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Vine, Kara L. Dr

Group Leader Targeted Cancer Therapeutics Laboratory

  • Centre for Medical and Molecular Bioscience
  • Faculty of Science, Medicine and Health
  • School of Biological Sciences

Top Publications


Research Overview


  • Dr Perrow’s Research Program is focused on developing novel nanostructures for site-specific drug delivery. Her projects are based on nanotechnology as applied to the development of innovative nano-sized drug carriers for the discriminate delivery of cytotoxic anti-cancer drugs to cancer cells but not healthy cells. These carriers are designed to deliver their therapeutic payload to specific sites in the body and release the drug at controlled rates. Her program of work includes (but is not limited to) the development of: (i) dual-drug encapsulated polymeric micelles to overcome multidrug resistance in cancer (ii) 3D drug-eluting polymeric scaffolds for the localized treatment of pancreatic cancer and (iii) uPA/uPAR and HER-2 targeted liposomes for the treatment of HER-2 positive breast cancer.

Available as Research Supervisor

Available for Collaborative Projects

Selected Publications


Investigator On


Available as Research Supervisor

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer Belfiore, Lisa
    Doctor of Philosophy Drug Loaded Coaxial Hydrogel Fibers as Drug Delivery Deports for Cancer Treatment Talebian, Sepehr
    Doctor of Philosophy Development and preclinical evaluation of implantable polymeric structures for local drug delivery in pancreatic cancer Wade, Samantha
    Doctor of Philosophy The Role of Ubiquitin Homeostasis in ALS Chisholm, Christen

Top Publications


Research Overview


  • Dr Perrow’s Research Program is focused on developing novel nanostructures for site-specific drug delivery. Her projects are based on nanotechnology as applied to the development of innovative nano-sized drug carriers for the discriminate delivery of cytotoxic anti-cancer drugs to cancer cells but not healthy cells. These carriers are designed to deliver their therapeutic payload to specific sites in the body and release the drug at controlled rates. Her program of work includes (but is not limited to) the development of: (i) dual-drug encapsulated polymeric micelles to overcome multidrug resistance in cancer (ii) 3D drug-eluting polymeric scaffolds for the localized treatment of pancreatic cancer and (iii) uPA/uPAR and HER-2 targeted liposomes for the treatment of HER-2 positive breast cancer.

Selected Publications


Investigator On


Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Development of dual HER2/uPAR-targeted drug-loaded liposomes to target heterogenous tumour cell populations in metastatic breast cancer Belfiore, Lisa
    Doctor of Philosophy Drug Loaded Coaxial Hydrogel Fibers as Drug Delivery Deports for Cancer Treatment Talebian, Sepehr
    Doctor of Philosophy Development and preclinical evaluation of implantable polymeric structures for local drug delivery in pancreatic cancer Wade, Samantha
    Doctor of Philosophy The Role of Ubiquitin Homeostasis in ALS Chisholm, Christen
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