Vine, Kara L.

Top Publications

Year	Title
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published in Anti-Cancer Agents in Medicinal Chemistry
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published in Bioorganic and Medicinal Chemistry
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published in Cancer Letters
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published in Bioorganic and Medicinal Chemistry
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published in Bioorganic and Medicinal Chemistry Letters
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published in Current Cancer Drug Targets
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published in BMC Biotechnology
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published in Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published in Molecular Neurodegeneration
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published in Internal Medicine Journal
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published in Bioorganic and Medicinal Chemistry
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published in Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published in Oncoscience
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published in Pharmaceutical Research
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published in Nuclear Medicine and Biology
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published in Journal of Medicinal Chemistry
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers
2013	Recent highlights in the development of isatin-based anticancer agents
2014	Cancer biology: molecular and genetic basis

Research Areas

Research Overview

Dr Perrow’s Research Program is focused on developing novel nanostructures for site-specific drug delivery. Her projects are based on nanotechnology as applied to the development of innovative nano-sized drug carriers for the discriminate delivery of cytotoxic anti-cancer drugs to cancer cells but not healthy cells. These carriers are designed to deliver their therapeutic payload to specific sites in the body and release the drug at controlled rates. Her program of work includes (but is not limited to) the development of: (i) dual-drug encapsulated polymeric micelles to overcome multidrug resistance in cancer (ii) 3D drug-eluting polymeric scaffolds for the localized treatment of pancreatic cancer and (iii) uPA/uPAR and HER-2 targeted liposomes for the treatment of HER-2 positive breast cancer.

Available as Research Supervisor

Available for Collaborative Projects

Head Of

Targeted Cancer Therapeutics Laboratory

Member Of

The Centre for Oncology Education and Research Translation (CONCERT) T1/T2 Working Research Committee member 2014 -
Illwarra Health and Medical Research Institute 2010 -
Centre for Medical and Molecular Bioscience 2007 -

Has Collaborator

Dr Foroughi, Javad ARC Research Fellow
Ranson, Marie Professor
Sluyter, Ronald Faculty Academic
Yerbury, Justin J. Professor
van Oijen, Antoine M. Distinguished Professor

Selected Publications

Journal Article

Year	Title
2018	Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook Published In Advanced Materials Volume 30 Pages 1706665-2 - 1706665-31 ISSN 0935-9648 Altmetric
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology Volume 24 Pages 810 - 818 ISSN 1007-9327 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS Published In Journal of Cell Science Volume 131 Pages jcs209122-1 - jcs209122-14 ISSN 0021-9533 Altmetric
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release Volume 277 Pages 1 - 13 ISSN 0168-3659 Altmetric
2017	How to find success as a woman in science Published In The Conversation Volume 10 February 2017 Pages 1 - 5
2017	Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles Published In Frontiers in Neuroscience Volume 11 Pages 476-1 - 476-12 ISSN 1662-453X Altmetric
2017	Preparation and in vitro assessment of wet-spun gemcitabine-loaded polymeric fibers: Towards localized drug delivery for the treatment of pancreatic cancer Published In Pancreatology Volume 17 Pages 795 - 804 ISSN 1424-3911 Altmetric
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry Volume 15 Pages 4172 - 4179 ISSN 1477-0520 Altmetric
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene Volume 36 Pages 1 - 11 ISSN 0950-9232 Altmetric
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget Volume 8 Pages 23099 - 23109 ISSN 1949-2553 Altmetric
2017	Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In Cell Communication and Signaling Volume 15 Pages 1 - 15 ISSN 1478-811X Altmetric
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology Volume 51 Pages 313 - 326 ISSN 0944-1174 Altmetric
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation Volume 2016 Page p. 2097219 ISSN 0962-9351 Altmetric
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon Volume 2 Pages e00060-1 - e00060-23 Altmetric
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research Volume 32 Pages 2808 - 2808 ISSN 0724-8741 Altmetric
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience Volume 2 Pages 207 - 224
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research Volume 32 Pages 1045 - 1054 ISSN 0724-8741 Altmetric
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published In Molecular Neurodegeneration Volume 10 Pages 57-1 - 57-17 ISSN 1750-1326 Altmetric
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 24 Pages 704 - 714 ISSN 0959-4973 Altmetric
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology Volume 39 Pages 833 - 839 ISSN 0969-8051 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal Volume 41 Pages 9 - 10 ISSN 1444-0903 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 0968-0896 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology Volume 9 Pages 1 - 9 ISSN 1472-6750 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric

Chapter

Year	Title
2014	Cancer biology: molecular and genetic basis Published In Clinical Oncology for Medical Students Publisher Sydney: Cancer Council Australia Oncology Education Committee Page p. On Line
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry Publisher Bentham Science Publishers Pages 254 - 312 Altmetric

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Featured In

Australian Geographic: Sea Snails Could Hold Cancer Killer Video

Investigator On

Year	Title
2019 - 2022	Implantable drug-eluting device: localised drug delivery for non-resectable pancreatic cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2019 - 2020	Is UBA1 a therapeutic target in ALS? Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2018	Delivery of ubiquitin to motor neurons using a targeted, sterically stabilized liposome delivery system Awarded by: U.S. Department of Defense Funding Scheme: Congressionally Directed Medical Research Program
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Specific targeting of Treg cells using immunomodulatory nanoparticles as adjunct therapy for triple negative breast cancer Awarded by: National Breast Cancer Foundation Funding Scheme: Innovator Grant
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Investigating the protective effect of PAI-2 in cancer Awarded by: Australian Academy of Science Funding Scheme: Scientific Visits
2009	In vivo assessment of small molecule uPA-directed prodrugs for the treatment of malignant disease Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
	Development of a biocompatible functionalised liposome drug delivery system to increase efficiency of delivery to motor neurons Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biomarkers and Systemic Treatment in Gastrointestinal Cancers	Brungs, Daniel
Doctor of Philosophy	Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer	Belfiore, Lisa
Doctor of Philosophy	Drug Loaded Coaxial Hydrogel Fibers as Drug Delivery Deports for Cancer Treatment	Talebian, Sepehr
Doctor of Philosophy	Development and preclinical evaluation of implantable polymeric structures for local drug delivery in pancreatic cancer	Wade, Samantha
Doctor of Philosophy	The Role of Ubiquitin Homeostasis in ALS	Chisholm, Christen

Orcid Id

http://orcid.org/0000-0001-6871-1149 (pending confirmation)

Scopus Id

15128286200

Top Publications

Year	Title
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published in Anti-Cancer Agents in Medicinal Chemistry
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published in Bioorganic and Medicinal Chemistry
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published in Cancer Letters
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published in Bioorganic and Medicinal Chemistry
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published in Bioorganic and Medicinal Chemistry Letters
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published in Current Cancer Drug Targets
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published in BMC Biotechnology
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published in Anti-Cancer Drugs: international journal on anti-cancer agents
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published in Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published in Molecular Neurodegeneration
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published in Internal Medicine Journal
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published in Bioorganic and Medicinal Chemistry
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published in Pharmaceutical Research
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published in Oncoscience
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published in Pharmaceutical Research
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published in Nuclear Medicine and Biology
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published in Journal of Medicinal Chemistry
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers
2013	Recent highlights in the development of isatin-based anticancer agents
2014	Cancer biology: molecular and genetic basis

Research Areas

Research Overview

Dr Perrow’s Research Program is focused on developing novel nanostructures for site-specific drug delivery. Her projects are based on nanotechnology as applied to the development of innovative nano-sized drug carriers for the discriminate delivery of cytotoxic anti-cancer drugs to cancer cells but not healthy cells. These carriers are designed to deliver their therapeutic payload to specific sites in the body and release the drug at controlled rates. Her program of work includes (but is not limited to) the development of: (i) dual-drug encapsulated polymeric micelles to overcome multidrug resistance in cancer (ii) 3D drug-eluting polymeric scaffolds for the localized treatment of pancreatic cancer and (iii) uPA/uPAR and HER-2 targeted liposomes for the treatment of HER-2 positive breast cancer.

Head Of

Targeted Cancer Therapeutics Laboratory

Member Of

The Centre for Oncology Education and Research Translation (CONCERT) T1/T2 Working Research Committee member 2014 -
Illwarra Health and Medical Research Institute 2010 -
Centre for Medical and Molecular Bioscience 2007 -

Has Collaborator

Dr Foroughi, Javad ARC Research Fellow
Ranson, Marie Professor
Sluyter, Ronald Faculty Academic
Yerbury, Justin J. Professor
van Oijen, Antoine M. Distinguished Professor

Selected Publications

Journal Article

Year	Title
2018	Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook Published In Advanced Materials Volume 30 Pages 1706665-2 - 1706665-31 ISSN 0935-9648 Altmetric
2018	Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer Published In World Journal of Gastroenterology Volume 24 Pages 810 - 818 ISSN 1007-9327 Altmetric
2018	Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging Published In Journal of Controlled Release Volume 278 Pages 80 - 86 ISSN 0168-3659 Altmetric
2018	SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS Published In Journal of Cell Science Volume 131 Pages jcs209122-1 - jcs209122-14 ISSN 0021-9533 Altmetric
2018	Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: Challenges and opportunities Published In Journal of Controlled Release Volume 277 Pages 1 - 13 ISSN 0168-3659 Altmetric
2017	How to find success as a woman in science Published In The Conversation Volume 10 February 2017 Pages 1 - 5
2017	Improving the Delivery of SOD1 Antisense Oligonucleotides to Motor Neurons Using Calcium Phosphate-Lipid Nanoparticles Published In Frontiers in Neuroscience Volume 11 Pages 476-1 - 476-12 ISSN 1662-453X Altmetric
2017	Preparation and in vitro assessment of wet-spun gemcitabine-loaded polymeric fibers: Towards localized drug delivery for the treatment of pancreatic cancer Published In Pancreatology Volume 17 Pages 795 - 804 ISSN 1424-3911 Altmetric
2017	Probing the pharmacokinetics of cucurbit[7, 8 and 10]uril: and a dinuclear ruthenium antimicrobial complex encapsulated in cucurbit[10]uril Published In Organic and Biomolecular Chemistry Volume 15 Pages 4172 - 4179 ISSN 1477-0520 Altmetric
2017	SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer Published In Oncogene Volume 36 Pages 1 - 11 ISSN 0950-9232 Altmetric
2017	The urokinase plasminogen activation system in gastroesophageal cancer: A systematic review and meta-analysis Published In Oncotarget Volume 8 Pages 23099 - 23109 ISSN 1949-2553 Altmetric
2017	Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin Published In Cell Communication and Signaling Volume 15 Pages 1 - 15 ISSN 1478-811X Altmetric
2016	Gastric cancer stem cells: evidence, potential markers, and clinical implications Published In Journal of Gastroenterology Volume 51 Pages 313 - 326 ISSN 0944-1174 Altmetric
2016	N-alkyl-substituted isatins enhance P2X7 receptor-induced interleukin-1β release from murine macrophages Published In Mediators of Inflammation Volume 2016 Page p. 2097219 ISSN 0962-9351 Altmetric
2016	N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines Published In Heliyon Volume 2 Pages e00060-1 - e00060-23 Altmetric
2015	Erratum to: Improved Pharmacokinetic and Biodistribution Properties of the Selective Urokinase Inhibitor PAI-2 (SerpinB2) by Site-Specific PEGylation: Implications for Drug Delivery Published In Pharmaceutical Research Volume 32 Pages 2808 - 2808 ISSN 0724-8741 Altmetric
2015	HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer Published In Oncoscience Volume 2 Pages 207 - 224
2015	Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery Published In Pharmaceutical Research Volume 32 Pages 1045 - 1054 ISSN 0724-8741 Altmetric
2015	SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation Published In Molecular Neurodegeneration Volume 10 Pages 57-1 - 57-17 ISSN 1750-1326 Altmetric
2013	The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 24 Pages 704 - 714 ISSN 0959-4973 Altmetric
2012	Anti-cancer activity of an acid-labile N-alkylisatin conjugate targeting the transferrin receptor Published In Cancer Letters Volume 316 Pages 151 - 156 ISSN 0304-3835 Altmetric
2012	Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms Published In Nuclear Medicine and Biology Volume 39 Pages 833 - 839 ISSN 0969-8051 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (UPA) inhibitors for imaging metastatic cancer Published In Internal Medicine Journal Volume 41 Pages 9 - 10 ISSN 1444-0903 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 0968-0896 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2009	Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008 Published In Anti-Cancer Agents in Medicinal Chemistry Volume 9 Pages 397 - 414 ISSN 1568-0118
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	PH-triggered release of potent isatin-derived cytotoxins conjugated to the tumour targeting protein PAI-2 Published In Annals of Oncology Volume 20 Pages iii34 - iii34 ISSN 0923-7534 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity Published In BMC Biotechnology Volume 9 Pages 1 - 9 ISSN 1472-6750 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 0968-0896 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 0968-0896 Altmetric

Chapter

Year	Title
2014	Cancer biology: molecular and genetic basis Published In Clinical Oncology for Medical Students Publisher Sydney: Cancer Council Australia Oncology Education Committee Page p. On Line
2013	Recent highlights in the development of isatin-based anticancer agents Published In Advances in Anticancer Agents in Medicinal Chemistry Publisher Bentham Science Publishers Pages 254 - 312 Altmetric

Conference Paper

Year	Title
2018	Drug and radio sensitivity profile of a primary CTC cell line derived from a patient with metastatic neuroendocrine tumour of the distal oesophagus Published In ESMO Open Pages A402 - A403 Altmetric
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938

Featured In

Australian Geographic: Sea Snails Could Hold Cancer Killer Video

Investigator On

Year	Title
2019 - 2022	Implantable drug-eluting device: localised drug delivery for non-resectable pancreatic cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2019 - 2020	Is UBA1 a therapeutic target in ALS? Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Innovator Grant
2019	GoBlot machines and Leica Objective Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016 - 2018	Delivery of ubiquitin to motor neurons using a targeted, sterically stabilized liposome delivery system Awarded by: U.S. Department of Defense Funding Scheme: Congressionally Directed Medical Research Program
2017	Lumenera Infinity 2-5 microscope colour camera Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Contributions to Leica Dmi8 microscope Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2016	Specific targeting of Treg cells using immunomodulatory nanoparticles as adjunct therapy for triple negative breast cancer Awarded by: National Breast Cancer Foundation Funding Scheme: Innovator Grant
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2014	COUNTESS 11 FL Cell Counter and Qubit Quant Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Equipment Grant
2011	Investigating the protective effect of PAI-2 in cancer Awarded by: Australian Academy of Science Funding Scheme: Scientific Visits
2009	In vivo assessment of small molecule uPA-directed prodrugs for the treatment of malignant disease Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
	Development of a biocompatible functionalised liposome drug delivery system to increase efficiency of delivery to motor neurons Awarded by: Motor Neurone Disease Research Institute Funding Scheme: Grants-in-Aid
	Optimisation of PAI-2 forms for non-invasive PET imaging of malignant tumours Awarded by: Australian Institute of Nuclear Science and Engineering (AINSE) Funding Scheme: Research Awards

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Biomarkers and Systemic Treatment in Gastrointestinal Cancers	Brungs, Daniel
Doctor of Philosophy	Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer	Belfiore, Lisa
Doctor of Philosophy	Drug Loaded Coaxial Hydrogel Fibers as Drug Delivery Deports for Cancer Treatment	Talebian, Sepehr
Doctor of Philosophy	Development and preclinical evaluation of implantable polymeric structures for local drug delivery in pancreatic cancer	Wade, Samantha
Doctor of Philosophy	The Role of Ubiquitin Homeostasis in ALS	Chisholm, Christen

Orcid Id

http://orcid.org/0000-0001-6871-1149 (pending confirmation)

Scopus Id

15128286200

Overview

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Research Overview

Available as Research Supervisor

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Available for Collaborative Projects

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Available as Research Supervisor

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Head Of

Member Of

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Featured In

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Identity

Orcid Id

Scopus Id

Visualisations

Research Areas