Developing next generation mass spectrometry imaging with isomer resolution

Collaborating Organisation

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• Maastricht University  Research Organization
• Queensland University of Technology  Research Organization
• Waters Corporation  Research Organization

Scheme

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• Linkage Projects

Abstract

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• Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid isomers. Resolution of lipid isomers using this instrumentation will afford researchers a first glimpse of isomer-resolved images that will be used to visualise tissue-specific changes resulting from underlying chemical, physical or metabolic processes; changes that are currently invisible to contemporary imaging technologies.

Research Areas

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• 030101 - ANALYTICAL SPECTROMETRY
• 060101 - ANALYTICAL BIOCHEMISTRY
• 110104 - MEDICAL BIOCHEMISTRY: LIPIDS

Awarded By

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• Australian Research Council (ARC) 

Contributor

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• Ellis, Shane - Partner Investigator
• Mitchell, Todd - Chief Investigator

Geographic Focus

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• Australia 
• Netherlands 
• United States of America 

Geographic Focus

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• Australia  Country
• Netherlands  Country
• United States of America  Country

Sponsor Award Id

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• LP180100238

Local Award Id

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• 130177