Beck, Jennifer L.

Overview

UOW Researcher Jenny Beck is using Mass Spectrometry as a technique to screen for new drugs which can bind to DNA (for use as anticancer agents). She explains how ‘telomerase biology research’ could unlock the mechanisms of a number of diseases, and possibly even ageing.

Professor Jenny Beck began her research career with an interest in proteins and enzymes. This was followed by postdoctoral work which investigated the molecular basis of how proteins involved in drug metabolism transfer electrons from one to another in reactions that are a prelude to elimination of drugs from the body.

Top Publications

Year	Title
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published in Nature Communications
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published in Proceedings of the National Academy of Sciences of USA
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published in The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published in Journal of the American Society for Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published in Journal of the American Society for Mass Spectrometry

Research Areas

Research Overview

- Investigating the assembly of the E.coli replisome and other biological molecular machines using a variety of techniques with electrospray ionization mass spectrometry as the major tool
- Studying drug-DNA interactions (including quadruplex DNA)
- Ion mobility mass spectrometry of proteins, drug and DNA
- Molecular interactions at telomeres

Has Collaborator

Dixon, Nicholas E. Professor
Oakley, Aaron J. A/Prof.

Selected Publications

Journal Article

Year	Title
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 256 - 267 ISSN 1044-0305 Altmetric
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published In Plant, Cell and Environment Volume Online First Pages 1 - 15 ISSN 0140-7791 Altmetric
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology Volume 204 Pages 396 - 405 ISSN 1047-8477 Altmetric
2018	Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes Published In Dalton Transactions: an international journal of inorganic chemistry Volume 47 Pages 13573 - 13591 ISSN 1477-9226 Altmetric
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry Volume 142 Pages 28 - 38 ISSN 0162-0134 Altmetric
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry Volume 58 Pages 4693 - 4702 ISSN 0022-2623 Altmetric
2015	ESI-MS investigation of an equilibrium between a bimolecular quadruplex DNA and a duplex DNA/RNA hybrid Published In Journal of the American Society for Mass Spectrometry Volume 26 Pages 1165 - 1173 ISSN 1044-0305 Altmetric
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published In Proceedings of the National Academy of Sciences of USA Volume 112 Pages 3564 - 3569 ISSN 0027-8424 Altmetric
2015	Synthesis and characterisation of nickel Schiff base complexes containing the meso-1,2-diphenylethylenediamine moiety: selective interactions with a tetramolecular DNA quadruplex Published In Dalton Transactions: an international journal of inorganic chemistry Volume 44 Pages 3136 - 3150 ISSN 1477-9226 Altmetric
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published In Nature Communications Volume 6 Pages 7643-1 - 7643-12 ISSN 2041-1723 Altmetric
2014	Binding interactions between nickel schiff base complexes and quadruplex DNA Published In Journal of Biological Inorganic Chemistry Volume 19 Pages S359 - S359 ISSN 0949-8257
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology Volume 21 Pages 481 - 487 ISSN 1074-5521 Altmetric
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry Volume 57 Pages 2799 - 2806 ISSN 0022-2623 Altmetric
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal Volume 32 Pages 1322 - 1333 ISSN 0261-4189 Altmetric
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published In Journal of the American Society for Mass Spectrometry Volume 24 Pages 274 - 285 ISSN 1044-0305 Altmetric
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry Volume 56 Pages 8665 - 8673 ISSN 0022-2623 Altmetric
2011	Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry Published In International Journal of Mass Spectrometry Volume 304 Pages 195 - 203 ISSN 1387-3806 Altmetric
2011	Book review: Protein and Peptide Analysis by LC-MS Experimental Strategies Published In European Journal of Mass Spectrometry Volume 17 Pages v - vi
2011	Developments in electrospray ionization mass spectrometry of non-covalent DNA-ligand complexes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 64 Pages 705 - 717 ISSN 0004-9425 Altmetric
2011	EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH Published In International Journal of Mass Spectrometry Volume 302 Pages 149 - 156 ISSN 1387-3806 Altmetric
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published In Journal of the American Society for Mass Spectrometry Volume 22 Pages 1588 - 1601 ISSN 1044-0305 Altmetric
2010	A Single subunit directs the assembly of the escherichia coli DNA sliding clamp loader Published In Structure Volume 18 Pages 285 - 292 ISSN 0969-2126 Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	ESI-MS and thermal melting studies of nanoscale platinum(ii) metallomacrocycles with DNA Published In Dalton Transactions: an international journal of inorganic chemistry Volume 39 Pages 11263 - 11271 ISSN 1477-9226 Altmetric
2009	A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity Published In Chemical Communications Pages 5546 - 5548 ISSN 1359-7345 Altmetric
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 3866 - 3872 ISSN 0968-0896 Altmetric
2009	Characterisation of anthracyclines from a cosmomycin D-producing species of Streptomyces by collisionally-activated dissociation and ion mobility mass spectrometry Published In European Journal of Mass Spectrometry Volume 15 Pages 73 - 81 ISSN 1469-0667 Altmetric
2009	Does the metal influence non-covalent binding of complexes to DNA? Published In Dalton Transactions: an international journal of inorganic chemistry Volume 3 Pages 504 - 513 ISSN 1477-9226 Altmetric
2009	Substrate-induced Assembly of Methanococcoides burtonii D-Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Dimers into Decamers Published In Journal of Biological Chemistry Volume 284 Pages 33876 - 33882 ISSN 0021-9258 Altmetric
2008	A comparison of the binding of metal complexes to duplex and quadruplex DNA Published In Dalton Transactions: an international journal of inorganic chemistry Volume 2008 Pages 1018 - 1026 ISSN 1477-9226 Altmetric
2008	Binding studies of nNOS-active amphibian peptides and Ca2+ calmodulin, using negative ion electrospray ionisation mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 22 Pages 3501 - 3509 ISSN 0951-4198 Altmetric
2008	Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA Published In Inorganic Chemistry: including bioinorganic chemistry Volume 47 Pages 6621 - 6632 ISSN 0020-1669 Altmetric
2008	Mass spectrometric investigation of the DNA-binding properties of an anthracycline with two trisaccharide chains Published In Archives of Biochemistry and Biophysics Volume 477 Pages 348 - 355 ISSN 0003-9861 Altmetric
2007	Effect of protein stabilization on charge state distribution in positive- and negative ion electrospray ionization mass spectra Published In Journal of the American Society for Mass Spectrometry Volume 18 Pages 1605 - 1611 ISSN 1044-0305 Altmetric
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry Volume 21 Pages 1759 - 1766 ISSN 0951-4198 Altmetric
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 7440 - 7443 ISSN 0040-4039 Altmetric
2007	The structure and function of a novel glycerophosphodiesterase from enterobacter aerogenes Published In Journal of Molecular Biology Volume 367 Pages 1047 - 1062 ISSN 0022-2836 Altmetric
2006	A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin Published In Journal of Biological Inorganic Chemistry Volume 11 Pages 559 - 570 ISSN 0949-8257 Altmetric
2006	An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery Published In Chemistry: A European Journal Volume 12 Pages 8000 - 8013 ISSN 0947-6539 Altmetric
2006	Proteomic dissection of DNA polymerization Published In Expert Review of Proteomics Volume 3 Pages 197 - 211 ISSN 1478-9450 Altmetric
2005	Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine Published In Rapid Communications in Mass Spectrometry Volume 19 Pages 2123 - 2130 ISSN 0951-4198 Altmetric
2005	Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA Published In Journal of Inorganic Biochemistry Volume 99 Pages 552 - 559 ISSN 0162-0134 Altmetric
2005	Stabilization of native protein fold by intein-mediated covalent cyclization Published In Journal of Molecular Biology Volume 346 Pages 1095 - 1108 ISSN 0022-2836 Altmetric
2005	Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 272 Pages 3162 - 3171 ISSN 1742-464X Altmetric
2004	A mass spectrometric investigation of non-covalent interactions between ruthenium compounds and DNA Published In Dalton Transactions: an international journal of inorganic chemistry Pages 2683 - 2690 ISSN 1477-9226 Altmetric
2004	Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the epsilon & theta subunits of DNA polymerase III Published In Protein Science Volume 13 Pages 2878 - 2887 ISSN 0961-8368 Altmetric
2004	Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry Volume 15 Pages 1382 - 1391 ISSN 1044-0305 Altmetric
2004	DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products Volume 57 Pages 647 - 654 ISSN 0021-8820 Altmetric
2004	Direct observation of covalent adducts with Cys34 of human serum albumin using mass spectrometry Published In Analytical Biochemistry Volume 325 Pages 326 - 336 ISSN 0003-2697 Altmetric
2003	Flexibility revealed by the 1.85.ANG. crystal structure of the B sliding-clamp subunit of Escherichia coli DNA polymerase III Published In Acta Crystallographica Section D: Biological Crystallography Volume 59 Pages 1192 - 1199 ISSN 0907-4449 Altmetric
2003	Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Chemical Communications Pages 626 - 627 ISSN 1359-7345 Altmetric
2003	Probing the DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Journal of Inorganic Biochemistry Volume 96 Page p. 214 ISSN 0162-0134
2002	Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes Published In Chemical Communications Pages 556 - 557 ISSN 1359-7345
2002	Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (E) subunit of Escherichia coli DNA polymerase III Published In Biochemistry Volume 41 Pages 5266 - 5275 ISSN 0006-2960 Altmetric
2002	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes. [Erratum to document cited in CA136:334875] Published In Rapid Communications in Mass Spectrometry Volume 16 Pages 240 - 241 ISSN 0951-4198
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published In Protein Science Volume 11 Pages 147 - 157 ISSN 0961-8368 Altmetric
2001	Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals and proteins Published In Mass Spectrometry Reviews Volume 20 Pages 61 - 87 ISSN 0277-7037
2001	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes Published In Rapid Communications in Mass Spectrometry Volume 15 Pages 2472 - 2480 ISSN 0951-4198
1999	Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides Published In European Journal of Mass Spectrometry Volume 5 Pages 489 - 500 ISSN 1469-0667
1999	Irreversible inactivation of purple acid phosphatase by hydrogen peroxide and ascorbate Published In Journal of Inorganic Biochemistry Volume 73 Pages 245 - 252 ISSN 0162-0134
1999	Observation of daunomycin and nogalamycin complexes with duplex DNA using electrospray ionization mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 13 Pages 2489 - 2497 ISSN 0951-4198

Chapter

Year	Title
2011	Mass spectrometric studies of non-covalent binding interactions between metallointercalators and DNA Published In Metallointercalators: Synthesis and Techniques to Probe Their Interactions With Biomolecules Publisher Springer-Verlag Pages 187 - 213 Altmetric
2006	DNA - ligand complexes Published In The Encyclopedia of Mass Spectrometry: Volume 3 Publisher Elsevier Pages 51 - 61

Conference Paper

Year	Title
2004	Electrospray mass spectrometry of gas phase macromolecular complexes Published In Advances in Mass Spectrometry - Volume 16 Pages 295 - 313
2001	Electrospray and tandem mass spectrometry of drug-DNA complexes Published In Advances in Mass Spectrometry Pages 175 - 192

Investigator On

Year	Title
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	Targeting Nucleic Acid Synthesis and Cell Division in Gram-Negative Bacterial Pathogens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	An Investigation Into the Struture of Protein Toxins of Australian Snake Venoms Structure to Therapeutics	Harrison, Julian

Education And Training

B.Sc. in Biochemistry/Chemistry, University of Queensland, Hons 1
Ph.D. in Biochemistry, University of Queensland
University of Illinois (Urbana-Champaign)
Australian National University

Keywords

mass spectrometry

Located In Facility

41.260

Top Publications

Year	Title
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published in Nature Communications
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published in Proceedings of the National Academy of Sciences of USA
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published in The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published in Journal of the American Society for Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published in Journal of the American Society for Mass Spectrometry

Research Areas

Research Overview

- Investigating the assembly of the E.coli replisome and other biological molecular machines using a variety of techniques with electrospray ionization mass spectrometry as the major tool
- Studying drug-DNA interactions (including quadruplex DNA)
- Ion mobility mass spectrometry of proteins, drug and DNA
- Molecular interactions at telomeres

Has Collaborator

Dixon, Nicholas E. Professor
Oakley, Aaron J. A/Prof.

Selected Publications

Journal Article

Year	Title
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published In Journal of the American Society for Mass Spectrometry Volume 30 Pages 256 - 267 ISSN 1044-0305 Altmetric
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published In Plant, Cell and Environment Volume Online First Pages 1 - 15 ISSN 0140-7791 Altmetric
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology Volume 204 Pages 396 - 405 ISSN 1047-8477 Altmetric
2018	Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes Published In Dalton Transactions: an international journal of inorganic chemistry Volume 47 Pages 13573 - 13591 ISSN 1477-9226 Altmetric
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry Volume 142 Pages 28 - 38 ISSN 0162-0134 Altmetric
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry Volume 58 Pages 4693 - 4702 ISSN 0022-2623 Altmetric
2015	ESI-MS investigation of an equilibrium between a bimolecular quadruplex DNA and a duplex DNA/RNA hybrid Published In Journal of the American Society for Mass Spectrometry Volume 26 Pages 1165 - 1173 ISSN 1044-0305 Altmetric
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published In Proceedings of the National Academy of Sciences of USA Volume 112 Pages 3564 - 3569 ISSN 0027-8424 Altmetric
2015	Synthesis and characterisation of nickel Schiff base complexes containing the meso-1,2-diphenylethylenediamine moiety: selective interactions with a tetramolecular DNA quadruplex Published In Dalton Transactions: an international journal of inorganic chemistry Volume 44 Pages 3136 - 3150 ISSN 1477-9226 Altmetric
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published In Nature Communications Volume 6 Pages 7643-1 - 7643-12 ISSN 2041-1723 Altmetric
2014	Binding interactions between nickel schiff base complexes and quadruplex DNA Published In Journal of Biological Inorganic Chemistry Volume 19 Pages S359 - S359 ISSN 0949-8257
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology Volume 21 Pages 481 - 487 ISSN 1074-5521 Altmetric
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry Volume 57 Pages 2799 - 2806 ISSN 0022-2623 Altmetric
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal Volume 32 Pages 1322 - 1333 ISSN 0261-4189 Altmetric
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published In Journal of the American Society for Mass Spectrometry Volume 24 Pages 274 - 285 ISSN 1044-0305 Altmetric
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry Volume 56 Pages 8665 - 8673 ISSN 0022-2623 Altmetric
2011	Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry Published In International Journal of Mass Spectrometry Volume 304 Pages 195 - 203 ISSN 1387-3806 Altmetric
2011	Book review: Protein and Peptide Analysis by LC-MS Experimental Strategies Published In European Journal of Mass Spectrometry Volume 17 Pages v - vi
2011	Developments in electrospray ionization mass spectrometry of non-covalent DNA-ligand complexes Published In Australian Journal of Chemistry: an international journal for chemical science Volume 64 Pages 705 - 717 ISSN 0004-9425 Altmetric
2011	EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH Published In International Journal of Mass Spectrometry Volume 302 Pages 149 - 156 ISSN 1387-3806 Altmetric
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published In Journal of the American Society for Mass Spectrometry Volume 22 Pages 1588 - 1601 ISSN 1044-0305 Altmetric
2010	A Single subunit directs the assembly of the escherichia coli DNA sliding clamp loader Published In Structure Volume 18 Pages 285 - 292 ISSN 0969-2126 Altmetric
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications Volume 46 Pages 6602 - 6604 ISSN 1359-7345 Altmetric
2010	ESI-MS and thermal melting studies of nanoscale platinum(ii) metallomacrocycles with DNA Published In Dalton Transactions: an international journal of inorganic chemistry Volume 39 Pages 11263 - 11271 ISSN 1477-9226 Altmetric
2009	A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity Published In Chemical Communications Pages 5546 - 5548 ISSN 1359-7345 Altmetric
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry Volume 17 Pages 3866 - 3872 ISSN 0968-0896 Altmetric
2009	Characterisation of anthracyclines from a cosmomycin D-producing species of Streptomyces by collisionally-activated dissociation and ion mobility mass spectrometry Published In European Journal of Mass Spectrometry Volume 15 Pages 73 - 81 ISSN 1469-0667 Altmetric
2009	Does the metal influence non-covalent binding of complexes to DNA? Published In Dalton Transactions: an international journal of inorganic chemistry Volume 3 Pages 504 - 513 ISSN 1477-9226 Altmetric
2009	Substrate-induced Assembly of Methanococcoides burtonii D-Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Dimers into Decamers Published In Journal of Biological Chemistry Volume 284 Pages 33876 - 33882 ISSN 0021-9258 Altmetric
2008	A comparison of the binding of metal complexes to duplex and quadruplex DNA Published In Dalton Transactions: an international journal of inorganic chemistry Volume 2008 Pages 1018 - 1026 ISSN 1477-9226 Altmetric
2008	Binding studies of nNOS-active amphibian peptides and Ca2+ calmodulin, using negative ion electrospray ionisation mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 22 Pages 3501 - 3509 ISSN 0951-4198 Altmetric
2008	Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA Published In Inorganic Chemistry: including bioinorganic chemistry Volume 47 Pages 6621 - 6632 ISSN 0020-1669 Altmetric
2008	Mass spectrometric investigation of the DNA-binding properties of an anthracycline with two trisaccharide chains Published In Archives of Biochemistry and Biophysics Volume 477 Pages 348 - 355 ISSN 0003-9861 Altmetric
2007	Effect of protein stabilization on charge state distribution in positive- and negative ion electrospray ionization mass spectra Published In Journal of the American Society for Mass Spectrometry Volume 18 Pages 1605 - 1611 ISSN 1044-0305 Altmetric
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry Volume 21 Pages 1759 - 1766 ISSN 0951-4198 Altmetric
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry Volume 48 Pages 7440 - 7443 ISSN 0040-4039 Altmetric
2007	The structure and function of a novel glycerophosphodiesterase from enterobacter aerogenes Published In Journal of Molecular Biology Volume 367 Pages 1047 - 1062 ISSN 0022-2836 Altmetric
2006	A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin Published In Journal of Biological Inorganic Chemistry Volume 11 Pages 559 - 570 ISSN 0949-8257 Altmetric
2006	An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery Published In Chemistry: A European Journal Volume 12 Pages 8000 - 8013 ISSN 0947-6539 Altmetric
2006	Proteomic dissection of DNA polymerization Published In Expert Review of Proteomics Volume 3 Pages 197 - 211 ISSN 1478-9450 Altmetric
2005	Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine Published In Rapid Communications in Mass Spectrometry Volume 19 Pages 2123 - 2130 ISSN 0951-4198 Altmetric
2005	Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA Published In Journal of Inorganic Biochemistry Volume 99 Pages 552 - 559 ISSN 0162-0134 Altmetric
2005	Stabilization of native protein fold by intein-mediated covalent cyclization Published In Journal of Molecular Biology Volume 346 Pages 1095 - 1108 ISSN 0022-2836 Altmetric
2005	Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins Published In The Federation of European Biochemical Societies (FEBS) Journal Volume 272 Pages 3162 - 3171 ISSN 1742-464X Altmetric
2004	A mass spectrometric investigation of non-covalent interactions between ruthenium compounds and DNA Published In Dalton Transactions: an international journal of inorganic chemistry Pages 2683 - 2690 ISSN 1477-9226 Altmetric
2004	Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the epsilon & theta subunits of DNA polymerase III Published In Protein Science Volume 13 Pages 2878 - 2887 ISSN 0961-8368 Altmetric
2004	Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry Volume 15 Pages 1382 - 1391 ISSN 1044-0305 Altmetric
2004	DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products Volume 57 Pages 647 - 654 ISSN 0021-8820 Altmetric
2004	Direct observation of covalent adducts with Cys34 of human serum albumin using mass spectrometry Published In Analytical Biochemistry Volume 325 Pages 326 - 336 ISSN 0003-2697 Altmetric
2003	Flexibility revealed by the 1.85.ANG. crystal structure of the B sliding-clamp subunit of Escherichia coli DNA polymerase III Published In Acta Crystallographica Section D: Biological Crystallography Volume 59 Pages 1192 - 1199 ISSN 0907-4449 Altmetric
2003	Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Chemical Communications Pages 626 - 627 ISSN 1359-7345 Altmetric
2003	Probing the DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Journal of Inorganic Biochemistry Volume 96 Page p. 214 ISSN 0162-0134
2002	Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes Published In Chemical Communications Pages 556 - 557 ISSN 1359-7345
2002	Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (E) subunit of Escherichia coli DNA polymerase III Published In Biochemistry Volume 41 Pages 5266 - 5275 ISSN 0006-2960 Altmetric
2002	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes. [Erratum to document cited in CA136:334875] Published In Rapid Communications in Mass Spectrometry Volume 16 Pages 240 - 241 ISSN 0951-4198
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published In Protein Science Volume 11 Pages 147 - 157 ISSN 0961-8368 Altmetric
2001	Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals and proteins Published In Mass Spectrometry Reviews Volume 20 Pages 61 - 87 ISSN 0277-7037
2001	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes Published In Rapid Communications in Mass Spectrometry Volume 15 Pages 2472 - 2480 ISSN 0951-4198
1999	Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides Published In European Journal of Mass Spectrometry Volume 5 Pages 489 - 500 ISSN 1469-0667
1999	Irreversible inactivation of purple acid phosphatase by hydrogen peroxide and ascorbate Published In Journal of Inorganic Biochemistry Volume 73 Pages 245 - 252 ISSN 0162-0134
1999	Observation of daunomycin and nogalamycin complexes with duplex DNA using electrospray ionization mass spectrometry Published In Rapid Communications in Mass Spectrometry Volume 13 Pages 2489 - 2497 ISSN 0951-4198

Chapter

Year	Title
2011	Mass spectrometric studies of non-covalent binding interactions between metallointercalators and DNA Published In Metallointercalators: Synthesis and Techniques to Probe Their Interactions With Biomolecules Publisher Springer-Verlag Pages 187 - 213 Altmetric
2006	DNA - ligand complexes Published In The Encyclopedia of Mass Spectrometry: Volume 3 Publisher Elsevier Pages 51 - 61

Conference Paper

Year	Title
2004	Electrospray mass spectrometry of gas phase macromolecular complexes Published In Advances in Mass Spectrometry - Volume 16 Pages 295 - 313
2001	Electrospray and tandem mass spectrometry of drug-DNA complexes Published In Advances in Mass Spectrometry Pages 175 - 192

Investigator On

Year	Title
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
	Targeting Nucleic Acid Synthesis and Cell Division in Gram-Negative Bacterial Pathogens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	An Investigation Into the Struture of Protein Toxins of Australian Snake Venoms Structure to Therapeutics	Harrison, Julian

Education And Training

B.Sc. in Biochemistry/Chemistry, University of Queensland, Hons 1
Ph.D. in Biochemistry, University of Queensland
University of Illinois (Urbana-Champaign)
Australian National University

Keywords

mass spectrometry

Located In Facility

41.260

Overview

Overview

Top Publications

Research Areas

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Top Publications

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