Ranson, Marie

Research Areas

Research Overview

Professor Marie Ranson received her PhD from the University of Sydney (1990). After a post-doctoral Fellowship at the National Institutes of Health in Bethesda MD, USA she obtained a Research Fellowship and then a tenured teaching and research academic position in the School of Biological Sciences at the University of Wollongong. Marie is also the Illawarra Lead and executive member of the Cancer Institute NSW funded CONCERT Translational Cancer Research Centre. Her main area of expertise is in molecular biomarkers of metastasis and she is recognised
internationally for her contributions to the field of the urokinase plasminogen activation system (PAS), particularly in solid tumour biology. Combined with her extensive experience with in vitro, ex vivo and animal tumour models, she has also successfully led and/or contributed IP to several drug development projects related, but not limited, to this field. She has supervised 16 PhD, 4 MSc and 35 Honours students to completion to date and was a past recipient of the University of Wollongong Vice-Chancellor’s Award for Excellence in Research Supervision.

Key current research areas:
- The plasminogen activation system in tumour invasion and metastasis.
- Genomic and expression analyses for the identification of biomarkers to predict cancer progression and responsiveness to single and combinatorial drug treatment using patient derived culture and animal models.
- Targeted drug development programmes against biomarkers of cancer and inflammation
- Molecular Horizons
- Illawarra Health and Medical Research Institute
- Centre for Oncology Education & Research Translation
- Cancer Drug Discovery Group
- Proteostasis and Disease Research Centre

Head Of

Cancer Cell and Molecular Biology Group leader 2009 -

Member Of

Molecular Horizons member 2019 -
The Centre for Oncology Education and Research Translation (CONCERT) Deputy Director 2014 -
International Society of Fibrinolysis and Proteolysis
Metastasis Research Society
The American Society for Biochemistry and Molecular Biology

Has Collaborator

Clinical Activities

Deflexifol Phase 1 trial Scientific advisor 2014 -

Selected Publications

Journal Article

Year	Title
2020	Assessing the role of pharyngeal cell surface glycans in group a streptococcus biofilm formation Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products
2020	Breast tumor cell invasion and pro-invasive activity of cancer-associated fibroblasts co-targeted by novel urokinase-derived decapeptides Published In Cancers
2020	Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I Published In Bioorganic and Medicinal Chemistry
2020	Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer Published In Scientific Reports
2020	N-alkylisatin-loaded liposomes target the urokinase plasminogen activator system in breast cancer Published In Pharmaceutics
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2019	Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection Published In Microbes and Infection: a journal on infectious agents and host defenses
2019	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2019	First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment Published In Asia Pacific Journal of Clinical Oncology
2019	Human pregnancy zone protein stabilizes misfoldedproteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide Published In Proceedings of the National Academy of Sciences of USA
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Paracrine recruitment and activation of fibroblasts by c-Myc expressing breast epithelial cells through the IGFs/IGF-1R axis Published In International Journal of Cancer
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release
2018	Safety and Efficacy of Oxaliplatin Doublet Adjuvant Chemotherapy in Elderly Patients With Stage III Colon Cancer Published In Clinical Colorectal Cancer
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene
2017	Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients Published In BMC Cancer
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry
2016	Adjuvant chemotherapy for stage III colorectal cancer in the elderly Published In Annals of Oncology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology
2015	Serglycin proteoglycan promotes progression and metastasis of triple-negative breast cancers Published In Cancer Research
2015	SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation Published In PLoS One
2015	Therapeutic drug monitoring for cancer patients receiving chemotherapy Published In Asia Pacific Journal of Clinical Oncology
2014	Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing Published In Journal of Innate Immunity
2013	A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection Published In PLoS Pathogens
2013	Comparative effectiveness of 5-fluorouracil with and without oxaliplatin in the treatment of colorectal cancer in clinical practice Published In Anticancer Research: international journal of cancer research and treatment
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters
2012	Bacterial plasminogen receptors: mediators of a multifaceted relationship Published In BioMed Research International
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology
2012	Gelapin, a degradable genipin cross-linked gelatin hydrogel Published In RSC Advances: an international journal to further the chemical sciences
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer
2011	Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer Published In Journal of Biological Chemistry
2011	Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy Published In Current Drug Targets
2011	Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma Published In Seminars in Thrombosis and Hemostasis
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal
2011	Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer Published In Cancer Letters
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters
2010	Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes Published In Thrombosis and Haemostasis
2010	Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM) Published In BBA: Proteins and Proteomics
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters
2009	Conformational rearrangements of plasminogen activator inhibitor type 2 Published In Cellular and Molecular Life Sciences
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology
2008	Allelic variants of strepokinase from Streptococcus pyogenes display functional differences in plasminogen activation Published In The FASEB Journal
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery
2008	Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions Published In Thrombosis and Haemostasis
2008	Revisiting the biological roles of PAI2 (SERPINB2) in cancer Published In Nature Reviews Cancer
2007	A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells Published In Biochemical Journal
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry
2007	Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Published In Breast Cancer Research
2007	Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma Published In Molecular Cancer Therapeutics
2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues Published In Journal of Bacteriology

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery
2007	Gene expression and tagging of Streptococcal proteins Published In Molecular Biology of Streptococci Publisher Wymondham

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7)
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2014 - 2021	Centre for Oncology Education and Research Translation (CONCERT) Awarded by: Cancer Institute NSW Funding Scheme: Translational Cancer Research Centre
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid
2016 - 2019	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2012	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant
2007	Avestin EmulsiFlex TM-C5 Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2007	Unified model for group A streptococcal invasive disease initiation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Potential Supervision Topics

Cutaneous Squamous Cell Carcinoma: Defining Prognostic Markers of Metastasis

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterising the role of pharyngeal cell surface glycans in Group A Streptococcus biofilm formation	Vyas, Heema
Doctor of Philosophy	Bismuth-NSAIDs as Colorectal Cancer Chemopreventatives	Oliver, Tara
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna
Doctor of Philosophy	Molecular and Clinical Biomarker assessment of gastric cancer	Tincknell, Gary

Web Of Science Researcher Id

A-6324-2008

Scopus Id

7005465112

Research Areas

Research Overview

Professor Marie Ranson received her PhD from the University of Sydney (1990). After a post-doctoral Fellowship at the National Institutes of Health in Bethesda MD, USA she obtained a Research Fellowship and then a tenured teaching and research academic position in the School of Biological Sciences at the University of Wollongong. Marie is also the Illawarra Lead and executive member of the Cancer Institute NSW funded CONCERT Translational Cancer Research Centre. Her main area of expertise is in molecular biomarkers of metastasis and she is recognised
internationally for her contributions to the field of the urokinase plasminogen activation system (PAS), particularly in solid tumour biology. Combined with her extensive experience with in vitro, ex vivo and animal tumour models, she has also successfully led and/or contributed IP to several drug development projects related, but not limited, to this field. She has supervised 16 PhD, 4 MSc and 35 Honours students to completion to date and was a past recipient of the University of Wollongong Vice-Chancellor’s Award for Excellence in Research Supervision.

Key current research areas:
- The plasminogen activation system in tumour invasion and metastasis.
- Genomic and expression analyses for the identification of biomarkers to predict cancer progression and responsiveness to single and combinatorial drug treatment using patient derived culture and animal models.
- Targeted drug development programmes against biomarkers of cancer and inflammation
- Molecular Horizons
- Illawarra Health and Medical Research Institute
- Centre for Oncology Education & Research Translation
- Cancer Drug Discovery Group
- Proteostasis and Disease Research Centre

Head Of

Cancer Cell and Molecular Biology Group leader 2009 -

Member Of

Molecular Horizons member 2019 -
The Centre for Oncology Education and Research Translation (CONCERT) Deputy Director 2014 -
International Society of Fibrinolysis and Proteolysis
Metastasis Research Society
The American Society for Biochemistry and Molecular Biology

Has Collaborator

Clinical Activities

Deflexifol Phase 1 trial Scientific advisor 2014 -

Selected Publications

Journal Article

Year	Title
2020	Assessing the role of pharyngeal cell surface glycans in group a streptococcus biofilm formation Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products
2020	Breast tumor cell invasion and pro-invasive activity of cancer-associated fibroblasts co-targeted by novel urokinase-derived decapeptides Published In Cancers
2020	Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I Published In Bioorganic and Medicinal Chemistry
2020	Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer Published In Scientific Reports
2020	N-alkylisatin-loaded liposomes target the urokinase plasminogen activator system in breast cancer Published In Pharmaceutics
2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease Published In Bioorganic and Medicinal Chemistry Letters
2019	Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection Published In Microbes and Infection: a journal on infectious agents and host defenses
2019	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2019	First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment Published In Asia Pacific Journal of Clinical Oncology
2019	Human pregnancy zone protein stabilizes misfoldedproteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide Published In Proceedings of the National Academy of Sciences of USA
2019	Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies? Published In Journal of Clinical Pathology
2019	Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma Published In Journal of Investigative Dermatology
2019	Paracrine recruitment and activation of fibroblasts by c-Myc expressing breast epithelial cells through the IGFs/IGF-1R axis Published In International Journal of Cancer
2019	The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets Published In Current Drug Targets
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release
2018	Safety and Efficacy of Oxaliplatin Doublet Adjuvant Chemotherapy in Elderly Patients With Stage III Colon Cancer Published In Clinical Colorectal Cancer
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene
2017	Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients Published In BMC Cancer
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry
2016	Adjuvant chemotherapy for stage III colorectal cancer in the elderly Published In Annals of Oncology
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology
2015	Serglycin proteoglycan promotes progression and metastasis of triple-negative breast cancers Published In Cancer Research
2015	SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation Published In PLoS One
2015	Therapeutic drug monitoring for cancer patients receiving chemotherapy Published In Asia Pacific Journal of Clinical Oncology
2014	Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing Published In Journal of Innate Immunity
2013	A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection Published In PLoS Pathogens
2013	Comparative effectiveness of 5-fluorouracil with and without oxaliplatin in the treatment of colorectal cancer in clinical practice Published In Anticancer Research: international journal of cancer research and treatment
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters
2012	Bacterial plasminogen receptors: mediators of a multifaceted relationship Published In BioMed Research International
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology
2012	Gelapin, a degradable genipin cross-linked gelatin hydrogel Published In RSC Advances: an international journal to further the chemical sciences
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer
2011	Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer Published In Journal of Biological Chemistry
2011	Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy Published In Current Drug Targets
2011	Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma Published In Seminars in Thrombosis and Hemostasis
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal
2011	Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer Published In Cancer Letters
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters
2010	Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes Published In Thrombosis and Haemostasis
2010	Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM) Published In BBA: Proteins and Proteomics
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters
2009	Conformational rearrangements of plasminogen activator inhibitor type 2 Published In Cellular and Molecular Life Sciences
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology
2008	Allelic variants of strepokinase from Streptococcus pyogenes display functional differences in plasminogen activation Published In The FASEB Journal
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery
2008	Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions Published In Thrombosis and Haemostasis
2008	Revisiting the biological roles of PAI2 (SERPINB2) in cancer Published In Nature Reviews Cancer
2007	A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells Published In Biochemical Journal
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry
2007	Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Published In Breast Cancer Research
2007	Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma Published In Molecular Cancer Therapeutics
2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues Published In Journal of Bacteriology

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery
2007	Gene expression and tagging of Streptococcal proteins Published In Molecular Biology of Streptococci Publisher Wymondham

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7)
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies

Investigator On

Year	Title
2020 - 2023	Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Ideas Grant
2014 - 2021	Centre for Oncology Education and Research Translation (CONCERT) Awarded by: Cancer Institute NSW Funding Scheme: Translational Cancer Research Centre
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid
2016 - 2019	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2012	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant
2007	Avestin EmulsiFlex TM-C5 Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2007	Unified model for group A streptococcal invasive disease initiation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Potential Supervision Topics

Cutaneous Squamous Cell Carcinoma: Defining Prognostic Markers of Metastasis

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Characterising the role of pharyngeal cell surface glycans in Group A Streptococcus biofilm formation	Vyas, Heema
Doctor of Philosophy	Bismuth-NSAIDs as Colorectal Cancer Chemopreventatives	Oliver, Tara
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna
Doctor of Philosophy	Molecular and Clinical Biomarker assessment of gastric cancer	Tincknell, Gary

Education And Training

Ph.D., University of Sydney 1990
B.Sc. in Biochemistry, University of New South Wales, Hons 1985

Awards And Honors

Vice-Chancellorâs Award for Excellence in Research Supervision , conferred by University of Wollongong, 2007
Gessellschaft fur Biotechnologische Forschung (GBF) , 2004
Biomedical Postgraduate Scholarship, conferred by NHMRC, 1989
Cancer Institute NSW Career Development and Support Fellowship , conferred by Cancer Institute NSW, 2005 - 2008
Fogarty Visiting Post-Doctoral Fellowship, conferred by NIH, 1990 - 1992
Australian National Heart Foundation Vacation Scholarships, conferred by Australian National Heart Foundation, 1983 - 1984

Orcid Id

http://orcid.org/0000-0002-5570-9645 (confirmed)

Web Of Science Researcher Id

A-6324-2008

Scopus Id

7005465112

Overview

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Has Collaborator

Clinical Activities

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Potential Supervision Topics

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Has Collaborator

Clinical Activities

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Potential Supervision Topics

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas