Ranson, Marie

Research Areas

Research Overview

Professor Marie Ranson received her PhD from the University of Sydney (1990). After a post-doctoral Fellowship at the National Institutes of Health in Bethesda MD, USA she obtained a Research Fellowship and then a tenured teaching and research academic position in the School of Biological Sciences at the University of Wollongong. Marie is also the Illawarra Lead and executive member of the Cancer Institute NSW funded CONCERT Translational Cancer Research Centre. Her main area of expertise is in molecular biomarkers of metastasis and she is recognised
internationally for her contributions to the field of the urokinase plasminogen activation system (PAS), particularly in solid tumour biology. Combined with her extensive experience with in vitro, ex vivo and animal tumour models, she has also successfully led and/or contributed IP to several drug development projects related, but not limited, to this field. She has supervised 16 PhD, 4 MSc and 35 Honours students to completion to date and was a past recipient of the University of Wollongong Vice-Chancellor’s Award for Excellence in Research Supervision.

Key current research areas:
- The plasminogen activation system in tumour invasion and metastasis.
- Genomic and expression analyses for the identification of biomarkers to predict cancer progression and responsiveness to single and combinatorial drug treatment using patient derived culture and animal models.
- Targeted drug development programmes against biomarkers of cancer and inflammation
- Molecular Horizons
- Illawarra Health and Medical Research Institute
- Centre for Oncology Education & Research Translation
- Cancer Drug Discovery Group
- Proteostasis and Disease Research Centre

Clinical Activities

Deflexifol Phase 1 trial Scientific advisor 2014 -

Selected Publications

Journal Article

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology Volume 31 Pages 275 - 287 ISSN 0893-3952 Altmetric
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology Volume 24 Pages 810 - 818 ISSN 1007-9327 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	Safety and Efficacy of Oxaliplatin Doublet Adjuvant Chemotherapy in Elderly Patients With Stage III Colon Cancer Published In Clinical Colorectal Cancer Volume 17 Pages e549 - e555 ISSN 1533-0028 Altmetric
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release Volume 277 Pages 1 - 13 ISSN 0168-3659 Altmetric
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry Volume 292 Pages 14425 - 14437 ISSN 0021-9258 Altmetric
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology Volume 49 Pages 499 - 505 ISSN 1465-3931 Altmetric
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry Volume 15 Pages 4172 - 4179 ISSN 1477-0520 Altmetric
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene Volume 36 Pages 1 - 11 ISSN 0950-9232 Altmetric
2017	Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients Published In BMC Cancer Volume 17 Pages 251-1 - 251-9 ISSN 1471-2407 Altmetric
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget Volume 8 Pages 23099 - 23109 ISSN 1949-2553 Altmetric
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology Volume 49 Pages 494 - 498 ISSN 1465-3931 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget Volume 7 Pages 47111 - 47115 ISSN 1949-2553 Altmetric
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology Volume 51 Pages 313 - 326 ISSN 0944-1174 Altmetric
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon Volume 2 Pages e00060-1 - e00060-23 Altmetric
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology Volume 79 Pages 113 - 117 ISSN 1878-5875 Altmetric
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters Volume 26 Pages 1813 - 1816 ISSN 0960-894X Altmetric
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research Volume 32 Pages 2808 - 2808 ISSN 0724-8741 Altmetric
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience Volume 2 Pages 207 - 224
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research Volume 32 Pages 1045 - 1054 ISSN 0724-8741 Altmetric
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology Volume 27 Pages 2111 - 2121 ISSN 0921-8971 Altmetric
2015	Serglycin proteoglycan promotes progression and metastasis of triple-negative breast cancers Published In Cancer Research Volume 75 Page p. 2251 ISSN 0008-5472 Altmetric
2015	SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation Published In PLoS One Volume 10 Pages e0130136-1 - e0130136-20 ISSN 1932-6203 Altmetric
2015	Therapeutic drug monitoring for cancer patients receiving chemotherapy Published In Asia Pacific Journal of Clinical Oncology Volume 11 Pages 8 - 8 ISSN 1743-7555 Altmetric
2014	Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing Published In Journal of Innate Immunity Volume 6 Pages 240 - 250 ISSN 1662-811X Altmetric
2013	A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection Published In PLoS Pathogens Volume 9 Pages e1003469-1 - e1003469-9 ISSN 1553-7374 Altmetric
2013	Comparative effectiveness of 5-fluorouracil with and without oxaliplatin in the treatment of colorectal cancer in clinical practice Published In Anticancer Research: international journal of cancer research and treatment Volume 33 Pages 1053 - 1060 ISSN 0250-7005
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 24 Pages 704 - 714 ISSN 0959-4973 Altmetric
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Bacterial plasminogen receptors: mediators of a multifaceted relationship Published In BioMed Research International Volume 2012 Pages 1 - 14 ISSN 2314-6133 Altmetric
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology Volume 39 Pages 833 - 839 ISSN 0969-8051 Altmetric
2012	Gelapin, a degradable genipin cross-linked gelatin hydrogel Published In RSC Advances: an international journal to further the chemical sciences Volume 3 Pages 1073 - 1081 ISSN 2046-2069 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer Volume 129 Pages 2051 - 2061 ISSN 0020-7136 Altmetric
2011	Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer Published In Journal of Biological Chemistry Volume 286 Pages 24467 - 24475 ISSN 0021-9258 Altmetric
2011	Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy Published In Current Drug Targets Volume 12 Pages 1 - 2 ISSN 1389-4501 Altmetric
2011	Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma Published In Seminars in Thrombosis and Hemostasis Volume 37 Pages 395 - 407 ISSN 0094-6176 Altmetric
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal Volume 41 Pages 9 - 10 ISSN 1444-0903 Altmetric
2011	Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer Published In Cancer Letters Volume 303 Pages 118 - 127 ISSN 0304-3835 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 2549 - 2556 ISSN 0968-0896 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 0968-0896 Altmetric
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters Volume 21 Pages 6760 - 6766 ISSN 0960-894X Altmetric
2010	Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes Published In Thrombosis and Haemostasis Volume 104 Pages 1133 - 1142 ISSN 0340-6245 Altmetric
2010	Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM) Published In BBA: Proteins and Proteomics Volume 1804 Pages 1342 - 1349 ISSN 1570-9639 Altmetric
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects Volume 1800 Pages 1173 - 1182 ISSN 0304-4165 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2009	Conformational rearrangements of plasminogen activator inhibitor type 2 Published In Cellular and Molecular Life Sciences Volume 66 Pages 1782 - 1783 ISSN 1420-9071 Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology Volume 9 Pages 1 - 9 ISSN 1472-6750 Altmetric
2008	Allelic variants of strepokinase from Streptococcus pyogenes display functional differences in plasminogen activation Published In The FASEB Journal Volume 22, Pages pp3146 - 3153 ISSN 0892-6638 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery Volume 3 Pages 1 - 13 ISSN 1574-8928 Altmetric
2008	Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions Published In Thrombosis and Haemostasis Volume 100 Pages 319 - 329 ISSN 0340-6245 Altmetric
2008	Revisiting the biological roles of PAI2 (SERPINB2) in cancer Published In Nature Reviews Cancer Volume 8 Pages 535 - 545 ISSN 1474-175X Altmetric
2007	A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells Published In Biochemical Journal Volume 408 Pages 203 - 210 ISSN 0264-6021 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric
2007	Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Published In Breast Cancer Research Volume 9 Pages R14-1 - R14-14 ISSN 1465-542X Altmetric
2007	Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma Published In Molecular Cancer Therapeutics Volume 6 Pages 203 - 212 ISSN 1535-7163 Altmetric
2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues Published In Journal of Bacteriology Volume 189 Pages 1435 - 1440 ISSN 0021-9193 Altmetric

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery Publisher Bentham Science Publishers Ltd Pages 55 - 78
2007	Gene expression and tagging of Streptococcal proteins Published In Molecular Biology of Streptococci Publisher Wymondham: Horizon Bioscience Pages 359 - 378 ISBN 9781904933328 Edition 1

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant
	missing activity
	Avestin EmulsiFlex TM-C5 Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Unified model for group A streptococcal invasive disease initiation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Molecular and genetic analysis of metastatic cutaneous Squamous Cell Carcinoma (SCC)	Ashford, Bruce
Doctor of Philosophy	Skin Deep: Understanding the Biology of Metatastic Cutaneous Squamous Cell Carcinoma	Perry, Jay
Doctor of Philosophy	Biomarkers and Systemic Treatment in Gastrointestinal Cancers	Brungs, Daniel
Doctor of Philosophy	Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer	Belfiore, Lisa
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar

Education And Training

Ph.D., University of Sydney 1990
B.Sc. in Biochemistry, University of New South Wales, Hons 1985

Awards And Honors

Vice-Chancellorâs Award for Excellence in Research Supervision , conferred by University of Wollongong, 2007
Gessellschaft fur Biotechnologische Forschung (GBF) , 2004
Biomedical Postgraduate Scholarship, conferred by NHMRC, 1989
Cancer Institute NSW Career Development and Support Fellowship , conferred by Cancer Institute NSW, 2005 - 2008
Fogarty Visiting Post-Doctoral Fellowship, conferred by NIH, 1990 - 1992
Australian National Heart Foundation Vacation Scholarships, conferred by Australian National Heart Foundation, 1983 - 1984

Orcid Id

http://orcid.org/0000-0002-5570-9645 (confirmed)

Web Of Science Researcher Id

A-6324-2008

Scopus Id

7005465112

Research Areas

Research Overview

Professor Marie Ranson received her PhD from the University of Sydney (1990). After a post-doctoral Fellowship at the National Institutes of Health in Bethesda MD, USA she obtained a Research Fellowship and then a tenured teaching and research academic position in the School of Biological Sciences at the University of Wollongong. Marie is also the Illawarra Lead and executive member of the Cancer Institute NSW funded CONCERT Translational Cancer Research Centre. Her main area of expertise is in molecular biomarkers of metastasis and she is recognised
internationally for her contributions to the field of the urokinase plasminogen activation system (PAS), particularly in solid tumour biology. Combined with her extensive experience with in vitro, ex vivo and animal tumour models, she has also successfully led and/or contributed IP to several drug development projects related, but not limited, to this field. She has supervised 16 PhD, 4 MSc and 35 Honours students to completion to date and was a past recipient of the University of Wollongong Vice-Chancellor’s Award for Excellence in Research Supervision.

Key current research areas:
- The plasminogen activation system in tumour invasion and metastasis.
- Genomic and expression analyses for the identification of biomarkers to predict cancer progression and responsiveness to single and combinatorial drug treatment using patient derived culture and animal models.
- Targeted drug development programmes against biomarkers of cancer and inflammation
- Molecular Horizons
- Illawarra Health and Medical Research Institute
- Centre for Oncology Education & Research Translation
- Cancer Drug Discovery Group
- Proteostasis and Disease Research Centre

Head Of

Cancer Cell and Molecular Biology Group leader 2009 -

Member Of

Molecular Horizons member 2019 -
The Centre for Oncology Education and Research Translation (CONCERT) Deputy Director 2014 -
International Society of Fibrinolysis and Proteolysis
Metastasis Research Society
The American Society for Biochemistry and Molecular Biology

Has Collaborator

Aghmesheh, Morteza Person
Ashford, Bruce G. Person
Kelso, Michael J. Available as Research Supervisor
Vine, Kara L. Dr

Clinical Activities

Deflexifol Phase 1 trial Scientific advisor 2014 -

Selected Publications

Journal Article

Year	Title
2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer Published In Journal of Medicinal Chemistry Volume 61 Pages 8299 - 8320 ISSN 0022-2623 Altmetric
2018	Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma Published In Modern Pathology Volume 31 Pages 275 - 287 ISSN 0893-3952 Altmetric
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology Volume 24 Pages 810 - 818 ISSN 1007-9327 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	Safety and Efficacy of Oxaliplatin Doublet Adjuvant Chemotherapy in Elderly Patients With Stage III Colon Cancer Published In Clinical Colorectal Cancer Volume 17 Pages e549 - e555 ISSN 1533-0028 Altmetric
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release Volume 277 Pages 1 - 13 ISSN 0168-3659 Altmetric
2017	Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones Published In Journal of Biological Chemistry Volume 292 Pages 14425 - 14437 ISSN 0021-9258 Altmetric
2017	PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma Published In Pathology Volume 49 Pages 499 - 505 ISSN 1465-3931 Altmetric
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry Volume 15 Pages 4172 - 4179 ISSN 1477-0520 Altmetric
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene Volume 36 Pages 1 - 11 ISSN 0950-9232 Altmetric
2017	Sidedness is prognostic in locoregional colon cancer: an analysis of 9509 Australian patients Published In BMC Cancer Volume 17 Pages 251-1 - 251-9 ISSN 1471-2407 Altmetric
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget Volume 8 Pages 23099 - 23109 ISSN 1949-2553 Altmetric
2017	p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis Published In Pathology Volume 49 Pages 494 - 498 ISSN 1465-3931 Altmetric
2016	5′-substituted amiloride derivatives as allosteric modulators binding in the sodium ion pocket of the adenosine A_2A receptor Published In Journal of Medicinal Chemistry Volume 59 Pages 4769 - 4777 ISSN 0022-2623 Altmetric
2016	Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: a pilot study Published In Oncotarget Volume 7 Pages 47111 - 47115 ISSN 1949-2553 Altmetric
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology Volume 51 Pages 313 - 326 ISSN 0944-1174 Altmetric
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon Volume 2 Pages e00060-1 - e00060-23 Altmetric
2016	PZP and PAI-2: structurally-diverse, functionally similar pregnancy proteins? Published In The International Journal of Biochemistry and Cell Biology Volume 79 Pages 113 - 117 ISSN 1878-5875 Altmetric
2016	Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors Published In Bioorganic and Medicinal Chemistry Letters Volume 26 Pages 1813 - 1816 ISSN 0960-894X Altmetric
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research Volume 32 Pages 2808 - 2808 ISSN 0724-8741 Altmetric
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience Volume 2 Pages 207 - 224
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research Volume 32 Pages 1045 - 1054 ISSN 0724-8741 Altmetric
2015	Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity Published In Journal of Applied Phycology Volume 27 Pages 2111 - 2121 ISSN 0921-8971 Altmetric
2015	Serglycin proteoglycan promotes progression and metastasis of triple-negative breast cancers Published In Cancer Research Volume 75 Page p. 2251 ISSN 0008-5472 Altmetric
2015	SerpinB2 (PAI-2) modulates proteostasis via binding misfolded proteins and promotion of cytoprotective inclusion formation Published In PLoS One Volume 10 Pages e0130136-1 - e0130136-20 ISSN 1932-6203 Altmetric
2015	Therapeutic drug monitoring for cancer patients receiving chemotherapy Published In Asia Pacific Journal of Clinical Oncology Volume 11 Pages 8 - 8 ISSN 1743-7555 Altmetric
2014	Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing Published In Journal of Innate Immunity Volume 6 Pages 240 - 250 ISSN 1662-811X Altmetric
2013	A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection Published In PLoS Pathogens Volume 9 Pages e1003469-1 - e1003469-9 ISSN 1553-7374 Altmetric
2013	Comparative effectiveness of 5-fluorouracil with and without oxaliplatin in the treatment of colorectal cancer in clinical practice Published In Anticancer Research: international journal of cancer research and treatment Volume 33 Pages 1053 - 1060 ISSN 0250-7005
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 24 Pages 704 - 714 ISSN 0959-4973 Altmetric
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Bacterial plasminogen receptors: mediators of a multifaceted relationship Published In BioMed Research International Volume 2012 Pages 1 - 14 ISSN 2314-6133 Altmetric
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology Volume 39 Pages 833 - 839 ISSN 0969-8051 Altmetric
2012	Gelapin, a degradable genipin cross-linked gelatin hydrogel Published In RSC Advances: an international journal to further the chemical sciences Volume 3 Pages 1073 - 1081 ISSN 2046-2069 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty? Published In International Journal of Cancer Volume 129 Pages 2051 - 2061 ISSN 0020-7136 Altmetric
2011	Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer Published In Journal of Biological Chemistry Volume 286 Pages 24467 - 24475 ISSN 0021-9258 Altmetric
2011	Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy Published In Current Drug Targets Volume 12 Pages 1 - 2 ISSN 1389-4501 Altmetric
2011	Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma Published In Seminars in Thrombosis and Hemostasis Volume 37 Pages 395 - 407 ISSN 0094-6176 Altmetric
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal Volume 41 Pages 9 - 10 ISSN 1444-0903 Altmetric
2011	Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer Published In Cancer Letters Volume 303 Pages 118 - 127 ISSN 0304-3835 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 2549 - 2556 ISSN 0968-0896 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 0968-0896 Altmetric
2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA) Published In Bioorganic and Medicinal Chemistry Letters Volume 21 Pages 6760 - 6766 ISSN 0960-894X Altmetric
2010	Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes Published In Thrombosis and Haemostasis Volume 104 Pages 1133 - 1142 ISSN 0340-6245 Altmetric
2010	Effects on human plasminogen conformation and activation rate caused by interaction with VEK-30, a peptide derived from the group A streptococcal M-like protein (PAM) Published In BBA: Proteins and Proteomics Volume 1804 Pages 1342 - 1349 ISSN 1570-9639 Altmetric
2010	P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells Published In BBA: General Subjects Volume 1800 Pages 1173 - 1182 ISSN 0304-4165 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2009	Conformational rearrangements of plasminogen activator inhibitor type 2 Published In Cellular and Molecular Life Sciences Volume 66 Pages 1782 - 1783 ISSN 1420-9071 Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology Volume 9 Pages 1 - 9 ISSN 1472-6750 Altmetric
2008	Allelic variants of strepokinase from Streptococcus pyogenes display functional differences in plasminogen activation Published In The FASEB Journal Volume 22, Pages pp3146 - 3153 ISSN 0892-6638 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2008	Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer Published In Recent Patents on Anti-Cancer Drug Discovery Volume 3 Pages 1 - 13 ISSN 1574-8928 Altmetric
2008	Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions Published In Thrombosis and Haemostasis Volume 100 Pages 319 - 329 ISSN 0340-6245 Altmetric
2008	Revisiting the biological roles of PAI2 (SERPINB2) in cancer Published In Nature Reviews Cancer Volume 8 Pages 535 - 545 ISSN 1474-175X Altmetric
2007	A structural basis for differential cell signalling by PAI-1 and PAI-2 in breast cancer cells Published In Biochemical Journal Volume 408 Pages 203 - 210 ISSN 0264-6021 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric
2007	Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Published In Breast Cancer Research Volume 9 Pages R14-1 - R14-14 ISSN 1465-542X Altmetric
2007	Preclinical evaluation of 213Bi-labeled plasminogen activator inhibitor type 2 in an orthotopic murine xenogenic model of human breast carcinoma Published In Molecular Cancer Therapeutics Volume 6 Pages 203 - 212 ISSN 1535-7163 Altmetric
2007	The plasminogen-binding group A streptococcal M protein-related protein Prp binds plasminogen via arginine and histidine residues Published In Journal of Bacteriology Volume 189 Pages 1435 - 1440 ISSN 0021-9193 Altmetric

Chapter

Year	Title
2010	Inhibitors of the Plasminogen Activation System - Promising New Agents for Suppressing Breat Cancer Metastasis Published In Frontiers in Anti-Cancer Drug Discovery Publisher Bentham Science Publishers Ltd Pages 55 - 78
2007	Gene expression and tagging of Streptococcal proteins Published In Molecular Biology of Streptococci Publisher Wymondham: Horizon Bioscience Pages 359 - 378 ISBN 9781904933328 Edition 1

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Investigator On

Year	Title
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2019	Novel uPA-targeting small molecules for the treatment of rheumatoid arthritis Awarded by: Arthritis Australia Funding Scheme: Grant-in-Aid
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Unravelling genetic markers of progression and metastases in head and neck cutaneous squamous cell carcinoma Awarded by: Australian and New Zealand Head and Neck Cancer Society Research Foundation Funding Scheme: Research Grant
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013	Neon Transfection System: Workstation for transfer of genetic material into hard-to-work-with cells Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Regional facility for macomolecular X-ray crystallography Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant
	missing activity
	Avestin EmulsiFlex TM-C5 Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
	Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Unified model for group A streptococcal invasive disease initiation Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Molecular and genetic analysis of metastatic cutaneous Squamous Cell Carcinoma (SCC)	Ashford, Bruce
Doctor of Philosophy	Skin Deep: Understanding the Biology of Metatastic Cutaneous Squamous Cell Carcinoma	Perry, Jay
Doctor of Philosophy	Biomarkers and Systemic Treatment in Gastrointestinal Cancers	Brungs, Daniel
Doctor of Philosophy	Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer	Belfiore, Lisa
Doctor of Philosophy	Investigations of the roles of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAl-2) in extracellular proteostasis	Cater, Jordan
Doctor of Philosophy	Biochemical, cell biology and pharmacological evaluation of novel 6-substituted amiloride and 6-substituted hexamethyleneamiloride (HMA) derivatives as new agents for breast cancer	Ali, Umar

Education And Training

Ph.D., University of Sydney 1990
B.Sc. in Biochemistry, University of New South Wales, Hons 1985

Awards And Honors

Vice-Chancellorâs Award for Excellence in Research Supervision , conferred by University of Wollongong, 2007
Gessellschaft fur Biotechnologische Forschung (GBF) , 2004
Biomedical Postgraduate Scholarship, conferred by NHMRC, 1989
Cancer Institute NSW Career Development and Support Fellowship , conferred by Cancer Institute NSW, 2005 - 2008
Fogarty Visiting Post-Doctoral Fellowship, conferred by NIH, 1990 - 1992
Australian National Heart Foundation Vacation Scholarships, conferred by Australian National Heart Foundation, 1983 - 1984

Orcid Id

http://orcid.org/0000-0002-5570-9645 (confirmed)

Web Of Science Researcher Id

A-6324-2008

Scopus Id

7005465112

Overview

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Research Overview

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Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Overview

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Has Collaborator

Clinical Activities

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Awards And Honors

Identity

Orcid Id

Web Of Science Researcher Id

Scopus Id

Visualisations

Research Areas