Perrow, Kara

Overview

In 2014 Dr Vine-Perrow established the Targeted Cancer Therapeutics Research Laboratory based in the Illawarra Health and Medical Research Institute at the University of Wollongong (UOW). Her independent research program is focused on (i) understanding the mechanisms that drive chemotherapeutic drug resistance in cancer and (ii) the development and characterization of novel nanomedicines and medical devices for site‐specific drug delivery.

Conventional drug administration often requires high dosages or repeated administration to initiate a therapeutic response. In the context of cancer, this can result in the patient experiencing toxic side effects and resistance to therapy, leading to cessation of treatment and ultimately, disease relapse. To address these problems, Dr Vine-Perrow's lab designs customisable drug delivery platforms that enhance drug solubility, enable targeted delivery, and provide improved therapeutic efficacy with reduced toxicity profiles. Specifically her Group focuses on the development of (i) drug encapsulated polymeric micelles to overcome multidrug resistance in cancer; (ii) dual‐drug eluting polymeric implants for the treatment of locally advanced pancreatic cancer; and (iii) targeted liposomes for the treatment of metastatic breast cancer.
More recently the Vine-Perrow group has applied their drug delivery knowledge to neurodegenerative diseases, specifically Motor Neurone Disease, to improve the delivery of antisense oligonucleotides to the CNS using calcium phosphate lipid nanoparticles.

Dr Vine-Perrow has longstanding experience in the development of pharmaceutical formulations for small molecule drugs, proteins/antibodies and nucleic acids. Importantly she has built the necessary infrastructure to characterise these technology platforms both in vitro and in vivo to expedite clinical translation.

Research Areas

Available as Research Supervisor

Available for Collaborative Projects

Selected Publications

Journal Article

Year	Title
2021	CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1 ^G93A mice with a C57BL/6 background Published In Scientific Reports
2021	Experimental and clinical evidence supports the use of urokinase plasminogen activation system components as clinically relevant biomarkers in gastroesophageal adenocarcinoma Published In Cancers
2021	Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy Published In Nano Select
2021	Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives Published In Molecular Pharmaceutics
2020	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2020	Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery Published In Journal of Materials Chemistry B
2020	Dual Delivery of Gemcitabine and Paclitaxel by Wet-Spun Coaxial Fibers Induces Pancreatic Ductal Adenocarcinoma Cell Death, Reduces Tumor Volume, and Sensitizes Cells to Radiation Published In Advanced Healthcare Materials
2020	Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer Published In Scientific Reports
2020	N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity Published In CANCER CELL INTERNATIONAL
2020	N-alkylisatin-loaded liposomes target the urokinase plasminogen activator system in breast cancer Published In Pharmaceutics
2020	Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS Published In iScience
2019	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2018	Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook Published In Advanced Materials
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release
2018	SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS Published In Journal of Cell Science
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release
2017	How to find success as a woman in science Published In The Conversation
2017	Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles Published In Frontiers in Neuroscience
2017	Preparation and in vitro assessment of wet-spun gemcitabine-loaded polymeric fibers: Towards localized drug delivery for the treatment of pancreatic cancer Published In Pancreatology
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget
2017	Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In Cell Communication and Signaling
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published In Molecular Neurodegeneration
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry
2007	Corrigendum to "In vitro cytotoxicity evaluation of some substituted isatin derivatives" [Bioorg. Med. Chem. 15 (2007) 931-938] (DOI:10.1016/j.bmc.2006.10.035) Published In Bioorganic and Medicinal Chemistry
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry

Chapter

Year	Title
2014	Cancer biology: molecular and genetic basis Published In Clinical Oncology for Medical Students Publisher Sydney
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry

Conference Paper

Year	Title
2018	Cancer stem cell markers in metastatic gastroesophageal adenocarcinoma Published In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open
2015	TCTP is induced early in colorectal cancer, it is translationally regulated via the Akt/mTORC1 pathway, and it contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In FEBS JOURNAL
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7)
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies
2006	A proposed functional role for indole derivatives in reproduction and defense of the Muricidae (Neogastropoda : Mollusca) Published In INDIRUBIN, THE RED SHADE OF INDIGO

Featured In

Australian Geographic: Sea Snails Could Hold Cancer Killer Video

Investigator On

Year	Title
2022 - 2025	Targeting misfolded proteins with MisfoldUbLs as a therapeutic strategy for ALS Awarded by: FightMND Funding Scheme: Drug Discovery Grants
2022 - 2024	Enhancing delivery of gene therapy to motor neurons and glial cells using focused ultrasound Awarded by: FightMND Funding Scheme: Impact Research Grants
2021 - 2024	Localised Immunotherapy for Pancreatic Cancer: Priming the tumour microenvironment to enhance tumour immunity to checkpoint blockade Awarded by: Cancer Institute NSW Funding Scheme: Career Development Fellowship (CDF)
2020 - 2022	Implantable drug-eluting device: localised drug delivery for non-resectable pancreatic cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2021	Non-invasive drug delivery across the blood brain barrier: Improving the bioavailability of drugs for MND Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Bridge Funding Grant
2020	Localised Immunotherapy for Pancreatic Cancer: Targeting CD40 to enhance tumour immunity to checkpoint blockade Awarded by: Centre for Oncology Education and Research Translation (CONCERT) Funding Scheme: ECR Grants Scheme
2020	Non-invasive drug delivery across the blood brain barrier: Improving the bioavailability of drugs for MND Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
2016 - 2018	Delivery of ubiquitin to motor neurons using a targeted, sterically stabilized liposome delivery system Awarded by: U.S. Department of Defense Funding Scheme: Congressionally Directed Medical Research Program
2016 - 2017	Development of a biocompatible functionalised liposome drug delivery system to increase efficiency of delivery to motor neurons Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2012	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
2011	Investigating the protective effect of PAI-2 in cancer Awarded by: Australian Academy of Science Funding Scheme: Scientific Visits
2009	In vivo assessment of small molecule uPA-directed prodrugs for the treatment of malignant disease Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Is UBA1 a therapeutic target in ALS? Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Specific targeting of Treg cells using immunomodulatory nanoparticles as adjunct therapy for triple negative breast cancer Awarded by: National Breast Cancer Foundation Funding Scheme: Innovator Grant

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	The Role of Ubiquitin Homeostasis in ALS	Chisholm, Christen
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna
Doctor of Philosophy	Molecular and Clinical Biomarker assessment of gastric cancer	Tincknell, Gary
Doctor of Philosophy	Localized delivery of chemotherapy and Immunotherapy for Triple-negative breast cancer.	Minaei, Elahe

Orcid Id

http://orcid.org/0000-0001-6871-1149 (pending confirmation)

Scopus Id

15128286200

Research Areas

Head Of

Targeted Cancer Therapeutics Laboratory

Member Of

Illwarra Health and Medical Research Institute 2010 -
Centre for Medical and Molecular Bioscience 2007 -
The Centre for Oncology Education and Research Translation (CONCERT) T1/T2 Working Research Committee member

Has Collaborator

Ranson, Marie Professor
Yerbury, Justin Professor
van Oijen, Antoine M. Distinguished Professor

Selected Publications

Journal Article

Year	Title
2021	CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1 ^G93A mice with a C57BL/6 background Published In Scientific Reports
2021	Experimental and clinical evidence supports the use of urokinase plasminogen activation system components as clinically relevant biomarkers in gastroesophageal adenocarcinoma Published In Cancers
2021	Implantable coaxial nanocomposite biofibers for local chemo-photothermal combinational cancer therapy Published In Nano Select
2021	Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives Published In Molecular Pharmaceutics
2020	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2020	Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery Published In Journal of Materials Chemistry B
2020	Dual Delivery of Gemcitabine and Paclitaxel by Wet-Spun Coaxial Fibers Induces Pancreatic Ductal Adenocarcinoma Cell Death, Reduces Tumor Volume, and Sensitizes Cells to Radiation Published In Advanced Healthcare Materials
2020	Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer Published In Scientific Reports
2020	N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity Published In CANCER CELL INTERNATIONAL
2020	N-alkylisatin-loaded liposomes target the urokinase plasminogen activator system in breast cancer Published In Pharmaceutics
2020	Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS Published In iScience
2019	Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma Published In Pathology
2018	Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook Published In Advanced Materials
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release
2018	SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS Published In Journal of Cell Science
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release
2017	How to find success as a woman in science Published In The Conversation
2017	Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles Published In Frontiers in Neuroscience
2017	Preparation and in vitro assessment of wet-spun gemcitabine-loaded polymeric fibers: Towards localized drug delivery for the treatment of pancreatic cancer Published In Pancreatology
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget
2017	Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In Cell Communication and Signaling
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published In Molecular Neurodegeneration
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry
2007	Corrigendum to "In vitro cytotoxicity evaluation of some substituted isatin derivatives" [Bioorg. Med. Chem. 15 (2007) 931-938] (DOI:10.1016/j.bmc.2006.10.035) Published In Bioorganic and Medicinal Chemistry
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry

Chapter

Year	Title
2014	Cancer biology: molecular and genetic basis Published In Clinical Oncology for Medical Students Publisher Sydney
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry

Conference Paper

Year	Title
2018	Cancer stem cell markers in metastatic gastroesophageal adenocarcinoma Published In ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open
2015	TCTP is induced early in colorectal cancer, it is translationally regulated via the Akt/mTORC1 pathway, and it contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In FEBS JOURNAL
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7)
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies
2006	A proposed functional role for indole derivatives in reproduction and defense of the Muricidae (Neogastropoda : Mollusca) Published In INDIRUBIN, THE RED SHADE OF INDIGO

Featured In

Australian Geographic: Sea Snails Could Hold Cancer Killer Video

Investigator On

Year	Title
2022 - 2025	Targeting misfolded proteins with MisfoldUbLs as a therapeutic strategy for ALS Awarded by: FightMND Funding Scheme: Drug Discovery Grants
2022 - 2024	Enhancing delivery of gene therapy to motor neurons and glial cells using focused ultrasound Awarded by: FightMND Funding Scheme: Impact Research Grants
2021 - 2024	Localised Immunotherapy for Pancreatic Cancer: Priming the tumour microenvironment to enhance tumour immunity to checkpoint blockade Awarded by: Cancer Institute NSW Funding Scheme: Career Development Fellowship (CDF)
2020 - 2022	Implantable drug-eluting device: localised drug delivery for non-resectable pancreatic cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2021	Non-invasive drug delivery across the blood brain barrier: Improving the bioavailability of drugs for MND Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Bridge Funding Grant
2020	Localised Immunotherapy for Pancreatic Cancer: Targeting CD40 to enhance tumour immunity to checkpoint blockade Awarded by: Centre for Oncology Education and Research Translation (CONCERT) Funding Scheme: ECR Grants Scheme
2020	Non-invasive drug delivery across the blood brain barrier: Improving the bioavailability of drugs for MND Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
2016 - 2018	Delivery of ubiquitin to motor neurons using a targeted, sterically stabilized liposome delivery system Awarded by: U.S. Department of Defense Funding Scheme: Congressionally Directed Medical Research Program
2016 - 2017	Development of a biocompatible functionalised liposome drug delivery system to increase efficiency of delivery to motor neurons Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2012	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards
2011	Investigating the protective effect of PAI-2 in cancer Awarded by: Australian Academy of Science Funding Scheme: Scientific Visits
2009	In vivo assessment of small molecule uPA-directed prodrugs for the treatment of malignant disease Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Is UBA1 a therapeutic target in ALS? Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
	Specific targeting of Treg cells using immunomodulatory nanoparticles as adjunct therapy for triple negative breast cancer Awarded by: National Breast Cancer Foundation Funding Scheme: Innovator Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	The Role of Ubiquitin Homeostasis in ALS	Chisholm, Christen
Doctor of Philosophy	Pharmacological Profiling of Amiloride Analogues as Inhibitors of the Urokinase Plasminogen Activation System in Pancreatic Ductal Adenocarcinoma	Kumar, Ashna
Doctor of Philosophy	Molecular and Clinical Biomarker assessment of gastric cancer	Tincknell, Gary
Doctor of Philosophy	Localized delivery of chemotherapy and Immunotherapy for Triple-negative breast cancer.	Minaei, Elahe

Orcid Id

http://orcid.org/0000-0001-6871-1149 (pending confirmation)

Scopus Id

15128286200

Overview

Overview

Research Areas

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Featured In

Funding

Investigator On

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Overview

Research Areas

Affiliation

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Featured In

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas