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The effects of alpha-2-macroglobulin on amyloid formation and toxicity

Grant


Scheme


  • Linkage International

Abstract


  • Amyloid is a fibrillar protein aggregate, associated with ageing and disease, that can form from any destabilized protein; early stage aggregates can be toxic. We recently demonstrated that the very abundant blood protein alpha-2-macroglobulin (A2M) potently inhibits amyloid formation. This suggests that A2M may protect the body from many amyloid-related diseases (e.g. Alzheimer's disease). Exploiting collaborations with world-leading researchers at the University of Cambridge, this project will determine the mechanism by which A2M inhibits amyloid formation and its effects on amyloid toxicity. Furthermore, by creating unique transgenic fly models, the project will establish whether A2M protects against amyloid pathology in vivo.

Date/time Interval


  • 2008

Sponsor Award Id


  • LX0881953

Local Award Id


  • 9834

Scheme


  • Linkage International

Abstract


  • Amyloid is a fibrillar protein aggregate, associated with ageing and disease, that can form from any destabilized protein; early stage aggregates can be toxic. We recently demonstrated that the very abundant blood protein alpha-2-macroglobulin (A2M) potently inhibits amyloid formation. This suggests that A2M may protect the body from many amyloid-related diseases (e.g. Alzheimer's disease). Exploiting collaborations with world-leading researchers at the University of Cambridge, this project will determine the mechanism by which A2M inhibits amyloid formation and its effects on amyloid toxicity. Furthermore, by creating unique transgenic fly models, the project will establish whether A2M protects against amyloid pathology in vivo.

Date/time Interval


  • 2008

Sponsor Award Id


  • LX0881953

Local Award Id


  • 9834