Skip to main content
placeholder image

Lifestyle Treatment of Cardiovascular Disease in patients with Type 2 Diabetes

Grant


Scheme


  • Cardiovascular Early-Mid Career Researcher Grants

Abstract


  • Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease (CVD). Peaks in blood glucose, particularly those following meals, promotes inflammation and damage to the artery wall, leading to narrowing of arteries. Diabetes and its related CVD complications are an extensive global health issue. The total estimated cost of diabetes in 2017 was $327 billion. Diet and exercise are the cornerstone of modifiable lifestyle therapies to target CVD in patients with T2D. However, evidence-based guidelines are not established. This project proposes a Randomised Clinical Trial (RCT) to address NSW Health Strategic Priority 5 that will test whether diet and/or exercise will improve the vascular health of patients with T2D. This research will address a significant gap in the management and treatment of CVD in T2D.Firstly, we will determine the efficacy of two lifestyle therapies, carbohydrate-restriction and postmeal exercise, to reduce CVD risk factors. Secondly, we will conduct a translational RCT (strategic priority 5.2) to test the effectiveness and adherence of these therapies in clinical practice, ultimately identifying which method best reduces diabetes-related CVD. These studies are novel as no previous research has targeted postmeal peaks in blood glucose with lifestyle treatment and comprehensively examined their effects on vascular function and cardiovascular health. These proposed studies will use novel technology to measure the impact of lifestyle interventions on the structure and function of human blood vessels. These techniques include non-invasive ultrasound and pulse-wave analysis to test dilation, wall thickness and stiffness of blood vessels in patients. These techniques are gold-standard, and can detect early manifestations of vascular disease. Our lab has developed a close working relationship with the Illawarra Shoalhaven Diabetes Service that will allow direct implementation of our findings into their clinical practice. A partnership grant is working towards improving the standard-care treatment for gestational diabetes (GDM) and a community engagement grant aims to prevent future diabetes in postpartum women. This is in addition to the current trial of postmeal exercise in type 2 diabetes. Together we are leading the way in lifestyle management of GDM in the Illawarra Shoalhaven LHD. The proposed knowledge translationC7 will provide further guidelines of exercise and diet for T2D, and thus inform clinical practice and poli

Date/time Interval


  • 2020

Local Award Id


  • 133081

Scheme


  • Cardiovascular Early-Mid Career Researcher Grants

Abstract


  • Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease (CVD). Peaks in blood glucose, particularly those following meals, promotes inflammation and damage to the artery wall, leading to narrowing of arteries. Diabetes and its related CVD complications are an extensive global health issue. The total estimated cost of diabetes in 2017 was $327 billion. Diet and exercise are the cornerstone of modifiable lifestyle therapies to target CVD in patients with T2D. However, evidence-based guidelines are not established. This project proposes a Randomised Clinical Trial (RCT) to address NSW Health Strategic Priority 5 that will test whether diet and/or exercise will improve the vascular health of patients with T2D. This research will address a significant gap in the management and treatment of CVD in T2D.Firstly, we will determine the efficacy of two lifestyle therapies, carbohydrate-restriction and postmeal exercise, to reduce CVD risk factors. Secondly, we will conduct a translational RCT (strategic priority 5.2) to test the effectiveness and adherence of these therapies in clinical practice, ultimately identifying which method best reduces diabetes-related CVD. These studies are novel as no previous research has targeted postmeal peaks in blood glucose with lifestyle treatment and comprehensively examined their effects on vascular function and cardiovascular health. These proposed studies will use novel technology to measure the impact of lifestyle interventions on the structure and function of human blood vessels. These techniques include non-invasive ultrasound and pulse-wave analysis to test dilation, wall thickness and stiffness of blood vessels in patients. These techniques are gold-standard, and can detect early manifestations of vascular disease. Our lab has developed a close working relationship with the Illawarra Shoalhaven Diabetes Service that will allow direct implementation of our findings into their clinical practice. A partnership grant is working towards improving the standard-care treatment for gestational diabetes (GDM) and a community engagement grant aims to prevent future diabetes in postpartum women. This is in addition to the current trial of postmeal exercise in type 2 diabetes. Together we are leading the way in lifestyle management of GDM in the Illawarra Shoalhaven LHD. The proposed knowledge translationC7 will provide further guidelines of exercise and diet for T2D, and thus inform clinical practice and poli

Date/time Interval


  • 2020

Local Award Id


  • 133081