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Large scale production of stemona alkaloids for agricultural applications and new drug discovery

Grant


Scheme


  • Discovery Projects

Abstract


  • The Stemona alkaloids are an expanding group of natural products that have significant potential as agricultural and pharmaceutical drugs. However many of these alkaloids are only available in small quantities which severely limits their application. A significant and innovative aspect of this project will be the development of new processes for the large scale production of Stemona alkaloids. The major alkaloids will be used as novel building blocks to prepare more structurally complex and less abundant Stemona alkaloids and their analogues. These studies will allow systematic structure-biological activity relationship studies to be performed.

Date/time Interval


  • 2008

Sponsor Award Id


  • DP0879491

Local Award Id


  • 9662

Scheme


  • Discovery Projects

Abstract


  • The Stemona alkaloids are an expanding group of natural products that have significant potential as agricultural and pharmaceutical drugs. However many of these alkaloids are only available in small quantities which severely limits their application. A significant and innovative aspect of this project will be the development of new processes for the large scale production of Stemona alkaloids. The major alkaloids will be used as novel building blocks to prepare more structurally complex and less abundant Stemona alkaloids and their analogues. These studies will allow systematic structure-biological activity relationship studies to be performed.

Date/time Interval


  • 2008

Sponsor Award Id


  • DP0879491

Local Award Id


  • 9662