics and Engineering Express Volume 4 Pages 034001-1 - 034001-14 Altmetric
2018	Thulium Oxide Nanoparticles: A new candidate for image-guided radiotherapy Published In Biomedical Physics and Engineering Express Volume 4 Pages 044001-1 - 044001-11 Altmetric
2018	TiO2/(BiO)2CO3nanocomposites for ultraviolet filtration with reduced photocatalytic activity Published In Journal of Materials Chemistry C Volume 6 Pages 5639 - 5650 ISSN 2050-7534 Altmetric
2017	In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses Published In Applied Radiation and Isotopes Volume 128 Pages 114 - 119 ISSN 0969-8043 Altmetric
2017	Nanostructures, concentrations and energies: an ideal equation to extend therapeutic efficiency on radioresistant 9L tumour cells using Ta2O5 ceramic nanostructured particles Published In Biomedical Physics & Engineering Express Volume 3 Pages 015018-1 - 015018-13 Altmetric
2017	Synchrotron activation radiotherapy: Effects of dose-rate and energy spectra to tantalum oxide nanoparticles selective tumour cell radiosensitization enhancement Published In Journal of Physics: Conference Series Volume 777 Pages 012011-1 - 012011-4 Altmetric
2016	First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1444 - 1452 ISSN 1724-191X Altmetric
2016	Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1584 - 1593 ISSN 1724-191X Altmetric
2016	Multifunctional Fe2O3/CeO2 nanocomposites for free radical scavenging ultraviolet protection Published In RSC Advances: an international journal to further the chemical sciences Volume 6 Pages 65397 - 65402 ISSN 2046-2069 Altmetric
2016	Optimizing dose enhancement with Ta2O5 nanoparticles for synchrotron microbeam activated radiation therapy Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1852 - 1861 ISSN 1724-191X Altmetric
2016	Study of the effect of ceramic TaO₅ nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1216 - 1224 ISSN 1724-191X Altmetric
2016	Synthesis-dependent surface defects and morphology of hematite nanoparticles and their effect on cytotoxicity in vitro Published In ACS Applied Materials and Interfaces Volume 8 Pages 5867 - 5876 ISSN 1944-8244 Altmetric
2015	Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy Published In Physics in Medicine and Biology Volume 60 Pages 7847 - 7859 ISSN 1361-6560 Altmetric
2014	Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds Published In Journal of the Royal Society Interface Volume 11 Pages 20140372-1 - 20140372-9 ISSN 1742-5662 Altmetric
2014	Engineering of bismuth oxide nanoparticles to induce differential biochemical activity in malignant and nonmalignant cells Published In Particle and Particle Systems Characterization Volume 31 Pages 960 - 964 ISSN 0934-0866 Altmetric
2014	High-Z nanostructured ceramics in radiotherapy: first evidence of Ta2O5-induced dose enhancement on radioresistant cancer cells in an MV photon field Published In Particle and Particle Systems Characterization Volume 31 Pages 500 - 505 ISSN 0934-0866 Altmetric
2014	Highly porous hematite nanorods prepared via direct spray precipitation method Published In Materials Letters Volume 117 Pages 279 - 282 ISSN 0167-577X Altmetric
2014	Synthesis of potential theranostic system consisting of methotrexate-immobilized (3-aminopropyl)trimethoxysilane coated α-Bi2O3 nanoparticles for cancer treatment Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 24412 - 24419 ISSN 2046-2069 Altmetric
2014	Thermal fluctuations in amphipol A8-35 particles: a neutron scattering and molecular dynamics study Published In Journal of Membrane Biology: an international journal for studies on the structure, function and genesis of biomembranes Volume 247 Pages 897 - 908 ISSN 0022-2631 Altmetric
2013	Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation Published In Nanomedicine Volume 9 Pages 1098 - 1105 ISSN 1743-5889 Altmetric
2013	High hydrostatic pressure effects investigated by neutron scattering on lipid multilamellar vesicles Published In Physical Chemistry Chemical Physics Volume 15 Pages 20951 - 20956 ISSN 1463-9076 Altmetric
2013	Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain Published In Nucleic Acids Research Volume 41 Pages 5354 - 5367 ISSN 0305-1048 Altmetric
2013	Relation between dynamics, activity and thermal stability within the cholinesterase family Published In Chemico-Biological Interactions Volume 25 Pages 14 - 18 ISSN 0009-2797 Altmetric
2012	Activity and molecular dynamics relationship within the family of human cholinesterase Published In Physical Chemistry Chemical Physics Volume 14 Pages 6764 - 6770 ISSN 1463-9076 Altmetric
2012	Energy landscapes of human acetylcholinesterase and its huperzine A-inhibited counterpart Published In The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter Volume 116 Pages 14744 - 14753 ISSN 1520-5207 Altmetric
2012	Water in extremophiles [L'eau dans les extremophiles] Published In Biofutur Pages 28 - 30
2010	Activity and dynamics of an enzyme, pig liver esterase, in near-anhydrous conditions Published In Biophysical Journal Volume 99 Pages L62 - L64 ISSN 0006-3495 Altmetric
2010	Elastic scattering studies of aligned DMPC multilayers on different hydrations Published In Spectroscopy: an international journal Volume 24 Pages 461 - 466 Altmetric
2010	Hydration dependent studies of highly aligned multilayer lipid membranes by neutron scattering Published In Journal of Chemical Physics Volume 133 Pages 164505-1 - 164505-7 ISSN 0021-9606 Altmetric
2010	Specific cellular water dynamics observed in vivo by neutron scattering and NMR. Published In Physical Chemistry Chemical Physics Volume 12 Pages 10154 - 10160 ISSN 1463-9076 Altmetric
2009	Dynamics of apomyoglobin in the x-toB transition and of partially unfolded aggregated protein Published In European Biophysics Journal Volume 38 Pages 237 - 244 ISSN 0175-7571 Altmetric
2009	From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature Published In Biophysical Journal Volume 96 Pages 5073 - 5081 ISSN 0006-3495 Altmetric
2009	From shell to cell: neutron scattering studies of biological water dynamics and coupling to activity Published In Faraday Discussions Volume 141 Pages 117 - 130 ISSN 1359-6640 Altmetric
2008	Down to atomic scale intracellular water dynamics Published In EMBO Reports Volume 9 Pages 543 - 547 ISSN 1469-221X Altmetric
2008	In vivo measurement of internal and global macromolecular motions in Escherichia coli Published In Biophysical Journal Volume 95 Pages 857 - 864 ISSN 0006-3495 Altmetric
2008	Molecular Biophysics: Understanding living processes, Neutrons and Health Published In Neutrons & Health, ESS Scandinavia report Pages 6 - 7
2008	New sources and instrumentation for neutrons in biology Published In Chemical Physics Volume 345 Pages 133 - 151 ISSN 0301-0104 Altmetric
2008	Protein dynamics and stability: The distribution of atomic fluctuations in thermophilic and mesophilic dihydrofolate reductase derived using elastic incoherent neutron scattering Published In Biophysical Journal Volume 94 Pages 4812 - 4818 ISSN 0006-3495 Altmetric
2008	Solvent isotope effect on macromolecular dynamics in E coli Published In European Biophysics Journal Volume 37 Pages 613 - 617 ISSN 0175-7571 Altmetric
2007	Adaptation to high temperatures through macromolecular dynamics Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 274 Pages 4034 - 4043 ISSN 1742-464X Altmetric
2007	Backscattering Spectrometer for the investigation of the dynamics of biological molecules Published In Materials Research Society Volume 183
2007	Neutron scattering reveals extremely slow water in a Dead Sea organism Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 766 - 771 ISSN 0027-8424 Altmetric

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2010	9th AINSE / ANBUG neutron scattering symposium Published In Conference Handbook Pages 1 - 13
2010	Structure, dynamics and function of replisomal Protein complex Published In 9th AINSE / ANBUG Neutron Scattering Symposium: AANSS 2010 Pages 23 - 23

Investigator On

Year	Title
2015 - 2018	Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Investigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the X-tream dosimetry system Awarded by: Australian Synchrotron Company P/L Funding Scheme: Travel Grant
2017	Investigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the x-tream dosimetry system and characterisation of DNA damage-repair with yH2AX Awarded by: Australian Synchrotron Research Program Funding Scheme: Beamtime at the AS XAS Beamline
2015 - 2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2015 - 2016	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Size-Exchusion Chromatography Coupled SAXS of Macromolecular Complexes: the Replisome and the Divisome Awarded by: Australian Synchrotron Research Program Funding Scheme: Grant
2013	Size-exclusion chromatography coupled SAXS for structural measurement of replisomal and cell division proteins Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2012	Helicase loading and translocation in Bacillus Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	Helicase loading and translocation in Bacillus Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	Mapping protein and water dynamics in replisomal macromolecular assemblies Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2011	Water dynamics measured in Halomonas, an ectoine producing bacterium Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2010	Dynamics studies of protein-protein and protein-drug complexes Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2009	Dynamics of Human Acetylcholinersterase Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2009	Mapping protein contacts and conformational changes in macromolecular assemblies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Mapping protein dynamics conformational changes in replisomal macromolecular assemblies Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2008	Dynamics Studies of Model Membranes and Membrane/Protein Complexes Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2007	Study of relationships between function, structure and dynamics of biological molecules by neutron scattering Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Fellowships
	Enhancing synchrotron microbeam radiation therapy in vivo with high-Z nanoparticles Awarded by: Australian Synchrotron Research Program Funding Scheme: Imaging and Medical Beamline
	Investigation of the effects of tantalum pentoxide and bismuth oxide nano particles on 9L gliosarcoma and MDCK non cancerour cells using both synchrotron generated broad and micro-beams monitored by the X-tream dosimetry system. Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant

Impact Story

Available as Research Supervisor

Potential Supervision Topics

Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer
Investigations into the dynamics involved in the magnetic transitions in Nanoparticles
Oncothermia in normal and cancerous cell lines
Targeted Nano-Therapies - Investigating uptake and distribution of high-Z in rodents for optimized radiation therapies guided multi-imaging
Targeted Nano-Therapies - Synchrotron Microbeam Activated Radiation Therapy
Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

Biophysics, Nanomedicine, Radiation Biology, Neutron Scattering, Nanophysics, Solid State Physics

Teaching Activities

Biomolecular Physics Course Director
PHYS369: Imaging, Structure and Dynamics of Living and Soft Matter Coordinator
PHYS476 Coordinator

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biomedical applications of multifunctional iron oxide-based nanomaterials	Cardillo, Dean
Doctor of Philosophy	Engineering and study of biocompatible nanoceramics	Bogusz, Kathrin
Doctor of Philosophy	Drug Delivery Multifunctional Systems Based on Nanoceramic Particles for Cancer Treatment	Hsu, Nai-sheng
Doctor of Philosophy	Synthesis and Characterisation of Nanoparticles Such As Bismuth Ferrite For Implementation in MRI and CT	Westlake, Matt
Doctor of Philosophy	Lanthanide nanoparticles for image guided multimodal therapies	Engels, Elette
Doctor of Philosophy (Integrated)	Multimodal Therapy: A Combination of Oncothermia, Microbeam Radiation Therapy and Nano Therapy	Hollis, Carolyn
Master of Philosophy - EIS	Lanthanum Manganite nanoparticles combined with Methotrexate for radiation dose enhancement and theranostic applications	Khochaiche, Abass
Master of Science - Research (Faculty of Engineering)	Cerium Oxide Nanoparticles: A sSudy of Ce^3+ ion Influence on Radioprotection	Taylor, Lee
Doctor of Philosophy	Improving the Efficacy of Radiotherapy for Cancer Treatment	McDonald, Marjorie

Outreach Overview

EDITORIAL BOARD MEMBER
Scientific Reports (Nature Publishing Group)

PEER REVIEWER IN SCIENTIFIC JOURNALS
Nanoscale
Small
Nanomedicine: Nanotechnology, Biology, and Medicine
Physics Review Letters
Physics Review E, A
International Journal of Radiation Biology
BBA - General Subjects
Biophysical Journal
Physical Chemistry Chemical Physics
Interfaces
Soft Matter
The Journal of Physical Chemistry
Journal of the American Chemical Society
The FEBS Journal
The Journal of Biological Chemistry
European Journal of Biophysics

Organizer Of Event

Innovation in Radiation Applications 2017

Education And Training

Ph.D. in Physics, Université Joseph Fourier (Grenoble I) 1999 - 2002

Full Name

Dr Moeava Tehei

Mailing Address

School of Physics - University of Wollongong

Faculty of Engineering and Information Sciences

Northfields Ave - Wollongong

NSW

2522

Australia

Research Overview

From Neutron Scattering and Instrumentation through Physical Chemistry to Human Health Applications

Tehei is a recognized expert in the use of radiation (neutrons, X-rays and Synchrotron) to study biological systems. During his Ph.D. in Physics, Dr Tehei initiated neutron scattering experiments on complex biological samples (ribosomes, proteins, entire cells). He was financed by a competitive studentship from the Région Rhône-Alpes (France), and worked on the development of neutron scattering methods, coupled with protein purification and biochemical sample characterization. The studies were highly successful, yielding publications in high impact journals and the Thesis Prize from the French Neutron Society. His postdoctoral period in New Zealand fostered Tehei's capacity for high quality research in different biomedical/biotechnology fields. For his Ph.D. and postdoctoral works, he was awarded the Young Researcher Prize from the French Society of Biophysics. In 2004, he was physicist and co-manager of the backscattering instrument IN13 at the world leader neutron centre Institut Laue Langevin in Grenoble. In parallel with his neutron work on protein dynamics, he has used SANS and synchrotron radiation to characterize the structures of the systems studied.

Dr Tehei's neutron studies of molecular dynamics in whole cells and in DHFR combined with his work on the medical beam line at the European Synchrotron Radiation Facility (ESRF-Grenoble-France), led to his interest in human health applications of his work and inspired him to develop an independent research program on the effects of radiation and drugs on various cell types in a cancer context.

At the University of Wollongong from 2008, he initiated a collaborative interaction with Prof. Nick Dixon. Prof. Dixon strives for a better understanding of the relations between dynamics, structures and function of proteins in the multiprotein molecular machine that synthesizes and repairs DNA. The study of DNA replication and reparation not only reveal the elegance of the cellular world, but also has potential to guide the rational design of new therapeutics and to optimize our cancer treatment approach. Since January 2010, Tehei started to collaborate with all the investigators from the CMRP at the UOW and founded the team Targeted Nano Therapies at the Illawarra Health and Medical Research Institute. The main research program of the team is to elaborate cancer therapies by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale.

Geographic Focus

Australia Country

Member Of

Animal House User Group Member
Centre for Medical Radiation Physics THEME LEADER: TARGETED NANO-THERAPY TECHNOLOGIES
Illawarra Health and Medical Research Institute Diagnostics and Therapeutics Theme Leadership Group Member
The Centre for Oncology Education and Research Translation (CONCERT) Member

Selected Publications

Journal Article

Year	Title
2018	Biocompatible Bi(OH)3nanoparticles with reduced photocatalytic activityas possible ultraviolet ﬁlter in sunscreens Published In Materials Research Bulletin Volume 108 Pages 130 - 141 ISSN 0025-5408 Altmetric
2018	High toxicity of Bi(OH)3 and α-Bi2O3 nanoparticles towards malignant 9L and MCF-7 cells Published In Materials Science and Engineering C: Materials for Biological Applications Volume 93 Pages 958 - 967 ISSN 0928-4931 Altmetric
2018	Investigation of track structure and condensed history physics models for applications in radiation dosimetry on a micro and nano scale in Geant4 Published In Biomedical Physics and Engineering Express Volume 4 Pages 024001-1 - 024001-11 Altmetric
2018	Radiosensitisation enhancement effect of BrUdR and Ta2O5 NSPs in combination with 5-Fluorouracil antimetabolite in kilovoltage and megavoltage radiation Published In Biomedical Physics and Engineering Express Volume 4 Pages 034001-1 - 034001-14 Altmetric
2018	Thulium Oxide Nanoparticles: A new candidate for image-guided radiotherapy Published In Biomedical Physics and Engineering Express Volume 4 Pages 044001-1 - 044001-11 Altmetric
2018	TiO2/(BiO)2CO3nanocomposites for ultraviolet filtration with reduced photocatalytic activity Published In Journal of Materials Chemistry C Volume 6 Pages 5639 - 5650 ISSN 2050-7534 Altmetric
2017	In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses Published In Applied Radiation and Isotopes Volume 128 Pages 114 - 119 ISSN 0969-8043 Altmetric
2017	Nanostructures, concentrations and energies: an ideal equation to extend therapeutic efficiency on radioresistant 9L tumour cells using Ta2O5 ceramic nanostructured particles Published In Biomedical Physics & Engineering Express Volume 3 Pages 015018-1 - 015018-13 Altmetric
2017	Synchrotron activation radiotherapy: Effects of dose-rate and energy spectra to tantalum oxide nanoparticles selective tumour cell radiosensitization enhancement Published In Journal of Physics: Conference Series Volume 777 Pages 012011-1 - 012011-4 Altmetric
2016	First proof of bismuth oxide nanoparticles as efficient radiosensitisers on highly radioresistant cancer cells Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1444 - 1452 ISSN 1724-191X Altmetric
2016	Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1584 - 1593 ISSN 1724-191X Altmetric
2016	Multifunctional Fe2O3/CeO2 nanocomposites for free radical scavenging ultraviolet protection Published In RSC Advances: an international journal to further the chemical sciences Volume 6 Pages 65397 - 65402 ISSN 2046-2069 Altmetric
2016	Optimizing dose enhancement with Ta2O5 nanoparticles for synchrotron microbeam activated radiation therapy Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1852 - 1861 ISSN 1724-191X Altmetric
2016	Study of the effect of ceramic TaO₅ nanoparticle distribution on cellular dose enhancement in a kilovoltage photon field Published In Physica Medica: an international journal devoted to the applications of physics to medicine and biology Volume 32 Pages 1216 - 1224 ISSN 1724-191X Altmetric
2016	Synthesis-dependent surface defects and morphology of hematite nanoparticles and their effect on cytotoxicity in vitro Published In ACS Applied Materials and Interfaces Volume 8 Pages 5867 - 5876 ISSN 1944-8244 Altmetric
2015	Indirect radio-chemo-beta therapy: a targeted approach to increase biological efficiency of x-rays based on energy Published In Physics in Medicine and Biology Volume 60 Pages 7847 - 7859 ISSN 1361-6560 Altmetric
2014	Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds Published In Journal of the Royal Society Interface Volume 11 Pages 20140372-1 - 20140372-9 ISSN 1742-5662 Altmetric
2014	Engineering of bismuth oxide nanoparticles to induce differential biochemical activity in malignant and nonmalignant cells Published In Particle and Particle Systems Characterization Volume 31 Pages 960 - 964 ISSN 0934-0866 Altmetric
2014	High-Z nanostructured ceramics in radiotherapy: first evidence of Ta2O5-induced dose enhancement on radioresistant cancer cells in an MV photon field Published In Particle and Particle Systems Characterization Volume 31 Pages 500 - 505 ISSN 0934-0866 Altmetric
2014	Highly porous hematite nanorods prepared via direct spray precipitation method Published In Materials Letters Volume 117 Pages 279 - 282 ISSN 0167-577X Altmetric
2014	Synthesis of potential theranostic system consisting of methotrexate-immobilized (3-aminopropyl)trimethoxysilane coated α-Bi2O3 nanoparticles for cancer treatment Published In RSC Advances: an international journal to further the chemical sciences Volume 4 Pages 24412 - 24419 ISSN 2046-2069 Altmetric
2014	Thermal fluctuations in amphipol A8-35 particles: a neutron scattering and molecular dynamics study Published In Journal of Membrane Biology: an international journal for studies on the structure, function and genesis of biomembranes Volume 247 Pages 897 - 908 ISSN 0022-2631 Altmetric
2013	Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation Published In Nanomedicine Volume 9 Pages 1098 - 1105 ISSN 1743-5889 Altmetric
2013	High hydrostatic pressure effects investigated by neutron scattering on lipid multilamellar vesicles Published In Physical Chemistry Chemical Physics Volume 15 Pages 20951 - 20956 ISSN 1463-9076 Altmetric
2013	Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain Published In Nucleic Acids Research Volume 41 Pages 5354 - 5367 ISSN 0305-1048 Altmetric
2013	Relation between dynamics, activity and thermal stability within the cholinesterase family Published In Chemico-Biological Interactions Volume 25 Pages 14 - 18 ISSN 0009-2797 Altmetric
2012	Activity and molecular dynamics relationship within the family of human cholinesterase Published In Physical Chemistry Chemical Physics Volume 14 Pages 6764 - 6770 ISSN 1463-9076 Altmetric
2012	Energy landscapes of human acetylcholinesterase and its huperzine A-inhibited counterpart Published In The Journal of Physical Chemistry B: Biophysical Chemistry, Biomaterials, Liquids, and Soft Matter Volume 116 Pages 14744 - 14753 ISSN 1520-5207 Altmetric
2012	Water in extremophiles [L'eau dans les extremophiles] Published In Biofutur Pages 28 - 30
2010	Activity and dynamics of an enzyme, pig liver esterase, in near-anhydrous conditions Published In Biophysical Journal Volume 99 Pages L62 - L64 ISSN 0006-3495 Altmetric
2010	Elastic scattering studies of aligned DMPC multilayers on different hydrations Published In Spectroscopy: an international journal Volume 24 Pages 461 - 466 Altmetric
2010	Hydration dependent studies of highly aligned multilayer lipid membranes by neutron scattering Published In Journal of Chemical Physics Volume 133 Pages 164505-1 - 164505-7 ISSN 0021-9606 Altmetric
2010	Specific cellular water dynamics observed in vivo by neutron scattering and NMR. Published In Physical Chemistry Chemical Physics Volume 12 Pages 10154 - 10160 ISSN 1463-9076 Altmetric
2009	Dynamics of apomyoglobin in the x-toB transition and of partially unfolded aggregated protein Published In European Biophysics Journal Volume 38 Pages 237 - 244 ISSN 0175-7571 Altmetric
2009	From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature Published In Biophysical Journal Volume 96 Pages 5073 - 5081 ISSN 0006-3495 Altmetric
2009	From shell to cell: neutron scattering studies of biological water dynamics and coupling to activity Published In Faraday Discussions Volume 141 Pages 117 - 130 ISSN 1359-6640 Altmetric
2008	Down to atomic scale intracellular water dynamics Published In EMBO Reports Volume 9 Pages 543 - 547 ISSN 1469-221X Altmetric
2008	In vivo measurement of internal and global macromolecular motions in Escherichia coli Published In Biophysical Journal Volume 95 Pages 857 - 864 ISSN 0006-3495 Altmetric
2008	Molecular Biophysics: Understanding living processes, Neutrons and Health Published In Neutrons & Health, ESS Scandinavia report Pages 6 - 7
2008	New sources and instrumentation for neutrons in biology Published In Chemical Physics Volume 345 Pages 133 - 151 ISSN 0301-0104 Altmetric
2008	Protein dynamics and stability: The distribution of atomic fluctuations in thermophilic and mesophilic dihydrofolate reductase derived using elastic incoherent neutron scattering Published In Biophysical Journal Volume 94 Pages 4812 - 4818 ISSN 0006-3495 Altmetric
2008	Solvent isotope effect on macromolecular dynamics in E coli Published In European Biophysics Journal Volume 37 Pages 613 - 617 ISSN 0175-7571 Altmetric
2007	Adaptation to high temperatures through macromolecular dynamics Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 274 Pages 4034 - 4043 ISSN 1742-464X Altmetric
2007	Backscattering Spectrometer for the investigation of the dynamics of biological molecules Published In Materials Research Society Volume 183
2007	Neutron scattering reveals extremely slow water in a Dead Sea organism Published In Proceedings of the National Academy of Sciences of USA Volume 104 Pages 766 - 771 ISSN 0027-8424 Altmetric

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2010	9th AINSE / ANBUG neutron scattering symposium Published In Conference Handbook Pages 1 - 13
2010	Structure, dynamics and function of replisomal Protein complex Published In 9th AINSE / ANBUG Neutron Scattering Symposium: AANSS 2010 Pages 23 - 23

Investigator On

Year	Title
2015 - 2018	Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Investigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the X-tream dosimetry system Awarded by: Australian Synchrotron Company P/L Funding Scheme: Travel Grant
2017	Investigation of the effects of thulium oxide nanoparticles and anti-cancer drugs on tumorous 9L gliosarcoma and MDCK non cancerous cells using micro-beams monitored by the x-tream dosimetry system and characterisation of DNA damage-repair with yH2AX Awarded by: Australian Synchrotron Research Program Funding Scheme: Beamtime at the AS XAS Beamline
2015 - 2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2015 - 2016	Small animal stereotaxic instrument and microinjection unit Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2014	Size-Exchusion Chromatography Coupled SAXS of Macromolecular Complexes: the Replisome and the Divisome Awarded by: Australian Synchrotron Research Program Funding Scheme: Grant
2013	Size-exclusion chromatography coupled SAXS for structural measurement of replisomal and cell division proteins Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2012	Helicase loading and translocation in Bacillus Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	Helicase loading and translocation in Bacillus Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant
2011	Mapping protein and water dynamics in replisomal macromolecular assemblies Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2011	Water dynamics measured in Halomonas, an ectoine producing bacterium Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2010	Dynamics studies of protein-protein and protein-drug complexes Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2009	Dynamics of Human Acetylcholinersterase Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2009	Mapping protein contacts and conformational changes in macromolecular assemblies Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2009	Mapping protein dynamics conformational changes in replisomal macromolecular assemblies Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2008	Dynamics Studies of Model Membranes and Membrane/Protein Complexes Awarded by: Australian Nuclear Science and Technology Organisation (ANSTO) Funding Scheme: Access to Major Research Facility Program
2007	Study of relationships between function, structure and dynamics of biological molecules by neutron scattering Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Fellowships
	Enhancing synchrotron microbeam radiation therapy in vivo with high-Z nanoparticles Awarded by: Australian Synchrotron Research Program Funding Scheme: Imaging and Medical Beamline
	Investigation of the effects of tantalum pentoxide and bismuth oxide nano particles on 9L gliosarcoma and MDCK non cancerour cells using both synchrotron generated broad and micro-beams monitored by the X-tream dosimetry system. Awarded by: Australian Synchrotron Research Program Funding Scheme: Travel Grant

Impact Story

Potential Supervision Topics

Design and application of new nanomaterials theranostic platforms for targeted treatment of cancer
Investigations into the dynamics involved in the magnetic transitions in Nanoparticles
Oncothermia in normal and cancerous cell lines
Targeted Nano-Therapies - Investigating uptake and distribution of high-Z in rodents for optimized radiation therapies guided multi-imaging
Targeted Nano-Therapies - Synchrotron Microbeam Activated Radiation Therapy
Scientific research on the relation amongst dynamics, structure and function of proteins for optimisation of cancer treatment at the molecular drug target level. Elaboration of cancer therapies and imaging by combining the effects of targeted radiations and drugs or nanoparticles at the nano-scale level.

Biophysics, Nanomedicine, Radiation Biology, Neutron Scattering, Nanophysics, Solid State Physics

Teaching Activities

Biomolecular Physics Course Director
PHYS369: Imaging, Structure and Dynamics of Living and Soft Matter Coordinator
PHYS476 Coordinator

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biomedical applications of multifunctional iron oxide-based nanomaterials	Cardillo, Dean
Doctor of Philosophy	Engineering and study of biocompatible nanoceramics	Bogusz, Kathrin
Doctor of Philosophy	Drug Delivery Multifunctional Systems Based on Nanoceramic Particles for Cancer Treatment	Hsu, Nai-sheng
Doctor of Philosophy	Synthesis and Characterisation of Nanoparticles Such As Bismuth Ferrite For Implementation in MRI and CT	Westlake, Matt
Doctor of Philosophy	Lanthanide nanoparticles for image guided multimodal therapies	Engels, Elette
Doctor of Philosophy (Integrated)	Multimodal Therapy: A Combination of Oncothermia, Microbeam Radiation Therapy and Nano Therapy	Hollis, Carolyn
Master of Philosophy - EIS	Lanthanum Manganite nanoparticles combined with Methotrexate for radiation dose enhancement and theranostic applications	Khochaiche, Abass
Master of Science - Research (Faculty of Engineering)	Cerium Oxide Nanoparticles: A sSudy of Ce^3+ ion Influence on Radioprotection	Taylor, Lee
Doctor of Philosophy	Improving the Efficacy of Radiotherapy for Cancer Treatment	McDonald, Marjorie

Outreach Overview

EDITORIAL BOARD MEMBER
Scientific Reports (Nature Publishing Group)

PEER REVIEWER IN SCIENTIFIC JOURNALS
Nanoscale
Small
Nanomedicine: Nanotechnology, Biology, and Medicine
Physics Review Letters
Physics Review E, A
International Journal of Radiation Biology
BBA - General Subjects
Biophysical Journal
Physical Chemistry Chemical Physics
Interfaces
Soft Matter
The Journal of Physical Chemistry
Journal of the American Chemical Society
The FEBS Journal
The Journal of Biological Chemistry
European Journal of Biophysics

Organizer Of Event

Innovation in Radiation Applications 2017

Education And Training

Ph.D. in Physics, Université Joseph Fourier (Grenoble I) 1999 - 2002

Full Name

Dr Moeava Tehei

Mailing Address

School of Physics - University of Wollongong

Faculty of Engineering and Information Sciences

Northfields Ave - Wollongong

NSW

2522

Australia

Geographic Location

University of Wollongong

Located In Facility

Building 4 Room G60

Orcid Id

http://orcid.org/0000-0003-3654-6833 (confirmed)

Scopus Id

6506235955

Overview

Overview

Research Areas

Research Overview

Geographic Focus

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Member Of

Publications

Selected Publications

Journal Article

Conference Paper

Funding

Investigator On

Impact

Impact Story

Supervision

Available as Research Supervisor

Potential Supervision Topics

Teaching Activities

Advisees

Graduate Advising Relationship

Service

Outreach Overview

Organizer Of Event

Background

Education And Training

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Scopus Id

Overview

Research Areas

Research Overview

Geographic Focus

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Conference Paper

Funding

Investigator On

Impact

Impact Story

Supervision

Potential Supervision Topics

Teaching Activities

Advisees

Graduate Advising Relationship

Service

Outreach Overview

Organizer Of Event

Background

Education And Training

Contact

Full Name

Mailing Address

Geographic Location

Located In Facility

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas

Geographic Focus