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Discovery mechanisms for quality control of extracellular protein folding

Grant


Scheme


  • Discovery Projects

Abstract


  • Extracellular protein misfolding underpins a variety of serious human diseases, including Alzheimerâ¬"s disease. Our recent results suggest that a primary quality control mechanism for extracellular protein folding is mediated by extracellular chaperones, which bind to misfolded client proteins and direct them to cell surface receptors where they are internalised and degraded in lysosomes. Our goals are to further characterise the interactions between chaperone-client protein complexes and cell surface receptors and, using an animal model, to show that these interactions are integral to an in vivo disposal mechanism for damaged proteins. This project may identify mechanisms suitable to target for the treatment of protein misfolding diseases.

Date/time Interval


  • 2007

Sponsor Award Id


  • DP0773555

Local Award Id


  • 8980

Scheme


  • Discovery Projects

Abstract


  • Extracellular protein misfolding underpins a variety of serious human diseases, including Alzheimerâ¬"s disease. Our recent results suggest that a primary quality control mechanism for extracellular protein folding is mediated by extracellular chaperones, which bind to misfolded client proteins and direct them to cell surface receptors where they are internalised and degraded in lysosomes. Our goals are to further characterise the interactions between chaperone-client protein complexes and cell surface receptors and, using an animal model, to show that these interactions are integral to an in vivo disposal mechanism for damaged proteins. This project may identify mechanisms suitable to target for the treatment of protein misfolding diseases.

Date/time Interval


  • 2007

Sponsor Award Id


  • DP0773555

Local Award Id


  • 8980