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Ecroyd, Heath

Faculty Member

  • Fellow - Illawarra Health and Medical Research Institute
  • Professor - School of Chemistry and Molecular Bioscience

Overview


Professor Heath Ecroyd (PhD, Newcastle University, 2003) was an NHMRC Peter Doherty Fellow (2005-2009, University of Adelaide) and ARC Future Fellow (2012-2016; University of Wollongong). He heads a laboratory at the University of Wollongong researching the biochemistry and cellular biology of neurodegenerative disease. His main research focus is the role protein homeostasis (proteostasis) plays in preventing the aggregation of proteins associated with these diseases.

Top Publications


Research Overview


  • My research focus is in the field of protein homeostasis (proteostasis). Disturbances in proteostasis can lead to protein aggregation (i.e. the clumping of proteins into large deposits), a pathological hallmark of many human diseases, including Alzheimer’s disease, Parkinson’s disease and Motor Neurone Disease (MND). My work focuses on the role of molecular chaperone proteins in proteostasis. This is because these are the body’s front-line defenders against protein aggregation. By identifying innovative approaches to activate molecular chaperones, my work aims to develop new drugs to treat, and ultimately prevent, neurodegenerative diseases such as MND.

Available as Research Supervisor

Selected Publications


Investigator On


Available as Research Supervisor

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Disease-causing mutations in the small heat shock protein Hsp27 alter its structure, chaperone activity and protein interactome Rote, Anthea
    Doctor of Philosophy Studying the Chaperone Function of Small Heat-Shock Proteins Using Single-Molecule Fluorescence Microscopy Johnston, Caitlin
    Doctor of Philosophy The Development of Single-Molecule Approaches to Study Molecular Chaperone Function Marzano, Nicholas
    Doctor of Philosophy Investigating the role of proteostasis pathways in regulating the intracellular inclusion formation of firefly luciferase: a model system to study protein aggregation in cells McMahon, Shannon
    Doctor of Philosophy High Throughput Flow Cytometric Drug Screen for Motor Neuron Disease Miles, Nicole
    Doctor of Philosophy Investigating heat shock factor 1 as a potential therapeutic strategy for the treatment of neurodegenerative diseases Claesson, Kristian
    Doctor of Philosophy Developing Single-Molecule Approaches to Investigate Interactions Between Alpha-Synuclein and Heat Shock Protein Molecular Chaperones Rice, Lauren
    Doctor of Philosophy Is FUS a prion in ALS Walker, Tom

Top Publications


Research Overview


  • My research focus is in the field of protein homeostasis (proteostasis). Disturbances in proteostasis can lead to protein aggregation (i.e. the clumping of proteins into large deposits), a pathological hallmark of many human diseases, including Alzheimer’s disease, Parkinson’s disease and Motor Neurone Disease (MND). My work focuses on the role of molecular chaperone proteins in proteostasis. This is because these are the body’s front-line defenders against protein aggregation. By identifying innovative approaches to activate molecular chaperones, my work aims to develop new drugs to treat, and ultimately prevent, neurodegenerative diseases such as MND.

Selected Publications


Investigator On


Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Disease-causing mutations in the small heat shock protein Hsp27 alter its structure, chaperone activity and protein interactome Rote, Anthea
    Doctor of Philosophy Studying the Chaperone Function of Small Heat-Shock Proteins Using Single-Molecule Fluorescence Microscopy Johnston, Caitlin
    Doctor of Philosophy The Development of Single-Molecule Approaches to Study Molecular Chaperone Function Marzano, Nicholas
    Doctor of Philosophy Investigating the role of proteostasis pathways in regulating the intracellular inclusion formation of firefly luciferase: a model system to study protein aggregation in cells McMahon, Shannon
    Doctor of Philosophy High Throughput Flow Cytometric Drug Screen for Motor Neuron Disease Miles, Nicole
    Doctor of Philosophy Investigating heat shock factor 1 as a potential therapeutic strategy for the treatment of neurodegenerative diseases Claesson, Kristian
    Doctor of Philosophy Developing Single-Molecule Approaches to Investigate Interactions Between Alpha-Synuclein and Heat Shock Protein Molecular Chaperones Rice, Lauren
    Doctor of Philosophy Is FUS a prion in ALS Walker, Tom
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