Kelso, Michael J.

Overview

The Kelso Research Group focuses on early stage antimicrobial and anticancer medicinal chemistry, drug discovery and chemical biology. We work with an extensive network of world leading local, national and international collaborators to explore the biological activities, both in vitro and in vivo, of innovative drug molecules designed and synthesised by the group at UOW.

Available as Research Supervisor

Selected Publications

Journal Article

Year	Title
2020	Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa Published In Journal of Antimicrobial Chemotherapy Volume 75 Pages 117 - 125 ISSN 0305-7453 Altmetric
2020	Characterization of five novel anti-mrsa compounds identified using a whole-animal caenorhabditis elegans/galleria mellonella sequential-screening approach Published In Antibiotics Volume 9 Pages 449-1 - 449-12 Altmetric
2020	Discovery of Cephalosporin-3'-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model Published In ACS infectious diseases Volume 6 Pages 1460 - 1479 Altmetric
2020	Synthesis, structural/photophysical characterization and theoretical investigations with new β-pyridinium/quinolinium and β-bromine substituted bis(1,3-dimethylbarbituric acid) trimethine oxonol dyes that display large Stokes shifts Published In Dyes and Pigments Volume 172 Pages 107758-1 - 107758-11 ISSN 0143-7208 Altmetric
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 126753-1 - 126753-6 ISSN 0960-894X Altmetric
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry Volume 91 Pages 9901 - 9909 ISSN 0003-2700 Altmetric
2019	Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 1215 - 1219 ISSN 0960-894X Altmetric
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets Volume 20 Pages 970 - 981 ISSN 1389-4501 Altmetric
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2018	Antibacterial Properties of Four Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus-Caenorhabditis elegans High-Throughput Screen Published In Microbial Drug Resistance: mechanism, epidemiology, and disease Volume 24 Pages 666 - 674 ISSN 1076-6294 Altmetric
2018	Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 2736 - 2740 ISSN 0960-894X Altmetric
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology Volume 204 Pages 396 - 405 ISSN 1047-8477 Altmetric
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research Volume 59 Pages 1510 - 1518 ISSN 0022-2275 Altmetric
2018	Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): A new bacteriostatic agent against methicillin - Resistant Staphylococcus aureus Published In Scientific Reports Volume 8 Pages 7062 - 7062 ISSN 2045-2322 Altmetric
2018	Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin–resistant Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 3526 - 3528 ISSN 0960-894X Altmetric
2017	Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus Published In Future Medicinal Chemistry Volume 9 Pages 1401 - 1411 ISSN 1756-8927 Altmetric
2017	Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo Published In ACS Infectious Diseases Volume 3 Pages 756 - 766 Altmetric
2017	Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms Published In Antimicrobial Agents and Chemotherapy Volume 61 Pages e02086-16-1 - e02086-16-12 ISSN 0066-4804 Altmetric
2017	Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms Published In Nitric Oxide: Biology and Chemistry Volume 65 Pages 43 - 49 ISSN 1089-8603 Altmetric
2017	Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis Published In Molecular Therapy Volume 25 Pages 2104 - 2116 ISSN 1525-0016 Altmetric
2017	Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation Published In European Respiratory Journal Volume 50 Pages 1700612-1 - 1700612-12 ISSN 0903-1936 Altmetric
2017	Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 47 Pages 62 - 67 ISSN 0039-7911 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 30 Pages 2351 - 2359 ISSN 0951-4198 Altmetric
2016	Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin Published In Future Medicinal Chemistry Volume 8 Pages 1941 - 1952 ISSN 1756-8927 Altmetric
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters Volume 26 Pages 1813 - 1816 ISSN 0960-894X Altmetric
2015	Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile Published In Bioorganic and Medicinal Chemistry Letters Volume 25 Pages 5203 - 5207 ISSN 0960-894X Altmetric
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry Volume 58 Pages 4693 - 4702 ISSN 0022-2623 Altmetric
2015	Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases Published In Current Pharmaceutical Design Volume 21 Pages 31 - 42 ISSN 1381-6128 Altmetric
2014	Clostridium difficile infection: molecular pathogenesis and novel therapeutics Published In Expert Review of Anti-infective Therapy Volume 12 Pages 131 - 150 ISSN 1478-7210 Altmetric
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology Volume 21 Pages 481 - 487 ISSN 1074-5521 Altmetric
2014	Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells Published In Bioorganic and Medicinal Chemistry Letters Volume 24 Pages 595 - 600 ISSN 0960-894X Altmetric
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry Volume 57 Pages 2799 - 2806 ISSN 0022-2623 Altmetric
2014	Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 70 Pages 7645 - 7650 ISSN 0040-4020 Altmetric
2014	On the mechanism of berberine-INF55 (5-Nitro-2-phenylindole) hybrid antibacterials Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1471 - 1480 ISSN 0004-9425 Altmetric
2014	RATNO - reducing antibiotic tolerance using nitric oxide in cystic fibrosis: report of a proof of concept clinical trial Published In Archives of Disease in Childhood Volume 99 Pages A159 - A159 ISSN 0003-9888 Altmetric
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 7417 - 7423 ISSN 0146-0404 Altmetric
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry Volume 56 Pages 8665 - 8673 ISSN 0022-2623 Altmetric
2013	Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase Published In Chemical Communications Volume 49 Pages 4791 - 4793 ISSN 1359-7345 Altmetric
2013	Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®) Published In Australian Journal of Chemistry: an international journal for chemical science Volume 66 Pages 864 - 873 ISSN 0004-9425 Altmetric
2012	Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms Published In Angewandte Chemie International Edition Volume 51 Pages 9057 - 9060 ISSN 1433-7851 Altmetric
2012	Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes Published In Photochemistry and Photobiology Volume 88 Pages 499 - 511 ISSN 0031-8655 Altmetric
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer Volume 129 Pages 2051 - 2061 ISSN 0020-7136 Altmetric
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 2549 - 2556 ISSN 0968-0896 Altmetric
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters Volume 21 Pages 6760 - 6766 ISSN 0960-894X Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components Published In Antimicrobial Agents and Chemotherapy Volume 54 Pages 3219 - 3224 ISSN 0066-4804 Altmetric
2010	Synthesis of berberine-efflux pump inhibitor hybrid antibacterials Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 40 Pages 3561 - 3568 ISSN 0039-7911 Altmetric
2008	Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)(3)His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation Published In Inorganic Chemistry: including bioinorganic chemistry Volume 47 Pages 9439 - 9449 ISSN 0020-1669 Altmetric
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 7787 - 7795 ISSN 0040-4020 Altmetric
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery Volume 3 Pages 1 - 13 ISSN 1574-8928 Altmetric
2008	Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 18 Pages 4294 - 4297 ISSN 0960-894X Altmetric
2007	Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Published In Journal of Medicinal Chemistry Volume 50 Pages 3359 - 3368 ISSN 0022-2623 Altmetric
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 7440 - 7443 ISSN 0040-4039 Altmetric

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery Publisher Bentham Science Publishers Ltd Pages 55 - 78

Conference Paper

Year	Title
2011	Synthesis and evaluation of dual-action hybrid antimicrobials and prodrugs Published In Abstracts of Papers of the American Chemical Society Pages 1 - 1

Investigator On

Year	Title
2020	Organic & Medicinal Chemistry (OMC 2020) Conference Awarded by: NSW Government Department of Industry Funding Scheme: NSW Research Attraction and Acceleration Program
2018 - 2020	Molecular Interactions with an Antibiotic Target in DNA Replication Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Antimicrobial Research Taskforce Awarded by: NUW Alliance Funding Scheme: Grant
2015 - 2018	Multi-Action antibiotics to treat chronic biofilm infections Awarded by: Cystic Fibrosis Australia (CFA) Funding Scheme: Research Grant
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Investigation of novel adjunctive therapies to improve treatment success in paediatric middle ear infection (otitis media) Awarded by: Sparks - The Children's Medical Research Charity (UK) Funding Scheme: Sparks Innovation and Patient Benefit Grant (UK)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The use of nitric oxide to control infections by biofilm forming bacteria Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	A synergy-based therapy against C.difficle Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
	Repurposing Amiloride Derivatives as New Agents for Drug-Resistant Tuberculosis Awarded by: Health Research Council of New Zealand (HRC) Funding Scheme: Grant
	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy (Integrated)	Synthesis and Evaluation of Novel Antimicrobials against Methicillin-Resistant Staphylococcus aureus and Mycobacterium tuberculosis
Doctor of Philosophy	Medicinal Chemistry Studies into 6-Substituted Amiloride Analogues as Inhibitors of the Human and Murine Urokinase Plasminogen Activators	Elsalamouny, Nehad
Doctor of Philosophy	Swimming In Chiral Pnictogen Pools - The Exploration of 3-Membered Bicyclic Chiral Pool Intermediates for the Synthesis of Libraries of Chiral 1,2-Dipnictogens	Gaston, Jayden
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Master of Philosophy -SMAH	Towards targeted nitric oxide delivery using β-lactamase antibody conjugates	Wu, Andrew
Doctor of Philosophy	Synthesis and Evaluation of Amiloride Analogues as New Agents for Drug Resistant Tuberculosis	Bujaroski, Richard
Doctor of Philosophy	Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials	Smith, Zander
Doctor of Philosophy	A Two-Pronged Approach for Treating Ischaemic Reperfusion Injury Following Stroke Using In-house Derived Amiloride Analogues	Kumar, Ashna
Doctor of Philosophy	A Proposed Mechanism for the Disruption of the Body's Calcium Homeostasis by Absorbed Solvents and Gases and its Relevance to Anaesthesia and Industrial Solvent Exposure	Cantrell, Phillip

Orcid Id

http://orcid.org/0000-0001-7809-6637 (confirmed)

Selected Publications

Journal Article

Year	Title
2020	Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa Published In Journal of Antimicrobial Chemotherapy Volume 75 Pages 117 - 125 ISSN 0305-7453 Altmetric
2020	Characterization of five novel anti-mrsa compounds identified using a whole-animal caenorhabditis elegans/galleria mellonella sequential-screening approach Published In Antibiotics Volume 9 Pages 449-1 - 449-12 Altmetric
2020	Discovery of Cephalosporin-3'-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model Published In ACS infectious diseases Volume 6 Pages 1460 - 1479 Altmetric
2020	Synthesis, structural/photophysical characterization and theoretical investigations with new β-pyridinium/quinolinium and β-bromine substituted bis(1,3-dimethylbarbituric acid) trimethine oxonol dyes that display large Stokes shifts Published In Dyes and Pigments Volume 172 Pages 107758-1 - 107758-11 ISSN 0143-7208 Altmetric
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 126753-1 - 126753-6 ISSN 0960-894X Altmetric
2019	Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids Published In Analytical Chemistry Volume 91 Pages 9901 - 9909 ISSN 0003-2700 Altmetric
2019	Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 1215 - 1219 ISSN 0960-894X Altmetric
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets Volume 20 Pages 970 - 981 ISSN 1389-4501 Altmetric
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2018	Antibacterial Properties of Four Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus-Caenorhabditis elegans High-Throughput Screen Published In Microbial Drug Resistance: mechanism, epidemiology, and disease Volume 24 Pages 666 - 674 ISSN 1076-6294 Altmetric
2018	Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 2736 - 2740 ISSN 0960-894X Altmetric
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology Volume 204 Pages 396 - 405 ISSN 1047-8477 Altmetric
2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research Volume 59 Pages 1510 - 1518 ISSN 0022-2275 Altmetric
2018	Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): A new bacteriostatic agent against methicillin - Resistant Staphylococcus aureus Published In Scientific Reports Volume 8 Pages 7062 - 7062 ISSN 2045-2322 Altmetric
2018	Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin–resistant Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 3526 - 3528 ISSN 0960-894X Altmetric
2017	Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus Published In Future Medicinal Chemistry Volume 9 Pages 1401 - 1411 ISSN 1756-8927 Altmetric
2017	Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo Published In ACS Infectious Diseases Volume 3 Pages 756 - 766 Altmetric
2017	Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms Published In Antimicrobial Agents and Chemotherapy Volume 61 Pages e02086-16-1 - e02086-16-12 ISSN 0066-4804 Altmetric
2017	Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms Published In Nitric Oxide: Biology and Chemistry Volume 65 Pages 43 - 49 ISSN 1089-8603 Altmetric
2017	Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis Published In Molecular Therapy Volume 25 Pages 2104 - 2116 ISSN 1525-0016 Altmetric
2017	Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation Published In European Respiratory Journal Volume 50 Pages 1700612-1 - 1700612-12 ISSN 0903-1936 Altmetric
2017	Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 47 Pages 62 - 67 ISSN 0039-7911 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric
2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 30 Pages 2351 - 2359 ISSN 0951-4198 Altmetric
2016	Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin Published In Future Medicinal Chemistry Volume 8 Pages 1941 - 1952 ISSN 1756-8927 Altmetric
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters Volume 26 Pages 1813 - 1816 ISSN 0960-894X Altmetric
2015	Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile Published In Bioorganic and Medicinal Chemistry Letters Volume 25 Pages 5203 - 5207 ISSN 0960-894X Altmetric
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry Volume 58 Pages 4693 - 4702 ISSN 0022-2623 Altmetric
2015	Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases Published In Current Pharmaceutical Design Volume 21 Pages 31 - 42 ISSN 1381-6128 Altmetric
2014	Clostridium difficile infection: molecular pathogenesis and novel therapeutics Published In Expert Review of Anti-infective Therapy Volume 12 Pages 131 - 150 ISSN 1478-7210 Altmetric
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology Volume 21 Pages 481 - 487 ISSN 1074-5521 Altmetric
2014	Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells Published In Bioorganic and Medicinal Chemistry Letters Volume 24 Pages 595 - 600 ISSN 0960-894X Altmetric
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry Volume 57 Pages 2799 - 2806 ISSN 0022-2623 Altmetric
2014	Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 70 Pages 7645 - 7650 ISSN 0040-4020 Altmetric
2014	On the mechanism of berberine-INF55 (5-Nitro-2-phenylindole) hybrid antibacterials Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1471 - 1480 ISSN 0004-9425 Altmetric
2014	RATNO - reducing antibiotic tolerance using nitric oxide in cystic fibrosis: report of a proof of concept clinical trial Published In Archives of Disease in Childhood Volume 99 Pages A159 - A159 ISSN 0003-9888 Altmetric
2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 7417 - 7423 ISSN 0146-0404 Altmetric
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry Volume 56 Pages 8665 - 8673 ISSN 0022-2623 Altmetric
2013	Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase Published In Chemical Communications Volume 49 Pages 4791 - 4793 ISSN 1359-7345 Altmetric
2013	Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®) Published In Australian Journal of Chemistry: an international journal for chemical science Volume 66 Pages 864 - 873 ISSN 0004-9425 Altmetric
2012	Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms Published In Angewandte Chemie International Edition Volume 51 Pages 9057 - 9060 ISSN 1433-7851 Altmetric
2012	Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes Published In Photochemistry and Photobiology Volume 88 Pages 499 - 511 ISSN 0031-8655 Altmetric
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer Volume 129 Pages 2051 - 2061 ISSN 0020-7136 Altmetric
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 2549 - 2556 ISSN 0968-0896 Altmetric
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters Volume 21 Pages 6760 - 6766 ISSN 0960-894X Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components Published In Antimicrobial Agents and Chemotherapy Volume 54 Pages 3219 - 3224 ISSN 0066-4804 Altmetric
2010	Synthesis of berberine-efflux pump inhibitor hybrid antibacterials Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 40 Pages 3561 - 3568 ISSN 0039-7911 Altmetric
2008	Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)(3)His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation Published In Inorganic Chemistry: including bioinorganic chemistry Volume 47 Pages 9439 - 9449 ISSN 0020-1669 Altmetric
2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 7787 - 7795 ISSN 0040-4020 Altmetric
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery Volume 3 Pages 1 - 13 ISSN 1574-8928 Altmetric
2008	Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 18 Pages 4294 - 4297 ISSN 0960-894X Altmetric
2007	Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Published In Journal of Medicinal Chemistry Volume 50 Pages 3359 - 3368 ISSN 0022-2623 Altmetric
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 7440 - 7443 ISSN 0040-4039 Altmetric

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery Publisher Bentham Science Publishers Ltd Pages 55 - 78

Conference Paper

Year	Title
2011	Synthesis and evaluation of dual-action hybrid antimicrobials and prodrugs Published In Abstracts of Papers of the American Chemical Society Pages 1 - 1

Investigator On

Year	Title
2020	Organic & Medicinal Chemistry (OMC 2020) Conference Awarded by: NSW Government Department of Industry Funding Scheme: NSW Research Attraction and Acceleration Program
2018 - 2020	Molecular Interactions with an Antibiotic Target in DNA Replication Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2019	Antimicrobial Research Taskforce Awarded by: NUW Alliance Funding Scheme: Grant
2015 - 2018	Multi-Action antibiotics to treat chronic biofilm infections Awarded by: Cystic Fibrosis Australia (CFA) Funding Scheme: Research Grant
2014	Characterisation of tear film lipids Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Projects
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2011	Investigation of novel adjunctive therapies to improve treatment success in paediatric middle ear infection (otitis media) Awarded by: Sparks - The Children's Medical Research Charity (UK) Funding Scheme: Sparks Innovation and Patient Benefit Grant (UK)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	The use of nitric oxide to control infections by biofilm forming bacteria Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2008	A synergy-based therapy against C.difficle Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
	Repurposing Amiloride Derivatives as New Agents for Drug-Resistant Tuberculosis Awarded by: Health Research Council of New Zealand (HRC) Funding Scheme: Grant
	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy (Integrated)	Synthesis and Evaluation of Novel Antimicrobials against Methicillin-Resistant Staphylococcus aureus and Mycobacterium tuberculosis
Doctor of Philosophy	Medicinal Chemistry Studies into 6-Substituted Amiloride Analogues as Inhibitors of the Human and Murine Urokinase Plasminogen Activators	Elsalamouny, Nehad
Doctor of Philosophy	Swimming In Chiral Pnictogen Pools - The Exploration of 3-Membered Bicyclic Chiral Pool Intermediates for the Synthesis of Libraries of Chiral 1,2-Dipnictogens	Gaston, Jayden
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Master of Philosophy -SMAH	Towards targeted nitric oxide delivery using β-lactamase antibody conjugates	Wu, Andrew
Doctor of Philosophy	Synthesis and Evaluation of Amiloride Analogues as New Agents for Drug Resistant Tuberculosis	Bujaroski, Richard
Doctor of Philosophy	Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials	Smith, Zander
Doctor of Philosophy	A Two-Pronged Approach for Treating Ischaemic Reperfusion Injury Following Stroke Using In-house Derived Amiloride Analogues	Kumar, Ashna
Doctor of Philosophy	A Proposed Mechanism for the Disruption of the Body's Calcium Homeostasis by Absorbed Solvents and Gases and its Relevance to Anaesthesia and Industrial Solvent Exposure	Cantrell, Phillip

Orcid Id

http://orcid.org/0000-0001-7809-6637 (confirmed)

Kelso, Michael J. Professor

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Available as Research Supervisor

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Overview

Publications

Selected Publications

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Conference Paper

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Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

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