Ooi, Lezanne Associate Professor

Principal Research Fellow; NHMRC Boosting Dementia Research Leadership Fellow

  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Biological Sciences
  • Boosting Dementia Research Leadership Fellow - NHMRC 2017 - 2021

Top Publications


Research Overview


    • Use of induced pluripotent stem cells in disease modelling and drug discovery.
    • Global control of gene expression and protein function: transcriptional regulation and epigenetics in glioblastoma.
    • Neurodegenerative disease: effects of inflammation and oxidative stress on neuronal function.

    Brief Biography

     

    • 2012-present School of Biological Sciences, University of Wollongong
    • 2011-2012 School of Medicine, University of Western Sydney
    • 2008-2011 Postdoctoral research fellow, Institute of Membrane and Systems Biology, University of Leeds, UK
    • 2002-2006 Wellcome Trust prize PhD studentship. School of Biochemistry and Molecular Biology, University of Leeds, UK 
    • 2000-2001 Neuroscience Research, GlaxoSmithKline, UK

     

Selected Publications


Investigator On


Impact Story


  • <p>In my lab we try to understand the causes of a range of neurological diseases. I have a personal connection to most of the diseases that I work on, usually because they have affected my family or friends.  In June 2017 one of my colleagues, Justin Yerbury, had been contacted by a local Illawarra family and he talked to me about whether we could help this family. Their daughter has been diagnosed with Vanishing White Matter Disease, a very rare and devastating disorder that usually affects young children and has a life expectancy of 3-5 years after diagnosis. Because of how rare this disease is there has been very little research into it and there is no cure. We were able to secure some funding through the support of the Illawarra Health and Medical Research Institute to start a research project in February 2018. Following this the charity founded by the family ('Chloe Saxby and Vanishing White Matter Disease') held a number of fund-raising events and were further supported by the local Illawarra community at the Great Illawarra Walk in March 2018. Together this has provided the funds for a post-doctoral researcher in my lab to work on finding a treatment for Vanishing White Matter Disease. We are now also working with a second local family that has a young daughter suffering from this disease. Being involved in this project has been incredibly moving, especially seeing the local community rally support for Chloe and her family. It reminds me why we do what we do.</p>

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Understanding Motor Neuron Loss In Motor Neurone Disease Using Induced Pluripotent Stem Cell Derived Motor Neurons From Patients With A Novel E3 Ubiquitin Ligase Mutation Bax, Monique
    Doctor of Philosophy Modelling the neurobiology of alzheimer's disease Sanz Munoz, Sonia
    Doctor of Philosophy Investigating the cell autonomous and non-cell autonomous effect in ALS Do-Ha, Dzung
    Doctor of Philosophy The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease Balez, Rachelle
    Doctor of Philosophy Characterisation of P2X4 and P2Y12 receptors in humans and companion animals Sophocleous, Reece
    Doctor of Philosophy Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation Bony, Anuja
    Doctor of Philosophy Nicotinic acetylcholine receptor structure and function probed with venom derived peptides. Bye, Lydia
    Doctor of Philosophy Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration Maksour, Simon
    Doctor of Philosophy The Role of Phosphorylated Tau in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Guthrie, Natalie
    Doctor of Philosophy Investigating the mechanisms of neuronal excitability in neurodegeneration and neuroinflammation Seah, Winston
    Doctor of Philosophy Investigating the Treatment of Movement Disorders Using Stem Cells and Neurotechnologies Newbery, Michelle
    Doctor of Philosophy Exploring group 1 metabotropic glutamate receptors in the pathology and treatment of schizophrenia Lum, Jeremy

Top Publications


Research Overview


    • Use of induced pluripotent stem cells in disease modelling and drug discovery.
    • Global control of gene expression and protein function: transcriptional regulation and epigenetics in glioblastoma.
    • Neurodegenerative disease: effects of inflammation and oxidative stress on neuronal function.

    Brief Biography

     

    • 2012-present School of Biological Sciences, University of Wollongong
    • 2011-2012 School of Medicine, University of Western Sydney
    • 2008-2011 Postdoctoral research fellow, Institute of Membrane and Systems Biology, University of Leeds, UK
    • 2002-2006 Wellcome Trust prize PhD studentship. School of Biochemistry and Molecular Biology, University of Leeds, UK 
    • 2000-2001 Neuroscience Research, GlaxoSmithKline, UK

     

Selected Publications


Investigator On


Impact Story


  • <p>In my lab we try to understand the causes of a range of neurological diseases. I have a personal connection to most of the diseases that I work on, usually because they have affected my family or friends.  In June 2017 one of my colleagues, Justin Yerbury, had been contacted by a local Illawarra family and he talked to me about whether we could help this family. Their daughter has been diagnosed with Vanishing White Matter Disease, a very rare and devastating disorder that usually affects young children and has a life expectancy of 3-5 years after diagnosis. Because of how rare this disease is there has been very little research into it and there is no cure. We were able to secure some funding through the support of the Illawarra Health and Medical Research Institute to start a research project in February 2018. Following this the charity founded by the family ('Chloe Saxby and Vanishing White Matter Disease') held a number of fund-raising events and were further supported by the local Illawarra community at the Great Illawarra Walk in March 2018. Together this has provided the funds for a post-doctoral researcher in my lab to work on finding a treatment for Vanishing White Matter Disease. We are now also working with a second local family that has a young daughter suffering from this disease. Being involved in this project has been incredibly moving, especially seeing the local community rally support for Chloe and her family. It reminds me why we do what we do.</p>

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Understanding Motor Neuron Loss In Motor Neurone Disease Using Induced Pluripotent Stem Cell Derived Motor Neurons From Patients With A Novel E3 Ubiquitin Ligase Mutation Bax, Monique
    Doctor of Philosophy Modelling the neurobiology of alzheimer's disease Sanz Munoz, Sonia
    Doctor of Philosophy Investigating the cell autonomous and non-cell autonomous effect in ALS Do-Ha, Dzung
    Doctor of Philosophy The Effect of Liposome Treatment on Calcium Signalling and Nitric Oxide in Cholinergic Neurons During Alzheimer's Disease Balez, Rachelle
    Doctor of Philosophy Characterisation of P2X4 and P2Y12 receptors in humans and companion animals Sophocleous, Reece
    Doctor of Philosophy Conotoxin modulation of voltage-gated calcium and potassium channels via GABA-B receptor activation Bony, Anuja
    Doctor of Philosophy Nicotinic acetylcholine receptor structure and function probed with venom derived peptides. Bye, Lydia
    Doctor of Philosophy Study of Repressor Element 1-Silencing Transcription Factor (REST) function in Neurodevelopment and Neurodegeneration Maksour, Simon
    Doctor of Philosophy The Role of Phosphorylated Tau in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis Guthrie, Natalie
    Doctor of Philosophy Investigating the mechanisms of neuronal excitability in neurodegeneration and neuroinflammation Seah, Winston
    Doctor of Philosophy Investigating the Treatment of Movement Disorders Using Stem Cells and Neurotechnologies Newbery, Michelle
    Doctor of Philosophy Exploring group 1 metabotropic glutamate receptors in the pathology and treatment of schizophrenia Lum, Jeremy
uri icon