Blanchard, Helen

Overview

Professor Helen Blanchard was appointed Head of School of Chemistry and Molecular Bioscience in October 2019. She obtained her B.Sc (Chemistry) and PhD (X-ray crystallography and chemistry) from the University of London. She has worked in academia, research institutes and industry in Canada, USA, Australia and Switzerland; establishing her research group in structural glycobiology at the Institute for Glycomics, Griffith University in 2002.

Professor Blanchard's research interests are in understanding structure and function of proteins involved in disease progression. Elucidating atomic structure and using this information toward the design of therapeutics, including those to reduce cancer growth and metastasis.

In 2006 Professor Blanchard was deemed a Fellow of the Royal Society of Chemistry (FRSC) in recognition of her contributions to structural biology and inhibitor design. She received the 2017 Pro Vice Chancellor's (Science) Award for Excellence in Research Supervision. At Griffith she held positions of Director of Higher Degree Research and Deputy Dean Research (Griffith Sciences).

Research Areas

Selected Publications

Journal Article

Year	Title
2022	Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3 Published In International Journal of Molecular Sciences
2022	Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. Published In Journal of medicinal chemistry
2021	Overcoming microenvironment-mediated chemoprotection through stromal galectin-3 inhibition in acute lymphoblastic leukemia Published In International Journal of Molecular Sciences
2020	Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides Published In FASEB Journal
2020	Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development Published In Chemical Biology and Drug Design
2020	Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists Published In Journal of Medicinal Chemistry
2020	Tenth scientific biennial meeting of the australasian virology society - AVS10 2019 Published In Viruses
2019	Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides Published In FASEB Journal
2018	Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands Published In RSC Advances
2018	Corrigendum to: Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8 (ChemMedChem, (2018), 13, 16, (1664-1672), 10.1002/cmdc.201800224) Published In ChemMedChem
2018	Lactulose as a novel template for anticancer drug development targeting galectins Published In Chemical Biology and Drug Design
2018	Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate-binding domain (VP8) Published In* Journal of Molecular Recognition
2018	Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8 Published In ChemMedChem
2016	A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model Published In Journal of Medicinal Chemistry
2016	Galectin-1 inhibitors and their potential therapeutic applications: A patent review Published In Expert Opinion on Therapeutic Patents
2016	Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition Published In ChemBioChem
2016	Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose Published In Scientific Reports
2016	Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8 Published In Scientific Reports
2015	Functional and structural characterization of a heparanase Published In Nature Chemical Biology
2015	Galectin-3 Inhibition As a Novel Therapeutic Approach in Acute Lymphoblastic Leukemia (ALL) Published In BLOOD
2015	Inside Cover: Substantial Receptor¿induced Structural Rearrangement of Rotavirus VP8: Potential Implications for Cross¿Species Infection (ChemBioChem 15/2015) Published In* ChemBioChem
2015	Redox state influence on human galectin-1 function Published In Biochimie
2015	Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation Published In PLoS Pathogens
2015	Structural characterization of human galectin-4 C-terminal domain: Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens Published In FEBS Journal
2015	Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8: Potential Implications for Cross-Species Infection Published In ChemBioChem
2014	Carbohydrate recognition by rotaviruses Published In Journal of structural and functional genomics
2014	Galectin-3 Interactions with Glycosphingolipids Published In Journal of Molecular Biology
2014	Galectin-3 inhibitors: A patent review (2008-present) Published In Expert Opinion on Therapeutic Patents
2014	Inhibitors of galectins and implications for structure-based design of galectin-specific therapeutics Published In Australian Journal of Chemistry
2014	Relative roles of GM1 ganglioside, N-acylneuraminic acids, and a2ß1 integrin in mediating rotavirus infection Published In Journal of Virology
2013	Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors Published In ChemBioChem
2012	Galectin-1 as a potent target for cancer therapy: Role in the tumor microenvironment Published In Cancer and Metastasis Reviews
2012	Structural basis of rotavirus strain preference toward N-acetyl-or N-glycolylneuraminic acid-containing receptors Published In Journal of Virology
2012	Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins Published In Carbohydrate Research
2012	Taloside Inhibitors of Galectin-1 and Galectin-3 Published In Chemical Biology and Drug Design
2011	Back Cover: Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles (Angew. Chem. Int. Ed. 5/2011) Published In Angewandte Chemie International Edition
2011	CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins Published In Organic and Biomolecular Chemistry
2011	Novel structural insights into rotavirus recognition of ganglioside glycan receptors Published In Journal of Molecular Biology
2011	Recognition of the GM3 ganglioside glycan by rhesus rotavirus particles Published In Angewandte Chemie - International Edition
2011	Rhesus¿Rotaviren erkennen Glykane des GM3¿Gangliosids Published In Angewandte Chemie
2011	Rücktitelbild: Rhesus¿Rotaviren erkennen Glykane des GM3¿Gangliosids (Angew. Chem. 5/2011) Published In Angewandte Chemie
2011	Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress Published In Angiogenesis
2010	Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2 Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2010	Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model Published In Cancer Letters
2009	Characterisation of oxidized recombinant human Galectin-1 Published In Protein and Peptide Letters
2009	Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein Published In Glycobiology
2009	Sialic acid dependence in rotavirus host cell invasion Published In Nature Chemical Biology
2008	Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8) of bovine rotavirus strain NCDV Published In* Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2008	Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans Published In Glycobiology
2008	Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8 Published In Bioorganic and Medicinal Chemistry Letters
2008	The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to candida albicans Published In Journal of Immunology
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin-1 Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin-1 Published In Acta Crystallographica Section F: Structural Biology Communications
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin¿1 Published In Acta Crystallographica Section F: Structural Biology Communications
2007	Insight into Host Cell Carbohydrate-recognition by Human and Porcine Rotavirus from Crystal Structures of the Virion Spike Associated Carbohydrate-binding Domain (VP8) Published In* Journal of Molecular Biology
2007	STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core Published In Glycobiology
2007	Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: Possible implications for ligand-exchange protocols Published In Acta Crystallographica Section D: Biological Crystallography
2005	Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2005	Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8) of porcine rotavirus strain CRW-8 Published In* Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2002	Crystallization and structural details of Ca(2+)-induced conformational changes in the EF-hand domain VI of calpain. Published In Methods in molecular biology (Clifton, N.J.)
2001	Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases Published In Acta Crystallographica Section D: Biological Crystallography
2000	Caspase-8 specificity probed at subsite S4: Crystal structure of the caspase-8-Z-DEVD-cho complex Published In Journal of Molecular Biology
1999	The three-dimensional structure of caspase-8: An initiator enzyme in apoptosis Published In Structure
1997	Structure of a calpain Ca²⁺-binding domain reveals a novel EF-hand and Ca²⁺-induced conformational changes Published In Nature Structural Biology
1997	Structure-function studies on recombinant calpain Published In FASEB Journal
1996	CRYSTAL STRUCTURE OF CALCIUM-FREE C-TERMINAL DOMAIN OF SMALL SUBUNIT OF RAT CALPAIN Published In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
1996	Ca²⁺-Binding domain VI of rat calpain is a homodimer in solution: Hydrodynamic, crystallization and preliminary X-ray diffraction studies Published In Protein Science
1994	A Crystallographic Re-investigation into the Structure of Streptomyces griseus Proteinase A Reveals an Acyl-enzyme Intermediate Published In Journal of Molecular Biology
1994	Structural and kinetic characterization of a ß-lactamase-inhibitor protein Published In Nature
1993	STRUCTURE OF (+)-(5R,6R)-5-CHLORO-6-METHOXY-5,6-DIHYDRO-1-(2',3'-DIDEHYDRO-2',3'-DIDEOXY-BETA-D-GLYCERO-2-ENOPENTOFURANOSYL)THYMINE Published In ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
1992	Erratum: Structural and spectroscopic studies of rhodium-(I) and-(III) nitrato complexes (Journal of the Chemical Society, Dalton Transactions (1992) (2533)) Published In Journal of the Chemical Society, Dalton Transactions
1992	STRUCTURAL AND SPECTROSCOPIC STUDIES OF RHODIUM-(I) AND RHODIUM-(III) NITRATO COMPLEXES (J CHEM SOC DALTON TRANS, SEP PG 2533, 1992) Published In JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
1992	Structural and spectroscopic studies of rhodium-(I) and -(III) nitrato complexes Published In Journal of the Chemical Society, Dalton Transactions
1988	Some dimethyl{tris(trimethylsilyl)methyl} silanolato derivatives of tantalum(V), chromium(III) and manganese(II) Published In Journal of Organometallic Chemistry

Chapter

Year	Title
2002	Crystallization and Structural Details of Ca2+-Induced Conformational Changes in the EF-Hand Domain VI of Calpain Published In Calcium-Binding Protein Protocols

Conference Paper

Year	Title
1994	CRYSTALLOGRAPHIC REINVESTIGATION INTO THE STRUCTURE OF SGPA REVEALS A POSSIBLE ACYL-ENZYME INTERMEDIATE Published In JOURNAL OF CELLULAR BIOCHEMISTRY

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Structure based design of inhibitors targeting galectins	Siddiqui, Muhammad Zahir

Research Areas

Selected Publications

Journal Article

Year	Title
2022	Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3 Published In International Journal of Molecular Sciences
2022	Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. Published In Journal of medicinal chemistry
2021	Overcoming microenvironment-mediated chemoprotection through stromal galectin-3 inhibition in acute lymphoblastic leukemia Published In International Journal of Molecular Sciences
2020	Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides Published In FASEB Journal
2020	Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development Published In Chemical Biology and Drug Design
2020	Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists Published In Journal of Medicinal Chemistry
2020	Tenth scientific biennial meeting of the australasian virology society - AVS10 2019 Published In Viruses
2019	Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides Published In FASEB Journal
2018	Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands Published In RSC Advances
2018	Corrigendum to: Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8 (ChemMedChem, (2018), 13, 16, (1664-1672), 10.1002/cmdc.201800224) Published In ChemMedChem
2018	Lactulose as a novel template for anticancer drug development targeting galectins Published In Chemical Biology and Drug Design
2018	Specificity and affinity of neuraminic acid exhibited by canine rotavirus strain K9 carbohydrate-binding domain (VP8) Published In* Journal of Molecular Recognition
2018	Structure-Based Design of a Monosaccharide Ligand Targeting Galectin-8 Published In ChemMedChem
2016	A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model Published In Journal of Medicinal Chemistry
2016	Galectin-1 inhibitors and their potential therapeutic applications: A patent review Published In Expert Opinion on Therapeutic Patents
2016	Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition Published In ChemBioChem
2016	Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose Published In Scientific Reports
2016	Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8 Published In Scientific Reports
2015	Functional and structural characterization of a heparanase Published In Nature Chemical Biology
2015	Galectin-3 Inhibition As a Novel Therapeutic Approach in Acute Lymphoblastic Leukemia (ALL) Published In BLOOD
2015	Inside Cover: Substantial Receptor¿induced Structural Rearrangement of Rotavirus VP8: Potential Implications for Cross¿Species Infection (ChemBioChem 15/2015) Published In* ChemBioChem
2015	Redox state influence on human galectin-1 function Published In Biochimie
2015	Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation Published In PLoS Pathogens
2015	Structural characterization of human galectin-4 C-terminal domain: Elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens Published In FEBS Journal
2015	Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8: Potential Implications for Cross-Species Infection Published In ChemBioChem
2014	Carbohydrate recognition by rotaviruses Published In Journal of structural and functional genomics
2014	Galectin-3 Interactions with Glycosphingolipids Published In Journal of Molecular Biology
2014	Galectin-3 inhibitors: A patent review (2008-present) Published In Expert Opinion on Therapeutic Patents
2014	Inhibitors of galectins and implications for structure-based design of galectin-specific therapeutics Published In Australian Journal of Chemistry
2014	Relative roles of GM1 ganglioside, N-acylneuraminic acids, and a2ß1 integrin in mediating rotavirus infection Published In Journal of Virology
2013	Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors Published In ChemBioChem
2012	Galectin-1 as a potent target for cancer therapy: Role in the tumor microenvironment Published In Cancer and Metastasis Reviews
2012	Structural basis of rotavirus strain preference toward N-acetyl-or N-glycolylneuraminic acid-containing receptors Published In Journal of Virology
2012	Synthesis of lactosylated glycoclusters and inhibition studies with plant and human lectins Published In Carbohydrate Research
2012	Taloside Inhibitors of Galectin-1 and Galectin-3 Published In Chemical Biology and Drug Design
2011	Back Cover: Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles (Angew. Chem. Int. Ed. 5/2011) Published In Angewandte Chemie International Edition
2011	CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins Published In Organic and Biomolecular Chemistry
2011	Novel structural insights into rotavirus recognition of ganglioside glycan receptors Published In Journal of Molecular Biology
2011	Recognition of the GM3 ganglioside glycan by rhesus rotavirus particles Published In Angewandte Chemie - International Edition
2011	Rhesus¿Rotaviren erkennen Glykane des GM3¿Gangliosids Published In Angewandte Chemie
2011	Rücktitelbild: Rhesus¿Rotaviren erkennen Glykane des GM3¿Gangliosids (Angew. Chem. 5/2011) Published In Angewandte Chemie
2011	Thiodigalactoside inhibits murine cancers by concurrently blocking effects of galectin-1 on immune dysregulation, angiogenesis and protection against oxidative stress Published In Angiogenesis
2010	Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2 Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2010	Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model Published In Cancer Letters
2009	Characterisation of oxidized recombinant human Galectin-1 Published In Protein and Peptide Letters
2009	Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein Published In Glycobiology
2009	Sialic acid dependence in rotavirus host cell invasion Published In Nature Chemical Biology
2008	Crystallization and preliminary X-ray diffraction analysis of the carbohydrate-recognizing domain (VP8) of bovine rotavirus strain NCDV Published In* Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2008	Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans Published In Glycobiology
2008	Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8 Published In Bioorganic and Medicinal Chemistry Letters
2008	The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to candida albicans Published In Journal of Immunology
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin-1 Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin-1 Published In Acta Crystallographica Section F: Structural Biology Communications
2007	Crystallization and preliminary crystallographic analysis of recombinant human galectin¿1 Published In Acta Crystallographica Section F: Structural Biology Communications
2007	Insight into Host Cell Carbohydrate-recognition by Human and Porcine Rotavirus from Crystal Structures of the Virion Spike Associated Carbohydrate-binding Domain (VP8) Published In* Journal of Molecular Biology
2007	STD NMR spectroscopy and molecular modeling investigation of the binding of N-acetylneuraminic acid derivatives to rhesus rotavirus VP8* core Published In Glycobiology
2007	Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: Possible implications for ligand-exchange protocols Published In Acta Crystallographica Section D: Biological Crystallography
2005	Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the VP8* carbohydrate-binding protein of the human rotavirus strain Wa Published In Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2005	Crystallization and preliminary X-ray diffraction analysis of the sialic acid-binding domain (VP8) of porcine rotavirus strain CRW-8 Published In* Acta Crystallographica Section F: Structural Biology and Crystallization Communications
2002	Crystallization and structural details of Ca(2+)-induced conformational changes in the EF-hand domain VI of calpain. Published In Methods in molecular biology (Clifton, N.J.)
2001	Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases Published In Acta Crystallographica Section D: Biological Crystallography
2000	Caspase-8 specificity probed at subsite S4: Crystal structure of the caspase-8-Z-DEVD-cho complex Published In Journal of Molecular Biology
1999	The three-dimensional structure of caspase-8: An initiator enzyme in apoptosis Published In Structure
1997	Structure of a calpain Ca²⁺-binding domain reveals a novel EF-hand and Ca²⁺-induced conformational changes Published In Nature Structural Biology
1997	Structure-function studies on recombinant calpain Published In FASEB Journal
1996	CRYSTAL STRUCTURE OF CALCIUM-FREE C-TERMINAL DOMAIN OF SMALL SUBUNIT OF RAT CALPAIN Published In ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
1996	Ca²⁺-Binding domain VI of rat calpain is a homodimer in solution: Hydrodynamic, crystallization and preliminary X-ray diffraction studies Published In Protein Science
1994	A Crystallographic Re-investigation into the Structure of Streptomyces griseus Proteinase A Reveals an Acyl-enzyme Intermediate Published In Journal of Molecular Biology
1994	Structural and kinetic characterization of a ß-lactamase-inhibitor protein Published In Nature
1993	STRUCTURE OF (+)-(5R,6R)-5-CHLORO-6-METHOXY-5,6-DIHYDRO-1-(2',3'-DIDEHYDRO-2',3'-DIDEOXY-BETA-D-GLYCERO-2-ENOPENTOFURANOSYL)THYMINE Published In ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
1992	Erratum: Structural and spectroscopic studies of rhodium-(I) and-(III) nitrato complexes (Journal of the Chemical Society, Dalton Transactions (1992) (2533)) Published In Journal of the Chemical Society, Dalton Transactions
1992	STRUCTURAL AND SPECTROSCOPIC STUDIES OF RHODIUM-(I) AND RHODIUM-(III) NITRATO COMPLEXES (J CHEM SOC DALTON TRANS, SEP PG 2533, 1992) Published In JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
1992	Structural and spectroscopic studies of rhodium-(I) and -(III) nitrato complexes Published In Journal of the Chemical Society, Dalton Transactions
1988	Some dimethyl{tris(trimethylsilyl)methyl} silanolato derivatives of tantalum(V), chromium(III) and manganese(II) Published In Journal of Organometallic Chemistry

Chapter

Year	Title
2002	Crystallization and Structural Details of Ca2+-Induced Conformational Changes in the EF-Hand Domain VI of Calpain Published In Calcium-Binding Protein Protocols

Conference Paper

Year	Title
1994	CRYSTALLOGRAPHIC REINVESTIGATION INTO THE STRUCTURE OF SGPA REVEALS A POSSIBLE ACYL-ENZYME INTERMEDIATE Published In JOURNAL OF CELLULAR BIOCHEMISTRY

Advisees

Graduate Advising Relationship

Degree	Research Title	Advisee
Doctor of Philosophy	Structure based design of inhibitors targeting galectins	Siddiqui, Muhammad Zahir

Blanchard, Helen Prof.

Head of School of Chemistry and Molecular Bioscience

Overview

Overview

Research Areas

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Supervision

Advisees

Graduate Advising Relationship

Overview

Research Areas

Publications

Selected Publications

Journal Article

Chapter

Conference Paper

Supervision

Advisees

Graduate Advising Relationship

Visualisations

Research Areas