Dottori, Mirella

Overview

Associate Professor Mirella Dottori is Principal Research Fellow at Illawarra Health and Medical Research Institute, University of Wollongong. She obtained her PhD in Medical Biology at Walter and Eliza Hall Institute, University of Melbourne. She undertook her postdoctoral training at the Salk Institute for Biological Sciences (USA) followed by Monash University. In 2007 A/Prof Dottori established her research group at the University of Melbourne and moved in 2017 to a Faculty position within the School of Medicine at the University of Wollongong.

A/Prof Dottori is a recipient of the Human Frontiers Fellowship, NHMRC Peter Doherty Fellowship, and Australian Research Council Future Fellowship Awards. She has authored over 65 publications, including in Nature Methods, Nature Protocols, PNAS, Development and Stem Cells. She is an Editorial Board member for the multidisciplinary journals, Scientific Reports and Plos One and an Associate Member of the ARC Stem Cells Australia.

Top Publications

Year	Title
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published in Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published in Stem Cells and Development
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published in Scientific Reports
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published in Stem Cells
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published in PLoS One

Research Areas

Research Overview

A/Prof Dottori’s research combines technologies in stem cell biology, neuroscience and bio-engineering to develop cellular models of the human nervous system. Her major research focus is in understanding how to direct human stem cells to differentiate towards neuronal lineages of the central and peripheral nervous system. These studies are significant in expanding our knowledge about human neurodevelopment and also for clinical application of stem cells in regenerative medicine. Her research has contributed to advancing cellular models to study and develop therapies for a diverse range of neurological conditions, including progressive ataxias, Parkinson’s disease, sensory neuropathies and dementia.

Member Of

Scientific Reports Editor 2018 -
The University of Melbourne Honorary Research Fellow 2017 -
Plos One Editor 2012 -
Stem Cells Australia Associate 2012 -
Centre for Eye Research Australia Scientific Advisory Board Member 2009 - 2014
Australasian Society for Stem Cell Research Secretary 2008 - 2010

Selected Publications

Journal Article

Year	Title
2021	Abnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder Published In Neurobiology of Disease
2021	Abstracts from the Spectra 2018 Symposium Part 5: Contexts Published In Leonardo
2021	Cellular pathophysiology of Friedreich's ataxia cardiomyopathy Published In International Journal of Cardiology
2021	Development of functional thyroid C cell-like cells from human pluripotent cells in 2D and in 3D scaffold Published In Cells
2021	In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia Published In Stem Cells Translational Medicine
2021	Neural differentiation medium for human pluripotent stem cells to model physiological glucose levels in human brain Published In Brain Research Bulletin
2020	Abstracts from the Spectra 2018 Symposium: Contexts Published In Leonardo
2020	Differential susceptibility of human neural progenitors and neurons to ischaemic injury Published In Brain Research Bulletin
2020	Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density Published In Biomacromolecules
2020	If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? Published In Neuroscientist
2020	Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons Published In Frontiers in Cellular Neuroscience
2020	More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment Published In eNeuro
2020	Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia Published In Biomaterials Science
2019	Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells Published In Methods in Molecular Biology
2019	Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System Published In Frontiers In Cell And Developmental Biology
2019	Inner ear organoids derived from human pluripotent stem cells using rotary cell culture Published In IBRO Reports
2019	Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices Published In Stem Cells International
2018	Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods Published In Journal of Neuroscience Methods
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published In Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published In Stem Cells and Development
2018	Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease Published In Stem Cell Research
2018	Graphene foam as a biocompatible scaffold for culturing human neurons Published In Royal Society Open Science
2018	Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies Published In The International Journal of Biochemistry and Cell Biology
2018	NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons Published In Journal of Stroke and Cerebrovascular Diseases
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published In Scientific Reports
2018	Self-organized nanostructure modified microelectrode for sensitive electrochemical glutamate detection in stem cells-derived brain organoids Published In Biosensors
2018	The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development Published In Molecular Neurobiology
2017	Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency Published In Aging
2017	Long-distance axonal growth and protracted functional maturation of neurons derived from human induced pluripotent stem cells after intracerebral transplantation Published In Stem Cells Translational Medicine
2017	No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism Published In Molecular Autism
2017	WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells Published In Stem Cells International
2016	Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Published In Cellular and Molecular Gastroenterology and Hepatology
2016	Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons in Vitro Published In Stem Cells International
2015	Direct Conversion of Adult Human Fibroblasts into Induced Neural Precursor Cells by Non-Viral Transfection. Published In Protocol Exchange
2015	Innervation of peripheral and central auditory tissues by human embryonic stem cell-derived neurons in vitro Published In International Journal of Developmental Neuroscience
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published In Stem Cells
2015	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation Published In Human Genetics
2015	Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors Published In Small
2014	A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells Published In Stem Cell Research and Therapy
2014	Cell and gene therapy for friedreich ataxia: Progress to date Published In Human Gene Therapy
2014	Directing Human Induced Pluripotent Stem Cells into a Neurosensory Lineage for Auditory Neuron Replacement Published In BioResearch Open Access
2014	Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells Published In Stem Cell Research
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published In PLoS One
2014	Hypothermia protects human neurons Published In International Journal of Stroke
2013	An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants Published In Stem Cells and Development
2013	Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines Published In Frontiers in Cellular Neuroscience
2013	Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid Published In Journal of Lipid Research
2012	Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage Published In Stem Cells
2012	In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation Published In Biochemical and Biophysical Research Communications
2012	Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation Published In Frontiers in Cellular Neuroscience
2012	Non-viral generation of neural precursor-like cells from adult human fibroblasts Published In Journal of Stem Cells and Regenerative Medicine
2012	Stem cells as in vitro models of disease Published In Stem Cells International
2012	The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy Published In Stem Cell Reviews
2011	Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients Published In Stem Cell Reviews
2011	Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation Published In Cell Transplantation
2011	Neural development in human embryonic stem cells-applications of lentiviral vectors Published In Journal of Cellular Biochemistry
2011	Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells Published In Stem Cell Research and Therapy
2010	Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease Published In Cell Transplantation
2010	Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells Published In Stem Cells and Development
2010	Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells Published In Stem Cells
2009	A New Feeder-Free Technique to Expand Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Published In The Open Stem Cell Journal
2009	Generation of human embryonic stem cell reporter knock-in lines by homologous recombination Published In Current Protocols in Stem Cell Biology
2009	Human embryonic stem cell models of Huntington disease Published In Reproductive BioMedicine Online
2009	S3.5 Induction of neural crest stem cells from human ES-derived neural progenitor cells: Migration and differentiation in avian embryos and explants of embryonic mouse gut Published In Autonomic Neuroscience
2009	Signals involved in neural differentiation of human embryonic stem cells Published In NeuroSignals
2009	Small-molecule induction of neural crest-like cells derived from human neural progenitors Published In Stem Cells
2009	Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres Published In BMC Biotechnology
2008	Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells Published In Stem Cells
2008	Neural differentiation of human embryonic stem cells Published In Methods in Molecular Biology
2007	A method for genetic modification of human embryonic stem cells using electroporation Published In Nature Protocols
2007	Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells Published In Molecular and Cellular Neuroscience
2006	Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system Published In Biochemical and Biophysical Research Communications
2006	Neural stem cells express non-neural markers during embryoid body coculture Published In Stem Cells
2005	The hESC line Envy expresses high levels of GFP in all differentiated progeny Published In Nature Methods
2002	EphA4 is not required for Purkinje cell compartmentation Published In Developmental Brain Research
2002	Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord Published In Neuron
2001	Development and reorganization of corticospinal projections in EphA4 deficient mice Published In Journal of Comparative Neurology
2001	Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo Published In Neuron
2001	The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate Published In Development
1999	Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells Published In Blood
1998	Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization Published In Journal of Biological Chemistry
1998	EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract Published In Proceedings of the National Academy of Sciences of the United States of America
1994	The role of the hek RTK in hematopoiesis & oncogenesis Published In Cytokine

Chapter

Year	Title
2012	Generation of Pluripotent Stem Cells and their Developmental Potential Published In Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-To-Bedside Publisher Dubai, United Arab Emirates
2011	Neural differentiation of induced pluripotent stem cells Published In Neurodegeneration: Methods and Protocols Publisher New York, United States
2009	Neural Differentiation of Human Embryonic Stem Cells Published In Protocols for Neural Cell Culture Publisher Humana Press
2008	Human embryonic stem cells: Key characteristics and main applications in disease research Published In Stem Cell Applications in Diseases
2005	Stem cells and their developmental potential Published In Stem Cells: From Bench to Bedside Publisher WORLD SCIENTIFIC

Investigator On

Year	Title
2019 - 2022	Use of brain organoids and artificial intelligence for understanding Dementia Awarded by: Dementia Australia Research Foundation Funding Scheme: Yulgilbar Foundation Grant
2016 - 2020	Personalised Medicine for Mitochondrial Disorders: Targeting Pathogenic Mechanisms Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018 - 2019	Stem Cells Australia Awarded by: Australian Research Council (ARC) Funding Scheme: Special Research Initiatives
2014 - 2018	Modelling the human nervous system with human pluripotent stem cells Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	ARC Training Centre for Personalised Therapeutics Technologies Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres
	Developing therapies for Friedreich's Ataxia using nanoparticles Awarded by: National Ataxia Foundation Funding Scheme: Seed Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Nanoparticle-Mediated Gene Delivery of Frataxin to Neurons Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
	Novel SMART AAV vectors for gene therapy for Friedreich¿s ataxia Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cell Therapies Mission Grant
	Targeted Delivery of Frataxin DNA to Proprioceptors of the Dorsal Root Ganglia Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
	Understanding RAB39B-mediated Parkinson's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Understanding platinum dissolution in biomedical stimulating electrodes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
	echanisms and targeted treatment for neurogenetic disorders: SCN2A Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cells Australia

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy (Integrated)	Glutamatergic and Neurotrophic Signalling in the Pathology and Treatment of Psychiatric Illness.	Jarbou, Noor
Doctor of Philosophy	Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration	Maksour, Simon
Doctor of Philosophy	Specification of Dorsal Root Ganglia Neuronal Subpopulations and Characterization of their Neuropathology in Friedreich's Ataxia	Hulme, Amy
Doctor of Philosophy	Development of an innervated full-thickness human skin model by three-dimensional bioprinting	St Clair-Glover, Mitchell
Doctor of Philosophy	Development of a 3D Bioprinting System to Fabricate Full-thickness Skin-equivalents with Improved Sensory Function	Wallace, Eileen

Education And Training

Ph.D. in Medical Biology, The University of Melbourne, Walter and Eliza Hall Institute 1993 - 1998
B Science (Hon) in Pathology, The University of Melbourne 1989 - 1992
Monash University 2003 - 2006
Salk Institute for Biological Studies 1999 - 2002

Awards And Honors

Australian Research Council Future Fellowship, 2013
National Ataxia Foundation Young Investigator’s Award , 2010
NHMRC Howard Florey Centenary Fellowship, 2003 - 2005
Human Frontiers Science Program Organization Fellowship, 1999 - 2001
Australian Postgraduate Research Scholarship, 1993 - 1996

Full Name

A/Prof Mirella Dottori

Mailing Address

Building 32, Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Top Publications

Year	Title
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published in Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published in Stem Cells and Development
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published in Scientific Reports
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published in Stem Cells
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published in PLoS One

Research Areas

Research Overview

A/Prof Dottori’s research combines technologies in stem cell biology, neuroscience and bio-engineering to develop cellular models of the human nervous system. Her major research focus is in understanding how to direct human stem cells to differentiate towards neuronal lineages of the central and peripheral nervous system. These studies are significant in expanding our knowledge about human neurodevelopment and also for clinical application of stem cells in regenerative medicine. Her research has contributed to advancing cellular models to study and develop therapies for a diverse range of neurological conditions, including progressive ataxias, Parkinson’s disease, sensory neuropathies and dementia.

Member Of

Scientific Reports Editor 2018 -
The University of Melbourne Honorary Research Fellow 2017 -
Plos One Editor 2012 -
Stem Cells Australia Associate 2012 -
Centre for Eye Research Australia Scientific Advisory Board Member 2009 - 2014
Australasian Society for Stem Cell Research Secretary 2008 - 2010

Selected Publications

Journal Article

Year	Title
2021	Abnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder Published In Neurobiology of Disease
2021	Abstracts from the Spectra 2018 Symposium Part 5: Contexts Published In Leonardo
2021	Cellular pathophysiology of Friedreich's ataxia cardiomyopathy Published In International Journal of Cardiology
2021	Development of functional thyroid C cell-like cells from human pluripotent cells in 2D and in 3D scaffold Published In Cells
2021	In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia Published In Stem Cells Translational Medicine
2021	Neural differentiation medium for human pluripotent stem cells to model physiological glucose levels in human brain Published In Brain Research Bulletin
2020	Abstracts from the Spectra 2018 Symposium: Contexts Published In Leonardo
2020	Differential susceptibility of human neural progenitors and neurons to ischaemic injury Published In Brain Research Bulletin
2020	Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density Published In Biomacromolecules
2020	If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? Published In Neuroscientist
2020	Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons Published In Frontiers in Cellular Neuroscience
2020	More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment Published In eNeuro
2020	Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia Published In Biomaterials Science
2019	Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells Published In Methods in Molecular Biology
2019	Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System Published In Frontiers In Cell And Developmental Biology
2019	Inner ear organoids derived from human pluripotent stem cells using rotary cell culture Published In IBRO Reports
2019	Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices Published In Stem Cells International
2018	Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods Published In Journal of Neuroscience Methods
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published In Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published In Stem Cells and Development
2018	Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease Published In Stem Cell Research
2018	Graphene foam as a biocompatible scaffold for culturing human neurons Published In Royal Society Open Science
2018	Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies Published In The International Journal of Biochemistry and Cell Biology
2018	NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons Published In Journal of Stroke and Cerebrovascular Diseases
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published In Scientific Reports
2018	Self-organized nanostructure modified microelectrode for sensitive electrochemical glutamate detection in stem cells-derived brain organoids Published In Biosensors
2018	The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development Published In Molecular Neurobiology
2017	Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency Published In Aging
2017	Long-distance axonal growth and protracted functional maturation of neurons derived from human induced pluripotent stem cells after intracerebral transplantation Published In Stem Cells Translational Medicine
2017	No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism Published In Molecular Autism
2017	WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells Published In Stem Cells International
2016	Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Published In Cellular and Molecular Gastroenterology and Hepatology
2016	Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons in Vitro Published In Stem Cells International
2015	Direct Conversion of Adult Human Fibroblasts into Induced Neural Precursor Cells by Non-Viral Transfection. Published In Protocol Exchange
2015	Innervation of peripheral and central auditory tissues by human embryonic stem cell-derived neurons in vitro Published In International Journal of Developmental Neuroscience
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published In Stem Cells
2015	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation Published In Human Genetics
2015	Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors Published In Small
2014	A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells Published In Stem Cell Research and Therapy
2014	Cell and gene therapy for friedreich ataxia: Progress to date Published In Human Gene Therapy
2014	Directing Human Induced Pluripotent Stem Cells into a Neurosensory Lineage for Auditory Neuron Replacement Published In BioResearch Open Access
2014	Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells Published In Stem Cell Research
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published In PLoS One
2014	Hypothermia protects human neurons Published In International Journal of Stroke
2013	An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants Published In Stem Cells and Development
2013	Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines Published In Frontiers in Cellular Neuroscience
2013	Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid Published In Journal of Lipid Research
2012	Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage Published In Stem Cells
2012	In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation Published In Biochemical and Biophysical Research Communications
2012	Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation Published In Frontiers in Cellular Neuroscience
2012	Non-viral generation of neural precursor-like cells from adult human fibroblasts Published In Journal of Stem Cells and Regenerative Medicine
2012	Stem cells as in vitro models of disease Published In Stem Cells International
2012	The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy Published In Stem Cell Reviews
2011	Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients Published In Stem Cell Reviews
2011	Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation Published In Cell Transplantation
2011	Neural development in human embryonic stem cells-applications of lentiviral vectors Published In Journal of Cellular Biochemistry
2011	Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells Published In Stem Cell Research and Therapy
2010	Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease Published In Cell Transplantation
2010	Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells Published In Stem Cells and Development
2010	Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells Published In Stem Cells
2009	A New Feeder-Free Technique to Expand Human Embryonic Stem Cells and Induced Pluripotent Stem Cells Published In The Open Stem Cell Journal
2009	Generation of human embryonic stem cell reporter knock-in lines by homologous recombination Published In Current Protocols in Stem Cell Biology
2009	Human embryonic stem cell models of Huntington disease Published In Reproductive BioMedicine Online
2009	S3.5 Induction of neural crest stem cells from human ES-derived neural progenitor cells: Migration and differentiation in avian embryos and explants of embryonic mouse gut Published In Autonomic Neuroscience
2009	Signals involved in neural differentiation of human embryonic stem cells Published In NeuroSignals
2009	Small-molecule induction of neural crest-like cells derived from human neural progenitors Published In Stem Cells
2009	Unrestricted somatic stem cells from human umbilical cord blood grow in serum-free medium as spheres Published In BMC Biotechnology
2008	Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells Published In Stem Cells
2008	Neural differentiation of human embryonic stem cells Published In Methods in Molecular Biology
2007	A method for genetic modification of human embryonic stem cells using electroporation Published In Nature Protocols
2007	Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells Published In Molecular and Cellular Neuroscience
2006	Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system Published In Biochemical and Biophysical Research Communications
2006	Neural stem cells express non-neural markers during embryoid body coculture Published In Stem Cells
2005	The hESC line Envy expresses high levels of GFP in all differentiated progeny Published In Nature Methods
2002	EphA4 is not required for Purkinje cell compartmentation Published In Developmental Brain Research
2002	Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord Published In Neuron
2001	Development and reorganization of corticospinal projections in EphA4 deficient mice Published In Journal of Comparative Neurology
2001	Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo Published In Neuron
2001	The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate Published In Development
1999	Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells Published In Blood
1998	Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization Published In Journal of Biological Chemistry
1998	EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract Published In Proceedings of the National Academy of Sciences of the United States of America
1994	The role of the hek RTK in hematopoiesis & oncogenesis Published In Cytokine

Chapter

Year	Title
2012	Generation of Pluripotent Stem Cells and their Developmental Potential Published In Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-To-Bedside Publisher Dubai, United Arab Emirates
2011	Neural differentiation of induced pluripotent stem cells Published In Neurodegeneration: Methods and Protocols Publisher New York, United States
2009	Neural Differentiation of Human Embryonic Stem Cells Published In Protocols for Neural Cell Culture Publisher Humana Press
2008	Human embryonic stem cells: Key characteristics and main applications in disease research Published In Stem Cell Applications in Diseases
2005	Stem cells and their developmental potential Published In Stem Cells: From Bench to Bedside Publisher WORLD SCIENTIFIC

Investigator On

Year	Title
2019 - 2022	Use of brain organoids and artificial intelligence for understanding Dementia Awarded by: Dementia Australia Research Foundation Funding Scheme: Yulgilbar Foundation Grant
2016 - 2020	Personalised Medicine for Mitochondrial Disorders: Targeting Pathogenic Mechanisms Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2018 - 2019	Stem Cells Australia Awarded by: Australian Research Council (ARC) Funding Scheme: Special Research Initiatives
2014 - 2018	Modelling the human nervous system with human pluripotent stem cells Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
	ARC Training Centre for Personalised Therapeutics Technologies Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres
	Developing therapies for Friedreich's Ataxia using nanoparticles Awarded by: National Ataxia Foundation Funding Scheme: Seed Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Nanoparticle-Mediated Gene Delivery of Frataxin to Neurons Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
	Novel SMART AAV vectors for gene therapy for Friedreich¿s ataxia Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cell Therapies Mission Grant
	Targeted Delivery of Frataxin DNA to Proprioceptors of the Dorsal Root Ganglia Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
	Understanding RAB39B-mediated Parkinson's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Understanding platinum dissolution in biomedical stimulating electrodes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
	echanisms and targeted treatment for neurogenetic disorders: SCN2A Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cells Australia

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy (Integrated)	Glutamatergic and Neurotrophic Signalling in the Pathology and Treatment of Psychiatric Illness.	Jarbou, Noor
Doctor of Philosophy	Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration	Maksour, Simon
Doctor of Philosophy	Specification of Dorsal Root Ganglia Neuronal Subpopulations and Characterization of their Neuropathology in Friedreich's Ataxia	Hulme, Amy
Doctor of Philosophy	Development of an innervated full-thickness human skin model by three-dimensional bioprinting	St Clair-Glover, Mitchell
Doctor of Philosophy	Development of a 3D Bioprinting System to Fabricate Full-thickness Skin-equivalents with Improved Sensory Function	Wallace, Eileen

Education And Training

Ph.D. in Medical Biology, The University of Melbourne, Walter and Eliza Hall Institute 1993 - 1998
B Science (Hon) in Pathology, The University of Melbourne 1989 - 1992
Monash University 2003 - 2006
Salk Institute for Biological Studies 1999 - 2002

Awards And Honors

Australian Research Council Future Fellowship, 2013
National Ataxia Foundation Young Investigator’s Award , 2010
NHMRC Howard Florey Centenary Fellowship, 2003 - 2005
Human Frontiers Science Program Organization Fellowship, 1999 - 2001
Australian Postgraduate Research Scholarship, 1993 - 1996

Full Name

A/Prof Mirella Dottori

Mailing Address

Building 32, Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

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Overview

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Research Overview

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Selected Publications

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Supervision

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Background

Education And Training

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Located In Facility

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Contact

Full Name

Mailing Address

Located In Facility

Visualisations

Research Areas