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Functional Dissection of the Bacterial Replisome

Grant


Scheme


  • Discovery Projects

Abstract


  • A major challenge in understanding cell function is to define the dynamic interactions that occur in large multiprotein complexes as they function as molecular machines. This program will dissect functions of components of the large multiprotein complex that synthesizes bacterial DNA, using a unique combination of state-of-the-art techniques including mass spectrometry and single-molecule experiments, coupled with structure determination. This will bring new technology to Australia, and will underpin advances in antibacterial drug design and applications in nanotechnology.

Date/time Interval


  • 2008

Sponsor Award Id


  • DP0877658

Local Award Id


  • 9694

Scheme


  • Discovery Projects

Abstract


  • A major challenge in understanding cell function is to define the dynamic interactions that occur in large multiprotein complexes as they function as molecular machines. This program will dissect functions of components of the large multiprotein complex that synthesizes bacterial DNA, using a unique combination of state-of-the-art techniques including mass spectrometry and single-molecule experiments, coupled with structure determination. This will bring new technology to Australia, and will underpin advances in antibacterial drug design and applications in nanotechnology.

Date/time Interval


  • 2008

Sponsor Award Id


  • DP0877658

Local Award Id


  • 9694