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Magneto-Microbeam Radiation Therapy: Effect of magnetic field on absorbed dose distribution and cell survival

Grant


Scheme


  • International Science Linkages

Abstract


  • Microbeam Radiation Therapy (MRT) is an emerging radiation oncology modality that is under development at the Medical Department of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France and at the Centre for Medical Radiation Physics (CMRP), University of Wollongong (UOW), Australia. MRT research will be also performed in the near future at the Australian synchrotron when its construction and commissioning are completed in 2007.The aim of the proposed project is the improvement of MRT radiation oncology modality by the introduction of permanent or pulsed magnetic field during radiation treatment. Clinical benefits will be achieved by improvement of the physical dose distribution within the microbeam, and expected enhancement in radiobiological efficiency (RBE) in array of synchrotron microbeams, due to the confining of scattering electrons and changing of their spatial and energy distribution. Experimental research on the MRT beamline at ESRF will be carried out by a collaborative team of Australian and French experienced researchers and PhD students to investigate the effect of magnetic field on absorbed dose distribution, cell survival and cancer treatment in small animals in magneto-MRT. The experimental program was recently supported at ESRF by the granting of a long term project grant: 2 years access to the MRT beamline ID17.

Date/time Interval


  • 2007

Sponsor Award Id


  • FR070099

Local Award Id


  • 9456

Scheme


  • International Science Linkages

Abstract


  • Microbeam Radiation Therapy (MRT) is an emerging radiation oncology modality that is under development at the Medical Department of the European Synchrotron Radiation Facility (ESRF) in Grenoble, France and at the Centre for Medical Radiation Physics (CMRP), University of Wollongong (UOW), Australia. MRT research will be also performed in the near future at the Australian synchrotron when its construction and commissioning are completed in 2007.The aim of the proposed project is the improvement of MRT radiation oncology modality by the introduction of permanent or pulsed magnetic field during radiation treatment. Clinical benefits will be achieved by improvement of the physical dose distribution within the microbeam, and expected enhancement in radiobiological efficiency (RBE) in array of synchrotron microbeams, due to the confining of scattering electrons and changing of their spatial and energy distribution. Experimental research on the MRT beamline at ESRF will be carried out by a collaborative team of Australian and French experienced researchers and PhD students to investigate the effect of magnetic field on absorbed dose distribution, cell survival and cancer treatment in small animals in magneto-MRT. The experimental program was recently supported at ESRF by the granting of a long term project grant: 2 years access to the MRT beamline ID17.

Date/time Interval


  • 2007

Sponsor Award Id


  • FR070099

Local Award Id


  • 9456