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Ecroyd, Heath

Faculty Member

  • Fellow - Illawarra Health and Medical Research Institute
  • Molecular Horizons
  • Professor - School of Chemistry and Molecular Bioscience

Overview


Professor Heath Ecroyd (PhD, Newcastle University, 2003) was an NHMRC Peter Doherty Fellow (2005-2009, University of Adelaide) and ARC Future Fellow (2012-2016; University of Wollongong). He heads a laboratory at the Illawarra Health and Medical Research Institute (IHMRI) researching the biochemistry and cellular biology of neurodegenerative disease. His main research focus is the role protein homeostasis (proteostasis) plays in preventing the aggregation of proteins associated with these diseases.

Top Publications


Research Overview


  • My research focus is in the field of protein homeostasis (proteostasis), an important area of research as disturbances in proteostasis can lead to protein aggregation (i.e. the clumping of proteins into large deposits), a pathological hallmark of many human diseases, including Alzheimer’s disease, Parkinson’s disease and Motor Neurone Disease (MND). My work focuses on the role of molecular chaperone proteins in proteostasis. This is because these are the body’s front-line defenders against protein aggregation. By identifying innovative approaches to activate molecular chaperones, my work aims to develop new drugs to treat, and ultimately prevent, neurodegenerative diseases such as MND.

Available as Research Supervisor

Selected Publications


Investigator On


Available as Research Supervisor

Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Extracellular chaperones- Roles in Protein Aggregation and Disease West, Jennifer
    Doctor of Philosophy Investigating the structural and functional consequences of disease-related mutations in the small heat shock protein Hsp27 Rote, Anthea
    Doctor of Philosophy Ecroyd, Heath advising Johnston, Caitlin Johnston, Caitlin
    Doctor of Philosophy Deciphering the structure-function relationships of the extracellular chaperone clusterin Satapathy, Sandeep
    Doctor of Philosophy The development of a protein folding-sensor to study molecular chaperones at the single-molecule level Marzano, Nicholas
    Doctor of Philosophy Investigating the role of proteostasis pathways in regulating the intracellular protein aggregation of firefly luciferase: a model system to study protein aggregation in cells McMahon, Shannon
    Doctor of Philosophy High Throughput Flow Cytometric Drug Screen for Motor Neuron Disease Miles, Nicole
    Doctor of Philosophy Are proteostasis defects responsible for ALS. Lambert-Smith, Isabella

Top Publications


Research Overview


  • My research focus is in the field of protein homeostasis (proteostasis), an important area of research as disturbances in proteostasis can lead to protein aggregation (i.e. the clumping of proteins into large deposits), a pathological hallmark of many human diseases, including Alzheimer’s disease, Parkinson’s disease and Motor Neurone Disease (MND). My work focuses on the role of molecular chaperone proteins in proteostasis. This is because these are the body’s front-line defenders against protein aggregation. By identifying innovative approaches to activate molecular chaperones, my work aims to develop new drugs to treat, and ultimately prevent, neurodegenerative diseases such as MND.

Selected Publications


Investigator On


Advisees


  • Graduate Advising Relationship

    Degree Research Title Advisee
    Doctor of Philosophy Extracellular chaperones- Roles in Protein Aggregation and Disease West, Jennifer
    Doctor of Philosophy Investigating the structural and functional consequences of disease-related mutations in the small heat shock protein Hsp27 Rote, Anthea
    Doctor of Philosophy Ecroyd, Heath advising Johnston, Caitlin Johnston, Caitlin
    Doctor of Philosophy Deciphering the structure-function relationships of the extracellular chaperone clusterin Satapathy, Sandeep
    Doctor of Philosophy The development of a protein folding-sensor to study molecular chaperones at the single-molecule level Marzano, Nicholas
    Doctor of Philosophy Investigating the role of proteostasis pathways in regulating the intracellular protein aggregation of firefly luciferase: a model system to study protein aggregation in cells McMahon, Shannon
    Doctor of Philosophy High Throughput Flow Cytometric Drug Screen for Motor Neuron Disease Miles, Nicole
    Doctor of Philosophy Are proteostasis defects responsible for ALS. Lambert-Smith, Isabella
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