Dottori, Mirella

Overview

Associate Professor Mirella Dottori is Principal Research Fellow at Illawarra Health and Medical Research Institute, University of Wollongong. She obtained her PhD in Medical Biology at Walter and Eliza Hall Institute, University of Melbourne. She undertook her postdoctoral training at the Salk Institute for Biological Sciences (USA) followed by Monash University. In 2007 A/Prof Dottori established her research group at the University of Melbourne and moved in 2017 to a Faculty position within the School of Medicine at the University of Wollongong.

A/Prof Dottori is a recipient of the Human Frontiers Fellowship, NHMRC Peter Doherty Fellowship, and Australian Research Council Future Fellowship Awards. She has authored over 65 publications, including in Nature Methods, Nature Protocols, PNAS, Development and Stem Cells. She is an Editorial Board member for the multidisciplinary journals, Scientific Reports and Plos One and an Associate Member of the ARC Stem Cells Australia.

Top Publications

Year	Title
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published in Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published in Stem Cells and Development
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published in Scientific Reports
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published in Stem Cells
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published in PLoS One

Research Areas

Research Overview

A/Prof Dottori’s research combines technologies in stem cell biology, neuroscience and bio-engineering to develop cellular models of the human nervous system. Her major research focus is in understanding how to direct human stem cells to differentiate towards neuronal lineages of the central and peripheral nervous system. These studies are significant in expanding our knowledge about human neurodevelopment and also for clinical application of stem cells in regenerative medicine. Her research has contributed to advancing cellular models to study and develop therapies for a diverse range of neurological conditions, including progressive ataxias, Parkinson’s disease, sensory neuropathies and dementia.

Member Of

Scientific Reports Editor 2018 -
The University of Melbourne Honorary Research Fellow 2017 -
Plos One Editor 2012 -
Stem Cells Australia Associate 2012 -
Centre for Eye Research Australia Scientific Advisory Board Member 2009 - 2014
Australasian Society for Stem Cell Research Secretary 2008 - 2010

Selected Publications

Journal Article

Year	Title
2020	Differential susceptibility of human neural progenitors and neurons to ischaemic injury Published In Brain Research Bulletin Volume 156 Pages 25 - 32 Altmetric
2020	If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? Published In Neuroscientist Altmetric
2020	More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment Published In eNeuro Volume 7 Pages 1 - 12 Altmetric
2019	Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells Published In Methods in Molecular Biology Volume 1976 Pages 37 - 47 ISSN 1064-3745 Altmetric
2019	Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System Published In Frontiers In Cell And Developmental Biology Volume 7 Pages 25-1 - 25-12 Altmetric
2019	Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices Published In Stem Cells International Volume 2019 Pages 8419493-1 - 8419493-14 Altmetric
2018	Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods Published In Journal of Neuroscience Methods Volume 308 Pages 286 - 293 ISSN 0165-0270 Altmetric
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published In Stem Cell Reports Volume 10 Pages 134 - 150 Altmetric
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published In Stem Cells and Development Volume 27 Pages 848 - 857 ISSN 1557-8534 Altmetric
2018	Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease Published In Stem Cell Research Volume 28 Pages 161 - 164 ISSN 1873-5061 Altmetric
2018	Graphene foam as a biocompatible scaffold for culturing human neurons Published In Royal Society Open Science Volume 5 Pages 171364-1 - 171364-11 Altmetric
2018	Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies Published In The International Journal of Biochemistry and Cell Biology Volume 100 Pages 61 - 68 ISSN 1357-2725 Altmetric
2018	NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons Published In Journal of Stroke and Cerebrovascular Diseases Volume 27 Pages 2158 - 2165 ISSN 1052-3057 Altmetric
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published In Scientific Reports Volume 8 Pages 603-1 - 603-12 ISSN 2045-2322 Altmetric
2018	Self-organized nanostructure modified microelectrode for sensitive electrochemical glutamate detection in stem cells-derived brain organoids Published In Biosensors Volume 8 Pages 14-1 - 14-11 Altmetric
2018	The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development Published In Molecular Neurobiology Volume 55 Pages 5409 - 5424 ISSN 0893-7648 Altmetric
2017	Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency Published In Aging Volume 9 Pages 1440 - 1452 ISSN 1945-4589 Altmetric
2017	Long-distance axonal growth and protracted functional maturation of neurons derived from human induced pluripotent stem cells after intracerebral transplantation Published In Stem Cells Translational Medicine Volume 6 Pages 1547 - 1556 ISSN 2157-6580 Altmetric
2017	No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism Published In Molecular Autism Volume 8 Pages 64-1 - 64-8 Altmetric
2017	WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells Published In Stem Cells International Volume 2017 Pages 7848932-1 - 7848932-9 Altmetric
2016	Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Published In Cellular and Molecular Gastroenterology and Hepatology Volume 2 Pages 92 - 109 Altmetric
2016	Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons in Vitro Published In Stem Cells International Volume 2016 Pages 1781202-1 - 1781202-10 Altmetric
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published In Stem Cells Volume 33 Pages 1759 - 1770 ISSN 1066-5099 Altmetric
2015	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation Published In Human Genetics Volume 134 Pages 1099 - 1115 Altmetric
2015	Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors Published In Small Volume 11 Pages 2862 - 2868 ISSN 1613-6810 Altmetric
2014	A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells Published In Stem Cell Research and Therapy Volume 5 Pages 64-1 - 64-14 ISSN 1757-6512 Altmetric
2014	Cell and gene therapy for friedreich ataxia: Progress to date Published In Human Gene Therapy Volume 25 Pages 684 - 693 ISSN 1043-0342 Altmetric
2014	Directing Human Induced Pluripotent Stem Cells into a Neurosensory Lineage for Auditory Neuron Replacement Published In BioResearch Open Access Volume 3 Pages 162 - 175 Altmetric
2014	Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells Published In Stem Cell Research Volume 12 Pages 241 - 249 ISSN 1873-5061 Altmetric
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published In PLoS One Volume 9 Pages e101718-1 - e101718-10 ISSN 1932-6203 Altmetric
2014	Hypothermia protects human neurons Published In International Journal of Stroke Volume 9 Pages 544 - 552 ISSN 1747-4930 Altmetric
2013	An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants Published In Stem Cells and Development Volume 22 Pages 901 - 912 ISSN 1557-8534 Altmetric
2013	Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines Published In Frontiers in Cellular Neuroscience Volume 7 Pages 37-1 - 37-13 ISSN 1662-5102 Altmetric
2013	Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid Published In Journal of Lipid Research Volume 54 Pages 1192 - 1206 ISSN 0022-2275 Altmetric
2012	Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage Published In Stem Cells Volume 30 Pages 2400 - 2411 ISSN 1066-5099 Altmetric
2012	In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation Published In Biochemical and Biophysical Research Communications Volume 422 Pages 75 - 79 ISSN 0006-291X Altmetric
2012	Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation Published In Frontiers in Cellular Neuroscience Pages 11-1 - 11-14 ISSN 1662-5102 Altmetric
2012	Non-viral generation of neural precursor-like cells from adult human fibroblasts Published In Journal of Stem Cells and Regenerative Medicine Volume 8 Pages 162 - 170
2012	Stem cells as in vitro models of disease Published In Stem Cells International Volume 2012 Pages 565083-1 - 565083-2 Altmetric
2012	The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy Published In Stem Cell Reviews Volume 8 Pages 741 - 754 ISSN 1550-8943 Altmetric
2011	Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients Published In Stem Cell Reviews Volume 7 Pages 703 - 713 ISSN 1550-8943 Altmetric
2011	Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation Published In Cell Transplantation Volume 20 Pages 193 - 203 Altmetric
2011	Neural development in human embryonic stem cells-applications of lentiviral vectors Published In Journal of Cellular Biochemistry Volume 112 Pages 1955 - 1962 ISSN 0730-2312 Altmetric
2011	Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells Published In Stem Cell Research and Therapy Volume 2 Pages 16-1 - 16-14 ISSN 1757-6512 Altmetric
2010	Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease Published In Cell Transplantation Volume 19 Pages 1055 - 1062 ISSN 0963-6897 Altmetric
2010	Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells Published In Stem Cells and Development Volume 19 Pages 569 - 577 ISSN 1557-8534 Altmetric
2010	Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells Published In Stem Cells Volume 28 Pages 1805 - 1815 ISSN 1066-5099 Altmetric

Chapter

Year	Title
2012	Generation of Pluripotent Stem Cells and their Developmental Potential Published In Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-To-Bedside Publisher Dubai, United Arab Emirates: Bentham Books Pages 41 - 55 ISBN 9781608052899
2011	Neural differentiation of induced pluripotent stem cells Published In Neurodegeneration: Methods and Protocols Publisher New York, United States: Humana Press Pages 99 - 110 ISBN 9781617793288

Investigator On

Year	Title
2019 - 2022	Use of brain organoids and artificial intelligence for understanding Dementia Awarded by: Dementia Australia Research Foundation Funding Scheme: Yulgilbar Foundation Grant
2019 - 2020	Developing therapies for Friedreich's Ataxia using nanoparticles Awarded by: National Ataxia Foundation Funding Scheme: Seed Grant
2018 - 2020	Understanding RAB39B-mediated Parkinson's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Personalised Medicine for Mitochondrial Disorders: Targeting Pathogenic Mechanisms Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Nanoparticle-Mediated Gene Delivery of Frataxin to Neurons Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
2019	Understanding platinum dissolution in biomedical stimulating electrodes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2019	echanisms and targeted treatment for neurogenetic disorders: SCN2A Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cells Australia
2018 - 2019	Stem Cells Australia Awarded by: Australian Research Council (ARC) Funding Scheme: Special Research Initiatives
2014 - 2018	Modelling the human nervous system with human pluripotent stem cells Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2017	ARC Training Centre for Personalised Therapeutics Technologies Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration	Maksour, Simon
Doctor of Philosophy	Specification of Dorsal Root Ganglia Neuronal Subpopulations and Characterization of their Neuropathology in Friedreich's Ataxia	Hulme, Amy
Doctor of Philosophy	Development of an Innervated Full Thickness Human Skin Model by 3D Printing	St Clair-Glover, Mitchell

Education And Training

Ph.D. in Medical Biology, The University of Melbourne, Walter and Eliza Hall Institute 1993 - 1998
B Science (Hon) in Pathology, The University of Melbourne 1989 - 1992
Monash University 2003 - 2006
Salk Institute for Biological Studies 1999 - 2002

Awards And Honors

Australian Research Council Future Fellowship, 2013
National Ataxia Foundation Young Investigator’s Award , 2010
NHMRC Howard Florey Centenary Fellowship, 2003 - 2005
Human Frontiers Science Program Organization Fellowship, 1999 - 2001
Australian Postgraduate Research Scholarship, 1993 - 1996

Full Name

A/Prof Mirella Dottori

Mailing Address

Building 32, Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Top Publications

Year	Title
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published in Stem Cell Reports
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published in Stem Cells and Development
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published in Scientific Reports
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published in Stem Cells
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published in PLoS One

Research Areas

Research Overview

A/Prof Dottori’s research combines technologies in stem cell biology, neuroscience and bio-engineering to develop cellular models of the human nervous system. Her major research focus is in understanding how to direct human stem cells to differentiate towards neuronal lineages of the central and peripheral nervous system. These studies are significant in expanding our knowledge about human neurodevelopment and also for clinical application of stem cells in regenerative medicine. Her research has contributed to advancing cellular models to study and develop therapies for a diverse range of neurological conditions, including progressive ataxias, Parkinson’s disease, sensory neuropathies and dementia.

Member Of

Scientific Reports Editor 2018 -
The University of Melbourne Honorary Research Fellow 2017 -
Plos One Editor 2012 -
Stem Cells Australia Associate 2012 -
Centre for Eye Research Australia Scientific Advisory Board Member 2009 - 2014
Australasian Society for Stem Cell Research Secretary 2008 - 2010

Selected Publications

Journal Article

Year	Title
2020	Differential susceptibility of human neural progenitors and neurons to ischaemic injury Published In Brain Research Bulletin Volume 156 Pages 25 - 32 Altmetric
2020	If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions? Published In Neuroscientist Altmetric
2020	More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment Published In eNeuro Volume 7 Pages 1 - 12 Altmetric
2019	Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells Published In Methods in Molecular Biology Volume 1976 Pages 37 - 47 ISSN 1064-3745 Altmetric
2019	Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System Published In Frontiers In Cell And Developmental Biology Volume 7 Pages 25-1 - 25-12 Altmetric
2019	Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices Published In Stem Cells International Volume 2019 Pages 8419493-1 - 8419493-14 Altmetric
2018	Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods Published In Journal of Neuroscience Methods Volume 308 Pages 286 - 293 ISSN 0165-0270 Altmetric
2018	Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells Published In Stem Cell Reports Volume 10 Pages 134 - 150 Altmetric
2018	Generation of Neural Organoids from Human Embryonic Stem Cells Using the Rotary Cell Culture System: Effects of Microgravity on Neural Progenitor Cell Fate Published In Stem Cells and Development Volume 27 Pages 848 - 857 ISSN 1557-8534 Altmetric
2018	Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease Published In Stem Cell Research Volume 28 Pages 161 - 164 ISSN 1873-5061 Altmetric
2018	Graphene foam as a biocompatible scaffold for culturing human neurons Published In Royal Society Open Science Volume 5 Pages 171364-1 - 171364-11 Altmetric
2018	Modelling the dorsal root ganglia using human pluripotent stem cells: A platform to study peripheral neuropathies Published In The International Journal of Biochemistry and Cell Biology Volume 100 Pages 61 - 68 ISSN 1357-2725 Altmetric
2018	NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons Published In Journal of Stroke and Cerebrovascular Diseases Volume 27 Pages 2158 - 2165 ISSN 1052-3057 Altmetric
2018	Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells Published In Scientific Reports Volume 8 Pages 603-1 - 603-12 ISSN 2045-2322 Altmetric
2018	Self-organized nanostructure modified microelectrode for sensitive electrochemical glutamate detection in stem cells-derived brain organoids Published In Biosensors Volume 8 Pages 14-1 - 14-11 Altmetric
2018	The Role of WD40-Repeat Protein 62 (MCPH2) in Brain Growth: Diverse Molecular and Cellular Mechanisms Required for Cortical Development Published In Molecular Neurobiology Volume 55 Pages 5409 - 5424 ISSN 0893-7648 Altmetric
2017	Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency Published In Aging Volume 9 Pages 1440 - 1452 ISSN 1945-4589 Altmetric
2017	Long-distance axonal growth and protracted functional maturation of neurons derived from human induced pluripotent stem cells after intracerebral transplantation Published In Stem Cells Translational Medicine Volume 6 Pages 1547 - 1556 ISSN 2157-6580 Altmetric
2017	No preliminary evidence of differences in astrocyte density within the white matter of the dorsolateral prefrontal cortex in autism Published In Molecular Autism Volume 8 Pages 64-1 - 64-8 Altmetric
2017	WDR62 Regulates Early Neural and Glial Progenitor Specification of Human Pluripotent Stem Cells Published In Stem Cells International Volume 2017 Pages 7848932-1 - 7848932-9 Altmetric
2016	Enteric Neural Cells From Hirschsprung Disease Patients Form Ganglia in Autologous Aneuronal Colon Published In Cellular and Molecular Gastroenterology and Hepatology Volume 2 Pages 92 - 109 Altmetric
2016	Innervation of Cochlear Hair Cells by Human Induced Pluripotent Stem Cell-Derived Neurons in Vitro Published In Stem Cells International Volume 2016 Pages 1781202-1 - 1781202-10 Altmetric
2015	Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system Published In Stem Cells Volume 33 Pages 1759 - 1770 ISSN 1066-5099 Altmetric
2015	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation Published In Human Genetics Volume 134 Pages 1099 - 1115 Altmetric
2015	Vertical Nanowire Electrode Arrays as Novel Electrochemical Label-Free Immunosensors Published In Small Volume 11 Pages 2862 - 2868 ISSN 1613-6810 Altmetric
2014	A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells Published In Stem Cell Research and Therapy Volume 5 Pages 64-1 - 64-14 ISSN 1757-6512 Altmetric
2014	Cell and gene therapy for friedreich ataxia: Progress to date Published In Human Gene Therapy Volume 25 Pages 684 - 693 ISSN 1043-0342 Altmetric
2014	Directing Human Induced Pluripotent Stem Cells into a Neurosensory Lineage for Auditory Neuron Replacement Published In BioResearch Open Access Volume 3 Pages 162 - 175 Altmetric
2014	Electrophysiological properties of neurosensory progenitors derived from human embryonic stem cells Published In Stem Cell Research Volume 12 Pages 241 - 249 ISSN 1873-5061 Altmetric
2014	Functional characterization of Friedreich ataxia iPS-derived neuronal progenitors and their integration in the adult brain Published In PLoS One Volume 9 Pages e101718-1 - e101718-10 ISSN 1932-6203 Altmetric
2014	Hypothermia protects human neurons Published In International Journal of Stroke Volume 9 Pages 544 - 552 ISSN 1747-4930 Altmetric
2013	An in vitro model of developmental synaptogenesis using cocultures of human neural progenitors and cochlear explants Published In Stem Cells and Development Volume 22 Pages 901 - 912 ISSN 1557-8534 Altmetric
2013	Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines Published In Frontiers in Cellular Neuroscience Volume 7 Pages 37-1 - 37-13 ISSN 1662-5102 Altmetric
2013	Rho/ROCK pathway is essential to the expansion, differentiation, and morphological rearrangements of human neural stem/progenitor cells induced by lysophosphatidic acid Published In Journal of Lipid Research Volume 54 Pages 1192 - 1206 ISSN 0022-2275 Altmetric
2012	Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage Published In Stem Cells Volume 30 Pages 2400 - 2411 ISSN 1066-5099 Altmetric
2012	In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation Published In Biochemical and Biophysical Research Communications Volume 422 Pages 75 - 79 ISSN 0006-291X Altmetric
2012	Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation Published In Frontiers in Cellular Neuroscience Pages 11-1 - 11-14 ISSN 1662-5102 Altmetric
2012	Non-viral generation of neural precursor-like cells from adult human fibroblasts Published In Journal of Stem Cells and Regenerative Medicine Volume 8 Pages 162 - 170
2012	Stem cells as in vitro models of disease Published In Stem Cells International Volume 2012 Pages 565083-1 - 565083-2 Altmetric
2012	The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy Published In Stem Cell Reviews Volume 8 Pages 741 - 754 ISSN 1550-8943 Altmetric
2011	Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients Published In Stem Cell Reviews Volume 7 Pages 703 - 713 ISSN 1550-8943 Altmetric
2011	Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation Published In Cell Transplantation Volume 20 Pages 193 - 203 Altmetric
2011	Neural development in human embryonic stem cells-applications of lentiviral vectors Published In Journal of Cellular Biochemistry Volume 112 Pages 1955 - 1962 ISSN 0730-2312 Altmetric
2011	Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells Published In Stem Cell Research and Therapy Volume 2 Pages 16-1 - 16-14 ISSN 1757-6512 Altmetric
2010	Comparison of transplant efficiency between spontaneously derived and noggin-primed human embryonic stem cell neural precursors in the quinolinic acid rat model of Huntington's disease Published In Cell Transplantation Volume 19 Pages 1055 - 1062 ISSN 0963-6897 Altmetric
2010	Effective adenovirus-mediated gene transfer into neural stem cells derived from human embryonic stem cells Published In Stem Cells and Development Volume 19 Pages 569 - 577 ISSN 1557-8534 Altmetric
2010	Gli1 is an inducing factor in generating floor plate progenitor cells from human embryonic stem cells Published In Stem Cells Volume 28 Pages 1805 - 1815 ISSN 1066-5099 Altmetric

Chapter

Year	Title
2012	Generation of Pluripotent Stem Cells and their Developmental Potential Published In Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials: Bench-To-Bedside Publisher Dubai, United Arab Emirates: Bentham Books Pages 41 - 55 ISBN 9781608052899
2011	Neural differentiation of induced pluripotent stem cells Published In Neurodegeneration: Methods and Protocols Publisher New York, United States: Humana Press Pages 99 - 110 ISBN 9781617793288

Investigator On

Year	Title
2019 - 2022	Use of brain organoids and artificial intelligence for understanding Dementia Awarded by: Dementia Australia Research Foundation Funding Scheme: Yulgilbar Foundation Grant
2019 - 2020	Developing therapies for Friedreich's Ataxia using nanoparticles Awarded by: National Ataxia Foundation Funding Scheme: Seed Grant
2018 - 2020	Understanding RAB39B-mediated Parkinson's Disease Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2016 - 2020	Personalised Medicine for Mitochondrial Disorders: Targeting Pathogenic Mechanisms Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Nanoparticle-Mediated Gene Delivery of Frataxin to Neurons Awarded by: Friedreich¿s Ataxia Research Alliance (FARA) Funding Scheme: Research Grant
2019	Understanding platinum dissolution in biomedical stimulating electrodes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2019	echanisms and targeted treatment for neurogenetic disorders: SCN2A Awarded by: Medical Research Future Fund (MRFF) Funding Scheme: Stem Cells Australia
2018 - 2019	Stem Cells Australia Awarded by: Australian Research Council (ARC) Funding Scheme: Special Research Initiatives
2014 - 2018	Modelling the human nervous system with human pluripotent stem cells Awarded by: Australian Research Council (ARC) Funding Scheme: Future Fellowships
2017	ARC Training Centre for Personalised Therapeutics Technologies Awarded by: Australian Research Council (ARC) Funding Scheme: Industrial Transformation Training Centres

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration	Maksour, Simon
Doctor of Philosophy	Specification of Dorsal Root Ganglia Neuronal Subpopulations and Characterization of their Neuropathology in Friedreich's Ataxia	Hulme, Amy
Doctor of Philosophy	Development of an Innervated Full Thickness Human Skin Model by 3D Printing	St Clair-Glover, Mitchell

Education And Training

Ph.D. in Medical Biology, The University of Melbourne, Walter and Eliza Hall Institute 1993 - 1998
B Science (Hon) in Pathology, The University of Melbourne 1989 - 1992
Monash University 2003 - 2006
Salk Institute for Biological Studies 1999 - 2002

Awards And Honors

Australian Research Council Future Fellowship, 2013
National Ataxia Foundation Young Investigator’s Award , 2010
NHMRC Howard Florey Centenary Fellowship, 2003 - 2005
Human Frontiers Science Program Organization Fellowship, 1999 - 2001
Australian Postgraduate Research Scholarship, 1993 - 1996

Full Name

A/Prof Mirella Dottori

Mailing Address

Building 32, Northfields Ave

University of Wollongong

Wollongong

NSW

2522

Australia

Located In Facility

Illawarra Health and Medical Research Institute

Overview

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Contact

Full Name

Mailing Address

Located In Facility

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Member Of

Publications

Selected Publications

Journal Article

Chapter

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Contact

Full Name

Mailing Address

Located In Facility

Visualisations

Research Areas