Kelso, Michael J.

Selected Publications

• Journal Article

  Year	Title
  2019	Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study Published In Bioorganic and Medicinal Chemistry Letters Volume 29 Pages 1215 - 1219 ISSN 0960-894X Altmetric
  2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets Volume 20 Pages 970 - 981 ISSN 1389-4501 Altmetric
  2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
  2018	Antibacterial Properties of Four Novel Hit Compounds from a Methicillin-Resistant Staphylococcus aureus-Caenorhabditis elegans High-Throughput Screen Published In Microbial Drug Resistance: mechanism, epidemiology, and disease Volume 24 Pages 666 - 674 ISSN 1076-6294 Altmetric
  2018	Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 2736 - 2740 ISSN 0960-894X Altmetric
  2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology Volume 204 Pages 396 - 405 ISSN 1047-8477 Altmetric
  2018	Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids Published In Journal of Lipid Research Volume 59 Pages 1510 - 1518 ISSN 0022-2275 Altmetric
  2018	Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): A new bacteriostatic agent against methicillin - Resistant Staphylococcus aureus Published In Scientific Reports Volume 8 Pages 7062 - 7062 ISSN 2045-2322 Altmetric
  2018	Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin–resistant Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume Online First Pages 1 - 3 ISSN 0960-894X Altmetric
  2017	Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus Published In Future Medicinal Chemistry Volume 9 Pages 1401 - 1411 ISSN 1756-8927 Altmetric
  2017	Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo Published In ACS Infectious Diseases Volume 3 Pages 756 - 766 Altmetric
  2017	Cephalosporin-3’ -diazeniumdiolate NO-donor prodrug PYRRO-C3D enhances azithromycin susceptibility of Non-typeable Haemophilus influenzae biofilms Published In Antimicrobial Agents and Chemotherapy Volume 61 Pages e02086-16-1 - e02086-16-12 ISSN 0066-4804 Altmetric
  2017	Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms Published In Nitric Oxide: Biology and Chemistry Volume 65 Pages 43 - 49 ISSN 1089-8603 Altmetric
  2017	Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis Published In Molecular Therapy Volume 25 Pages 2104 - 2116 ISSN 1525-0016 Altmetric
  2017	Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation Published In European Respiratory Journal Volume 50 Pages 1700612-1 - 1700612-12 ISSN 0903-1936 Altmetric
  2017	Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 47 Pages 62 - 67 ISSN 1532-2432 Altmetric
  2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric
  2016	Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry Volume 30 Pages 2351 - 2359 ISSN 0951-4198 Altmetric
  2016	Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin Published In Future Medicinal Chemistry Volume 8 Pages 1941 - 1952 ISSN 1756-8927 Altmetric
  2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters Volume 26 Pages 1813 - 1816 ISSN 0960-894X Altmetric
  2015	Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile Published In Bioorganic and Medicinal Chemistry Letters Volume 25 Pages 5203 - 5207 ISSN 0960-894X Altmetric
  2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry Volume 58 Pages 4693 - 4702 ISSN 0022-2623 Altmetric
  2015	Nitric oxide: a key mediator of biofilm dispersal with applications in infectious diseases Published In Current Pharmaceutical Design Volume 21 Pages 31 - 42 ISSN 1381-6128 Altmetric
  2014	Clostridium difficile infection: molecular pathogenesis and novel therapeutics Published In Expert Review of Anti-infective Therapy Volume 12 Pages 131 - 150 ISSN 1478-7210 Altmetric
  2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology Volume 21 Pages 481 - 487 ISSN 1074-5521 Altmetric
  2014	Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells Published In Bioorganic and Medicinal Chemistry Letters Volume 24 Pages 595 - 600 ISSN 0960-894X Altmetric
  2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry Volume 57 Pages 2799 - 2806 ISSN 0022-2623 Altmetric
  2014	Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 70 Pages 7645 - 7650 ISSN 0040-4020 Altmetric
  2014	On the mechanism of berberine-INF55 (5-Nitro-2-phenylindole) hybrid antibacterials Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1471 - 1480 ISSN 0004-9425 Altmetric
  2014	RATNO - reducing antibiotic tolerance using nitric oxide in cystic fibrosis: report of a proof of concept clinical trial Published In Archives of Disease in Childhood Volume 99 Pages A159 - A159 ISSN 0003-9888 Altmetric
  2013	A comparison of patient matched meibum and tear lipidomes Published In Investigative Ophthalmology and Visual Science Volume 54 Pages 7417 - 7423 ISSN 0146-0404 Altmetric
  2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry Volume 56 Pages 8665 - 8673 ISSN 0022-2623 Altmetric
  2013	Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase Published In Chemical Communications Volume 49 Pages 4791 - 4793 ISSN 1364-548X Altmetric
  2013	Synthesis, structural characterisation, and preliminary evaluation of non-indolin-2-one-based angiogenesis inhibitors related to sunitinib (Sutent®) Published In Australian Journal of Chemistry: an international journal for chemical science Volume 66 Pages 864 - 873 ISSN 0004-9425 Altmetric
  2012	Cephalosporin-3'-diazeniumdiolates: Targeted NO-donor prodrugs for dispersing bacterial biofilms Published In Angewandte Chemie International Edition Volume 51 Pages 9057 - 9060 ISSN 1433-7851 Altmetric
  2012	Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes Published In Photochemistry and Photobiology Volume 88 Pages 499 - 511 ISSN 0031-8655 Altmetric
  2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer Volume 129 Pages 2051 - 2061 ISSN 0020-7136 Altmetric
  2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 2549 - 2556 ISSN 0968-0896 Altmetric
  2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters Volume 21 Pages 6760 - 6766 ISSN 0960-894X Altmetric
  2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1364-548X Altmetric
  2010	Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components Published In Antimicrobial Agents and Chemotherapy Volume 54 Pages 3219 - 3224 ISSN 0066-4804 Altmetric
  2010	Synthesis of berberine-efflux pump inhibitor hybrid antibacterials Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 40 Pages 3561 - 3568 ISSN 1532-2432 Altmetric
  2008	Linkage Isomerism in the Binding of Pentapeptide Ac-His(Ala)(3)His-NH2 to (Ethylenediamine)Palladium(II): Effect of the Binding Mode on Peptide Conformation Published In Inorganic Chemistry: including bioinorganic chemistry Volume 47 Pages 9439 - 9449 ISSN 0020-1669 Altmetric
  2008	Oxidative coupling of indoles using thallium(III) trifluoroacetate Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 7787 - 7795 ISSN 0040-4020 Altmetric
  2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery Volume 3 Pages 1 - 13 ISSN 1574-8928 Altmetric
  2008	Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 18 Pages 4294 - 4297 ISSN 0960-894X Altmetric
  2007	Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase Published In Journal of Medicinal Chemistry Volume 50 Pages 3359 - 3368 ISSN 0022-2623 Altmetric
  2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 7440 - 7443 ISSN 0040-4039 Altmetric

• Chapter

  Year	Title
  2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery Publisher Bentham Science Publishers Ltd Pages 55 - 78

• Conference Paper

  Year	Title
  2011	Synthesis and evaluation of dual-action hybrid antimicrobials and prodrugs Published In Abstracts of Papers of the American Chemical Society Pages 1 - 1