Tae, Han Shen Dr.

Selected Publications

• Journal Article

  Year	Title
  2021	(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by ¿7 nicotinic acetylcholine receptor potentiation Published In Neurological Research
  2021	Alkyne-Bridged ¿-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models Published In Journal of Medicinal Chemistry
  2021	Globular and ribbon isomers of Conus geographus ¿-conotoxins antagonize human nicotinic acetylcholine receptors Published In Biochemical Pharmacology
  2021	Mechanism of interactions between ¿-conotoxin RegIIA and carbohydrates at the human ¿3ß4 nicotinic acetylcholine receptor Published In Marine Life Science and Technology
  2021	Medicinal chemistry, pharmacology, and therapeutic potential of ¿-conotoxins antagonizing the ¿9¿10 nicotinic acetylcholine receptor Published In Pharmacology and Therapeutics
  2021	Small-molecule mimicry hunting strategy in the imperial cone snail, Conus imperialis Published In Science Advances
  2020	(E)-3-Furan-2-yl- N- p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by ¿7 Nicotinic Acetylcholine Receptor Potentiation Published In ACS Chemical Neuroscience
  2020	Coronaridine congeners decrease neuropathic pain in mice and inhibit ¿9¿10 nicotinic acetylcholine receptors and CaV2.2 channels Published In Neuropharmacology
  2020	Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors Published In Journal of Medicinal Chemistry
  2020	Rational Design of ¿-Conotoxin RegIIA Analogues Selectively Inhibiting the Human ¿3ß2 Nicotinic Acetylcholine Receptor through Computational Scanning Published In ACS Chemical Neuroscience
  2019	Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor Published In British Journal of Pharmacology
  2019	α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement Published In ACS Chemical Neuroscience
  2018	Molecular Determinants Conferring the Stoichiometric-Dependent Activity of alpha-Conotoxins at the Human alpha 9 alpha 10 Nicotinic Acetylcholine Receptor Subtype Published In Journal of Medicinal Chemistry
  2018	Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Published In Biochemical Pharmacology
  2018	Structure-Activity Studies Reveal the Molecular Basis for GABA(B)-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1 Published In ACS Chemical Biology
  2018	Targeting of N-Type Calcium Channels via GABAB-Receptor Activation by α-Conotoxin Vc1.1 Variants Displaying Improved Analgesic Activity Published In Journal of Medicinal Chemistry
  2018	α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition Published In British Journal of Pharmacology
  2017	A novel lid-covering peptide inhibitor of nicotinic acetylcholine receptors derived from αd-conotoxin GeXXA Published In Marine Drugs
  2017	Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer Published In Journal of Biological Chemistry
  2017	Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening Published In Journal of Chemical Information and Modeling
  2017	Gabapentin modulates HCN4 channel voltage-dependence Published In Frontiers in Pharmacology
  2017	Identification of a novel O-conotoxin reveals an unusual and potent inhibitor of the human α9α10 nicotinic acetylcholine receptor Published In Marine Drugs
  2017	In vivo and in vitro testing of native α-conotoxins from the injected venom of Conus purpurascens Published In Neuropharmacology
  2017	Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors Published In Scientific Reports
  2017	Role of Cys(I)-Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors Published In ACS Omega
  2016	Key structural determinants in the agonist binding loops of human β2 and β4 nicotinic acetylcholine receptor subunits contribute to α3β4 subtype selectivity of α-conotoxins Published In Journal of Biological Chemistry
  2016	Structure-activity studies of cysteine-rich α-Conotoxins that inhibit high voltage-activated calcium channels via GABAB receptor activation reveal a minimal functional motif Published In Angewandte Chemie International Edition
  2015	Assembly, trafficking and function of α1β2γ2 GABAA receptors are regulated by N‐terminal regions, in a subunit‐specific manner Published In Journal of Neurochemistry
  2015	α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors Published In Journal of the American Chemical Society
  2014	Role of the ρ1 GABAC Receptor N‑Terminus in Assembly, Trafficking and Function Published In ACS Chemical Neuroscience
  2012	Agonist Interactions and Selectivity in Inhibitory Cys-Loop Ligand-Gated Ion Channels Published In Biophysical Journal
  2011	3D mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM Published In PLoS One
  2011	Cyclization of the intrinsically disordered a1Sdihydropyridine receptor II-III loop enhances secondary structure and in vitro function Published In Journal of Biological Chemistry
  2011	The elusive role of the SPRY2 domain in RyR1. Published In Channels (Austin, Tex.)
  2009	A dihydropyridine receptor ¿1s loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor Published In International Journal of Biochemistry and Cell Biology