Beck, Jennifer L.

Overview

UOW Researcher Jenny Beck is using Mass Spectrometry as a technique to screen for new drugs which can bind to DNA (for use as anticancer agents). She explains how ‘telomerase biology research’ could unlock the mechanisms of a number of diseases, and possibly even ageing.

Professor Jenny Beck began her research career with an interest in proteins and enzymes. This was followed by postdoctoral work which investigated the molecular basis of how proteins involved in drug metabolism transfer electrons from one to another in reactions that are a prelude to elimination of drugs from the body.

Top Publications

Year	Title
2020	A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Published in eLife
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published in Journal of the American Society for Mass Spectrometry
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published in Plant, Cell and Environment
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published in Nature Communications
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published in Proceedings of the National Academy of Sciences of USA
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published in The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published in Journal of the American Society for Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published in Journal of the American Society for Mass Spectrometry
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published in Protein Science

Research Areas

Research Overview

- Investigating the assembly of the E.coli replisome and other biological molecular machines using a variety of techniques with electrospray ionization mass spectrometry as the major tool
- Studying drug-DNA interactions (including quadruplex DNA)
- Ion mobility mass spectrometry of proteins, drug and DNA
- Molecular interactions at telomeres

Available as Research Supervisor

Available for Collaborative Projects

Has Collaborator

Dixon, Nicholas E. Professor
Oakley, Aaron J. A/Prof.

Selected Publications

Journal Article

Year	Title
2020	A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Published In eLife
2020	A new class of quadruplex DNA-binding nickel Schiff base complexes Published In Dalton Transactions
2020	A study of Pt(II)–phenanthroline complex interactions with double-stranded and G-quadruplex DNA by ESI–MS, circular dichroism, and computational docking Published In Journal of Biological Inorganic Chemistry
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published In Journal of the American Society for Mass Spectrometry
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published In Plant, Cell and Environment
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology
2018	Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes Published In Dalton Transactions: an international journal of inorganic chemistry
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry
2015	ESI-MS investigation of an equilibrium between a bimolecular quadruplex DNA and a duplex DNA/RNA hybrid Published In Journal of the American Society for Mass Spectrometry
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published In Proceedings of the National Academy of Sciences of USA
2015	Synthesis and characterisation of nickel Schiff base complexes containing the meso-1,2-diphenylethylenediamine moiety: selective interactions with a tetramolecular DNA quadruplex Published In Dalton Transactions: an international journal of inorganic chemistry
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published In Nature Communications
2014	Binding interactions between nickel schiff base complexes and quadruplex DNA Published In Journal of Biological Inorganic Chemistry
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published In Journal of the American Society for Mass Spectrometry
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry
2011	Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry Published In International Journal of Mass Spectrometry
2011	Book review: Protein and Peptide Analysis by LC-MS Experimental Strategies Published In European Journal of Mass Spectrometry
2011	Developments in electrospray ionization mass spectrometry of non-covalent DNA-ligand complexes Published In Australian Journal of Chemistry: an international journal for chemical science
2011	EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH Published In International Journal of Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published In Journal of the American Society for Mass Spectrometry
2010	A Single subunit directs the assembly of the escherichia coli DNA sliding clamp loader Published In Structure
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications
2010	ESI-MS and thermal melting studies of nanoscale platinum(ii) metallomacrocycles with DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2009	A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity Published In Chemical Communications
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry
2009	Characterisation of anthracyclines from a cosmomycin D-producing species of Streptomyces by collisionally-activated dissociation and ion mobility mass spectrometry Published In European Journal of Mass Spectrometry
2009	Does the metal influence non-covalent binding of complexes to DNA? Published In Dalton Transactions: an international journal of inorganic chemistry
2009	Substrate-induced Assembly of Methanococcoides burtonii D-Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Dimers into Decamers Published In Journal of Biological Chemistry
2008	A comparison of the binding of metal complexes to duplex and quadruplex DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2008	Binding studies of nNOS-active amphibian peptides and Ca2+ calmodulin, using negative ion electrospray ionisation mass spectrometry Published In Rapid Communications in Mass Spectrometry
2008	Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA Published In Inorganic Chemistry: including bioinorganic chemistry
2008	Mass spectrometric investigation of the DNA-binding properties of an anthracycline with two trisaccharide chains Published In Archives of Biochemistry and Biophysics
2007	Effect of protein stabilization on charge state distribution in positive- and negative ion electrospray ionization mass spectra Published In Journal of the American Society for Mass Spectrometry
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2007	The structure and function of a novel glycerophosphodiesterase from enterobacter aerogenes Published In Journal of Molecular Biology
2006	A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin Published In Journal of Biological Inorganic Chemistry
2006	An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery Published In Chemistry: A European Journal
2006	Proteomic dissection of DNA polymerization Published In Expert Review of Proteomics
2005	Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine Published In Rapid Communications in Mass Spectrometry
2005	Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA Published In Journal of Inorganic Biochemistry
2005	Stabilization of native protein fold by intein-mediated covalent cyclization Published In Journal of Molecular Biology
2005	Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins Published In The Federation of European Biochemical Societies (FEBS) Journal
2004	A mass spectrometric investigation of non-covalent interactions between ruthenium compounds and DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2004	Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the epsilon & theta subunits of DNA polymerase III Published In Protein Science
2004	Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry
2004	DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products
2004	Direct observation of covalent adducts with Cys34 of human serum albumin using mass spectrometry Published In Analytical Biochemistry
2003	Flexibility revealed by the 1.85.ANG. crystal structure of the B sliding-clamp subunit of Escherichia coli DNA polymerase III Published In Acta Crystallographica Section D: Biological Crystallography
2003	Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Chemical Communications
2003	Probing the DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Journal of Inorganic Biochemistry
2002	Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes Published In Chemical Communications
2002	Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (E) subunit of Escherichia coli DNA polymerase III Published In Biochemistry
2002	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes. [Erratum to document cited in CA136:334875] Published In Rapid Communications in Mass Spectrometry
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published In Protein Science
2001	Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals and proteins Published In Mass Spectrometry Reviews
2001	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes Published In Rapid Communications in Mass Spectrometry
1999	Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides Published In European Journal of Mass Spectrometry
1999	Irreversible inactivation of purple acid phosphatase by hydrogen peroxide and ascorbate Published In Journal of Inorganic Biochemistry
1999	Observation of daunomycin and nogalamycin complexes with duplex DNA using electrospray ionization mass spectrometry Published In Rapid Communications in Mass Spectrometry

Chapter

Year	Title
2011	Mass spectrometric studies of non-covalent binding interactions between metallointercalators and DNA Published In Metallointercalators: Synthesis and Techniques to Probe Their Interactions With Biomolecules Publisher New York
2006	DNA - ligand complexes Published In The Encyclopedia of Mass Spectrometry: Volume 3

Conference Paper

Year	Title
2004	Electrospray mass spectrometry of gas phase macromolecular complexes Published In Advances in Mass Spectrometry - Volume 16
2001	Electrospray and tandem mass spectrometry of drug-DNA complexes Published In Advances in Mass Spectrometry

Investigator On

Year	Title
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Targeting Nucleic Acid Synthesis and Cell Division in Gram-Negative Bacterial Pathogens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials	Smith, Zander

Education And Training

B.Sc. in Biochemistry/Chemistry, University of Queensland, Hons 1
Ph.D. in Biochemistry, University of Queensland
University of Illinois (Urbana-Champaign)

Keywords

mass spectrometry

Located In Facility

41.260

Orcid Id

http://orcid.org/0000-0001-6058-4886 (confirmed)

Web Of Science Researcher Id

B-6151-2016

Top Publications

Year	Title
2020	A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Published in eLife
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published in Journal of the American Society for Mass Spectrometry
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published in Plant, Cell and Environment
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published in Nature Communications
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published in Proceedings of the National Academy of Sciences of USA
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published in The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published in Journal of the American Society for Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published in Journal of the American Society for Mass Spectrometry
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published in Protein Science

Research Areas

Research Overview

- Investigating the assembly of the E.coli replisome and other biological molecular machines using a variety of techniques with electrospray ionization mass spectrometry as the major tool
- Studying drug-DNA interactions (including quadruplex DNA)
- Ion mobility mass spectrometry of proteins, drug and DNA
- Molecular interactions at telomeres

Has Collaborator

Dixon, Nicholas E. Professor
Oakley, Aaron J. A/Prof.

Selected Publications

Journal Article

Year	Title
2020	A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Published In eLife
2020	A new class of quadruplex DNA-binding nickel Schiff base complexes Published In Dalton Transactions
2020	A study of Pt(II)–phenanthroline complex interactions with double-stranded and G-quadruplex DNA by ESI–MS, circular dichroism, and computational docking Published In Journal of Biological Inorganic Chemistry
2019	Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS Published In Journal of the American Society for Mass Spectrometry
2018	BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco Published In Plant, Cell and Environment
2018	Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens. Published In Journal of Structural Biology
2018	Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes Published In Dalton Transactions: an international journal of inorganic chemistry
2015	An investigation into the interactions of gold nanoparticles and anti-arthritic drugs with macrophages, and their reactivity towards thioredoxin reductase Published In Journal of Inorganic Biochemistry
2015	Bacterial sliding clamp inhibitors that mimic the sequential binding mechanism of endogenous linear motifs Published In Journal of Medicinal Chemistry
2015	ESI-MS investigation of an equilibrium between a bimolecular quadruplex DNA and a duplex DNA/RNA hybrid Published In Journal of the American Society for Mass Spectrometry
2015	Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone Published In Proceedings of the National Academy of Sciences of USA
2015	Synthesis and characterisation of nickel Schiff base complexes containing the meso-1,2-diphenylethylenediamine moiety: selective interactions with a tetramolecular DNA quadruplex Published In Dalton Transactions: an international journal of inorganic chemistry
2015	Telomeric G-quadruplexes are a substrate and site of localization for human telomerase Published In Nature Communications
2014	Binding interactions between nickel schiff base complexes and quadruplex DNA Published In Journal of Biological Inorganic Chemistry
2014	DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs Published In Chemistry and Biology
2014	Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach Published In Journal of Medicinal Chemistry
2013	A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode Published In The EMBO Journal
2013	Escherichia coli single-stranded DNA-binding protein: nanoESI-MS studies of salt-modulated subunit exchange and DNA binding transactions Published In Journal of the American Society for Mass Spectrometry
2013	Structural and thermodynamic dissection of linear motif recognition by the E. coli sliding clamp Published In Journal of Medicinal Chemistry
2011	Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry Published In International Journal of Mass Spectrometry
2011	Book review: Protein and Peptide Analysis by LC-MS Experimental Strategies Published In European Journal of Mass Spectrometry
2011	Developments in electrospray ionization mass spectrometry of non-covalent DNA-ligand complexes Published In Australian Journal of Chemistry: an international journal for chemical science
2011	EX1 hydrogen-deuterium exchange in an all-helical protein and its cyclized derivative at neutral pH Published In International Journal of Mass Spectrometry
2011	NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates Published In Journal of the American Society for Mass Spectrometry
2010	A Single subunit directs the assembly of the escherichia coli DNA sliding clamp loader Published In Structure
2010	A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives Published In Chemical Communications
2010	ESI-MS and thermal melting studies of nanoscale platinum(ii) metallomacrocycles with DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2009	A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity Published In Chemical Communications
2009	Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group Published In Bioorganic and Medicinal Chemistry
2009	Characterisation of anthracyclines from a cosmomycin D-producing species of Streptomyces by collisionally-activated dissociation and ion mobility mass spectrometry Published In European Journal of Mass Spectrometry
2009	Does the metal influence non-covalent binding of complexes to DNA? Published In Dalton Transactions: an international journal of inorganic chemistry
2009	Substrate-induced Assembly of Methanococcoides burtonii D-Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Dimers into Decamers Published In Journal of Biological Chemistry
2008	A comparison of the binding of metal complexes to duplex and quadruplex DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2008	Binding studies of nNOS-active amphibian peptides and Ca2+ calmodulin, using negative ion electrospray ionisation mass spectrometry Published In Rapid Communications in Mass Spectrometry
2008	Comparison of Mass Spectrometry and Other Techniques for Probing Interactions Between Metal Complexes and DNA Published In Inorganic Chemistry: including bioinorganic chemistry
2008	Mass spectrometric investigation of the DNA-binding properties of an anthracycline with two trisaccharide chains Published In Archives of Biochemistry and Biophysics
2007	Effect of protein stabilization on charge state distribution in positive- and negative ion electrospray ionization mass spectra Published In Journal of the American Society for Mass Spectrometry
2007	Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA Published In Rapid Communications in Mass Spectrometry
2007	Synthesis of an anthracyclinone bearing an unprecedented aromatic ring-fused bridgehead-hydroxylated bicyclo[3.1.1]heptanol Published In Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry
2007	The structure and function of a novel glycerophosphodiesterase from enterobacter aerogenes Published In Journal of Molecular Biology
2006	A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin Published In Journal of Biological Inorganic Chemistry
2006	An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery Published In Chemistry: A European Journal
2006	Proteomic dissection of DNA polymerization Published In Expert Review of Proteomics
2005	Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine Published In Rapid Communications in Mass Spectrometry
2005	Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA Published In Journal of Inorganic Biochemistry
2005	Stabilization of native protein fold by intein-mediated covalent cyclization Published In Journal of Molecular Biology
2005	Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins Published In The Federation of European Biochemical Societies (FEBS) Journal
2004	A mass spectrometric investigation of non-covalent interactions between ruthenium compounds and DNA Published In Dalton Transactions: an international journal of inorganic chemistry
2004	Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the epsilon & theta subunits of DNA polymerase III Published In Protein Science
2004	Comparison of the binding stoichiometries of positively charged DNA-binding drugs using positive and negative ion electrospray ionization mass spectrometry Published In Journal of the American Society for Mass Spectrometry
2004	DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains Published In Journal of Antibiotics: an international journal devoted to research on bioactive microbial products
2004	Direct observation of covalent adducts with Cys34 of human serum albumin using mass spectrometry Published In Analytical Biochemistry
2003	Flexibility revealed by the 1.85.ANG. crystal structure of the B sliding-clamp subunit of Escherichia coli DNA polymerase III Published In Acta Crystallographica Section D: Biological Crystallography
2003	Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Chemical Communications
2003	Probing the DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry Published In Journal of Inorganic Biochemistry
2002	Electrospray ionisation mass spectrometric detection of weak non-covalent interactions in nogalamycin-DNA complexes Published In Chemical Communications
2002	Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (E) subunit of Escherichia coli DNA polymerase III Published In Biochemistry
2002	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes. [Erratum to document cited in CA136:334875] Published In Rapid Communications in Mass Spectrometry
2002	Use of electrospray ionization mass spectrometry to study binding interactions between a replication terminator protein and DNA Published In Protein Science
2001	Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals and proteins Published In Mass Spectrometry Reviews
2001	Positive ion electrospray ionization mass spectrometry of double-stranded DNA/drug complexes Published In Rapid Communications in Mass Spectrometry
1999	Electrospray ionisation mass spectrometry of ruthenium and palladium complexes with oligonucleotides Published In European Journal of Mass Spectrometry
1999	Irreversible inactivation of purple acid phosphatase by hydrogen peroxide and ascorbate Published In Journal of Inorganic Biochemistry
1999	Observation of daunomycin and nogalamycin complexes with duplex DNA using electrospray ionization mass spectrometry Published In Rapid Communications in Mass Spectrometry

Chapter

Year	Title
2011	Mass spectrometric studies of non-covalent binding interactions between metallointercalators and DNA Published In Metallointercalators: Synthesis and Techniques to Probe Their Interactions With Biomolecules Publisher New York
2006	DNA - ligand complexes Published In The Encyclopedia of Mass Spectrometry: Volume 3

Conference Paper

Year	Title
2004	Electrospray mass spectrometry of gas phase macromolecular complexes Published In Advances in Mass Spectrometry - Volume 16
2001	Electrospray and tandem mass spectrometry of drug-DNA complexes Published In Advances in Mass Spectrometry

Investigator On

Year	Title
2011 - 2014	Fragment-Based Screening Approaches for New Antibiotics Directed Against the Bacterial Sliding Clamp Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2012	Multiplexed capabilities for surface analysis and imaging by mass spectrometry Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2012	Targeting Nucleic Acid Synthesis and Cell Division in Gram-Negative Bacterial Pathogens Awarded by: National Health and Medical Research Council (NHMRC) Funding Scheme: Project Grant
2011	Establishment of a comprehensive regional biophysical analysis facility Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2010	Regional facility for molecular characterisation and mapping Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Regional facility for real time analysis of molecular interactions Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2009	Unique state-of-the-art lipidomics infrastructure Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)
2008	Functional Dissection of the Bacterial Replisome Awarded by: Australian Research Council (ARC) Funding Scheme: Discovery Projects
2008	Mass Spectrometric Investigations of Conformation and Dynamics of Biological Complexes Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage International
2008	New generation mass spectrometers for characterisation of molecular shape and size Awarded by: Australian Research Council (ARC) Funding Scheme: Linkage Infrastructure Equipment & Facilities (LIEF)

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Design, Synthesis and Evaluation of Irreversible Inhibitors of Bacterial Sliding Clamps as New Antibacterials	Smith, Zander

Education And Training

B.Sc. in Biochemistry/Chemistry, University of Queensland, Hons 1
Ph.D. in Biochemistry, University of Queensland
University of Illinois (Urbana-Champaign)

Keywords

mass spectrometry

Located In Facility

41.260

Orcid Id

http://orcid.org/0000-0001-6058-4886 (confirmed)

Web Of Science Researcher Id

B-6151-2016

Overview

Overview

Top Publications

Research Areas

Research Overview

Available as Research Supervisor

Affiliation

Available for Collaborative Projects

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Available as Research Supervisor

Advisees

Graduate Advising Relationship

Background

Education And Training

Keywords

Contact

Located In Facility

Identity

Orcid Id

Web Of Science Researcher Id

Overview

Top Publications

Research Areas

Research Overview

Affiliation

Has Collaborator

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Funding

Investigator On

Supervision

Advisees

Graduate Advising Relationship

Background

Education And Training

Keywords

Contact

Located In Facility

Identity

Orcid Id

Web Of Science Researcher Id

Visualisations

Research Areas