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Unified model for group A streptococcal invasive disease initiation

Grant


Scheme


  • Project Grant

Abstract


  • A unified model for Streptococcus pyogenes (Streptococcus pyogenes; GAS) invasive disease initiation is under investigation. We hypothesise (1) that the human plasminogen (Plg) system plays a crucial role in GAS invasive disease and (2) that neutrophil killing of GAS at the site of infection, inadvertently selects for an invasive GAS phenotype.

Date/time Interval


  • 2007

Sponsor Award Id


  • 459103

Local Award Id


  • 9037

Scheme


  • Project Grant

Abstract


  • A unified model for Streptococcus pyogenes (Streptococcus pyogenes; GAS) invasive disease initiation is under investigation. We hypothesise (1) that the human plasminogen (Plg) system plays a crucial role in GAS invasive disease and (2) that neutrophil killing of GAS at the site of infection, inadvertently selects for an invasive GAS phenotype.

Date/time Interval


  • 2007

Sponsor Award Id


  • 459103

Local Award Id


  • 9037