McAlary, Luke

Year	Title
2022	Assessment of protein inclusions in cultured cells using automated image analysis Published in STAR Protocols
2022	A copper chaperone��mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis Published in Journal of Biological Chemistry
2020	The prion-like nature of amyotrophic lateral sclerosis

Selected Publications

Journal Article

Year	Title
2022	A copper chaperone��mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis Published In Journal of Biological Chemistry
2022	Assessment of protein inclusions in cultured cells using automated image analysis Published In STAR Protocols
2022	Cells Overexpressing ALS-Associated SOD1 Variants Are Differentially Susceptible to CuATSM-Associated Toxicity Published In ACS Chemical Neuroscience
2021	CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1 ^G93A mice with a C57BL/6 background Published In Scientific Reports
2020	Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises Published In Frontiers in Cellular Neuroscience
2020	Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein e Published In Molecular Neurodegeneration
2020	Cerebrovascular amyloid angiopathy in bioengineered vessels is reduced by high��density lipoprotein particles enriched in apolipoprotein E Published In Alzheimer's & Dementia
2020	Corrigendum: Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis (Frontiers in Molecular Neuroscience, (2019), 12, 10.3389/fnmol.2019.00262) Published In Frontiers in Molecular Neuroscience
2020	Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells Published In Journal of cell science
2020	Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Published In J Cell Sci
2020	Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells
2020	Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis Published In Trends in Neurosciences
2020	The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins Published In Glia
2020	The prion-like nature of amyotrophic lateral sclerosis
2020	Thulium oxide nanoparticles as radioenhancers for the treatment of metastatic cutaneous squamous cell carcinoma Published In Physics in Medicine and Biology
2020	Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation Published In Analytical Chemistry
2020	Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection Published In PLoS One
2020	Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1
2020	Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS Published In iScience
2019	CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)^G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1 Published In Journal of Biological Chemistry
2019	Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases Published In CNS Drugs
2019	P4��163: THE PATHOLOGICAL INTERACTOME OF TDP��43 INCLUDES HUMAN WILDTYPE SOD1 Published In Alzheimer's & Dementia
2019	Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis Published In Frontiers in Molecular Neuroscience
2019	Strategies to promote the maturation of ALS-associated SOD1 mutants: Small molecules return to the fold Published In Neural Regeneration Research
2018	In Silico Determined Properties of Designed Superoxide Dismutase-1 Mutants Predict ALS-like Phenotypes In Vitro and In Vivo
2018	CuATSM Protects Against the in Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding Published In ACS Chemical Neuroscience
2018	SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS Published In Journal of Cell Science
2018	The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation Published In Nature Communications
2018	Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells Published In Scientific Reports
2017	Flow cytometric measurement of the cellular propagation of TDP-43 aggregation Published In Prion
2016	Rapid flow cytometric measurement of protein inclusions and nuclear trafficking Published In Scientific Reports
2016	Susceptibility of mutant SOD1 to form a destabilized monomer predicts cellular aggregation and toxicity but not in vitro aggregation propensity Published In Frontiers in Neuroscience
2013	Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis Published In Scientific Reports

Chapter

Year	Title
2021	Protein Aggregation in Amyotrophic Lateral Sclerosis Published In Spectrums of Amyotrophic Lateral Sclerosis Publisher : Wiley

Year	Title
2020 - 2023	Targeting Prion-Like Strains of TDP-43 Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Postdoctoral Fellowship
2020 - 2022	Prion-like strains of TDP-43 aggregates in MND and FTLD Awarded by: FightMND Funding Scheme: Impact Research Grants

Year	Title
2020 - 2023	Targeting Prion-Like Strains of TDP-43 Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Postdoctoral Fellowship
2020 - 2022	Prion-like strains of TDP-43 aggregates in MND and FTLD Awarded by: FightMND Funding Scheme: Impact Research Grants

McAlary, Luke Dr.

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