Newell, Kelly A. A/Prof

Selected Publications

• Journal Article

  Year	Title
  2020	The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 101 Altmetric
  2019	Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders Published In Brain, Behavior, and Immunity Volume 81 Pages 574 - 587 ISSN 0889-1591 Altmetric
  2019	Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 95 Pages 109666-1 - 109666-10 ISSN 0364-7722 Altmetric
  2019	Increased translocator protein (TSPO) binding throughout neurodevelopment in the perinatal phencyclidine rodent model of schizophrenia Published In Schizophrenia Research Volume 212 Pages 243 - 245 ISSN 0920-9964 Altmetric
  2019	Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression Published In Journal of Psychopharmacology Volume 33 Pages 230 - 243 ISSN 1461-7285 Altmetric
  2019	Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease Published In ACS Chemical Neuroscience Volume 10 Pages 3500 - 3509 ISSN 1948-7193 Altmetric
  2018	A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia Published In Journal of Psychiatry and Neuroscience Volume 43 Pages 102 - 110 ISSN 1180-4882 Altmetric
  2018	Chronic Adolescent CDPPB Treatment Alters Short-Term, but not Long-Term, Glutamatergic Receptor Expression Published In Neurochemical Research Volume 43 Pages 1 - 9 ISSN 0364-3190 Altmetric
  2018	Could an allied health care approach reduce the unacceptable incidence of suicide after psychiatric hospital discharge? Published In Bipolar Disorders: an international journal of psychiatry and neurosciences Volume 20 Pages 403 - 404 ISSN 1398-5647 Altmetric
  2018	Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia Published In Brain Imaging and Behavior: an international journal Volume 12 Pages 509 - 517 ISSN 1931-7557 Altmetric
  2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research Volume 260 Pages 152 - 157 ISSN 0165-1781 Altmetric
  2018	Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice Published In Journal of Neuroinflammation Volume 15 Pages 112-1 - 112-15 ISSN 1742-2094 Altmetric
  2018	Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats Published In Neuronal Signaling Volume 2 Pages 1 - 12 Altmetric
  2017	Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies Published In Journal of Psychiatric Research Volume 90 Pages 31 - 39 ISSN 0022-3956 Altmetric
  2017	Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice Published In Scientific Reports Volume 7 Pages 12203 -1 - 12203 -13 ISSN 2045-2322 Altmetric
  2017	Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics Published In Gene Reports Volume 6 Pages 121 - 127 Altmetric
  2017	Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway Published In Scientific Reports Volume 7 Pages 7877-1 - 7877-11 ISSN 2045-2322 Altmetric
  2017	Shifting towards a model of mGluR5 dysregulation in schizophrenia: consequences for future schizophrenia treatment Published In Neuropharmacology Volume 115 Pages 73 - 91 ISSN 0028-3908 Altmetric
  2017	The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders Published In Neuroscience and Biobehavioral Reviews Volume 80 Pages 743 - 765 ISSN 0149-7634 Altmetric
  2016	Molecular evidence of synaptic pathology in CA1 in schizophrenia Published In Biological Psychiatry Volume 79 Pages 66S - 66S ISSN 0006-3223 Altmetric
  2016	Molecular evidence of synaptic pathology in the CA1 region in schizophrenia Published In NPJ Schizophrenia Volume 2 Pages 16022-1 - 16022-8
  2016	Neurodevelopmental expression profile of dimeric and monomeric group 1 mGluRs: relevance to schizophrenia pathogenesis and treatment Published In Scientific Reports Volume 6 Pages 34391-1 - 34391-10 ISSN 2045-2322 Altmetric
  2016	Possibility of a sex-specific role for a genetic variant in FRMPD4 in schizophrenia, but not cognitive function Published In NeuroReport Volume 27 Pages 33 - 38 ISSN 0959-4965 Altmetric
  2016	The Neurodevelopmental Profile of Group 1 Metabotropic Glutamate Receptors: Implications for Novel Therapeutics Published In International Journal of Neuropsychopharmacology Volume 19 Pages 78 - 79 ISSN 1461-1457 Altmetric
  2016	mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia Published In Psychopharmacology Volume 233 Pages 1349 - 1359 ISSN 1432-2072 Altmetric
  2015	Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation Published In Acta Neuropathologica Volume 130 Pages 119 - 129 ISSN 0001-6322 Altmetric
  2015	Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 63 Pages 91 - 97 ISSN 0364-7722 Altmetric
  2015	Genetic Variation in GRM5 is Associated with Cognition, Hippocampal Volume and Schizophrenia Published In Neuropsychopharmacology Volume 40 Pages S374 - S374 ISSN 0893-133X
  2015	Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia Published In Schizophrenia Research Volume 166 Pages 212 - 218 ISSN 0920-9964 Altmetric
  2015	NMDA receptor antagonism by phencyclidine reduces NWASP and WAVE1 protein expression and reduces levels of myelination markers in the prefrontal cortex of rats Published In Journal of Pharmaceutics & Pharmacology Volume 3 Pages 1 - 8
  2014	GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia Published In BMC Psychiatry Volume 14 Pages 274-1 - 274-7 ISSN 1471-244X Altmetric
  2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience Volume 39 Pages 407 - 416 ISSN 1180-4882 Altmetric
  2014	Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture Published In Disease Models and Mechanisms Volume 7 Pages 171 - 173 ISSN 1754-8403 Altmetric
  2014	Novel implications of Lingo-1 and its signaling partners in schizophrenia Published In Translational Psychiatry Volume 4 Pages e348-1 - e348-8 ISSN 2158-3188 Altmetric
  2014	Novel implications of lingo-1 signaling in the post-mortem schizophrenia brain Published In Biological Psychiatry Volume 75 Pages 186S - 186S ISSN 0006-3223 Altmetric
  2014	Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics Published In BMC Psychiatry Volume 14 Pages 23-1 - 23-6 ISSN 1471-244X Altmetric
  2013	A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice Published In Neuroscience Volume 248 Pages 670 - 680 ISSN 0306-4522 Altmetric
  2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research Volume 146 Pages 170 - 176 ISSN 0920-9964 Altmetric
  2013	Metabotropic glutamate receptor 5 in schizophrenia: emerging evidence for the development of antipsychotic drugs Published In Future Medicinal Chemistry Volume 5 Pages 1471 - 1474 ISSN 1756-8919 Altmetric
  2013	Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia Published In Neuroscience and Biobehavioral Reviews Volume 37 Pages 256 - 268 ISSN 0149-7634 Altmetric
  2013	Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia Published In Molecular Psychiatry Volume 18 Pages 1185 - 1192 ISSN 1359-4184 Altmetric
  2012	Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life Published In European Neuropsychopharmacology Volume 22 Pages 356 - 363 ISSN 0924-977X Altmetric
  2011	Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age Published In Schizophrenia Research Volume 128 Pages 56 - 60 ISSN 0920-9964 Altmetric
  2011	Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 35 Pages 896 - 904 ISSN 0364-7722 Altmetric
  2010	No change in 3H-Ifenprodil binding sites for the NR2B subunit in the prefrontal cortex in schizophrenia Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A49 ISSN 1440-1614
  2010	Perinatal phencyclidine (PCP) treatment in schizophrenia research: of mice and rats Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A13 ISSN 1440-1614
  2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology Volume 19 Pages 256 - 265 ISSN 0924-977X Altmetric
  2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology Volume 216 Pages 132 - 138 ISSN 0014-4886 Altmetric
  2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 37 - 40 ISSN 0364-7722 Altmetric
  2009	The effects of developmental NMDA receptor antagonism on glutamate and acetylcholine receptor systems: a preliminary investigation of a two-hit animal model for Schizophrenia Published In Biological Psychiatry Volume 65 Pages 46S - 46S ISSN 0006-3223
  2008	Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain Published In Neuroscience Volume 154 Pages 1100 - 1106 ISSN 0306-4522 Altmetric
  2008	Effects of antipsychotic medication on muscarinic M1 receptor mRNA expression in the rat brain Published In Journal of Neuroscience Research Volume 86 Pages 457 - 464 ISSN 0360-4012 Altmetric

Investigator On

Year	Title
2019	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2015	Defining the role of mGluR5 in the pathophysiology and treatment of schizophrenia Awarded by: Schizophrenia Fellowship of NSW Funding Scheme: Peter Meyer Fund
2014	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013 - 2014	Investigation of anti-Lingo-1 as an emergent actor in the therapy for schizophrenia Awarded by: Schizophrenia Research Institute Funding Scheme: Grant in Aid
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	NMDA receptor/neuregulin 1 signalling in response to phencyclidine administration Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Impact Story

Advisees

• Graduate Advising Relationship

  Degree	Research Title	Advisee
  Doctor of Philosophy	Characterisation of Alterations in Lipid Pathways in Huntington's Disease. A High-throughput Lipidomic Assessment of Disease Pathways .
  Doctor of Philosophy (Integrated)	Glutamatergic and Neurotrophic Signalling in the Pathology and Treatment of Psychiatric Illness.	Jarbou, Noor
  Doctor of Philosophy	Efficacy Investigation of Terpenes and Cannabidiol in a Rodent Model of Depression	Clunas, Helen
  Doctor of Philosophy (Integrated)	Optimising Exercise Prescription in Pregnancy for Type 1 Diabetes	Russell, Brooke
  Doctor of Philosophy	An Investigation of the Kynurenine Pathway in Major Depression	Brown, Samara

Keywords

• Animal model
• Antidepressant
• Brain development
• Depression
• Glutamate neurotransmission
• Maternal mental health
• Mental health
• Neurobiology
• Neuropharmacology
• Perinatal
• Postmortem human brain
• Pregnancy
• Psychopharmacology
• Schizophrenia

Orcid Id

• http://orcid.org/0000-0002-1245-5585 (confirmed)

Top Publications

Year	Title
2016	Neurodevelopmental expression profile of dimeric and monomeric group 1 mGluRs: relevance to schizophrenia pathogenesis and treatment Published in   Scientific Reports
2017	The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders Published in   Neuroscience and Biobehavioral Reviews
2019	Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression Published in   Journal of Psychopharmacology

Research Areas

• 1109 - NEUROSCIENCES
• Perinatal pharmacology (LCSH)
• Pharmacology (LCSH)
• Psychiatry (LCSH)
• Psychopharmacology (LCSH)

Research Overview

• Molecular psychiatry and neuro-psychopharmacology

  1. I use post-mortem human brain samples to investigate molecular changes that occur in psychiatric disorders, including schizophrenia and depression. I have a particular interest in the glutamatergic neurotransmission system in psychiatric disorders.

  2. I use animal models to investigate molecular changes that occur in the brain throughout normal brain development and how these neurodevelopmental molecular profiles change in animal models of  depression. I have a particular interest in the neurobiology of depression in special populations including pregnancy/postnatal and ageing and understanding the molecular mechanisms of treatments in these populations (including the impact of fetal exposure).

  3. I investigate the effects of current and novel antipsychotic and antidepressant drugs on brain molecules with a particular interest in how exposure to these drugs during the neonatal and adolescent periods, affects continued development of the brain and risk of developing subsequent psychiatric disorders.

  Brief Biography

  • Jan 2018 - : Associate Professor, School of Medicine, UoW
  • Jan 2012 - Dec 2017: Senior Lecturer, School of Medicine, UoW.
  • Dec 2007 – Dec 2011: Lecturer in Neuroscience, School of Health Sciences, UoW
  • 2007: PhD in Neuroscience (supervised by Prof Xu-Feng Huang and Dr Katerina Zavitsanou), School of Health Sciences, UoW.
  • 2006-2007: Short-term teaching contracts, School of Health Sciences, UoW.
  • 2002: Bachelor of Science (Biomedical Science) Honours, School of Health Sciences, UoW. 

Selected Publications

• Journal Article

  Year	Title
  2020	The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 101 Altmetric
  2019	Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders Published In Brain, Behavior, and Immunity Volume 81 Pages 574 - 587 ISSN 0889-1591 Altmetric
  2019	Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 95 Pages 109666-1 - 109666-10 ISSN 0364-7722 Altmetric
  2019	Increased translocator protein (TSPO) binding throughout neurodevelopment in the perinatal phencyclidine rodent model of schizophrenia Published In Schizophrenia Research Volume 212 Pages 243 - 245 ISSN 0920-9964 Altmetric
  2019	Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression Published In Journal of Psychopharmacology Volume 33 Pages 230 - 243 ISSN 1461-7285 Altmetric
  2019	Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease Published In ACS Chemical Neuroscience Volume 10 Pages 3500 - 3509 ISSN 1948-7193 Altmetric
  2018	A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia Published In Journal of Psychiatry and Neuroscience Volume 43 Pages 102 - 110 ISSN 1180-4882 Altmetric
  2018	Chronic Adolescent CDPPB Treatment Alters Short-Term, but not Long-Term, Glutamatergic Receptor Expression Published In Neurochemical Research Volume 43 Pages 1 - 9 ISSN 0364-3190 Altmetric
  2018	Could an allied health care approach reduce the unacceptable incidence of suicide after psychiatric hospital discharge? Published In Bipolar Disorders: an international journal of psychiatry and neurosciences Volume 20 Pages 403 - 404 ISSN 1398-5647 Altmetric
  2018	Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia Published In Brain Imaging and Behavior: an international journal Volume 12 Pages 509 - 517 ISSN 1931-7557 Altmetric
  2018	Effects of short- and long-term aripiprazole treatment on Group I mGluRs in the nucleus accumbens: Comparison with haloperidol Published In Psychiatry Research Volume 260 Pages 152 - 157 ISSN 0165-1781 Altmetric
  2018	Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice Published In Journal of Neuroinflammation Volume 15 Pages 112-1 - 112-15 ISSN 1742-2094 Altmetric
  2018	Perinatal administration of phencyclidine alters expression of Lingo-1 signaling pathway proteins in the prefrontal cortex of juvenile and adult rats Published In Neuronal Signaling Volume 2 Pages 1 - 12 Altmetric
  2017	Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies Published In Journal of Psychiatric Research Volume 90 Pages 31 - 39 ISSN 0022-3956 Altmetric
  2017	Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice Published In Scientific Reports Volume 7 Pages 12203 -1 - 12203 -13 ISSN 2045-2322 Altmetric
  2017	Effects of GRASP variation on memory in psychiatrically healthy individuals and cognitive dysfunction in schizophrenics Published In Gene Reports Volume 6 Pages 121 - 127 Altmetric
  2017	Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway Published In Scientific Reports Volume 7 Pages 7877-1 - 7877-11 ISSN 2045-2322 Altmetric
  2017	Shifting towards a model of mGluR5 dysregulation in schizophrenia: consequences for future schizophrenia treatment Published In Neuropharmacology Volume 115 Pages 73 - 91 ISSN 0028-3908 Altmetric
  2017	The effects of maternal antidepressant use on offspring behaviour and brain development: Implications for risk of neurodevelopmental disorders Published In Neuroscience and Biobehavioral Reviews Volume 80 Pages 743 - 765 ISSN 0149-7634 Altmetric
  2016	Molecular evidence of synaptic pathology in CA1 in schizophrenia Published In Biological Psychiatry Volume 79 Pages 66S - 66S ISSN 0006-3223 Altmetric
  2016	Molecular evidence of synaptic pathology in the CA1 region in schizophrenia Published In NPJ Schizophrenia Volume 2 Pages 16022-1 - 16022-8
  2016	Neurodevelopmental expression profile of dimeric and monomeric group 1 mGluRs: relevance to schizophrenia pathogenesis and treatment Published In Scientific Reports Volume 6 Pages 34391-1 - 34391-10 ISSN 2045-2322 Altmetric
  2016	Possibility of a sex-specific role for a genetic variant in FRMPD4 in schizophrenia, but not cognitive function Published In NeuroReport Volume 27 Pages 33 - 38 ISSN 0959-4965 Altmetric
  2016	The Neurodevelopmental Profile of Group 1 Metabotropic Glutamate Receptors: Implications for Novel Therapeutics Published In International Journal of Neuropsychopharmacology Volume 19 Pages 78 - 79 ISSN 1461-1457 Altmetric
  2016	mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia Published In Psychopharmacology Volume 233 Pages 1349 - 1359 ISSN 1432-2072 Altmetric
  2015	Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation Published In Acta Neuropathologica Volume 130 Pages 119 - 129 ISSN 0001-6322 Altmetric
  2015	Alterations of p75 neurotrophin receptor and Myelin transcription factor 1 in the hippocampus of perinatal phencyclidine treated rats Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 63 Pages 91 - 97 ISSN 0364-7722 Altmetric
  2015	Genetic Variation in GRM5 is Associated with Cognition, Hippocampal Volume and Schizophrenia Published In Neuropsychopharmacology Volume 40 Pages S374 - S374 ISSN 0893-133X
  2015	Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia Published In Schizophrenia Research Volume 166 Pages 212 - 218 ISSN 0920-9964 Altmetric
  2015	NMDA receptor antagonism by phencyclidine reduces NWASP and WAVE1 protein expression and reduces levels of myelination markers in the prefrontal cortex of rats Published In Journal of Pharmaceutics & Pharmacology Volume 3 Pages 1 - 8
  2014	GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia Published In BMC Psychiatry Volume 14 Pages 274-1 - 274-7 ISSN 1471-244X Altmetric
  2014	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics Published In Journal of Psychiatry and Neuroscience Volume 39 Pages 407 - 416 ISSN 1180-4882 Altmetric
  2014	Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture Published In Disease Models and Mechanisms Volume 7 Pages 171 - 173 ISSN 1754-8403 Altmetric
  2014	Novel implications of Lingo-1 and its signaling partners in schizophrenia Published In Translational Psychiatry Volume 4 Pages e348-1 - e348-8 ISSN 2158-3188 Altmetric
  2014	Novel implications of lingo-1 signaling in the post-mortem schizophrenia brain Published In Biological Psychiatry Volume 75 Pages 186S - 186S ISSN 0006-3223 Altmetric
  2014	Rethinking metabotropic glutamate receptor 5 pathological findings in psychiatric disorders: implications for the future of novel therapeutics Published In BMC Psychiatry Volume 14 Pages 23-1 - 23-6 ISSN 1471-244X Altmetric
  2013	A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice Published In Neuroscience Volume 248 Pages 670 - 680 ISSN 0306-4522 Altmetric
  2013	Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatment Published In Schizophrenia Research Volume 146 Pages 170 - 176 ISSN 0920-9964 Altmetric
  2013	Metabotropic glutamate receptor 5 in schizophrenia: emerging evidence for the development of antipsychotic drugs Published In Future Medicinal Chemistry Volume 5 Pages 1471 - 1474 ISSN 1756-8919 Altmetric
  2013	Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia Published In Neuroscience and Biobehavioral Reviews Volume 37 Pages 256 - 268 ISSN 0149-7634 Altmetric
  2013	Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia Published In Molecular Psychiatry Volume 18 Pages 1185 - 1192 ISSN 1359-4184 Altmetric
  2012	Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life Published In European Neuropsychopharmacology Volume 22 Pages 356 - 363 ISSN 0924-977X Altmetric
  2011	Density of metabotropic glutamate receptors 2 and 3 (mGluR2/3) in the dorsolateral prefrontal cortex does not differ with schizophrenia diagnosis but decreases with age Published In Schizophrenia Research Volume 128 Pages 56 - 60 ISSN 0920-9964 Altmetric
  2011	Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin 1 and their role in schizophrenia Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 35 Pages 896 - 904 ISSN 0364-7722 Altmetric
  2010	No change in 3H-Ifenprodil binding sites for the NR2B subunit in the prefrontal cortex in schizophrenia Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A49 ISSN 1440-1614
  2010	Perinatal phencyclidine (PCP) treatment in schizophrenia research: of mice and rats Published In Australian and New Zealand Journal of Psychiatry Volume 44 Page p. A13 ISSN 1440-1614
  2009	Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade Published In European Neuropsychopharmacology Volume 19 Pages 256 - 265 ISSN 0924-977X Altmetric
  2009	High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: the association with the up-regulation of NMDA receptor binding in the rat brain Published In Experimental Neurology Volume 216 Pages 132 - 138 ISSN 0014-4886 Altmetric
  2009	Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors Published In Progress in Neuro-Psychopharmacology and Biological Psychiatry Volume 33 Pages 37 - 40 ISSN 0364-7722 Altmetric
  2009	The effects of developmental NMDA receptor antagonism on glutamate and acetylcholine receptor systems: a preliminary investigation of a two-hit animal model for Schizophrenia Published In Biological Psychiatry Volume 65 Pages 46S - 46S ISSN 0006-3223
  2008	Chronic treatment with simvastatin upregulates muscarinic M1/4 receptor binding in the rat brain Published In Neuroscience Volume 154 Pages 1100 - 1106 ISSN 0306-4522 Altmetric
  2008	Effects of antipsychotic medication on muscarinic M1 receptor mRNA expression in the rat brain Published In Journal of Neuroscience Research Volume 86 Pages 457 - 464 ISSN 0360-4012 Altmetric

Investigator On

Year	Title
2019	Rat activity wheel and living chamber system Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2015	Defining the role of mGluR5 in the pathophysiology and treatment of schizophrenia Awarded by: Schizophrenia Fellowship of NSW Funding Scheme: Peter Meyer Fund
2014	SR-LAB ABS System Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2013 - 2014	Investigation of anti-Lingo-1 as an emergent actor in the therapy for schizophrenia Awarded by: Schizophrenia Research Institute Funding Scheme: Grant in Aid
2010	Precellys 24 tissue homogenizer and digital microplate shaker Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2009	NMDA receptor/neuregulin 1 signalling in response to phencyclidine administration Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
	Forced exercise/walking wheel system for rats Model 80805A Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant

Impact Story

Advisees

• Graduate Advising Relationship

  Degree	Research Title	Advisee
  Doctor of Philosophy	Characterisation of Alterations in Lipid Pathways in Huntington's Disease. A High-throughput Lipidomic Assessment of Disease Pathways .
  Doctor of Philosophy (Integrated)	Glutamatergic and Neurotrophic Signalling in the Pathology and Treatment of Psychiatric Illness.	Jarbou, Noor
  Doctor of Philosophy	Efficacy Investigation of Terpenes and Cannabidiol in a Rodent Model of Depression	Clunas, Helen
  Doctor of Philosophy (Integrated)	Optimising Exercise Prescription in Pregnancy for Type 1 Diabetes	Russell, Brooke
  Doctor of Philosophy	An Investigation of the Kynurenine Pathway in Major Depression	Brown, Samara

Keywords

• Animal model
• Antidepressant
• Brain development
• Depression
• Glutamate neurotransmission
• Maternal mental health
• Mental health
• Neurobiology
• Neuropharmacology
• Perinatal
• Postmortem human brain
• Pregnancy
• Psychopharmacology
• Schizophrenia

Orcid Id

• http://orcid.org/0000-0002-1245-5585 (confirmed)