Bremner, John B.

Overview

Emeritus Professor involved with some collaborative research activities both at the University of Wollongong and in Thailand.

Research Overview

Organic and medicinal chemistry. New methods of heterocyclic synthesis. Molecular basis of dyeing. Molecular design of multiply active antibacterials. Anti-cancer agents.

Selected Publications

Journal Article

Year	Title
2019	A kinetic and thermodynamic study of lac dye adsorption on silk yarn coated with microcrystalline chitosan Published In Coloration Technology Volume 135 Pages 224 - 233 ISSN 0037-9859 Altmetric
2019	Additive effects on cotton dyeing with dye extract from achiote seeds Published In Indian Journal of Fibre and Textile Research Volume 44 Pages 466 - 474
2019	Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1 H,3′ H]-3-Aryl-2,2′-diindol-3′-ones Published In Journal of Organic Chemistry Volume 84 Pages 11228 - 11239 ISSN 0022-3263 Altmetric
2019	Polydopamine-coated silk yarn for improving the light fastness of natural dyes Published In Coloration Technology Volume 135 Pages 143 - 151 ISSN 0037-9859 Altmetric
2018	Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 2736 - 2740 ISSN 0960-894X Altmetric
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry Volume 16 Pages 6006 - 6016 ISSN 1477-0520 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo Published In ACS Infectious Diseases Volume 3 Pages 756 - 766 Altmetric
2017	Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 47 Pages 62 - 67 ISSN 1532-2432 Altmetric
2016	Biosorption of lac dye by the red marine alga Gracilaria tenuistipitata: biosorption kinetics, isotherms, and thermodynamic parameters Published In Coloration Technology Volume 132 Pages 472 - 480 ISSN 0037-9859 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 8357 - 8367 ISSN 1464-5416 Altmetric
2015	Effects of additives on the dyeing of cotton yarn with the aqueous extract of Combretum latifolium Blume stems Published In Coloration Technology Volume 131 Pages 310 - 315 ISSN 0037-9859 Altmetric
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry Volume 11 Pages 481 - 492 ISSN 1860-5397 Altmetric
2015	Synthesis and X-ray Structural Studies of a Substituted 2,3,4,5-Tetrahydro-1H-3-benzazonine and a 1,2,3,5-Tetrahydro-4,3-benzoxazonine Published In Molecules Volume 20 Pages 487 - 502 ISSN 1420-3049 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2014	Annulation of eight-to ten-membered oxaza rings to the benzo[b]thiophene system by intramolecular nucleophilic displacement Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1217 - 1221 ISSN 0004-9425 Altmetric
2014	Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells Published In Bioorganic and Medicinal Chemistry Letters Volume 24 Pages 595 - 600 ISSN 0960-894X Altmetric
2014	On the mechanism of berberine-INF55 (5-Nitro-2-phenylindole) hybrid antibacterials Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1471 - 1480 ISSN 0004-9425 Altmetric
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry Volume 78 Pages 7639 - 7647 ISSN 0022-3263 Altmetric
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	Dyeing of cotton yarn with the aqueous extract of the leaves of Eupatorium odoratum L. in Thailand and associated extract toxicity studies Published In Coloration Technology Volume 127 Pages 346 - 353 ISSN 0037-9859 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 1464-3391 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 1464-3391 Altmetric
2011	Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride Published In Molecules Volume 16 Pages 7627 - 7633 ISSN 1420-3049 Altmetric
2011	Synthesis of new benzo[b]thieno fused ring systems via transition metal-mediated cyclisations Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 67 Pages 6895 - 6900 ISSN 1464-5416 Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum Published In Journal of Ethnopharmacology Volume 130 Pages 559 - 562 ISSN 0378-8741 Altmetric
2010	Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha Published In Phytotherapy Research Volume 24 Pages 481 - 485 ISSN 0951-418X Altmetric
2010	Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components Published In Antimicrobial Agents and Chemotherapy Volume 54 Pages 3219 - 3224 ISSN 0066-4804 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1521-3773 Altmetric
2010	Equilibrium and kinetic modeling of the adsorption of indigo carmine onto silk Published In Fibers and Polymers Volume 11 Pages 572 - 579 ISSN 1229-9197 Altmetric
2010	Novel technique shows different hydrophobic chemical signatures of exotic and indigenous plant soils with similar effects of extracts on indigenous species seedling growth Published In Plant and Soil: international journal on plant-soil relationships Volume 326 Pages 403 - 414 ISSN 1573-5036 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 1464-3391 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 1464-3391 Altmetric
2010	Synthesis of berberine-efflux pump inhibitor hybrid antibacterials Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 40 Pages 3561 - 3568 ISSN 1532-2432 Altmetric
2009	A Facile Approach to 2-Substituted Isoflav-3-enes via Isoflavylium Salts Published In Synlett: accounts and rapid communications in synthetic organic chemistry Volume 2 Pages 306 - 309 ISSN 0936-5214 Altmetric
2009	An adsorption study of alum-morin dyeing onto silk yarn Published In Fibers and Polymers Volume 10 Pages 481 - 487 ISSN 1229-9197 Altmetric
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 3866 - 3872 ISSN 1464-3391 Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	Evidence for allelopathy as a mechanism of community composition change by an invasive exotic shrub, Chrysanthemoides monilifera spp. rotundata Published In Plant and Soil: international journal on plant-soil relationships Volume 316 Pages 125 - 137 ISSN 1573-5036 Altmetric
2009	Identification of volatile compounds released by roots of an invasive plant, bitou bush (Chrysanthemoides monilifera spp. rotundata), and their inhibition of native seedling growth Published In Biological Invasions Volume 11 Pages 275 - 287 ISSN 1387-3547 Altmetric
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 6947 - 6950 ISSN 0040-4039 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2008	A compact approach to an Isomeric Iheyamine a system and x-ray crystal structure of 5-Methyl-5H-azepino[2,3-b:4,5-b']diindole Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 38 Pages 1931 - 1939 ISSN 1532-2432 Altmetric
2008	Adsorption kinetic study of lac dyeing on cotton Published In Dyes and Pigments Volume 76 Pages 435 - 439 ISSN 0143-7208 Altmetric
2008	Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids Published In Chemical and Pharmaceutical Bulletin Volume 56 Pages 194 - 198 ISSN 0009-2363 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 1464-3391 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 18 Pages 4294 - 4297 ISSN 0960-894X Altmetric
2007	A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 1637 - 1639 ISSN 0040-4039 Altmetric
2007	An adsorption and thermodynamic study of lac dyeing on cotton pretreated with chitosan Published In Dyes and Pigments Volume 72 Pages 88 - 96 ISSN 0143-7208 Altmetric
2007	An adsorption study of A1(III) ions onto chitosan Published In Journal of Hazardous Materials Volume 148 Pages 185 - 191 ISSN 0304-3894 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	Detection of Al(III) and Ga(III) complexes with morin by electrospray ionization mass spectrometry Published In Analytical Sciences Volume 23 Pages 1209 - 1214 ISSN 0910-6340 Altmetric
2007	Dual action-based approaches to antibacterial agents Published In Current Medicinal Chemistry Volume 14 Pages 1459 - 1477 ISSN 0929-8673 Altmetric
2007	Dyeing of cotton and silk yarn with the extracted dye from the fruit hulls of Mongosteen, Garcinia Mangostana Linn Published In Fibers and Polymers Volume 8 Pages 613 - 619 ISSN 1229-9197 Altmetric
2007	Hetisine-types diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum Published In Journal of Natural Products Volume 70 Pages 1808 - 1811 ISSN 0163-3864 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 1464-3391 Altmetric
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry Volume 21 Pages 1759 - 1766 ISSN 0951-4198 Altmetric
2007	Some approaches to new antibacterial agents Published In Pure and Applied Chemistry Volume 79 Pages 2143 - 2153 ISSN 0033-4545 Altmetric

Chapter

Year	Title
2008	1,2-Oxazepines and 1,2-Thiazepines Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 237 - 243
2008	1,3-Oxazepines and 1,3-Thiazepines Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 245 - 253
2008	Azepines and their Fused-ring Derivatives Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 1 - 42 Altmetric
2008	Seven-membered rings Published In Progress in Heterocyclic Chemistry Publisher Elsevier Pages 437 - 464
2007	Seven membered rings Published In Progress in Heterocyclic Chemistry Publisher Elsevier Pages 402 - 429

Conference Paper

Year	Title
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2011	Synthesis and evaluation of dual-action hybrid antimicrobials and prodrugs Published In Abstracts of Papers of the American Chemical Society Pages 1 - 1
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938
2008	Bitou bush invasion is facilitated by soil chemistry changes which inhibit the growth of native plants Published In Proceedings of the 16th Australian Weeds Conference Pages 104 - 106

Investigator On

Year	Title
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2008	A synergy-based therapy against C.difficle Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant

Orcid Id

http://orcid.org/0000-0002-7701-0034 (confirmed)

Research Overview

Organic and medicinal chemistry. New methods of heterocyclic synthesis. Molecular basis of dyeing. Molecular design of multiply active antibacterials. Anti-cancer agents.

Selected Publications

Journal Article

Year	Title
2019	A kinetic and thermodynamic study of lac dye adsorption on silk yarn coated with microcrystalline chitosan Published In Coloration Technology Volume 135 Pages 224 - 233 ISSN 0037-9859 Altmetric
2019	Additive effects on cotton dyeing with dye extract from achiote seeds Published In Indian Journal of Fibre and Textile Research Volume 44 Pages 466 - 474
2019	Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1 H,3′ H]-3-Aryl-2,2′-diindol-3′-ones Published In Journal of Organic Chemistry Volume 84 Pages 11228 - 11239 ISSN 0022-3263 Altmetric
2019	Polydopamine-coated silk yarn for improving the light fastness of natural dyes Published In Coloration Technology Volume 135 Pages 143 - 151 ISSN 0037-9859 Altmetric
2018	Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo Published In Bioorganic and Medicinal Chemistry Letters Volume 28 Pages 2736 - 2740 ISSN 0960-894X Altmetric
2018	Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro‐oxazocinodiindoles Published In Organic and Biomolecular Chemistry Volume 16 Pages 6006 - 6016 ISSN 1477-0520 Altmetric
2017	A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume Online First Pages 1 - 16 ISSN 1464-5416 Altmetric
2017	Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo Published In ACS Infectious Diseases Volume 3 Pages 756 - 766 Altmetric
2017	Unexpected synthesis of 3-imino-2-(pyrrol-2-yl) isatogen derivatives affords facile access to a 2-pyrrolyl isatogen Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 47 Pages 62 - 67 ISSN 1532-2432 Altmetric
2016	Biosorption of lac dye by the red marine alga Gracilaria tenuistipitata: biosorption kinetics, isotherms, and thermodynamic parameters Published In Coloration Technology Volume 132 Pages 472 - 480 ISSN 0037-9859 Altmetric
2016	The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction Published In Organic and Biomolecular Chemistry Volume 14 Pages 6010 - 6023 ISSN 1477-0520 Altmetric
2015	A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 71 Pages 8357 - 8367 ISSN 1464-5416 Altmetric
2015	Effects of additives on the dyeing of cotton yarn with the aqueous extract of Combretum latifolium Blume stems Published In Coloration Technology Volume 131 Pages 310 - 315 ISSN 0037-9859 Altmetric
2015	Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo Published In Beilstein Journal of Organic Chemistry Volume 11 Pages 481 - 492 ISSN 1860-5397 Altmetric
2015	Synthesis and X-ray Structural Studies of a Substituted 2,3,4,5-Tetrahydro-1H-3-benzazonine and a 1,2,3,5-Tetrahydro-4,3-benzoxazonine Published In Molecules Volume 20 Pages 487 - 502 ISSN 1420-3049 Altmetric
2015	Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics Published In Organic and Biomolecular Chemistry Volume 13 Pages 10813 - 10824 ISSN 1477-0520 Altmetric
2014	Annulation of eight-to ten-membered oxaza rings to the benzo[b]thiophene system by intramolecular nucleophilic displacement Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1217 - 1221 ISSN 0004-9425 Altmetric
2014	Diarylacylhydrazones: Clostridium-selective antibacterials with activity against stationary-phase cells Published In Bioorganic and Medicinal Chemistry Letters Volume 24 Pages 595 - 600 ISSN 0960-894X Altmetric
2014	On the mechanism of berberine-INF55 (5-Nitro-2-phenylindole) hybrid antibacterials Published In Australian Journal of Chemistry: an international journal for chemical science Volume 67 Pages 1471 - 1480 ISSN 0004-9425 Altmetric
2013	Rapid cascade synthesis of poly-heterocyclic architectures from indigo Published In Journal of Organic Chemistry Volume 78 Pages 7639 - 7647 ISSN 0022-3263 Altmetric
2012	Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations Published In Beilstein Journal of Organic Chemistry Volume 8 Pages 1265 - 1270 ISSN 1860-5397 Altmetric
2012	Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2- diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 68 Pages 6810 - 6819 ISSN 1464-5416 Altmetric
2012	Targeting urokinase and the transferrin receptor with novel, anti-mitotic N-Alkylisatin cytotoxin conjugates causes selective cancer cell death and reduces tumor growth Published In Current Cancer Drug Targets Volume 12 Pages 64 - 73 ISSN 1568-0096 Altmetric
2011	Dyeing of cotton yarn with the aqueous extract of the leaves of Eupatorium odoratum L. in Thailand and associated extract toxicity studies Published In Coloration Technology Volume 127 Pages 346 - 353 ISSN 0037-9859 Altmetric
2011	Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 22 Pages 24 - 34 ISSN 0959-4973 Altmetric
2011	Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives Published In European Journal of Medicinal Chemistry Volume 46 Pages 4201 - 4211 ISSN 0223-5234 Altmetric
2011	Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 3549 - 3557 ISSN 1464-3391 Altmetric
2011	Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems Published In Bioorganic and Medicinal Chemistry Volume 19 Pages 1771 - 1778 ISSN 1464-3391 Altmetric
2011	Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride Published In Molecules Volume 16 Pages 7627 - 7633 ISSN 1420-3049 Altmetric
2011	Synthesis of new benzo[b]thieno fused ring systems via transition metal-mediated cyclisations Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 67 Pages 6895 - 6900 ISSN 1464-5416 Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum Published In Journal of Ethnopharmacology Volume 130 Pages 559 - 562 ISSN 0378-8741 Altmetric
2010	Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha Published In Phytotherapy Research Volume 24 Pages 481 - 485 ISSN 0951-418X Altmetric
2010	Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components Published In Antimicrobial Agents and Chemotherapy Volume 54 Pages 3219 - 3224 ISSN 0066-4804 Altmetric
2010	Binaphthyl-based dicationic peptoids with therapeutic potential Published In Angewandte Chemie International Edition Volume 49 Pages 537 - 540 ISSN 1521-3773 Altmetric
2010	Equilibrium and kinetic modeling of the adsorption of indigo carmine onto silk Published In Fibers and Polymers Volume 11 Pages 572 - 579 ISSN 1229-9197 Altmetric
2010	Novel technique shows different hydrophobic chemical signatures of exotic and indigenous plant soils with similar effects of extracts on indigenous species seedling growth Published In Plant and Soil: international journal on plant-soil relationships Volume 326 Pages 403 - 414 ISSN 1573-5036 Altmetric
2010	Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro Published In Bioorganic and Medicinal Chemistry Letters Volume 20 Pages 2908 - 2911 ISSN 0960-894X Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 2611 - 2620 ISSN 1464-3391 Altmetric
2010	Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2 Published In Bioorganic and Medicinal Chemistry Volume 18 Pages 4793 - 4800 ISSN 1464-3391 Altmetric
2010	Synthesis of berberine-efflux pump inhibitor hybrid antibacterials Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 40 Pages 3561 - 3568 ISSN 1532-2432 Altmetric
2009	A Facile Approach to 2-Substituted Isoflav-3-enes via Isoflavylium Salts Published In Synlett: accounts and rapid communications in synthetic organic chemistry Volume 2 Pages 306 - 309 ISSN 0936-5214 Altmetric
2009	An adsorption study of alum-morin dyeing onto silk yarn Published In Fibers and Polymers Volume 10 Pages 481 - 487 ISSN 1229-9197 Altmetric
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 3866 - 3872 ISSN 1464-3391 Altmetric
2009	Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities Published In Bioorganic and Medicinal Chemistry Letters Volume 19 Pages 3010 - 3013 ISSN 0960-894X Altmetric
2009	Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate Published In Anti-Cancer Drugs: international journal on anti-cancer agents Volume 20 Pages 822 - 831 ISSN 0959-4973 Altmetric
2009	Evidence for allelopathy as a mechanism of community composition change by an invasive exotic shrub, Chrysanthemoides monilifera spp. rotundata Published In Plant and Soil: international journal on plant-soil relationships Volume 316 Pages 125 - 137 ISSN 1573-5036 Altmetric
2009	Identification of volatile compounds released by roots of an invasive plant, bitou bush (Chrysanthemoides monilifera spp. rotundata), and their inhibition of native seedling growth Published In Biological Invasions Volume 11 Pages 275 - 287 ISSN 1387-3547 Altmetric
2009	Novel spiro and fused heterocycles from the allylation of indigo Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 50 Pages 6947 - 6950 ISSN 0040-4039 Altmetric
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhabitator type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534
2009	Synthesis and in vitro anticancer activity of a targeted plasminogen activator inhibitor type II (PAI-2) cytotoxin conjugate Published In Annals of Oncology Volume 20 Pages iii30 - iii30 ISSN 0923-7534 Altmetric
2009	Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials Published In European Journal of Medicinal Chemistry Volume 44 Pages 1001 - 1009 ISSN 0223-5234 Altmetric
2008	A compact approach to an Isomeric Iheyamine a system and x-ray crystal structure of 5-Methyl-5H-azepino[2,3-b:4,5-b']diindole Published In Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry Volume 38 Pages 1931 - 1939 ISSN 1532-2432 Altmetric
2008	Adsorption kinetic study of lac dyeing on cotton Published In Dyes and Pigments Volume 76 Pages 435 - 439 ISSN 0143-7208 Altmetric
2008	Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids Published In Chemical and Pharmaceutical Bulletin Volume 56 Pages 194 - 198 ISSN 0009-2363 Altmetric
2008	N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents Published In Bioorganic and Medicinal Chemistry Volume 16 Pages 3118 - 3124 ISSN 1464-3391 Altmetric
2008	New cyclic peptides via ring-closing metathesis reactions and their anti-bacterial activities Published In Tetrahedron: the international journal for the rapid publication of full original research papers and critical reviews in organic chemistr Volume 64 Pages 11270 - 11290 ISSN 1464-5416 Altmetric
2008	Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Published In Bioorganic and Medicinal Chemistry Letters Volume 18 Pages 4294 - 4297 ISSN 0960-894X Altmetric
2007	A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 1637 - 1639 ISSN 0040-4039 Altmetric
2007	An adsorption and thermodynamic study of lac dyeing on cotton pretreated with chitosan Published In Dyes and Pigments Volume 72 Pages 88 - 96 ISSN 0143-7208 Altmetric
2007	An adsorption study of A1(III) ions onto chitosan Published In Journal of Hazardous Materials Volume 148 Pages 185 - 191 ISSN 0304-3894 Altmetric
2007	An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins Published In Journal of Medicinal Chemistry Volume 50 Pages 5109 - 5117 ISSN 0022-2623 Altmetric
2007	Detection of Al(III) and Ga(III) complexes with morin by electrospray ionization mass spectrometry Published In Analytical Sciences Volume 23 Pages 1209 - 1214 ISSN 0910-6340 Altmetric
2007	Dual action-based approaches to antibacterial agents Published In Current Medicinal Chemistry Volume 14 Pages 1459 - 1477 ISSN 0929-8673 Altmetric
2007	Dyeing of cotton and silk yarn with the extracted dye from the fruit hulls of Mongosteen, Garcinia Mangostana Linn Published In Fibers and Polymers Volume 8 Pages 613 - 619 ISSN 1229-9197 Altmetric
2007	Hetisine-types diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum Published In Journal of Natural Products Volume 70 Pages 1808 - 1811 ISSN 0163-3864 Altmetric
2007	In vitro cytotoxicity evaluation of some substituted isatin derivatives Published In Bioorganic and Medicinal Chemistry Volume 15 Pages 931 - 938 ISSN 1464-3391 Altmetric
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry Volume 21 Pages 1759 - 1766 ISSN 0951-4198 Altmetric
2007	Some approaches to new antibacterial agents Published In Pure and Applied Chemistry Volume 79 Pages 2143 - 2153 ISSN 0033-4545 Altmetric

Chapter

Year	Title
2008	1,2-Oxazepines and 1,2-Thiazepines Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 237 - 243
2008	1,3-Oxazepines and 1,3-Thiazepines Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 245 - 253
2008	Azepines and their Fused-ring Derivatives Published In Comprehensive Heterocyclic Chemistry III Publisher Elsevier Pages 1 - 42 Altmetric
2008	Seven-membered rings Published In Progress in Heterocyclic Chemistry Publisher Elsevier Pages 437 - 464
2007	Seven membered rings Published In Progress in Heterocyclic Chemistry Publisher Elsevier Pages 402 - 429

Conference Paper

Year	Title
2011	Selective Release of Potent N-Alkylisatin Based Cytotoxins via Hydrolysis of pH Sensitive Imine Linkers Published In 27th International Symposium on the Chemistry of Natural Products and the 7th International Conference on Biodiversity (ISCNP-27 & ICOB-7) Pages CT-19 - CT-19
2011	Synthesis and evaluation of dual-action hybrid antimicrobials and prodrugs Published In Abstracts of Papers of the American Chemical Society Pages 1 - 1
2010	Selective release of potent N-alkylisatin based cytotoxins via hydrolysis of pH sensitive imine linkers Published In 2010 International Chemical Congress of Pacific Basin Societies Pages 938 - 938
2008	Bitou bush invasion is facilitated by soil chemistry changes which inhibit the growth of native plants Published In Proceedings of the 16th Australian Weeds Conference Pages 104 - 106

Investigator On

Year	Title
2013 - 2016	Development of bifunctional anti-uPA/anti-HER-2 lipidic nanoparticles to target advanced breast cancer Awarded by: Cancer Australia Funding Scheme: Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
2008	A synergy-based therapy against C.difficle Awarded by: National Institute of Health (NIH) Funding Scheme: Grant
2008	Optimised delivery of chemotherapy for solid tumours Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Development Grant

Orcid Id

http://orcid.org/0000-0002-7701-0034 (confirmed)

Bremner, John B. Prof.

Emeritus Professor

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Overview

Research Overview

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Selected Publications

Journal Article

Chapter

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Orcid Id

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