Jennifer L. Martin AC FAA

Overview

Professor Jennifer Martin was appointed Deputy Vice-Chancellor (Research and Innovation) in March 2019. Prior to her current role, Professor Martin held the position of Director of the Griffith Institute for Drug Discovery at Griffith University in Queensland.

As DVC(R&I) at UOW, Professor Martin’s primary role is to lead the University’s strategy for research and innovation and continue to drive the performance of research across the University and to support a culture of innovation.

Research Areas

Research Overview

Prof Jennifer Martin is an internationally renowned protein crystallographer and structural biologist. She has made seminal discoveries in bacterial redox biochemistry, including revealing how the DsbA enzyme assembles bacterial ‘weapons’, and has validated DsbA as a target for novel antibacterials that are now being developed.

Professor Martin's work is widely recognised. She is current President of the Asian Crystallography Association and a member of the Executive for the International Union of Crystallography. She was elected Fellow of the Australian Academy of Science in 2017 and made a Companion of the Order of Australia in 2018 for "eminent service to scientific research, particularly in the field of biochemistry and protein crystallography applied to drug-resistant bacteria, as a role model, and as an advocate for gender equality in science". She was a founding member of the Science in Australia Gender Equity (SAGE) Steering Committee, that established the Athena SWAN pilot to address gender equity in science, technology, engineering, maths and medicine.

Member Of

Asian Crystallographic Association President 2016 - 2019
Australian Academy of Science Lead, Australian Lindau Delegation 2018
International Union of Crystallography Gender Quity and Diversity Committee Chair 2018
Australian Synchrotron Scientific Advisory Committee 2015 - 2018
NHMRC Women in Health Sciences Committee 2014 - 2018
International Union of Crystallography Executive Committee 2017
Academy of Science "Science in Australia Gender Equity" Steering Committee 2014 - 2015
International Structural Genomics Organisation Executive Committee 2011 - 2015
International Union of Crystallography Commission on Biological Macromolecules 2005 - 2014
Australian Academy of Science Chair, National Committee for Crystallography 2008 - 2011
Australian Synchrotron International Scientific Advisory Committee 2008 - 2009
Australian Synchrotron National Advisory Committee 2002 - 2007
Questacon, National Science and Technology Centre Council Member 2000 - 2006
Society of Crystallographers in Australia and New Zealand (SCANZ) President 2003 - 2005
Australian Society for Biochemistry and Molecular Biology (ASBMB) Queensland State Representative 2001 - 2003

Selected Publications

Journal Article

Year	Title
2020	Crystal structure and site-directed mutagenesis of circular bacteriocin plantacyclin B21AG reveals cationic and aromatic residues important for antimicrobial activity Published In Scientific Reports
2020	NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei Published In Journal of Biomolecular NMR
2020	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX) Published In Journal of Medicinal Chemistry
2019	A structural overview of the zinc transporters in the cation diffusion facilitator family Published In Acta Crystallographica Section D: Biological Crystallography
2019	Engineered variants provide new insight into the structural properties important for activity of the highly dynamic, trimeric protein disulfide isomerase ScsC from Proteus mirabilis Published In Acta Crystallographica Section D: Biological Crystallography
2019	How to Make the Invisible Women of STEM Visible Published In Australian Journal of Chemistry: an international journal for chemical science
2019	Life inside and out: making and breaking protein disulfide bonds in Chlamydia Published In Critical Reviews in Microbiology
2019	Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development Published In PLoS One
2019	Studying Munc18:syntaxin interactions using small-angle scattering Published In Methods in Molecular Biology
2019	The atypical thiol–disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase Published In Acta Crystallographica Section D: Biological Crystallography
2018	Disulfide isomerase activity of the dynamic, trimeric Proteus mirabilis ScsC protein is primed by the tandem immunoglobulin-fold domain of ScsB Published In Journal of Biological Chemistry
2018	Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens Published In Antioxidants and Redox Signaling
2018	Virulence of the melioidosis pathogen Burkholderia pseudomallei requires the oxidoreductase membrane protein DsbB Published In Infection and Immunity
2017	A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance Published In Nature Communications
2017	Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1 Published In PLoS One
2017	Responses to 'Atomic resolution': A badly abused term in structural biology Published In Acta Crystallographica Section D: Biological Crystallography
2017	Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins Published In PLoS One
2017	The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly Published In PLoS One
2016	Structural and biochemical characterization of Chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase Published In PLoS One
2015	Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA Published In Angewandte Chemie International Edition
2015	Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence Published In Journal of Medicinal Chemistry
2015	SEC-uring membrane fusion: A sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins Published In Nature Structural and Molecular Biology
2015	Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility Published In Acta Crystallographica Section D: Biological Crystallography
2015	Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system Published In ACS Chemical Biology
2015	Targeting virulence not viability in the search for future antibacterials Published In British Journal of Clinical Pharmacology
2015	Virtual screening of peptide and peptidomimetic fragments targeted to inhibit bacterial dithiol oxidase DsbA Published In PLoS One
2014	Crystal structure of the dithiol oxidase DsbA enzyme from Proteus mirabilis bound non-covalently to an active site peptide ligand Published In Journal of Biological Chemistry
2014	Disarming burkholderia pseudomallei: Structural and functional characterization of a disulfide oxidoreductase (DsbA) Required for virulence in Vivo Published In Antioxidants and Redox Signaling
2014	Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors Published In BBA: Proteins and Proteomics
2014	Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly Published In IUCrJ
2014	SNARE-ing the structures of Sec1/Munc18 proteins Published In Current Opinion in Structural Biology
2014	Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to Elongation Factor EF-Tu reveals a novel protein interaction site Published In Journal of Biological Chemistry
2014	Ten Simple Rules to Achieve Conference Speaker Gender Balance Published In PLoS Computational Biology
2014	The multidrug resistance IncA/C transferable plasmid encodes a novel domain-swapped dimeric protein-disulfide isomerase Published In Journal of Biological Chemistry
2014	Towards selective lysophospholipid GPCR modulators Published In Trends in Pharmacological Sciences
2013	Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a Published In Biomolecular NMR Assignments
2013	Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes Published In PLoS One
2013	Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins Published In Proceedings of the National Academy of Sciences of USA
2013	Interrogating fragments using a protein thermal shift assay Published In Australian Journal of Chemistry: an international journal for chemical science
2013	Milligram quantities of homogeneous recombinant full-length mouse Munc18c from escherichia coli cultures Published In PLoS One
2013	Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases Published In Acta Crystallographica Section D: Biological Crystallography
2013	Sexism: Conferences should seek a balance Published In Nature
2013	Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor Published In Journal of Biological Chemistry
2013	The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface Published In Journal of Biological Chemistry
2013	The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane Published In Journal of Cell Science
2013	The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized Published In Acta Crystallographica Section D: Biological Crystallography
2013	The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria Published In PLoS One
2012	Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide Published In Proceedings of the National Academy of Sciences of USA
2012	Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase Published In Journal of Biological Chemistry
2012	The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production Published In Acta Crystallographica Section D: Biological Crystallography
2012	The Weak Complex between RhoGAP Protein ARHGAP22 and Signal Regulatory Protein 14-3-3 Has 1:2 Stoichiometry and a Single Peptide Binding Mode Published In PLoS One
2012	The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer Published In Acta Crystallographica Section D: Biological Crystallography
2011	Bragging about Bragg Published In Australian Journal of Chemistry: an international journal for chemical science
2011	Crystal structure of toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection Published In Proceedings of the National Academy of Sciences of USA
2011	Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation Published In Proceedings of the National Academy of Sciences of USA
2011	Structure and function of DsbA, a key bacterial oxidative folding catalyst Published In Antioxidants and Redox Signaling
2010	Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus Published In Biomolecular NMR Assignments
2010	Characterization of the DsbA oxidative folding catalyst from pseudomonas aeruginosa reveals a highly oxidizing protein that binds small molecules Published In Antioxidants and Redox Signaling
2010	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors Published In Biochemical Journal
2010	In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling Published In Molecular Microbiology
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
2009	Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold Published In Journal of Biological Chemistry
2009	DSB proteins and bacterial pathogenicity Published In Nature Reviews Microbiology
2009	Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208-341 from Arabidopsis thaliana Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2009	Interaction between plate make and protein in protein crystallisation screening Published In PLoS One
2009	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity Published In Biochemical Journal
2009	Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue Published In Journal of Biological Chemistry
2009	Structural and functional characterization of the oxidoreductase α-DsbA1 from Wolbachia pipientis Published In Antioxidants and Redox Signaling
2009	Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation Published In Journal of Molecular Biology
2008	A general target selection method for crystallographic proteomics. Published In Methods in Molecular Biology
2008	A medium or high throughput protein refolding assay. Published In Methods in Molecular Biology
2008	Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis Published In Protein Expression and Purification
2008	Cortactin adopts a globular conformation and bundles actin into sheets Published In Journal of Biological Chemistry
2008	Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism Published In Biochemistry
2008	Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2008	Crystallography and protein-protein interactions: Biological interfaces and crystal contacts Published In Biochemical Society Transactions
2008	Evaluating protein:protein complex formation using synchrotron radiation circular dichroism spectroscopy Published In Proteins: Structure, Function, and Bioinformatics
2008	Federated repositories of X-ray diffraction images Published In Acta Crystallographica Section D: Biological Crystallography
2008	Increasing protein crystallization screening success with heterogeneous nucleating agents. Published In Methods in Molecular Biology
2008	Overview of the pipeline for structural and functional characterization of macrophage proteins at the university of queensland. Published In Methods in Molecular Biology
2008	Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Published In Methods in Molecular Biology
2008	Staphylococcus aureus DsbA does not have a destabilizing disulfide: A new paradigm for bacterial oxidative folding Published In Journal of Biological Chemistry
2008	United we stand: combining structural methods Published In Current Opinion in Structural Biology
2007	Crystallization and preliminary X-ray diffraction of the Munc18c-syntaxin41-29 complex Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2007	Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2007	Expression and crystallization of DsbA from Staphylococcus aureus Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2007	Human cytosolic sulfotransferase SULT1A1 Published In The International Journal of Biochemistry and Cell Biology
2007	Improved success of sparse matrix protein crystallization screening with heterogeneous nucleating agents Published In PLoS One
2007	Laboratory evolution of one disulfide isomerase to resemble another Published In Proceedings of the National Academy of Sciences of USA
2007	Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation Published In Proceedings of the National Academy of Sciences of USA
2007	Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins Published In Proceedings of the National Academy of Sciences of USA
2007	The name's bond......disulfide bond Published In Current Opinion in Structural Biology
2006	A method for screening the temperature dependence of three-dimensional crystal formation Published In Acta Crystallographica Section D: Biological Crystallography
2006	An automatable screen for the rapid identification of proteins amenable to refolding Published In Proteomics
2006	Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4- tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2006	Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2006	Focusing in on structural genomics: The University of Queensland structural biology pipeline Published In New Biotechnology
2006	Human sulfotransferases and their role in chemical metabolism Published In Toxicological Sciences
2006	Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins Published In Protein Expression and Purification
2006	Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking Published In Protein Engineering Design and Selection
2006	Molecular dissection of the Munc18c/syntaxin4 interaction: Implications for regulation of membrane trafficking Published In Traffic
2006	Protein disulfide isomerase: the structure of oxidative folding Published In Trends in Biochemical Sciences
2005	An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1 Published In Structure
2005	Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active Published In BBA: Proteins and Proteomics
2005	Mode of binding of methyl acceptor substrates to the adrenaline- synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis Published In Biochemistry
2005	Modification of recombinatorial cloning for small affinity tag fusion protein construct generation Published In Analytical Biochemistry
2005	Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system Published In Journal of Structural and Functional Genomics
2005	Post-crystallization treatments for improving diffraction quality of protein crystals Published In Acta Crystallographica Section D: Biological Crystallography
2005	Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2005	The structure of human SULT1A1 crystallized with estradiol: An insight into active site plasticity and substrate inhibition with multi-ring substrates Published In Journal of Biological Chemistry
2004	Active Site Mutations and Substrate Inhibition in Human Sulfotransferase 1A1 and 1A3 Published In Journal of Biological Chemistry
2004	Countering Cooperative Effects in Protease Inhibitors Using Constrained β-Strand-Mimicking Templates in Focused Combinatorial Libraries Published In Journal of Medicinal Chemistry
2004	Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide Published In Proceedings of the National Academy of Sciences of USA
2004	Molecular Recognition of Sub-micromolar Inhibitors by the Epinephrine-Synthesizing Enzyme Phenylethanolamine N-Methyltransferase Published In Journal of Medicinal Chemistry
2004	The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli Published In Journal of Bacteriology
2003	Comparison of three commercial sparse-matrix crystallization screens Published In Acta Crystallographica Section D: Biological Crystallography
2003	D-tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A 2 (IIa) with antiinflammatory activity Published In ChemBioChem: a European journal of chemical biology
2003	Dehydration converts DsbG crystal diffraction from low to high resolution Published In Structure
2003	Recombinant expression of Munc18c in a baculovirus system and interaction with syntaxin4 Published In Protein Expression and Purification
2003	Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition Published In Journal of Biological Chemistry
2002	Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography Published In Protein Expression and Purification
2002	Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase Published In Protein Science
2002	Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration Published In Acta Crystallographica Section D: Biological Crystallography
2002	SAM (dependent) I AM: The S-adenosylmethionine-dependent methyltransferase fold Published In Current Opinion in Structural Biology
2002	Structure of CcmG/DsbE at 1.14 Å resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment Published In Structure
2001	Activity of Recombinant Dengue 2 Virus NS3 Protease in the Presence of a Truncated NS2B Co-factor, Small Peptide Substrates, and Inhibitors Published In Journal of Biological Chemistry
2001	Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE) Published In Acta Crystallographica Section D: Biological Crystallography
2001	Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT Published In Structure
2000	Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease Published In Journal of Medicinal Chemistry
1999	Crystal structure of human catecholamine sulfotransferase Published In Journal of Molecular Biology
1999	Crystal structure of mammalian purple acid phosphatase Published In Structure
1999	Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase Published In Acta Crystallographica Section D: Biological Crystallography
1999	Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease Published In Biochemistry
1998	Crystal structures of reduced and oxidized DsbA: Investigation of domain motion and thiolate stabilization Published In Structure
1998	Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase Published In Journal of Molecular Biology
1998	The 1.1 Å Resolution Crystal Structure of [Tyr15]EpI, a NovelR-Conotoxin fromConus episcopatus, Solved by Direct Methods Published In Biochemistry
1997	Crystal structure at 1.1 Å resolution of α-conotoxin PnIB: Comparison with α-conotoxins PnIA and GI Published In Biochemistry
1997	Crystal structure of Escherichia coli xanthine phosphoribosyltransferase Published In Biochemistry
1997	Structural analysis of three His32 mutants of DsbA: Support for an electrostatic role of His32 in DsbA stability Published In Protein Science
1997	Structure of TcpG, the DsbA protein folding catalyst from Vibrio cholerae Published In Journal of Molecular Biology
1997	The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding Published In Protein Science
1996	Crystallization and preliminary X-ray crystallographic studies of Escherichia coli xanthine phosphoribosyltransferase Published In Journal of Structural Biology
1996	Protein crystallography and examples of its applications in medicinal chemistry Published In Current Medicinal Chemistry
1996	Secrets of the cone shell Published In Today's Life Science
1996	Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode Published In Journal of the American Chemical Society
1996	The 1.1 Å crystal structure of the neuronal acetylcholine receptor antagonist, α-conotoxin PnIA from Conus pennaceus Published In Structure
1995	Regioselective Structural and Functional Mimicry of Peptides. Design of Hydrolytically-Stable Cyclic Peptidomimetic Inhibitors of HIV-1 Protease Published In Journal of the American Chemical Society
1995	Thioredoxin -a fold for all reasons Published In Structure
1993	Crystal structure of the DsbA protein required for disulphide bond formation in vivo Published In Nature
1993	Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo Published In Journal of Molecular Biology
1993	Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b Published In Journal of Molecular Biology
1991	Glucose Analogue Inhibitors of Glycogen Phosphorylase: The Design of Potential Drugs for Diabetes Published In Biochemistry
1991	Towards time-resolved diffraction studies with glycogen phosphorylase. Published In Ciba Foundation symposium
1990	Comparison of the Binding of Glucose and Glucose 1-Phosphate Derivatives to T-State Glycogen Phosphorylase b Published In Biochemistry
1988	Channels at the Catalytic Site of Glycogen Phosphorylase b: Binding and Kinetic Studies with the 0-Glycosidase Inhibitor D-Gluconohydroximo-1,5-lactone N-Phenylurethane Published In Biochemistry
1986	Central nervous system drug design Published In Journal of Molecular Graphics
1984	Functional Group Contributions to Drug-Receptor Interactions Published In Journal of Medicinal Chemistry

Conference Paper

Year	Title
2009	Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study Published In e-Science 2009 - 5th IEEE International Conference on e-Science

Investigator On

Year	Title
2019 - 2021	Molecular Mechanisms of Novel Bacterial Copper Defense Proteins Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects

Research Areas

Research Overview

Prof Jennifer Martin is an internationally renowned protein crystallographer and structural biologist. She has made seminal discoveries in bacterial redox biochemistry, including revealing how the DsbA enzyme assembles bacterial ‘weapons’, and has validated DsbA as a target for novel antibacterials that are now being developed.

Professor Martin's work is widely recognised. She is current President of the Asian Crystallography Association and a member of the Executive for the International Union of Crystallography. She was elected Fellow of the Australian Academy of Science in 2017 and made a Companion of the Order of Australia in 2018 for "eminent service to scientific research, particularly in the field of biochemistry and protein crystallography applied to drug-resistant bacteria, as a role model, and as an advocate for gender equality in science". She was a founding member of the Science in Australia Gender Equity (SAGE) Steering Committee, that established the Athena SWAN pilot to address gender equity in science, technology, engineering, maths and medicine.

Member Of

Asian Crystallographic Association President 2016 - 2019
Australian Academy of Science Lead, Australian Lindau Delegation 2018
International Union of Crystallography Gender Quity and Diversity Committee Chair 2018
Australian Synchrotron Scientific Advisory Committee 2015 - 2018
NHMRC Women in Health Sciences Committee 2014 - 2018
International Union of Crystallography Executive Committee 2017
Academy of Science "Science in Australia Gender Equity" Steering Committee 2014 - 2015
International Structural Genomics Organisation Executive Committee 2011 - 2015
International Union of Crystallography Commission on Biological Macromolecules 2005 - 2014
Australian Academy of Science Chair, National Committee for Crystallography 2008 - 2011
Australian Synchrotron International Scientific Advisory Committee 2008 - 2009
Australian Synchrotron National Advisory Committee 2002 - 2007
Questacon, National Science and Technology Centre Council Member 2000 - 2006
Society of Crystallographers in Australia and New Zealand (SCANZ) President 2003 - 2005
Australian Society for Biochemistry and Molecular Biology (ASBMB) Queensland State Representative 2001 - 2003

Selected Publications

Journal Article

Year	Title
2020	Crystal structure and site-directed mutagenesis of circular bacteriocin plantacyclin B21AG reveals cationic and aromatic residues important for antimicrobial activity Published In Scientific Reports
2020	NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei Published In Journal of Biomolecular NMR
2020	Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX) Published In Journal of Medicinal Chemistry
2019	A structural overview of the zinc transporters in the cation diffusion facilitator family Published In Acta Crystallographica Section D: Biological Crystallography
2019	Engineered variants provide new insight into the structural properties important for activity of the highly dynamic, trimeric protein disulfide isomerase ScsC from Proteus mirabilis Published In Acta Crystallographica Section D: Biological Crystallography
2019	How to Make the Invisible Women of STEM Visible Published In Australian Journal of Chemistry: an international journal for chemical science
2019	Life inside and out: making and breaking protein disulfide bonds in Chlamydia Published In Critical Reviews in Microbiology
2019	Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development Published In PLoS One
2019	Studying Munc18:syntaxin interactions using small-angle scattering Published In Methods in Molecular Biology
2019	The atypical thiol–disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase Published In Acta Crystallographica Section D: Biological Crystallography
2018	Disulfide isomerase activity of the dynamic, trimeric Proteus mirabilis ScsC protein is primed by the tandem immunoglobulin-fold domain of ScsB Published In Journal of Biological Chemistry
2018	Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens Published In Antioxidants and Redox Signaling
2018	Virulence of the melioidosis pathogen Burkholderia pseudomallei requires the oxidoreductase membrane protein DsbB Published In Infection and Immunity
2017	A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance Published In Nature Communications
2017	Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1 Published In PLoS One
2017	Responses to 'Atomic resolution': A badly abused term in structural biology Published In Acta Crystallographica Section D: Biological Crystallography
2017	Revisiting interaction specificity reveals neuronal and adipocyte Munc18 membrane fusion regulatory proteins differ in their binding interactions with partner SNARE Syntaxins Published In PLoS One
2017	The nature of the Syntaxin4 C-terminus affects Munc18c-supported SNARE assembly Published In PLoS One
2016	Structural and biochemical characterization of Chlamydia trachomatis DsbA reveals a cysteine-rich and weakly oxidising oxidoreductase Published In PLoS One
2015	Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA Published In Angewandte Chemie International Edition
2015	Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence Published In Journal of Medicinal Chemistry
2015	SEC-uring membrane fusion: A sneak peek at SNARE-complex assembly driven by Sec1-Munc18 proteins Published In Nature Structural and Molecular Biology
2015	Sent packing: Protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility Published In Acta Crystallographica Section D: Biological Crystallography
2015	Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system Published In ACS Chemical Biology
2015	Targeting virulence not viability in the search for future antibacterials Published In British Journal of Clinical Pharmacology
2015	Virtual screening of peptide and peptidomimetic fragments targeted to inhibit bacterial dithiol oxidase DsbA Published In PLoS One
2014	Crystal structure of the dithiol oxidase DsbA enzyme from Proteus mirabilis bound non-covalently to an active site peptide ligand Published In Journal of Biological Chemistry
2014	Disarming burkholderia pseudomallei: Structural and functional characterization of a disulfide oxidoreductase (DsbA) Required for virulence in Vivo Published In Antioxidants and Redox Signaling
2014	Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors Published In BBA: Proteins and Proteomics
2014	Reconciling the regulatory role of Munc18 proteins in SNARE-complex assembly Published In IUCrJ
2014	SNARE-ing the structures of Sec1/Munc18 proteins Published In Current Opinion in Structural Biology
2014	Structure of the Acinetobacter baumannii dithiol oxidase DsbA bound to Elongation Factor EF-Tu reveals a novel protein interaction site Published In Journal of Biological Chemistry
2014	Ten Simple Rules to Achieve Conference Speaker Gender Balance Published In PLoS Computational Biology
2014	The multidrug resistance IncA/C transferable plasmid encodes a novel domain-swapped dimeric protein-disulfide isomerase Published In Journal of Biological Chemistry
2014	Towards selective lysophospholipid GPCR modulators Published In Trends in Pharmacological Sciences
2013	Backbone resonance assignments of the monomeric DUF59 domain of human Fam96a Published In Biomolecular NMR Assignments
2013	Comparative sequence, structure and redox analyses of Klebsiella pneumoniae DsbA show that anti-virulence target DsbA enzymes fall into distinct classes Published In PLoS One
2013	Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins Published In Proceedings of the National Academy of Sciences of USA
2013	Interrogating fragments using a protein thermal shift assay Published In Australian Journal of Chemistry: an international journal for chemical science
2013	Milligram quantities of homogeneous recombinant full-length mouse Munc18c from escherichia coli cultures Published In PLoS One
2013	Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases Published In Acta Crystallographica Section D: Biological Crystallography
2013	Sexism: Conferences should seek a balance Published In Nature
2013	Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor Published In Journal of Biological Chemistry
2013	The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface Published In Journal of Biological Chemistry
2013	The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane Published In Journal of Cell Science
2013	The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized Published In Acta Crystallographica Section D: Biological Crystallography
2013	The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria Published In PLoS One
2012	Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide Published In Proceedings of the National Academy of Sciences of USA
2012	Membrane curvature protein exhibits interdomain flexibility and binds a small GTPase Published In Journal of Biological Chemistry
2012	The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production Published In Acta Crystallographica Section D: Biological Crystallography
2012	The Weak Complex between RhoGAP Protein ARHGAP22 and Signal Regulatory Protein 14-3-3 Has 1:2 Stoichiometry and a Single Peptide Binding Mode Published In PLoS One
2012	The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer Published In Acta Crystallographica Section D: Biological Crystallography
2011	Bragging about Bragg Published In Australian Journal of Chemistry: an international journal for chemical science
2011	Crystal structure of toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection Published In Proceedings of the National Academy of Sciences of USA
2011	Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation Published In Proceedings of the National Academy of Sciences of USA
2011	Structure and function of DsbA, a key bacterial oxidative folding catalyst Published In Antioxidants and Redox Signaling
2010	Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus Published In Biomolecular NMR Assignments
2010	Characterization of the DsbA oxidative folding catalyst from pseudomonas aeruginosa reveals a highly oxidizing protein that binds small molecules Published In Antioxidants and Redox Signaling
2010	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors Published In Biochemical Journal
2010	In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling Published In Molecular Microbiology
2010	Solving the α-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists Published In Journal of the American Chemical Society
2009	Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold Published In Journal of Biological Chemistry
2009	DSB proteins and bacterial pathogenicity Published In Nature Reviews Microbiology
2009	Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1208-341 from Arabidopsis thaliana Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2009	Interaction between plate make and protein in protein crystallisation screening Published In PLoS One
2009	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity Published In Biochemical Journal
2009	Properties of the thioredoxin fold superfamily are modulated by a single amino acid residue Published In Journal of Biological Chemistry
2009	Structural and functional characterization of the oxidoreductase α-DsbA1 from Wolbachia pipientis Published In Antioxidants and Redox Signaling
2009	Structure of West Nile Virus NS3 Protease: Ligand Stabilization of the Catalytic Conformation Published In Journal of Molecular Biology
2008	A general target selection method for crystallographic proteomics. Published In Methods in Molecular Biology
2008	A medium or high throughput protein refolding assay. Published In Methods in Molecular Biology
2008	Cloning, expression, purification and characterization of a DsbA-like protein from Wolbachia pipientis Published In Protein Expression and Purification
2008	Cortactin adopts a globular conformation and bundles actin into sheets Published In Journal of Biological Chemistry
2008	Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism Published In Biochemistry
2008	Crystallization and preliminary diffraction analysis of a DsbA homologue from Wolbachia pipientis Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2008	Crystallography and protein-protein interactions: Biological interfaces and crystal contacts Published In Biochemical Society Transactions
2008	Evaluating protein:protein complex formation using synchrotron radiation circular dichroism spectroscopy Published In Proteins: Structure, Function, and Bioinformatics
2008	Federated repositories of X-ray diffraction images Published In Acta Crystallographica Section D: Biological Crystallography
2008	Increasing protein crystallization screening success with heterogeneous nucleating agents. Published In Methods in Molecular Biology
2008	Overview of the pipeline for structural and functional characterization of macrophage proteins at the university of queensland. Published In Methods in Molecular Biology
2008	Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling. Published In Methods in Molecular Biology
2008	Staphylococcus aureus DsbA does not have a destabilizing disulfide: A new paradigm for bacterial oxidative folding Published In Journal of Biological Chemistry
2008	United we stand: combining structural methods Published In Current Opinion in Structural Biology
2007	Crystallization and preliminary X-ray diffraction of the Munc18c-syntaxin41-29 complex Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2007	Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2007	Expression and crystallization of DsbA from Staphylococcus aureus Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2007	Human cytosolic sulfotransferase SULT1A1 Published In The International Journal of Biochemistry and Cell Biology
2007	Improved success of sparse matrix protein crystallization screening with heterogeneous nucleating agents Published In PLoS One
2007	Laboratory evolution of one disulfide isomerase to resemble another Published In Proceedings of the National Academy of Sciences of USA
2007	Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation Published In Proceedings of the National Academy of Sciences of USA
2007	Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins Published In Proceedings of the National Academy of Sciences of USA
2007	The name's bond......disulfide bond Published In Current Opinion in Structural Biology
2006	A method for screening the temperature dependence of three-dimensional crystal formation Published In Acta Crystallographica Section D: Biological Crystallography
2006	An automatable screen for the rapid identification of proteins amenable to refolding Published In Proteomics
2006	Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4- tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2006	Crystallization of the C-terminal domain of the mouse brain cytosolic long-chain acyl-CoA thioesterase Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications Online
2006	Focusing in on structural genomics: The University of Queensland structural biology pipeline Published In New Biotechnology
2006	Human sulfotransferases and their role in chemical metabolism Published In Toxicological Sciences
2006	Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins Published In Protein Expression and Purification
2006	Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking Published In Protein Engineering Design and Selection
2006	Molecular dissection of the Munc18c/syntaxin4 interaction: Implications for regulation of membrane trafficking Published In Traffic
2006	Protein disulfide isomerase: the structure of oxidative folding Published In Trends in Biochemical Sciences
2005	An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: Relationship to cystatins and the tumor suppressor TIG1 Published In Structure
2005	Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active Published In BBA: Proteins and Proteomics
2005	Mode of binding of methyl acceptor substrates to the adrenaline- synthesizing enzyme phenylethanolamine N-methyltransferase: Implications for catalysis Published In Biochemistry
2005	Modification of recombinatorial cloning for small affinity tag fusion protein construct generation Published In Analytical Biochemistry
2005	Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system Published In Journal of Structural and Functional Genomics
2005	Post-crystallization treatments for improving diffraction quality of protein crystals Published In Acta Crystallographica Section D: Biological Crystallography
2005	Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase Published In Journal of Medicinal Chemistry
2005	The structure of human SULT1A1 crystallized with estradiol: An insight into active site plasticity and substrate inhibition with multi-ring substrates Published In Journal of Biological Chemistry
2004	Active Site Mutations and Substrate Inhibition in Human Sulfotransferase 1A1 and 1A3 Published In Journal of Biological Chemistry
2004	Countering Cooperative Effects in Protease Inhibitors Using Constrained β-Strand-Mimicking Templates in Focused Combinatorial Libraries Published In Journal of Medicinal Chemistry
2004	Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide Published In Proceedings of the National Academy of Sciences of USA
2004	Molecular Recognition of Sub-micromolar Inhibitors by the Epinephrine-Synthesizing Enzyme Phenylethanolamine N-Methyltransferase Published In Journal of Medicinal Chemistry
2004	The acidic nature of the CcmG redox-active center is important for cytochrome c maturation in Escherichia coli Published In Journal of Bacteriology
2003	Comparison of three commercial sparse-matrix crystallization screens Published In Acta Crystallographica Section D: Biological Crystallography
2003	D-tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A 2 (IIa) with antiinflammatory activity Published In ChemBioChem: a European journal of chemical biology
2003	Dehydration converts DsbG crystal diffraction from low to high resolution Published In Structure
2003	Recombinant expression of Munc18c in a baculovirus system and interaction with syntaxin4 Published In Protein Expression and Purification
2003	Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition Published In Journal of Biological Chemistry
2002	Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography Published In Protein Expression and Purification
2002	Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase Published In Protein Science
2002	Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration Published In Acta Crystallographica Section D: Biological Crystallography
2002	SAM (dependent) I AM: The S-adenosylmethionine-dependent methyltransferase fold Published In Current Opinion in Structural Biology
2002	Structure of CcmG/DsbE at 1.14 Å resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment Published In Structure
2001	Activity of Recombinant Dengue 2 Virus NS3 Protease in the Presence of a Truncated NS2B Co-factor, Small Peptide Substrates, and Inhibitors Published In Journal of Biological Chemistry
2001	Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE) Published In Acta Crystallographica Section D: Biological Crystallography
2001	Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT Published In Structure
2000	Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease Published In Journal of Medicinal Chemistry
1999	Crystal structure of human catecholamine sulfotransferase Published In Journal of Molecular Biology
1999	Crystal structure of mammalian purple acid phosphatase Published In Structure
1999	Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase Published In Acta Crystallographica Section D: Biological Crystallography
1999	Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease Published In Biochemistry
1998	Crystal structures of reduced and oxidized DsbA: Investigation of domain motion and thiolate stabilization Published In Structure
1998	Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase Published In Journal of Molecular Biology
1998	The 1.1 Å Resolution Crystal Structure of [Tyr15]EpI, a NovelR-Conotoxin fromConus episcopatus, Solved by Direct Methods Published In Biochemistry
1997	Crystal structure at 1.1 Å resolution of α-conotoxin PnIB: Comparison with α-conotoxins PnIA and GI Published In Biochemistry
1997	Crystal structure of Escherichia coli xanthine phosphoribosyltransferase Published In Biochemistry
1997	Structural analysis of three His32 mutants of DsbA: Support for an electrostatic role of His32 in DsbA stability Published In Protein Science
1997	Structure of TcpG, the DsbA protein folding catalyst from Vibrio cholerae Published In Journal of Molecular Biology
1997	The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding Published In Protein Science
1996	Crystallization and preliminary X-ray crystallographic studies of Escherichia coli xanthine phosphoribosyltransferase Published In Journal of Structural Biology
1996	Protein crystallography and examples of its applications in medicinal chemistry Published In Current Medicinal Chemistry
1996	Secrets of the cone shell Published In Today's Life Science
1996	Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode Published In Journal of the American Chemical Society
1996	The 1.1 Å crystal structure of the neuronal acetylcholine receptor antagonist, α-conotoxin PnIA from Conus pennaceus Published In Structure
1995	Regioselective Structural and Functional Mimicry of Peptides. Design of Hydrolytically-Stable Cyclic Peptidomimetic Inhibitors of HIV-1 Protease Published In Journal of the American Chemical Society
1995	Thioredoxin -a fold for all reasons Published In Structure
1993	Crystal structure of the DsbA protein required for disulphide bond formation in vivo Published In Nature
1993	Crystallization of DsbA, an Escherichia coli protein required for disulphide bond formation in vivo Published In Journal of Molecular Biology
1993	Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b Published In Journal of Molecular Biology
1991	Glucose Analogue Inhibitors of Glycogen Phosphorylase: The Design of Potential Drugs for Diabetes Published In Biochemistry
1991	Towards time-resolved diffraction studies with glycogen phosphorylase. Published In Ciba Foundation symposium
1990	Comparison of the Binding of Glucose and Glucose 1-Phosphate Derivatives to T-State Glycogen Phosphorylase b Published In Biochemistry
1988	Channels at the Catalytic Site of Glycogen Phosphorylase b: Binding and Kinetic Studies with the 0-Glycosidase Inhibitor D-Gluconohydroximo-1,5-lactone N-Phenylurethane Published In Biochemistry
1986	Central nervous system drug design Published In Journal of Molecular Graphics
1984	Functional Group Contributions to Drug-Receptor Interactions Published In Journal of Medicinal Chemistry

Conference Paper

Year	Title
2009	Comparing METS and OAI-ORE for encapsulating scientific data products: A protein crystallography case study Published In e-Science 2009 - 5th IEEE International Conference on e-Science

Investigator On

Year	Title
2019 - 2021	Molecular Mechanisms of Novel Bacterial Copper Defense Proteins Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects

Other Research Activities

Compounds Australia Chief Investigator 2017 - 2023
DsbA foldases from multidrug resistant pathogens as targets for new antimicrobial Chief Investigator 2018 - 2021
Structure and function of human zinc transporter membrane proteins Chief Investigator 2016 - 2019
Automated high resolution & high contrast cryoTEM for 3D structural biology Chief Investigator 2018
Compounds Australia Plate Storage Chief Investigator 2018
High throughput label-free interaction analysis - from fragments to drug discovery Chief Investigator 2018
NHMRC Standard Equipment Grant Chief Investigator 2018
DsbA inhibitors: from hits to leads Chief Investigator 2016 - 2018
Unraveling the dynamic Munc18a:Syntaxin1a interaction required for neurotransmission Chief Investigator 2016 - 2018
Acoustic liquid handling robotics for bioactive compound discovery Chief Investigator 2017
Drug Discovery Separation Capability Chief Investigator 2017
Burkholderia pseudomallei disulfide-forming proteins: structure, function and inhibition Chief Investigator 2016
Molecular dissection of the Munc 18c: Syntaxin4 complex required for insulin-regulated exocytosis in adipocytes Chief Investigator 2016
Membrane proteins in innate immunity Chief Investigator 2013 - 2016

Outreach And Community Service Activities

International Crystallography School Erice Sicily Italy Co-Chair 2017
SCANZ Crystal 29 Conference, O'Reilly's, Qld Organising committee member, Program chair 2014
COMBIO2012 "Drug Design and Computational Modelling" session co-chair 2012
Asian Crystallography Association Meeting, Busan, Korea Program Chair 2010
AsCA meeting, Taipei, Taiwan Member of the International Program Committee 2007
Joint meeting of AsCA and Japanese Crystallography Society, Tsukuba, Japan International Program Committee 2006
International Union of Crystallography Congress XX, Florence, Italy International Scientific Program Committee 2005
Joint meeting SCANZ and Asian Crystallographic Association, Broome Organising Committee 2005
Crystal22 SCANZ Conference, Couran Cove, Qld Chair of the Organising Committee 2001
Combined Conference of the Australian Societies for Biochem and Mol Biol, Cell Biol and Dev Biol, & Plant Physiol, Gold Coast Program Co-ordinator 1999

Education And Training

London Business School, Senior Executive Programme 2015
D.Phil., University of Oxford 1990
Pharm.M., Victorian College of Pharmacy 1986
Pharm.B., Victorian College of Pharmacy, Gold Medallist 1982

Awards And Honors

Companion of the Order of Australia (AC), 2018
Suffrage Science Award, conferred by MRC London Institute of Medical Sciences, UK, 2018
Elected Eminent Fellow, conferred by Royal Australian Chemical Institute, 2017
Wunderly Oration and Medal, conferred by Thoracic Society of Australia and New Zealand, 2017
Elected Fellow, conferred by Australian Academy of Science, 2017
Inaugural ARC Australian Laureate Fellowship, conferred by Australia Research Council (ARC), 2010
Lady Masson Lecture, conferred by The University of Melbourne, 2010
Dorothy Hodgkin Memorial Lecture Oxford UK, 2007
NHMRC Senior Research Fellowship, conferred by National Health and Medical Research Council (NHMRC), 2007
Honorary Life Member, conferred by Questacon, Canberra, 2007
Roche Medal, conferred by Australian Society for Biochemistry and Molecular Biology, 2005
ARC Senior Research Fellowship, conferred by Australia Research Council (ARC), 1999
ARC Queen Elizabeth II Fellowship, conferred by Australia Research Council (ARC), 1993

Orcid Id

http://orcid.org/0000-0002-9225-8863 (confirmed)

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